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Volume 202, Issue 3
1 February 2019
Issue Cover
ISSN 0022-1767
EISSN 1550-6606

IN THIS ISSUE

In This Issue
J Immunol (2019) 202 (3): 627–628.
View articletitled, In This Issue
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PILLARS OF IMMUNOLOGY

The Tale of IL-12 and IL-23: A Paradigm Shift
Shabaana A. Khader; Shyamala Thirunavukkarasu
J Immunol (2019) 202 (3): 629–630.
View articletitled, The Tale of IL-12 and IL-23: A Paradigm Shift
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BRIEF REVIEWS

Manipulation of Ambient Housing Temperature To Study the Impact of Chronic Stress on Immunity and Cancer in Mice
Bonnie L. Hylander; Christopher J. Gordon; Elizabeth A. Repasky
J Immunol (2019) 202 (3): 631–636.
View articletitled, Manipulation of Ambient Housing Temperature To Study the Impact of Chronic Stress on Immunity and Cancer in Mice
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Dual TCR T Cells: Identity Crisis or Multitaskers?
Nathaniel J. Schuldt; Bryce A. Binstadt
J Immunol (2019) 202 (3): 637–644.
View articletitled, Dual TCR T Cells: Identity Crisis or Multitaskers?
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CUTTING EDGE

Cutting Edge: Early Attrition of Memory T Cells during Inflammation and Costimulation Blockade Is Regulated Concurrently by Proapoptotic Proteins Fas and Bim
Sonal Jangalwe; Varun N. Kapoor; Jia Xu; Nomeda Girnius; Norman J. Kennedy; Yvonne J. K. Edwards; Raymond M. Welsh; Roger J. Davis; Michael A. Brehm
J Immunol (2019) 202 (3): 647–651.
View articletitled, Cutting Edge: Early Attrition of Memory T Cells during Inflammation and Costimulation Blockade Is Regulated Concurrently by Proapoptotic Proteins Fas and Bim
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ANTIGEN RECOGNITION AND RESPONSES

Classical Type 1 Dendritic Cells Dominate Priming of Th1 Responses to Herpes Simplex Virus Type 1 Skin Infection
Christopher M. Harpur; Yu Kato; Shinta T. Dewi; Sanda Stankovic; Darryl N. Johnson; Sammy Bedoui; Paul G. Whitney; Mireille H. Lahoud; Irina Caminschi; William R. Heath; Andrew G. Brooks; Thomas Gebhardt
J Immunol (2019) 202 (3): 653–663.
View articletitled, Classical Type 1 Dendritic Cells Dominate Priming of Th1 Responses to Herpes Simplex Virus Type 1 Skin Infection
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AUTOIMMUNITY

B Cell ADAM10 Controls Murine Lupus Progression through Regulation of the ICOS:ICOS Ligand Axis
Joseph C. Lownik; Jessica L. Wimberly; Daniel H. Conrad; Rebecca K. Martin
J Immunol (2019) 202 (3): 664–674.
View articletitled, B Cell ADAM10 Controls Murine Lupus Progression through Regulation of the ICOS:ICOS Ligand Axis
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Lupus-Associated Immune Complexes Activate Human Neutrophils in an FcγRIIA-Dependent but TLR-Independent Response
Ramon G. Bonegio; Jessica D. Lin; Britte Beaudette-Zlatanova; Michael R. York; Hanni Menn-Josephy; Kei Yasuda
J Immunol (2019) 202 (3): 675–683.
View articletitled, Lupus-Associated Immune Complexes Activate Human Neutrophils in an FcγRIIA-Dependent but TLR-Independent Response
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CLINICAL AND HUMAN IMMUNOLOGY

