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Volume 202, Issue 6
15 March 2019
The Journal of Immunology Cover Image for Volume 202, Issue 6
ISSN 0022-1767
EISSN 1550-6606

IN THIS ISSUE

In This Issue
J Immunol (2019) 202 (6): 1647.
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BRIEF REVIEWS

Dysregulation of T Follicular Helper Cells in Lupus
John D. Mountz; Hui-Chen Hsu; Andre Ballesteros-Tato
J Immunol (2019) 202 (6): 1649–1658.
View articletitled, Dysregulation of T Follicular Helper Cells in Lupus
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Skin-Associated B Cells in Health and Inflammation
Gudrun F. Debes; Shannon E. McGettigan
J Immunol (2019) 202 (6): 1659–1666.
View articletitled, Skin-Associated B Cells in Health and Inflammation
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CUTTING EDGE

Cutting Edge: Core Binding Factor β Is Required for Group 2 Innate Lymphoid Cell Activation
Xiaofei Shen; Mingwei Liang; Xiangyu Chen; Muhammad Asghar Pasha; Shanti S. D’Souza; Kelsi Hidde; Jennifer Howard; Dil Afroz Sultana; Ivan Ting Hin Fung; Longyun Ye; Jiexue Pan; Gang Liu; James R. Drake; Lisa A. Drake; Jinfang Zhu; Avinash Bhandoola; Qi Yang
J Immunol (2019) 202 (6): 1669–1673.
View articletitled, Cutting Edge: Core Binding Factor β Is Required for Group 2 Innate Lymphoid Cell Activation
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Cutting Edge: Dysregulated Endocannabinoid-Rheostat for Plasmacytoid Dendritic Cell Activation in a Systemic Lupus Endophenotype
Oindrila Rahaman; Roopkatha Bhattacharya; Chinky Shiu Chen Liu; Deblina Raychaudhuri; Amrit Raj Ghosh; Purbita Bandopadhyay; Santu Pal; Rudra Prasad Goswami; Geetabali Sircar; Parasar Ghosh; Dipyaman Ganguly
J Immunol (2019) 202 (6): 1674–1679.
View articletitled, Cutting Edge: Dysregulated Endocannabinoid-Rheostat for Plasmacytoid Dendritic Cell Activation in a Systemic Lupus Endophenotype
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Cutting Edge: IL-27 Attenuates Autoimmune Neuroinflammation via Regulatory T Cell/Lag3–Dependent but IL-10–Independent Mechanisms In Vivo
Dongkyun Kim; Hongnga T. Le; Quang Tam Nguyen; Sohee Kim; Juyeun Lee; Booki Min
J Immunol (2019) 202 (6): 1680–1685.
View articletitled, Cutting Edge: IL-27 Attenuates Autoimmune Neuroinflammation via Regulatory T Cell/Lag3–Dependent but IL-10–Independent Mechanisms In Vivo
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AUTOIMMUNITY

Efficacy of Chemokine Receptor Inhibition in Treating IL-36α–Induced Psoriasiform Inflammation
James J. Campbell; Karen Ebsworth; Linda S. Ertl; Jeffrey P. McMahon; Yu Wang; Simon Yau; Venkat R. Mali; Vicky Chhina; Alice Kumamoto; Shirley Liu; Ton Dang; Dale Newland; Israel F. Charo; Penglie Zhang; Thomas J. Schall; Rajinder Singh
J Immunol (2019) 202 (6): 1687–1692.
View articletitled, Efficacy of Chemokine Receptor Inhibition in Treating IL-36α–Induced Psoriasiform Inflammation
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Increased GITRL Impairs the Function of Myeloid-Derived Suppressor Cells and Exacerbates Primary Sjögren Syndrome
Jie Tian; Ke Rui; Yue Hong; Xiaohui Wang; Fan Xiao; Xiang Lin; Jie Ma; Hongye Guo; Huaxi Xu; Kongyang Ma; Dong Xu; Dongzhou Liu; Yan Zhao; Liwei Lu; Shengjun Wang
J Immunol (2019) 202 (6): 1693–1703.
View articletitled, Increased GITRL Impairs the Function of Myeloid-Derived Suppressor Cells and Exacerbates Primary Sjögren Syndrome
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IMMUNE REGULATION

