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Volume 202, Issue 5
1 March 2019
Issue Cover
ISSN 0022-1767
EISSN 1550-6606

IN THIS ISSUE

In This Issue
J Immunol (2019) 202 (5): 1313.
View articletitled, In This Issue
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PILLARS OF IMMUNOLOGY

From RAG2 to T Cell Riches and Future Fortunes
Rebecca A. Glynn; Craig H. Bassing
J Immunol (2019) 202 (5): 1315–1316.
View articletitled, From RAG2 to T Cell Riches and Future Fortunes
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Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. Science. 1993. 259: 822-825
Yoichi Shinkai; Shigeo Koyasu; Kei-ichi Nakayama; Kenneth M. Murphy; Dennis Y. Loh; Ellis L. Reinherz; Frederick W. Alt
J Immunol (2019) 202 (5): 1317–1320.
View articletitled, Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. <em>Science</em>. 1993. 259: 822-825
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BRIEF REVIEWS

The Immune Function of Tuft Cells at Gut Mucosal Surfaces and Beyond
Hung-An Ting; Jakob von Moltke
J Immunol (2019) 202 (5): 1321–1329.
View articletitled, The Immune Function of Tuft Cells at Gut Mucosal Surfaces and Beyond
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ALLERGY AND OTHER HYPERSENSITIVITIES

Nrf2 Suppresses Allergic Lung Inflammation by Attenuating the Type 2 Innate Lymphoid Cell Response
Ryuichi Nagashima; Hitomi Kosai; Masahiro Masuo; Keiko Izumiyama; Taketo Noshikawaji; Motoko Morimoto; Satoru Kumaki; Yasunari Miyazaki; Hozumi Motohashi; Masayuki Yamamoto; Nobuyuki Tanaka
J Immunol (2019) 202 (5): 1331–1339.
View articletitled, Nrf2 Suppresses Allergic Lung Inflammation by Attenuating the Type 2 Innate Lymphoid Cell Response
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ANTIGEN RECOGNITION AND RESPONSES

Poor Antigen Processing of Poxvirus Particles Limits CD4+ T Cell Recognition and Impacts Immunogenicity of the Inactivated Vaccine
Katherine S. Forsyth; Brian DeHaven; Mark Mendonca; Sinu Paul; Alessandro Sette; Laurence C. Eisenlohr
J Immunol (2019) 202 (5): 1340–1349.
View articletitled, Poor Antigen Processing of Poxvirus Particles Limits CD4<sup>+</sup> T Cell Recognition and Impacts Immunogenicity of the Inactivated Vaccine
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AUTOIMMUNITY

MYMD-1, a Novel Immunometabolic Regulator, Ameliorates Autoimmune Thyroiditis via Suppression of Th1 Responses and TNF-α Release
Giulia Di Dalmazi; Paulina Chalan; Patrizio Caturegli
J Immunol (2019) 202 (5): 1350–1362.
View articletitled, MYMD-1, a Novel Immunometabolic Regulator, Ameliorates Autoimmune Thyroiditis via Suppression of Th1 Responses and TNF-α Release
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CLINICAL AND HUMAN IMMUNOLOGY

Upregulation of Chitinase 1 in Alveolar Macrophages of HIV-Infected Smokers
Eric C. Logue; C. Preston Neff; Douglas G. Mack; Allison K. Martin; Suzanne Fiorillo; James Lavelle; R. William Vandivier; Thomas B. Campbell; Brent E. Palmer; Andrew P. Fontenot
J Immunol (2019) 202 (5): 1363–1372.
View articletitled, Upregulation of Chitinase 1 in Alveolar Macrophages of HIV-Infected Smokers
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Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance
Simon Glatigny; Barbara Höllbacher; Samantha J. Motley; Cathy Tan; Christian Hundhausen; Jane H. Buckner; Dawn Smilek; Samia J. Khoury; Linna Ding; Tielin Qin; Jorge Pardo; Gerald T. Nepom; Laurence A. Turka; Kristina M. Harris; Daniel J. Campbell; Estelle Bettelli
J Immunol (2019) 202 (5): 1373–1382.
View articletitled, Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance
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IMMUNE REGULATION