High-Dose IL-2 Skews a Glucocorticoid-Driven IL-17+IL-10+ Memory CD4+ T Cell Response towards a Single IL-10–Producing Phenotype
Elizabeth H. Mann; Leona Gabryšová; Paul E. Pfeffer; Anne O’Garra; Catherine M. Hawrylowicz
J Immunol (2019) 202 (3): 684–693.
View articletitled, High-Dose IL-2 Skews a Glucocorticoid-Driven IL-17<sup>+</sup>IL-10<sup>+</sup> Memory CD4<sup>+</sup> T Cell Response towards a Single IL-10–Producing Phenotype
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Expression of a Functional IL-2 Receptor in Vascular Smooth Muscle Cells
Prakash Arumugam; Katie L. Carroll; Scott A. Berceli; Spencer Barnhill; Lucile E. Wrenshall
J Immunol (2019) 202 (3): 694–703.
View articletitled, Expression of a Functional IL-2 Receptor in Vascular Smooth Muscle Cells
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IMMUNE REGULATION

BCL6-Mediated Silencing of PD-1 Ligands in Germinal Center B Cells Maintains Follicular T Cell Population
Cheng Peng; Qianwen Hu; Fang Yang; Heng Zhang; Fubin Li; Chuanxin Huang
J Immunol (2019) 202 (3): 704–713.
View articletitled, BCL6-Mediated Silencing of PD-1 Ligands in Germinal Center B Cells Maintains Follicular T Cell Population
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Costimulation through TLR2 Drives Polyfunctional CD8+ T Cell Responses
Fiamma Salerno; Julian J. Freen-van Heeren; Aurelie Guislain; Benoit P. Nicolet; Monika C. Wolkers
J Immunol (2019) 202 (3): 714–723.
View articletitled, Costimulation through TLR2 Drives Polyfunctional CD8<sup>+</sup> T Cell Responses
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Ectonucleotidase Expression on Human Amnion Epithelial Cells: Adenosinergic Pathways and Dichotomic Effects on Immune Effector Cell Populations
Fabio Morandi; Alberto L. Horenstein; Valeria Quarona; Angelo Corso Faini; Barbara Castella; Raghuraman C. Srinivasan; Stephen C. Strom; Fabio Malavasi; Roberto Gramignoli
J Immunol (2019) 202 (3): 724–735.
View articletitled, Ectonucleotidase Expression on Human Amnion Epithelial Cells: Adenosinergic Pathways and Dichotomic Effects on Immune Effector Cell Populations
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Induction of the BIM Short Splice Variant Sensitizes Proliferating NK Cells to IL-15 Withdrawal
Benedikt Jacobs; Aline Pfefferle; Dennis Clement; Axel Berg-Larsen; Michelle L. Saetersmoen; Susanne Lorenz; Merete Thune Wiiger; Jodie P. Goodridge; Karl-Johan Malmberg
J Immunol (2019) 202 (3): 736–746.
View articletitled, Induction of the BIM Short Splice Variant Sensitizes Proliferating NK Cells to IL-15 Withdrawal
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Activation of the Omega-3 Fatty Acid Receptor GPR120 Protects against Focal Cerebral Ischemic Injury by Preventing Inflammation and Apoptosis in Mice
Zhiping Ren; Lin Chen; Yimeng Wang; Xinbing Wei; Shenglan Zeng; Yi Zheng; Chengjiang Gao; Huiqing Liu
J Immunol (2019) 202 (3): 747–759.
View articletitled, Activation of the Omega-3 Fatty Acid Receptor GPR120 Protects against Focal Cerebral Ischemic Injury by Preventing Inflammation and Apoptosis in Mice
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SRC3 Is a Cofactor for RORγt in Th17 Differentiation but Not Thymocyte Development
Zhiheng He; Jing Zhang; Qian Du; Jianming Xu; Yousang Gwack; Zuoming Sun
J Immunol (2019) 202 (3): 760–769.
View articletitled, SRC3 Is a Cofactor for RORγt in Th17 Differentiation but Not Thymocyte Development
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IMMUNE SYSTEM DEVELOPMENT

