IN THIS ISSUE
In This Issue
PILLARS OF IMMUNOLOGY
Unmasking the Mysteries of MYC
Friend or Foe: The Protective and Pathological Roles of Inducible Bronchus-Associated Lymphoid Tissue in Pulmonary Diseases
Cutting Edge: BCAP Promotes Lupus-like Disease and TLR-Mediated Type I IFN Induction in Plasmacytoid Dendritic Cells
TLR7-driven lupus-like disease is ameliorated in the absence of BCAP.
BCAP promotes TLR7/9-induced IFNα, but not IL-6, in pDC.
BCAP associates with DOCK2 and promotes CpG DNA-induced Rac1 and IKKα activation.
ANTIGEN RECOGNITION AND RESPONSES
TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2
Essential Role of NADPH Oxidase–Dependent Production of Reactive Oxygen Species in Maintenance of Sustained B Cell Receptor Signaling and B Cell Proliferation
BCR ligation induces ROS production in two phases.
ROS production in the late phase is essential for B cell proliferation and survival.
ROS production in the late phase is mediated by NADPH oxidases, especially NOX3.
Epitope Selection for HLA-DQ2 Presentation: Implications for Celiac Disease and Viral Defense
High DM overcomes poor DM/DQ2 interaction to inhibit DQ2 presentation of gliadin.
Relative low strength of gliadin peptide-DQ2 binding contributes when DM is high.
In contrast, abundant DM promotes DQ2 presentation of DM-resistant viral Ag.
Nanoparticles Bearing TSH Receptor Protein and a Tolerogenic Molecule Do Not Induce Immune Tolerance but Exacerbate Thyroid Autoimmunity in hTSHR/NOD.H2h4 Mice
TSHR A-subunit NOD.H2h4 mice spontaneously develop pathogenic TSHR Abs.
TSHR + ITE + A-subunit nanoparticles accelerated pathogenic TSHR Ab development.
TSHR A-subunit stimulation is required to generate pathogenic TSHR Abs.
CLINICAL AND HUMAN IMMUNOLOGY
Expanded CD14hiCD16− Immunosuppressive Monocytes Predict Disease Severity in Patients with Acute Pancreatitis
The proportion of CD14hiCD16− monocytes was increased in AP patients.
CD14hiCD16− monocyte proportions, together with their HLA-DR level, could predict AP severity.
Effector and Activated T Cells Induce Preterm Labor and Birth That Is Prevented by Treatment with Progesterone
Cholecystokinin Downregulates Psoriatic Inflammation by Its Possible Self-Regulatory Effect on Epidermal Keratinocytes
We found that epidermal keratinocytes expressed CCK octapeptide.
CCK octapeptide expression was markedly decreased in acanthotic lesions of psoriasis.
CCK may exert a self-regulatory effect on psoriatic inflammation.
Stromal Interaction Molecule Deficiency in T Cells Promotes Spontaneous Follicular Helper T Cell Development and Causes Type 2 Immune Disorders
Negligible Role for Deletion Mediated by cDC1 in CD8+ T Cell Tolerance
Batf3-lineage cDC1 are required for peripheral CD8+ T cell deletion.
The absence of cDC1 does not increase CD8+ T cell autoreactivity or alter the TCR repertoire.
Peripheral deletion by cDC1 does not significantly contribute to CD8+ T cell tolerance to self.
Diversity of KIR, HLA Class I, and Their Interactions in Seven Populations of Sub-Saharan Africans
High levels of KIR and HLA diversity are present in all seven African populations.
Although 28 novel KIR alleles were detected, all HLA class I alleles are familiar.
KIRtelA and telB are balanced in East Africa, but KIRtelA dominates in West Africa.
INFECTIOUS DISEASE AND HOST RESPONSE
Identification and Characterization of Functional Human Monoclonal Antibodies to Plasmodium vivax Duffy-Binding Protein
P. vivax DPB:DARC interaction is essential for RBC invasion.
P. vivax–exposed individuals acquire Abs that block this interaction.
Human-derived monoclonal Abs recognize a globally conserved blocking epitope.
Dragotcytosis: Elucidation of the Mechanism for Cryptococcus neoformans Macrophage-to-Macrophage Transfer
C. neoformans transfers between macrophages in coordinated exocytosis/phagocytosis.
Opsonin receptors are used for the transfer process.
C. neoformans must be viable for the transfer process to occur.
Brucella abortus Cyclic Dinucleotides Trigger STING-Dependent Unfolded Protein Response That Favors Bacterial Replication
Brucella abortus induces a STING-dependent UPR.
Bacterial c-di-GMP recognition by STING triggers B. abortus–induced UPR.
UPR blockade inhibits B. abortus replication in vitro and in vivo.
