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IN THIS ISSUE

J Immunol (2019) 203 (1): 1.

PILLARS OF IMMUNOLOGY

J Immunol (2019) 203 (1): 3–5.
J Immunol (2019) 203 (1): 6–10.

BRIEF REVIEWS

J Immunol (2019) 203 (1): 11–19.

ALLERGY AND OTHER HYPERSENSITIVITIES

J Immunol (2019) 203 (1): 21–30.

  • cHBIs display a drug metabolite, an Ab-targeting moiety, and a reactive group.

  • cHBI specifically targets drug allergy IgE and prevents drug-induced degranulation.

  • cHBIs to penicillin were synthesized and prevent penicillin allergies in vivo.

J Immunol (2019) 203 (1): 31–38.

  • We screened Alternaria B cell epitopes by the combination of s-IgE and phage.

  • We validated the binding ability of B cell mimotopes in humans and mice in vitro.

  • The B cell mimotope vaccines improved allergic inflammation in a mouse model.

J Immunol (2019) 203 (1): 39–47.

  • Intracellular HB-EGF expressed by CD4 T cells increases IL-5 expression by TH2 cells.

  • HB-EGF in CD4 T cells regulates IL-5 synthesis by inhibiting Bcl-6.

AUTOIMMUNITY

J Immunol (2019) 203 (1): 48–57.

  • A hybrid insulin peptide (HIP) neoepitope can tolerize diabetogenic T cells.

  • Tolerance induction promotes T cell anergy and increases Treg/Teff ratio.

  • HIPs are potential therapeutics in type 1 diabetes.

J Immunol (2019) 203 (1): 58–75.

  • CD40 antagonism reverses severe proteinuria and restores glomerular morphology.

  • CD40 antagonism normalizes nephrotic and injury-associated gene expression.

  • CD40 antagonism disrupts multiple disease-critical immunological mechanisms.

J Immunol (2019) 203 (1): 76–83.

  • CEACAM-1/TIM-3 interaction favors the apoptosis of MBP-specific cells in BEMS.

  • This pathway is reduced in PPMS by the upregulation of Bat3.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2019) 203 (1): 84–92.
J Immunol (2019) 203 (1): 93–104.

  • PP2A readily promotes IL-2R signaling in Tregs but not T effector cells.

  • PP2A enhances IL-2R signaling in Tregs by CD25-dependent and -independent mechanisms.

  • PP2A broadly regulates the stability, activation, and function of human Tregs.

IMMUNE REGULATION

J Immunol (2019) 203 (1): 105–116.

  • PAR1 is transiently expressed in osteoclast precursor cells during differentiation.

  • PAR1 deletion enhances osteoclastogenesis, whereas PAR1 overexpression inhibits it.

  • The enhanced osteoclastogenesis of PAR1-deletion is mediated by Notch2.

J Immunol (2019) 203 (1): 117–126.

  • MFSD2A is required for CD8+ memory T cell maintenance.

  • MFSD2A deficiency results in defective import of LPC species into CD8+ T cells.

  • Import of LPC helps to maintain memory T cell homeostasis.

J Immunol (2019) 203 (1): 127–136.

  • Metformin enhances immunomodulatory properties and migration capacity of MSCs.

  • Metformin-treated MSCs exert therapeutic property in OA rats.

J Immunol (2019) 203 (1): 137–147.

  • Afucosylated Abs offset PI3Kδ inhibitors to retain effective signaling and function.

  • Phosphorylation of S6 is temporally driven by PI3Kδ.

  • p-S6 temporally regulates late cytokine production by modulating transcription.

J Immunol (2019) 203 (1): 148–157.

  • The miR-511-3p regulates MR and DC-SIGN expression in human DCs.

  • Silencing miR-511-3p expression promotes anti-inflammatory DC phenotype.

  • Changes in miR-511-3p levels in DCs affect T cell polarization in DC–T coculture.

J Immunol (2019) 203 (1): 158–166.