NOTCH Activation at the Hematovascular Mesoderm Stage Facilitates Efficient Generation of T Cells with High Proliferation Potential from Human Pluripotent Stem Cells
Akhilesh Kumar; Jeong Hee Lee; Kran Suknuntha; Saritha S. D’Souza; Abir S. Thakur; Igor I. Slukvin
J Immunol (2019) 202 (3): 770–776.
View articletitled, NOTCH Activation at the Hematovascular Mesoderm Stage Facilitates Efficient Generation of T Cells with High Proliferation Potential from Human Pluripotent Stem Cells
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IMMUNOGENETICS

Common Heritable Immunological Variations Revealed in Genetically Diverse Inbred Mouse Strains of the Collaborative Cross
Roxanne Collin; Lois Balmer; Grant Morahan; Sylvie Lesage
J Immunol (2019) 202 (3): 777–786.
View articletitled, Common Heritable Immunological Variations Revealed in Genetically Diverse Inbred Mouse Strains of the Collaborative Cross
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IMMUNOTHERAPY AND VACCINES

IL-6 Signaling Blockade during CD40-Mediated Immune Activation Favors Antitumor Factors by Reducing TGF-β, Collagen Type I, and PD-L1/PD-1
Emma Eriksson; Ioanna Milenova; Jessica Wenthe; Rafael Moreno; Ramon Alemany; Angelica Loskog
J Immunol (2019) 202 (3): 787–798.
View articletitled, IL-6 Signaling Blockade during CD40-Mediated Immune Activation Favors Antitumor Factors by Reducing TGF-β, Collagen Type I, and PD-L1/PD-1
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INFECTIOUS DISEASE AND HOST RESPONSE

Human Anti–HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1
Melissa A. Gawron; Mark Duval; Claudia Carbone; Smita Jaiswal; Aaron Wallace; Joseph C. Martin, III; Ann Dauphin; Michael A. Brehm; Dale L. Greiner; Leonard D. Shultz; Jeremy Luban; Lisa A. Cavacini
J Immunol (2019) 202 (3): 799–804.
View articletitled, Human Anti–HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1
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Hepatitis B Virus Inhibits Neutrophil Extracellular Trap Release by Modulating Reactive Oxygen Species Production and Autophagy
Shengnan Hu; Xiaowen Liu; Ying Gao; Rongfang Zhou; Muyun Wei; Jing Dong; Huili Yan; Yueran Zhao
J Immunol (2019) 202 (3): 805–815.
View articletitled, Hepatitis B Virus Inhibits Neutrophil Extracellular Trap Release by Modulating Reactive Oxygen Species Production and Autophagy
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HIV Interferes with the Dendritic Cell–T Cell Axis of Macrophage Activation by Shifting Mycobacterium tuberculosis–Specific CD4 T Cells into a Dysfunctional Phenotype
Susmita K. Singh; Marie Larsson; Thomas Schön; Olle Stendahl; Robert Blomgran
J Immunol (2019) 202 (3): 816–826.
View articletitled, HIV Interferes with the Dendritic Cell–T Cell Axis of Macrophage Activation by Shifting <em>Mycobacterium tuberculosis</em>–Specific CD4 T Cells into a Dysfunctional Phenotype
Supplementary data
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Leishmania donovani Exploits Macrophage Heme Oxygenase-1 To Neutralize Oxidative Burst and TLR Signaling–Dependent Host Defense
Shriya Saha; Moumita Basu; Subham Guin; Purnima Gupta; Anna-Maria Mitterstiller; Guenter Weiss; Kuladip Jana; Anindita Ukil
J Immunol (2019) 202 (3): 827–840.
View articletitled, <em>Leishmania donovani</em> Exploits Macrophage Heme Oxygenase-1 To Neutralize Oxidative Burst and TLR Signaling–Dependent Host Defense
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Suppression of the IFN-α and -β Induction through Sequestering IRF7 into Viral Inclusion Bodies by Nonstructural Protein NSs in Severe Fever with Thrombocytopenia Syndrome Bunyavirus Infection
Ye Hong; Maosheng Bai; Xian Qi; Chuan Li; Mifang Liang; Dexin Li; Carol J. Cardona; Zheng Xing
J Immunol (2019) 202 (3): 841–856.
View articletitled, Suppression of the IFN-α and -β Induction through Sequestering IRF7 into Viral Inclusion Bodies by Nonstructural Protein NSs in Severe Fever with Thrombocytopenia Syndrome Bunyavirus Infection
Supplementary data
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CK11, a Teleost Chemokine with a Potent Antimicrobial Activity
Estefanía Muñoz-Atienza; Carolina Aquilino; Khairul Syahputra; Azmi Al-Jubury; Carlos Araújo; Jakob Skov; Per W. Kania; Pablo E. Hernández; Kurt Buchmann; Luis M. Cintas; Carolina Tafalla
J Immunol (2019) 202 (3): 857–870.
View articletitled, CK11, a Teleost Chemokine with a Potent Antimicrobial Activity
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INNATE IMMUNITY AND INFLAMMATION