The B Cell Activation-Induced miR-183 Cluster Plays a Minimal Role in Canonical Primary Humoral Responses
Joseph N. Pucella; Montserrat Cols; Wei-Feng Yen; Shunbin Xu; Jayanta Chaudhuri
J Immunol (2019) 202 (5): 1383–1396.
View articletitled, The B Cell Activation-Induced miR-183 Cluster Plays a Minimal Role in Canonical Primary Humoral Responses
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The PI3K p110δ Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function
Stalin Chellappa; Kushi Kushekhar; Ludvig A. Munthe; Geir E. Tjønnfjord; Einar M. Aandahl; Klaus Okkenhaug; Kjetil Taskén
J Immunol (2019) 202 (5): 1397–1405.
View articletitled, The PI3K p110δ Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function
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ARTD1 in Myeloid Cells Controls the IL-12/18–IFN-γ Axis in a Model of Sterile Sepsis, Chronic Bacterial Infection, and Cancer
Friedrich A. Kunze; Michael Bauer; Juliana Komuczki; Margit Lanzinger; Kapila Gunasekera; Ann-Katrin Hopp; Mareike Lehmann; Burkhard Becher; Anne Müller; Michael O. Hottiger
J Immunol (2019) 202 (5): 1406–1416.
View articletitled, ARTD1 in Myeloid Cells Controls the IL-12/18–IFN-γ Axis in a Model of Sterile Sepsis, Chronic Bacterial Infection, and Cancer
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Differences in Self-Recognition between Secreted Antibody and Membrane-Bound B Cell Antigen Receptor
Joseena Iype; Moumita Datta; Ahmad Khadour; Rudolf Übelhart; Antonella Nicolò; Tim Rollenske; Marcus Dühren-von Minden; Hedda Wardemann; Palash C. Maity; Hassan Jumaa
J Immunol (2019) 202 (5): 1417–1427.
View articletitled, Differences in Self-Recognition between Secreted Antibody and Membrane-Bound B Cell Antigen Receptor
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Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis
Nayuta Saito; Jun Araya; Saburo Ito; Kazuya Tsubouchi; Shunsuke Minagawa; Hiromichi Hara; Akihiko Ito; Takayuki Nakano; Yusuke Hosaka; Akihiro Ichikawa; Tsukasa Kadota; Masahiro Yoshida; Yu Fujita; Hirofumi Utsumi; Yusuke Kurita; Kenji Kobayashi; Mitsuo Hashimoto; Hiroshi Wakui; Takanori Numata; Yumi Kaneko; Hisatoshi Asano; Makoto Odaka; Takashi Ohtsuka; Toshiaki Morikawa; Katsutoshi Nakayama; Kazuyoshi Kuwano
J Immunol (2019) 202 (5): 1428–1440.
View articletitled, Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis
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Akt-1 and Akt-2 Differentially Regulate the Development of Experimental Autoimmune Encephalomyelitis by Controlling Proliferation of Thymus-Derived Regulatory T Cells
Song Ouyang; Qiuming Zeng; Na Tang; Hui Guo; Rong Tang; Weifan Yin; Aimin Wang; Hongyu Tang; Jiru Zhou; Hong Xie; Wallace Y. Langdon; Huan Yang; Jian Zhang
J Immunol (2019) 202 (5): 1441–1452.
View articletitled, Akt-1 and Akt-2 Differentially Regulate the Development of Experimental Autoimmune Encephalomyelitis by Controlling Proliferation of Thymus-Derived Regulatory T Cells
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INFECTIOUS DISEASE AND HOST RESPONSE

Resolution of Cutaneous Leishmaniasis and Persistence of Leishmania major in the Absence of Arginase 1
Katrin Paduch; Andrea Debus; Baplu Rai; Ulrike Schleicher; Christian Bogdan
J Immunol (2019) 202 (5): 1453–1464.
View articletitled, Resolution of Cutaneous Leishmaniasis and Persistence of <em>Leishmania major</em> in the Absence of Arginase 1
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HIV, Cytomegalovirus, and Malaria Infections during Pregnancy Lead to Inflammation and Shifts in Memory B Cell Subsets in Kenyan Neonates
Kee Thai Yeo; Paula Embury; Timothy Anderson; Peter Mungai; Indu Malhotra; Christopher King; James Kazura; Arlene Dent
J Immunol (2019) 202 (5): 1465–1478.
View articletitled, HIV, Cytomegalovirus, and Malaria Infections during Pregnancy Lead to Inflammation and Shifts in Memory B Cell Subsets in Kenyan Neonates
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Rel-Dependent Immune and Central Nervous System Mechanisms Control Viral Replication and Inflammation during Mouse Herpes Simplex Encephalitis
Mathieu Mancini; Grégory Caignard; Benoît Charbonneau; Anne Dumaine; Nila Wu; Gabriel A. Leiva-Torres; Steve Gerondakis; Angela Pearson; Salman T. Qureshi; Robert Sladek; Silvia M. Vidal
J Immunol (2019) 202 (5): 1479–1493.
View articletitled, <em>Rel</em>-Dependent Immune and Central Nervous System Mechanisms Control Viral Replication and Inflammation during Mouse Herpes Simplex Encephalitis
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Coexistent Helminth Infection–Mediated Modulation of Chemokine Responses in Latent Tuberculosis
Anuradha Rajamanickam; Saravanan Munisankar; Yukthi Bhootra; Chandra Kumar Dolla; Thomas B. Nutman; Subash Babu
J Immunol (2019) 202 (5): 1494–1500.
View articletitled, Coexistent Helminth Infection–Mediated Modulation of Chemokine Responses in Latent Tuberculosis
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INNATE IMMUNITY AND INFLAMMATION