Shifting Dynamics of Intestinal Macrophages during Simian Immunodeficiency Virus Infection in Adult Rhesus Macaques
Lamina propria macrophages are short-lived and destroyed after SIV infection.
Intestinal submucosa macrophages are long-lived and may become SIV/HIV reservoirs.
Gut biopsies are insufficient for monitoring submucosal long-lived macrophages.
Systemic Antibiotic Therapy Reduces Circulating Inflammatory Dendritic Cells and Treg–Th17 Plasticity in Periodontitis
AB therapy in PD patients ablated P. gingivalis from oral and hematogenous reservoirs.
This reduced inflammatory blood mDCs and IL-1R expression on Tregs in PD patients.
A favorable clinical response was related to P. gingivalis ablation and a decrease in Treg→Th17.
INNATE IMMUNITY AND INFLAMMATION
Distinctive Effects of GM-CSF and M-CSF on Proliferation and Polarization of Two Major Pulmonary Macrophage Populations
Identification of Residues Critical for FPR2 Activation by the Cryptic Peptide Mitocryptide-2 Originating from the Mitochondrial DNA–Encoded Cytochrome b
Critical structural elements are identified in MCT-2 that mediate FPR2 activation.
MCT-2 polymorphic variants activate human neutrophils with different potency.
Skin Wounding–Induced Monocyte Expansion in Mice Is Not Abrogated by IL-1 Receptor 1 Deficiency
Skin wounding promotes Mo expansion in mouse bone marrow.
IL-1R1 signaling is not involved in skin wounding–induced Mo expansion.
Leptin Promotes Monosodium Urate Crystal–Induced Inflammation in Human and Murine Models of Gout
Acute gout patients express higher level of leptin and leptin receptor.
Leptin promotes MSU-induced inflammation in human and murine models of acute gout.
Leptin-exacerbating inflammation in acute gout is mediated by mTORC1 signaling.
Dimethyl Fumarate Disrupts Human Innate Immune Signaling by Targeting the IRAK4–MyD88 Complex
DMF suppresses cytokine production in pDCs.
DMF blocks Myddosome formation by disrupting the MyD88–IRAK4 interaction.
DMF blocks the MyD88–IRAK4 interaction by targeting C13 in IRAK4.
The Immune Deficiency Pathway Regulates Metabolic Homeostasis in Drosophila
IMD activation in the fat body disrupts growth and energy stores.
Inhibition of IMD signaling in Drosophila disrupts metabolic homeostasis.
Insulin mutant flies have varied responses to bacterial infection.
Epithelial Expression of an Interstitial Lung Disease–Associated Mutation in Surfactant Protein-C Modulates Recruitment and Activation of Key Myeloid Cell Populations in Mice
In a murine model of lung fibrosis, an ontogeny of inflammatory events was defined.
Mutant SftpcI73T expression caused early lung injury marked by a polycellular alveolitis.
Depletion of peripheral monocytes was protective from SftpcI73T injury.
Imbalance of Ly-6Chi and Ly-6Clo Monocytes/Macrophages Worsens Hyperoxia-Induced Lung Injury and Is Rescued by IFN-γ
Ly-6Clo and Ly-6Chi monocytes/macrophages have unique roles in acute HILI.
Ly-6Clo monocytes/macrophages adopt proinflammatory phenotypes in CD11b-DTR+ mice.
Intranasal IFN-γ rescues CD11b-DTR+ mice from severe HILI.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
Integrin β1 Promotes the Interaction of Murine IgG3 with Effector Cells
The mouse α4/β1 integrin is important in the binding of IgG3 Abs to macrophages.
Phagocytosis mediated by mIgG3 Abs depends on the α4/β1 integrin.
The α4/β1 integrin is a new receptor and/or part of a receptor complex for IgG3.
Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality
Leukemic B Cell CTLA-4 Suppresses Costimulation of T Cells
Correction: Abrogation of Lupus Nephritis in Somatic Hypermutation–Deficient B6.MRL-Faslpr mice/J Mice
On the cover: Identification of mononuclear phagocyte populations in the newborn lung. t-Distributed Stochastic Neighbor Embedding was used to display multidimensional flow cytometry data and characterize alveolar macrophages (pink), Ly-6Chi interstitial monocytes/macrophages (blue), Ly-6Clo interstitial monocytes/macrophages (purple), and dendritic cells (green) in lungs from PN1 mice exposed to hyperoxia for 24 h. Eldredge, L. C., R. S. Creasy, S. Tanaka, J.-F. Lai, and S. F. Ziegler. 2019. Imbalance of Ly-6Chi and Ly-6Clo monocytes/macrophages worsens hyperoxia-induced lung injury and is rescued by IFN-γ. J. Immunol. 202: 2772–2781.
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