Critical Adverse Impact of IL-6 in Acute Pneumovirus Infection
Caroline M. Percopo; Michelle Ma; Todd A. Brenner; Julia O. Krumholz; Timothy J. Break; Karen Laky; Helene F. Rosenberg
J Immunol (2019) 202 (3): 871–882.
View articletitled, Critical Adverse Impact of IL-6 in Acute Pneumovirus Infection
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ATP-Gated P2X7 Receptors Require Chloride Channels To Promote Inflammation in Human Macrophages
Laura Janks; Randy S. Sprague; Terrance M. Egan
J Immunol (2019) 202 (3): 883–898.
View articletitled, ATP-Gated P2X7 Receptors Require Chloride Channels To Promote Inflammation in Human Macrophages
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IRAK-M Associates with Susceptibility to Adult-Onset Asthma and Promotes Chronic Airway Inflammation
Yi Liu; Mingqiang Zhang; Lili Lou; Lun Li; Youming Zhang; Wei Chen; Weixun Zhou; Yan Bai; Jinming Gao
J Immunol (2019) 202 (3): 899–911.
View articletitled, IRAK-M Associates with Susceptibility to Adult-Onset Asthma and Promotes Chronic Airway Inflammation
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CXCL4L1 Promoter Polymorphisms Are Associated with Improved Renal Function in Type 1 Diabetes
Tabea Armbrust; Meredith Paige Millis; Maria Lucrecia Alvarez; Aramesh Saremi; Johanna Kay DiStefano; Mahtab Nourbakhsh
J Immunol (2019) 202 (3): 912–919.
View articletitled, CXCL4L1 Promoter Polymorphisms Are Associated with Improved Renal Function in Type 1 Diabetes
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IRF5 Is Required for Bacterial Clearance in Human M1-Polarized Macrophages, and IRF5 Immune-Mediated Disease Risk Variants Modulate This Outcome
Matija Hedl; Jie Yan; Heiko Witt; Clara Abraham
J Immunol (2019) 202 (3): 920–930.
View articletitled, IRF5 Is Required for Bacterial Clearance in Human M1-Polarized Macrophages, and <em>IRF5</em> Immune-Mediated Disease Risk Variants Modulate This Outcome
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GM-CSF Administration Improves Defects in Innate Immunity and Sepsis Survival in Obese Diabetic Mice
Lynn M. Frydrych; Guowu Bian; Fatemeh Fattahi; Susan B. Morris; Robert W. O’Rourke; Carey N. Lumeng; Steven L. Kunkel; Peter A. Ward; Matthew J. Delano
J Immunol (2019) 202 (3): 931–942.
View articletitled, GM-CSF Administration Improves Defects in Innate Immunity and Sepsis Survival in Obese Diabetic Mice
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MUCOSAL IMMUNOLOGY