LRP1 Controls TNF Release via the TIMP-3/ADAM17 Axis in Endotoxin-Activated Macrophages
Kristin Schubert; Laura E. Collins; Patricia Green; Hideaki Nagase; Linda Troeberg
J Immunol (2019) 202 (5): 1501–1509.
View articletitled, LRP1 Controls TNF Release via the TIMP-3/ADAM17 Axis in Endotoxin-Activated Macrophages
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Gαi2 Signaling Regulates Inflammasome Priming and Cytokine Production by Biasing Macrophage Phenotype Determination
Ali Vural; Neel R. Nabar; Il-Young Hwang; Silke Sohn; Chung Park; Mikael C. I. Karlsson; Joe B. Blumer; John H. Kehrl
J Immunol (2019) 202 (5): 1510–1520.
View articletitled, Gα<sub>i2</sub> Signaling Regulates Inflammasome Priming and Cytokine Production by Biasing Macrophage Phenotype Determination
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Hydroxylase Inhibition Selectively Induces Cell Death in Monocytes
Bianca Crifo; Bettina Schaible; Eric Brown; Doug N. Halligan; Carsten C. Scholz; Susan F. Fitzpatrick; Anna Kirwan; Helen M. Roche; Mattia Criscuoli; Antonella Naldini; Hugh Giffney; Daniel Crean; Alfonso Blanco; Miguel A. Cavadas; Eoin P. Cummins; Zsolt Fabian; Cormac T. Taylor
J Immunol (2019) 202 (5): 1521–1530.
View articletitled, Hydroxylase Inhibition Selectively Induces Cell Death in Monocytes
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Hypercholesterolemia Induces a Mast Cell–CD4+ T Cell Interaction in Atherosclerosis
Eva Kritikou; Thomas van der Heijden; Maarten Swart; Janine van Duijn; Bram Slütter; Anouk Wezel; Harm J. Smeets; Pasquale Maffia; Johan Kuiper; Ilze Bot
J Immunol (2019) 202 (5): 1531–1539.
View articletitled, Hypercholesterolemia Induces a Mast Cell–CD4<sup>+</sup> T Cell Interaction in Atherosclerosis
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IL-17A Recruits Rab35 to IL-17R to Mediate PKCα-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility
Katarzyna Bulek; Xing Chen; Vandy Parron; Aparna Sundaram; Tomasz Herjan; Suidong Ouyang; Caini Liu; Alana Majors; Jarod Zepp; Ji Gao; Ashok Dongre; Malgorzata Bodaszewska-Lubas; Arnaud Echard; Mark Aronica; Julie Carman; Stavros Garantziotis; Dean Sheppard; Xiaoxia Li
J Immunol (2019) 202 (5): 1540–1548.
View articletitled, IL-17A Recruits Rab35 to IL-17R to Mediate PKCα-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility
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The Kinesin Light Chain–Related Protein PAT1 Promotes Superoxide Anion Production in Human Phagocytes
Riad Arabi-Derkawi; Yvonne O’Dowd; Ni Cheng; Loïc Rolas; Tarek Boussetta; Houssam Raad; Viviana Marzaioli; Coralie Pintard; Magali Fasseu; Yolande Kroviarski; Sahra A. Belambri; Pham My-Chan Dang; Richard D. Ye; Marie-Anne Gougerot-Pocidalo; Jamel El-Benna
J Immunol (2019) 202 (5): 1549–1558.
View articletitled, The Kinesin Light Chain–Related Protein PAT1 Promotes Superoxide Anion Production in Human Phagocytes
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Signals of the Neuropilin-1–MET Axis and Cues of Mechanical Force Exertion Converge to Elicit Inflammatory Activation in Coherent Endothelial Cells
Maryam Rezaei; Ana C. Martins Cavaco; Jochen Seebach; Stephan Niland; Jana Zimmermann; Eva-Maria Hanschmann; Rupert Hallmann; Hermann Schillers; Johannes A. Eble
J Immunol (2019) 202 (5): 1559–1572.
View articletitled, Signals of the Neuropilin-1–MET Axis and Cues of Mechanical Force Exertion Converge to Elicit Inflammatory Activation in Coherent Endothelial Cells
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MOLECULAR AND STRUCTURAL IMMUNOLOGY

