Issues

The rhesus MHC class I allele, Mamu-B*05104, presents 4-mer lipopeptides to CTLs.

Its large, hydrophobic B pocket accommodates the acylated glycine as an anchor.

The T cell epitopic diversity appears to be limited for lipopeptides.

Hp inhibits osteoclastogenesis via the TLR4–IFN-β axis.

Hp acts as a ligand for TLR4.

Hp promotes IFN-β expression through TLR4.

We identified an ARF epitope NS1-ARF2_1–8, encoded by NS1 mRNA of influenza A virus.

NS1-ARF2_1–8 elicits robust immunodominant T_CD8+ response in infected BALB/c mice.

NS1-ARF2_1–8 precursor (14-residue peptide) has no detectable biological function.

Low-dosage p110δ inhibitor therapy prevents PTEN- but not SHP-1–driven autoimmunity.

Effective p110δ inhibitor dosages spare immune responses to exogenous immunogens.

Low-dosage p110δ inhibitor therapy delays T1D progression in VH125.NOD mice.

MAIT cells require glycolytic metabolism for their cytokine production.

MAIT cell glycolysis is regulated by mTORC1 and SLC7A5.

MAIT cells display defective glycolytic metabolism in obese adults.

Loss of glia limitans and infiltration of T cells in the SN is evident in a monkey model of PD.

Oral maraviroc protected the endothelial monolayer and reduced T cell infiltration.

Oral maraviroc protected the nigrostriatum and improved locomotor activities.

Combined deficiency of Ssb1 and Ssb2 abrogates early B cell development.

SSB1/2 depletion causes defects in proliferation, genome fragility, and apoptosis.

Mature B cells largely tolerate SSB1/2 loss.

ISWI ATPase Smarca5 guides developmental mRNA program of β-selected thymocytes.

Inactivation of Smarca5 gene in developing thymocytes activates p53 and apoptosis.

Smarca5 regulates cell fate decisions of γδ thymocytes and survival of pro-B cells.

DCs engineered to overexpress 1,25(OH)₂D and RA augment gut-homing Treg cell induction.

Transfer of the engineered DCs robustly suppresses ongoing experimental colitis.

The engineered DCs require Foxp3⁺ Treg cells to maximally suppress experimental colitis.

TILs can be grown from primary bladder tumors.

Neoantigen-reactive TILs can be isolated from a bladder tumor specimen.

GSDMD-deficient mice are more susceptible to melioidosis.

In vivo production of IL-1β by neutrophils is independent of GSDMD.

GSDMD and pyroptosis are directly microbicidal.

PGE₂ treatment reduces the ability of PMN to kill Listeria monocytogenes.

Cells from the livers of infected BALB mice produced more PGE₂ than those from C57BL/6 mice.

Murine SIDT1 colocalizes with late endolysosomes and interacts with long dsRNA [poly(I:C)] but not siRNA or dsDNA.

SIDT1 expression is induced following type I IFN and poly(I:C) stimulation.

Loss of SIDT1 impairs IFNβ production following infection with HSV-1 but does not affect overall survival.

The bat MHC I exhibits distinctive structural characteristics.

Significant differences exist in the peptidome between inside the cell and outside the cell.

A cluster of uniquely inserted residues may help promote high-affinity peptide binding.

H2-relaxin–specific T cells are detected in the blood of healthy donors.

T cell response to H2-relaxin relies on several CD4 T cell epitopes.

An H2-relaxin–specific T cell repertoire might account for its clinical immunogenicity.

IL-3 induces allograft fibrosis and chronic rejection of heart transplants.

IL-3 exerts profibrotic effects by activation of infiltrating basophils.

IL-6 is an important basophil-derived mediator of fibrosis.

A single delivery of R-DOTAP plus peptide Ag induces regression of large tumors.

R-DOTAP possesses intrinsic immunostimulatory activity mediated by type I IFN.

R-DOTAP activity requires Myd88 but not STING or TRIF, and it activates TLR7 and 9.