  • NOD mice are deficient in number and function of CD8 Tregs that control the germinal center.

  • Treatment with IL-15 superagonist expands NOD CD8 Tregs and restores their activity.

  • IL-15–activated CD8 Tregs delay the adoptive transfer of type 1 diabetes.

IMMUNE SYSTEM DEVELOPMENT

J Immunol (2019) 203 (1): 167–177.

  • BMDNT cells are developed by default of thymic TCR-mediated selection.

  • BMDNT cells show the features of ILCs bearing many NK receptors.

  • BMDNT cells are rapidly increased and activated in response to systemic TLR ligands.

J Immunol (2019) 203 (1): 178–187.

  • Radiation induces S2053 phosphorylation of murine DNA-PKcs.

  • S2053 phosphorylation is dispensable for V(D)J and class switch recombination.

IMMUNOTHERAPY AND VACCINES

J Immunol (2019) 203 (1): 188–197.

  • rBCG-SOCS1DN enhanced the induction of Ag-specific T cells via the activation of DC.

  • Ag-specific T cell enhancement enhanced protection against M. tuberculosis infection.

J Immunol (2019) 203 (1): 198–207.

  • Inducibly expressed IL-12–armored GPC3-specific CARs were constructed in this study.

  • GPC3-28Z-NFAT-IL-12 T cells could lyse GPC3+ tumor cells specifically in vitro.

  • GPC3-28Z-NFAT-IL-12 T cells could enhance antitumor activity in vivo.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2019) 203 (1): 208–215.

  • Gastric PC acquire high rates of somatic hypermutations during H. pylori infection.

  • Gastric poly- and H. pylori–specific Ig evolve from Ag-driven and T cell–dependent responses.

  • VH genes of H. pylori–specific Ig resemble MALT B cell lymphoma Ig genes.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2019) 203 (1): 216–224.

  • Carp macrophages exhibit a trained immunity-like profile in vitro.

  • Both peptidoglycan and β-glucan can induce trained immunity in carp macrophages.

J Immunol (2019) 203 (1): 225–235.

  • Under inflammatory conditions, CRP is not only a marker but also a driver of inflammation by human macrophages.

  • CRP enhances inflammatory cytokine production via FcγR-induced metabolic reprogramming through kinases Syk, PI3K, and AKT2.

J Immunol (2019) 203 (1): 236–246.

  • Inflammasome-independent IL-1β production contributes to aspiration pneumonitis.

  • Acidic stress induces the production of mature IL-1β in macrophages.

  • A novel cleavage site of IL-1β in response to acidic stress was identified.

J Immunol (2019) 203 (1): 247–258.

  • Lung endothelial precursor cells are committed to EndoMT during experimental fibrosis.

  • Signals in the sera of patients with systemic sclerosis reproduce EndoMT in vitro.

  • Macrophages protect from both EndoMT induction and experimental fibrosis.

J Immunol (2019) 203 (1): 259–268.

  • USP19 negatively regulates TAK1-mediated NF-κB activation.

  • Usp19 deficiency promotes TNF-α– and IL-1β–induced inflammatory response.

  • USP19 removes K63- and K27-linked polyubiquitin chains from TAK1.

MOLECULAR AND STRUCTURAL IMMUNOLOGY

J Immunol (2019) 203 (1): 269–281.

  • CUL7-FBXW11 E3 ligase mediates the ubiquitination and degradation of AID.

  • DNA damage response promotes CUL7–FBXW11–AID interaction.

  • Knockout of CUL7 promotes IgA and IgG1 class switch recombination of B cells.

MUCOSAL IMMUNOLOGY

J Immunol (2019) 203 (1): 282–292.

  • Depletion of gut microbiota decreases the adjuvant activity of CT.

  • Gut microbiota-derived SCFAs facilitate mucosal adjuvant activity of CT via GPR43.

  • SCFA induction of BAFF and ALDH1a2 in DC promotes B cell Ab production.

CORRECTIONS

J Immunol (2019) 203 (1): 293.
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