IL-33 Augments Virus-Specific Memory T Cell Inflation and Potentiates the Efficacy of an Attenuated Cytomegalovirus-Based Vaccine
James E. McLaren; Mathew Clement; Morgan Marsden; Kelly L. Miners; Sian Llewellyn-Lacey; Emma J. Grant; Anzelika Rubina; Silvia Gimeno Brias; Emma Gostick; Maria A. Stacey; Selinda J. Orr; Richard J. Stanton; Kristin Ladell; David A. Price; Ian R. Humphreys
J Immunol (2019) 202 (3): 943–955.
View articletitled, IL-33 Augments Virus-Specific Memory T Cell Inflation and Potentiates the Efficacy of an Attenuated Cytomegalovirus-Based Vaccine
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IL-22 Preserves Gut Epithelial Integrity and Promotes Disease Remission during Chronic Salmonella Infection
Bernard C. Lo; Samuel B. Shin; Diana Canals Hernaez; Ido Refaeli; Hong B. Yu; Verena Goebeler; Alissa Cait; William W. Mohn; Bruce A. Vallance; Kelly M. McNagny
J Immunol (2019) 202 (3): 956–965.
View articletitled, IL-22 Preserves Gut Epithelial Integrity and Promotes Disease Remission during Chronic <em>Salmonella</em> Infection
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SYSTEMS IMMUNOLOGY

PSMB11 Orchestrates the Development of CD4 and CD8 Thymocytes via Regulation of Gene Expression in Cortical Thymic Epithelial Cells
Anca Apavaloaei; Sylvie Brochu; Mengqi Dong; Alexandre Rouette; Marie-Pierre Hardy; Geno Villafano; Shigeo Murata; Heather J. Melichar; Claude Perreault
J Immunol (2019) 202 (3): 966–978.
View articletitled, PSMB11 Orchestrates the Development of CD4 and CD8 Thymocytes via Regulation of Gene Expression in Cortical Thymic Epithelial Cells
Supplementary data
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Antigen-Specific TCR Signatures of Cytomegalovirus Infection
Alina Huth; Xiaoling Liang; Stefan Krebs; Helmut Blum; Andreas Moosmann
J Immunol (2019) 202 (3): 979–990.
View articletitled, Antigen-Specific TCR Signatures of Cytomegalovirus Infection
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TUMOR IMMUNOLOGY

Transthyretin Stimulates Tumor Growth through Regulation of Tumor, Immune, and Endothelial Cells
Chih-Chun Lee; Xinchun Ding; Ting Zhao; Lingyan Wu; Susan Perkins; Hong Du; Cong Yan
J Immunol (2019) 202 (3): 991–1002.
View articletitled, Transthyretin Stimulates Tumor Growth through Regulation of Tumor, Immune, and Endothelial Cells
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NOVEL IMMUNOLOGICAL METHODS

Inflammasome and Caspase-1 Activity Characterization and Evaluation: An Imaging Flow Cytometer–Based Detection and Assessment of Inflammasome Specks and Caspase-1 Activation
Abhinit Nagar; Richard A. DeMarco; Jonathan A. Harton
J Immunol (2019) 202 (3): 1003–1015.
View articletitled, Inflammasome and Caspase-1 Activity Characterization and Evaluation: An Imaging Flow Cytometer–Based Detection and Assessment of Inflammasome Specks and Caspase-1 Activation
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  • Cover Image

    Cover Image

    issue cover

    On the cover: The CK11 rainbow trout chemokine has a strong antiparasitic activity against Ichthyophthirius multifiliis, a parasitic ciliate that infects skin and gills of different fish species. Shown is a scanning electron micrograph of the parasite. Muñoz-Atienza, E., C. Aquilino, K. Syahputra, A. Al-Jubury, C. Araújo, J. Skov, P. W. Kania, P. E. Hernández, K. Buchmann, L. M. Cintas, and C. Tafalla. 2019. CK11, a teleost chemokine with a potent antimicrobial activity. J. Immunol. 202: 857–870.

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