Glycine Exhibits Neuroprotective Effects in Ischemic Stroke in Rats through the Inhibition of M1 Microglial Polarization via the NF-κB p65/Hif-1α Signaling Pathway
Rui Liu; Xin-Yu Liao; Meng-Xian Pan; Jun-Chun Tang; Song-Feng Chen; Ya Zhang; Pei-Xin Lu; Long J. Lu; Ying-Ying Zou; Xing-Ping Qin; Li-Hong Bu; Qi Wan
J Immunol (2019) 202 (6): 1704–1714.
View articletitled, Glycine Exhibits Neuroprotective Effects in Ischemic Stroke in Rats through the Inhibition of M1 Microglial Polarization via the NF-κB p65/Hif-1α Signaling Pathway
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Immunological Synapse Formation Induces Mitochondrial Clustering and Mitophagy in Dendritic Cells
Laura Gómez-Cabañas; Pilar López-Cotarelo; Olga Criado-García; Michael P. Murphy; Patricia Boya; José Luis Rodríguez-Fernández
J Immunol (2019) 202 (6): 1715–1723.
View articletitled, Immunological Synapse Formation Induces Mitochondrial Clustering and Mitophagy in Dendritic Cells
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NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity
Natalija Simonović; Agnieszka Witalisz-Siepracka; Katrin Meissl; Caroline Lassnig; Ursula Reichart; Thomas Kolbe; Matthias Farlik; Christoph Bock; Veronika Sexl; Mathias Müller; Birgit Strobl
J Immunol (2019) 202 (6): 1724–1734.
View articletitled, NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity
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IMMUNOTHERAPY AND VACCINES

Tonic Signaling and Its Effects on Lymphopoiesis of CAR-Armed Hematopoietic Stem and Progenitor Cells
Susann Albert; Stefanie Koristka; Alexander Gerbaulet; Marc Cartellieri; Claudia Arndt; Anja Feldmann; Nicole Berndt; Liliana R. Loureiro; Malte von Bonin; Gerhard Ehninger; Anne Eugster; Ezio Bonifacio; Martin Bornhäuser; Michael P. Bachmann; Armin Ehninger
J Immunol (2019) 202 (6): 1735–1746.
View articletitled, Tonic Signaling and Its Effects on Lymphopoiesis of CAR-Armed Hematopoietic Stem and Progenitor Cells
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INFECTIOUS DISEASE AND HOST RESPONSE

l-Arginine Synthesis from l-Citrulline in Myeloid Cells Drives Host Defense against Mycobacteria In Vivo
Shannon M. Lange; Melanie C. McKell; Stephanie M. Schmidt; Junfang Zhao; Rebecca R. Crowther; Lisa C. Green; Rebecca L. Bricker; Eusondia Arnett; S. Eleonore Köhler; Larry S. Schlesinger; Kenneth D. R. Setchell; Joseph E. Qualls
J Immunol (2019) 202 (6): 1747–1754.
View articletitled, <span class="small-caps">l</span>-Arginine Synthesis from <span class="small-caps">l</span>-Citrulline in Myeloid Cells Drives Host Defense against Mycobacteria In Vivo
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IL-10 and ICOS Differentially Regulate T Cell Responses in the Brain during Chronic Toxoplasma gondii Infection
Carleigh A. O’Brien; Samantha J. Batista; Katherine M. Still; Tajie H. Harris
J Immunol (2019) 202 (6): 1755–1766.
View articletitled, IL-10 and ICOS Differentially Regulate T Cell Responses in the Brain during Chronic <em>Toxoplasma gondii</em> Infection
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INNATE IMMUNITY AND INFLAMMATION

