Issues
EDITORIAL
INVITED COMMENTARY
Immunity to Influenza: Catching a Moving Target To Improve Vaccine Design
IN THIS ISSUE
BRIEF REVIEWS
Original Antigenic Sin: How First Exposure Shapes Lifelong Anti–Influenza Virus Immune Responses
Influenza Pathogenesis: The Effect of Host Factors on Severity of Disease
With a Little Help from T Follicular Helper Friends: Humoral Immunity to Influenza Vaccination
CUTTING EDGE
Cutting Edge: T Cell–Dependent Plasmablasts Form in the Absence of Single Differentiated CD4+ T Cell Subsets
AUTOIMMUNITY
Deficiency of β-Arrestin 2 in Dendritic Cells Contributes to Autoimmune Diseases
CLINICAL AND HUMAN IMMUNOLOGY
HBHA-Induced Polycytotoxic CD4+ T Lymphocytes Are Associated with the Control of Mycobacterium tuberculosis Infection in Humans
IMMUNE REGULATION
Zip6 Transporter Is an Essential Component of the Lymphocyte Activation Machinery
IMMUNOTHERAPY AND VACCINES
The Vacuolar Pathway of Long Peptide Cross-Presentation Can Be TAP Dependent
INFECTIOUS DISEASE AND HOST RESPONSE
Aging of Antiviral CD8+ Memory T Cells Fosters Increased Survival, Metabolic Adaptations, and Lymphoid Tissue Homing
Influenza A Virus Infection Induces Muscle Wasting via IL-6 Regulation of the E3 Ubiquitin Ligase Atrogin-1
Hif-1α–Induced Expression of Il-1β Protects against Mycobacterial Infection in Zebrafish
Complement Activation Occurs at the Surface of Platelets Activated by Streptococcal M1 Protein and This Results in Phagocytosis of Platelets
Development of Inflammatory Hypoxia and Prevalence of Glycolytic Metabolism in Progressing Herpes Stromal Keratitis Lesions
INNATE IMMUNITY AND INFLAMMATION
G2A Protects Mice against Sepsis by Modulating Kupffer Cell Activation: Cooperativity with Adenosine Receptor 2b
Charcot–Leyden Crystals Activate the NLRP3 Inflammasome and Cause IL-1β Inflammation in Human Macrophages
Zebrafish MVP Recruits and Degrades TBK1 To Suppress IFN Production
Mettl3 Deficiency Sustains Long-Chain Fatty Acid Absorption through Suppressing Traf6-Dependent Inflammation Response
MOLECULAR AND STRUCTURAL IMMUNOLOGY
The mTORC1/4E-BP/eIF4E Axis Promotes Antibody Class Switching in B Lymphocytes
Extent of MHC Clustering Regulates Selectivity and Effectiveness of T Cell Responses
MUCOSAL IMMUNOLOGY
IL-33 Induces Murine Intestinal Goblet Cell Differentiation Indirectly via Innate Lymphoid Cell IL-13 Secretion
NOVEL IMMUNOLOGICAL METHODS
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Cover Image
Cover Image
On the cover: Images from the influenza (flu) epidemic of 1918. Upper left, Policemen in Seattle, WA, wearing Red Cross masks during the flu epidemic (photograph courtesy of National Archives and Records Administration: https://catalog.archives.gov/id/45499339). Upper right, Illustration showing the “Spanish Flu”: a devil rising from pools of saliva, reaching out to attack, with text saying “stop spitting—everybody” (retrieved from George F. Tyler Poster Collection, Temple University Libraries). Lower left, Digitally colorized negative-stained transmission electron microscopic image shows re-created flu virions collected from supernatants of 1918-infected Madin–Darby canine kidney cell cultures 18 h after infection (photograph courtesy of Centers for Disease Control/Dr. Terrence Tumpey, credit Cythia Goldsmith: https://phil.cdc.gov/Details.aspx?pid=11098). Middle panel, Physicians vaccinating each other during the flu epidemic (photograph retrieved from Hamilton H. Dobbin collection, California State Library). Lower right, Poster features a Red Cross nurse with a gauze mask over her nose and mouth. Poster text provides tips to prevent flu (Illustrated Current News, 1918. Retrieved from National Library of Medicine: https://collections.nlm.nih.gov/catalog/nlm:nlmuid-101580385-img).
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