DNA Breaks in Ig V Regions Are Predominantly Single Stranded and Are Generated by UNG and MSH6 DNA Repair Pathways
Kimberly J. Zanotti; Robert W. Maul; William Yang; Patricia J. Gearhart
J Immunol (2019) 202 (5): 1573–1581.
View articletitled, DNA Breaks in Ig V Regions Are Predominantly Single Stranded and Are Generated by UNG and MSH6 DNA Repair Pathways
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Fc Sialylation Prolongs Serum Half-Life of Therapeutic Antibodies
Mathilde Bas; Aurélie Terrier; Emilie Jacque; Aurélie Dehenne; Virginie Pochet-Béghin; Cécile Beghin; Anne-Sophie Dezetter; Gilles Dupont; Anaïs Engrand; Benjamin Beaufils; Philippe Mondon; Nathalie Fournier; Christophe de Romeuf; Sylvie Jorieux; Alexandre Fontayne; Lennart T. Mars; Céline Monnet
J Immunol (2019) 202 (5): 1582–1594.
View articletitled, Fc Sialylation Prolongs Serum Half-Life of Therapeutic Antibodies
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Insertion of N-Terminal Hinge Glycosylation Enhances Interactions of the Fc Region of Human IgG1 Monomers with Glycan-Dependent Receptors and Blocks Hemagglutination by the Influenza Virus
Patricia A. Blundell; Dongli Lu; Mark Wilkinson; Anne Dell; Stuart Haslam; Richard J. Pleass
J Immunol (2019) 202 (5): 1595–1611.
View articletitled, Insertion of N-Terminal Hinge Glycosylation Enhances Interactions of the Fc Region of Human IgG1 Monomers with Glycan-Dependent Receptors and Blocks Hemagglutination by the Influenza Virus
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SYSTEMS IMMUNOLOGY

Identification of Variable and Joining Germline Genes and Alleles for Rhesus Macaque from B Cell Receptor Repertoires
Wei Zhang; Xinyue Li; Longlong Wang; Jianxiang Deng; Liya Lin; Lei Tian; Jinghua Wu; Chenling Tang; Huanming Yang; Jian Wang; Ping Qiu; Tong-Ming Fu; Nitin K. Saksena; I-Ming Wang; Xiao Liu
J Immunol (2019) 202 (5): 1612–1622.
View articletitled, Identification of Variable and Joining Germline Genes and Alleles for Rhesus Macaque from B Cell Receptor Repertoires
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TUMOR IMMUNOLOGY

Tumor Microenvironment Modulates Immunological Outcomes of Myeloid Cells with mTORC1 Disruption
Chuanlin Ding; Xiaomin Sun; Caijun Wu; Xiaoling Hu; Huang-ge Zhang; Jun Yan
J Immunol (2019) 202 (5): 1623–1634.
View articletitled, Tumor Microenvironment Modulates Immunological Outcomes of Myeloid Cells with mTORC1 Disruption
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NOVEL IMMUNOLOGICAL METHODS

A Multiparameter Flow Cytometry Analysis Panel to Assess CD163 mRNA and Protein in Monocyte and Macrophage Populations in Hyperinflammatory Diseases
Sherry Thornton; Rachel Tan; Alyssa Sproles; Thuy Do; Jonathan Schick; Alexei A. Grom; Monica DeLay; Grant S. Schulert
J Immunol (2019) 202 (5): 1635–1643.
View articletitled, A Multiparameter Flow Cytometry Analysis Panel to Assess CD163 mRNA and Protein in Monocyte and Macrophage Populations in Hyperinflammatory Diseases
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  • Cover Image

    Cover Image

    issue cover

    On the cover: Mouse airway smooth muscle cells (ASMCs) were treated with IL-17A for 12 h, fixed and stained with phalloidin-rhodamine (red) and Ab against smooth muscle–myosin H chain (green). IL-17A stimulation induced formation of stress fibers in ASMCs, including actin polymerization and actin/myosin bundling. Bulek, K., X. Chen, V. Parron, A. Sundaram, T. Herjan, S. Ouyang, C. Liu, A. Majors, J. Zepp, J. Gao, A. Dongre, M. Bodaszewska-Lubas, A. Echard, M. Aronica, J. Carman, S. Garantziotis, D. Sheppard, and X. Li. 2019. IL-17A recruits Rab35 to IL-17R to mediate PKCα-dependent stress fiber formation and airway smooth muscle contractility. J. Immunol. 202: 1540–1548.

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