Short-Chain Fatty Acids from Cutibacterium acnes Activate Both a Canonical and Epigenetic Inflammatory Response in Human Sebocytes
James A. Sanford; Alan M. O’Neill; Christos C. Zouboulis; Richard L. Gallo
J Immunol (2019) 202 (6): 1767–1776.
View articletitled, Short-Chain Fatty Acids from <em>Cutibacterium acnes</em> Activate Both a Canonical and Epigenetic Inflammatory Response in Human Sebocytes
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Histone Methylation Directs Myeloid TLR4 Expression and Regulates Wound Healing following Cutaneous Tissue Injury
Frank M. Davis; Andrew Kimball; Aaron denDekker; Amrita D. Joshi; Anna E. Boniakowski; Dylan Nysz; Ronald M. Allen; Andrea Obi; Kanakadurga Singer; Peter K. Henke; Bethany B. Moore; Steven L. Kunkel; Katherine A. Gallagher
J Immunol (2019) 202 (6): 1777–1785.
View articletitled, Histone Methylation Directs Myeloid TLR4 Expression and Regulates Wound Healing following Cutaneous Tissue Injury
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Insulin Resistance in Macrophages Alters Their Metabolism and Promotes an M2-Like Phenotype
Eleftheria Ieronymaki; Emmanouel M. Theodorakis; Konstantina Lyroni; Eleni Vergadi; Eleni Lagoudaki; Ahmed Al-Qahtani; Marina Aznaourova; Elpida Neofotistou-Themeli; Aristides G. Eliopoulos; Katerina Vaporidi; Christos Tsatsanis
J Immunol (2019) 202 (6): 1786–1797.
View articletitled, Insulin Resistance in Macrophages Alters Their Metabolism and Promotes an M2-Like Phenotype
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Treatment of Borrelia burgdorferi–Infected Mice with Apoptotic Cells Attenuates Lyme Arthritis via PPAR-γ
Kinsey A. Hilliard; Charles R. Brown
J Immunol (2019) 202 (6): 1798–1806.
View articletitled, Treatment of <em>Borrelia burgdorferi</em>–Infected Mice with Apoptotic Cells Attenuates Lyme Arthritis via PPAR-γ
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The Long Pentraxin 3 Contributes to Joint Inflammation in Gout by Facilitating the Phagocytosis of Monosodium Urate Crystals
Nathália V. Batista; Marialuisa Barbagallo; Vivian L. S. Oliveira; Thiago Castro-Gomes; Rene D. R. Oliveira; Paulo Louzada-Junior; Geraldo R. C. Pinheiro; Alberto Mantovani; Mauro M. Teixeira; Cecilia Garlanda; Flávio A. Amaral
J Immunol (2019) 202 (6): 1807–1814.
View articletitled, The Long Pentraxin 3 Contributes to Joint Inflammation in Gout by Facilitating the Phagocytosis of Monosodium Urate Crystals
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MEK2 Negatively Regulates Lipopolysaccharide-Mediated IL-1β Production through HIF-1α Expression
Harvinder Talwar; Mohamad Bouhamdan; Christian Bauerfeld; Jaya Talreja; Rifdat Aoidi; Nicolas Houde; Jean Charron; Lobelia Samavati
J Immunol (2019) 202 (6): 1815–1825.
View articletitled, MEK2 Negatively Regulates Lipopolysaccharide-Mediated IL-1β Production through HIF-1α Expression
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MOLECULAR AND STRUCTURAL IMMUNOLOGY

Characterization of Glucose Transporter 6 in Lipopolysaccharide-Induced Bone Marrow–Derived Macrophage Function
Beth T. Caruana; Frances L. Byrne; Alexander J. Knights; Kate G. R. Quinlan; Kyle L. Hoehn
J Immunol (2019) 202 (6): 1826–1832.
View articletitled, Characterization of Glucose Transporter 6 in Lipopolysaccharide-Induced Bone Marrow–Derived Macrophage Function
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MUCOSAL IMMUNOLOGY

IL-22–Independent Protection from Colitis in the Absence of Nkx2.3 Transcription Factor in Mice
Zoltán Kellermayer; Dóra Vojkovics; Tareq Abu Dakah; Kornélia Bodó; Bálint Botz; Zsuzsanna Helyes; Gergely Berta; Béla Kajtár; Angela Schippers; Norbert Wagner; Luigi Scotto; Owen A. O’Connor; Hans-Henning Arnold; Péter Balogh
J Immunol (2019) 202 (6): 1833–1844.
View articletitled, IL-22–Independent Protection from Colitis in the Absence of Nkx2.3 Transcription Factor in Mice
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SYSTEMS IMMUNOLOGY

Upper Airway Cell Transcriptomics Identify a Major New Immunological Phenotype with Strong Clinical Correlates in Young Children with Acute Wheezing
Siew-Kim Khoo; James Read; Kimberley Franks; Guicheng Zhang; Joelene Bizzintino; Laura Coleman; Christopher McCrae; Lisa Öberg; Niamh M. Troy; Franciska Prastanti; Janet Everard; Stephen Oo; Meredith L. Borland; Rose A. Maciewicz; Peter N. Le Souëf; Ingrid A. Laing; Anthony Bosco
J Immunol (2019) 202 (6): 1845–1858.
View articletitled, Upper Airway Cell Transcriptomics Identify a Major New Immunological Phenotype with Strong Clinical Correlates in Young Children with Acute Wheezing
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TRANSPLANTATION

Graft γδ TCR Sequencing Identifies Public Clonotypes Associated with Hematopoietic Stem Cell Transplantation Efficacy in Acute Myeloid Leukemia Patients and Unravels Cytomegalovirus Impact on Repertoire Distribution
Lucas C. M. Arruda; Ahmed Gaballa; Michael Uhlin
J Immunol (2019) 202 (6): 1859–1870.
View articletitled, Graft γδ TCR Sequencing Identifies Public Clonotypes Associated with Hematopoietic Stem Cell Transplantation Efficacy in Acute Myeloid Leukemia Patients and Unravels Cytomegalovirus Impact on Repertoire Distribution
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TUMOR IMMUNOLOGY

High-Dimensional Mass Cytometric Analysis Reveals an Increase in Effector Regulatory T Cells as a Distinguishing Feature of Colorectal Tumors
Samuel E. Norton; Kirsten A. Ward-Hartstonge; John L. McCall; Julia K. H. Leman; Edward S. Taylor; Fran Munro; Michael A. Black; Barbara Fazekas de St. Groth; Helen M. McGuire; Roslyn A. Kemp
J Immunol (2019) 202 (6): 1871–1884.
View articletitled, High-Dimensional Mass Cytometric Analysis Reveals an Increase in Effector Regulatory T Cells as a Distinguishing Feature of Colorectal Tumors
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NOVEL IMMUNOLOGICAL METHODS

Induction and Therapeutic Targeting of Human NPM1c+ Myeloid Leukemia in the Presence of Autologous Immune System in Mice
Mandeep Kaur; Adam C. Drake; Guangan Hu; Stephen Rudnick; Qingfeng Chen; Ryan Phennicie; Ricardo Attar; Jeffrey Nemeth; Francois Gaudet; Jianzhu Chen
J Immunol (2019) 202 (6): 1885–1894.
View articletitled, Induction and Therapeutic Targeting of Human NPM1c<sup>+</sup> Myeloid Leukemia in the Presence of Autologous Immune System in Mice
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Multiple Knockout of Classical HLA Class II β-Chains by CRISPR/Cas9 Genome Editing Driven by a Single Guide RNA
Pietro Crivello; Müberra Ahci; Fabienne Maaßen; Natalie Wossidlo; Esteban Arrieta-Bolaños; Andreas Heinold; Vinzenz Lange; J. H. Frederik Falkenburg; Peter A. Horn; Katharina Fleischhauer; Stefan Heinrichs
J Immunol (2019) 202 (6): 1895–1903.
View articletitled, Multiple Knockout of Classical HLA Class II β-Chains by CRISPR/Cas9 Genome Editing Driven by a Single Guide RNA
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CORRECTIONS

Correction: High-Resolution Genetic and Phenotypic Analysis of KIR2DL1 Alleles and Their Association with Pre-Eclampsia
Oisín Huhn; Olympe Chazara; Martin A. Ivarsson; Christelle Retière; Timothy C. Venkatesan; Paul J. Norman; Hugo G. Hilton; Jyothi Jayaraman; James A. Traherne; John Trowsdale; Mitsutero Ito; Christiane Kling; Peter Parham; Hormas Ghadially; Ashley Moffett; Andrew M. Sharkey; Francesco Colucci
J Immunol (2019) 202 (6): 1904.
View articletitled, Correction: High-Resolution Genetic and Phenotypic Analysis of KIR2DL1 Alleles and Their Association with Pre-Eclampsia
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Correction: A Novel Neutralizing Antibody Specific to the DE Loop of VP1 Can Inhibit EV-D68 Infection in Mice
Huiwen Zheng; Jingjing Wang; Bingxiang Li; Lei Guo; Heng Li; Jie Song; Zening Yang; Hongzhe Li; Haitao Fan; Xing Huang; Haiting Long; Chen Cheng; Manman Chu; Zhanlong He; Wenhai Yu; Jiaqi Li; You Gao; Ruotong Ning; Nan Li; Jinxi Yang; Qiongwen Wu; Haijing Shi; Ming Sun; Longding Liu
J Immunol (2019) 202 (6): 1905–1906.
View articletitled, Correction: A Novel Neutralizing Antibody Specific to the DE Loop of VP1 Can Inhibit EV-D68 Infection in Mice
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  • Cover Image

    Cover Image

    issue cover

    On the cover: High-dimensional analysis reveals the T cell signature in people with colorectal cancer. Shown is an x-shift cluster analysis in VorteX highlighting 16 distinct T cell populations enriched in either the tumor or nontumor bowel of people with colorectal cancer. Norton, S. E., K. A. Ward-Hartstonge, J. L. McCall, J. K. H. Leman, E. S. Taylor, F. Munro, M. A. Black, B. Fazekas de St. Groth, H. M. McGuire, and R. A. Kemp. 2019. High-dimensional mass cytometric analysis reveals an increase in effector regulatory T cells as a distinguishing feature of colorectal tumors. J. Immunol. 202: 1871–1884.

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