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J Immunol (2019) 203 (11): 2747–2748.

TRANSLATING IMMUNOLOGY

J Immunol (2019) 203 (11): 2749–2755.

BRIEF REVIEWS

J Immunol (2019) 203 (11): 2757–2769.

CUTTING EDGE

J Immunol (2019) 203 (11): 2771–2775.

  • TCR signal strength regulates acetyl-CoA metabolism.

  • Weak TCR signals promote phosphorylation of citrate synthase via Akt.

  • TCR signal strength differentially regulates acetyl-lysine containing proteins.

ALLERGY AND OTHER HYPERSENSITIVITIES

J Immunol (2019) 203 (11): 2777–2790.

  • LARI inhibits allergic reactivity while displaying an excellent safety profile.

  • LARI blunts allergic responses via multiple mechanisms at multiple steps.

AUTOIMMUNITY

J Immunol (2019) 203 (11): 2791–2806.

  • Autoreactive T cells drive the lethal disease in Malt1PD mice.

  • Malt1PD mice display B cell hyperactivation to environmental Ags.

  • IPEX-like disease occurs in Malt1PD mice despite in vitro Treg suppressive activity.

J Immunol (2019) 203 (11): 2807–2816.

  • CREMα induces DUSP4 phosphatase expression in CD4+ T cells.

  • DUSP4 promotes IL-17A and reduces IL-2 production by effector T cells.

  • The CREMα/DUSP4 axis is involved in the pathophysiology of SLE.

J Immunol (2019) 203 (11): 2817–2826.

  • CD11c+ ABCs exhibit functional characteristics of MBCs.

  • ABCs express polyreactive B cell receptors binding diverse self-antigens.

  • Adoptively transferred ABCs contribute to rapid recall responses to viral Ags.

J Immunol (2019) 203 (11): 2827–2836.

  • UBASH3A interacts with the TCR–CD3 complex and regulates its turnover.

  • UBASH3A facilitates the downmodulation of cell-surface TCR–CD3 upon TCR engagement.

  • UBASH3A binds to CBL-B, another T1D-associated protein that inhibits T cell function.

J Immunol (2019) 203 (11): 2837–2849.

  • TNF-Tg mice develop NSIP-like lung disease with increased cDC2 and macrophages.

  • Anti-TNF therapy modulates prefibrotic ILD in TNF-Tg mice.

IMMUNE REGULATION

J Immunol (2019) 203 (11): 2850–2861.

  • Regulatory T cells can undergo extensive intravascular crawling in skin vessels.

  • Mechanisms of regulatory T cell transmigration can be modulated dynamically.

J Immunol (2019) 203 (11): 2862–2871.

  • RELMα (hResistin) activates pulmonary macrophages in PAH patients and hypoxic mice.

  • RELMα (hResistin) induces HMGB1 acetylation by suppressing Sirt1 in macrophages.

  • The RELMα–HMGB1 axis causes macrophage-mediated PASMC proliferation.

J Immunol (2019) 203 (11): 2872–2886.

  • TLR2 directly regulates the anti-CD3–activated CD8+ T cells independently on APCs.

  • Bioenergy metabolism is important for TLR2-mediated enhancement of CD8+ T cells.

  • TLR2 enhances the antiviral CD8+ T cell response and the efficacy of HBV vaccine.

J Immunol (2019) 203 (11): 2887–2898.

  • MHCII molecule upregulation is not required for the development of skin moDCs.

  • Skin CD206+ moDCs do not migrate to LNs in the absence of MHCII ubiquitination.

  • GM-CSF restores the migration of skin moDCs by upregulating CCR7 and IRF4.

IMMUNE SYSTEM DEVELOPMENT

J Immunol (2019) 203 (11): 2899–2908.

  • Fnip1 is required for pre–B cell development/survival independent of p53 and Bcl-xL.

  • Fnip1 is required for optimal inhibition of mTORC1 in response to amino acid restriction.

  • Fnip1 regulates TFE3 nuclear translocation and lysosome biogenesis in pre–B cells.

IMMUNOGENETICS

J Immunol (2019) 203 (11): 2909–2916.

  • Two lamprey BCMA-like receptors interact with a single lamprey BAFF protein.

  • BCMAL1 and BCMAL2 genes are differentially expressed during VLRB cell stimulation.

  • BAFF-based mechanisms for B cell regulation appeared early in vertebrate evolution.

IMMUNOTHERAPY AND VACCINES

J Immunol (2019) 203 (11): 2917–2927.

  • MAIT cells comprise half the CD8 T cell IFN-γ response to BCG in blood.

  • Frequencies of MAIT cells were not sustainably modulated by BCG vaccination.

  • Innate cytokines mediate BCG-induced MAIT cell responses in whole blood.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2019) 203 (11): 2928–2943.

  • Anti–IL-15 depletes NK cells and disrupts TEM homeostasis in SIV-infected RM.

  • IL-15 inhibition does not alter SIV replication dynamics or CD4+ T cell depletion.

  • IL-15 inhibition does accelerate reactivation of an oncogenic γ-herpesvirus.

J Immunol (2019) 203 (11): 2944–2958.

  • NK cells are required for immune control of secondary T. gondii infection.

  • NK cells do not develop intrinsic memory-like features during T. gondii infection.

  • Secondary NK cell responses depend upon IL-12 and IL-23.

J Immunol (2019) 203 (11): 2959–2969.

  • FOH promotes CD1d expression in human DC via activation of PPARγ, RARα, and p38 MAPK.

  • FOH modulates cytokine release through nuclear receptors, MAPK, and NF-κB pathways.

  • FOH diminishes human DC capacity to activate iNKT, Th1, and FOXP3+ regulatory T cells.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2019) 203 (11): 2970–2978.

  • DR3 is highly expressed on human MAIT cells.

  • DR3 ligand TL1A licenses innate TNF-α production and boosts polyfunctionality.

  • TL1A equally augments TCR-dependent MAIT cell effector functions.

J Immunol (2019) 203 (11): 2979–2989.

  • Early monocyte infiltration causes long-term microgliosis in sepsis.

  • Brain microglia self-proliferate during severe sepsis.

  • Microglia proliferation is associated with local M-CSF.

J Immunol (2019) 203 (11): 2990–2999.

  • GSK3β interacts with Src tyrosine kinase.

  • Src positively regulates antiviral immune response.

  • Src undergoes K63-linked ubiquitination by TRAF2.

J Immunol (2019) 203 (11): 3000–3012.

  • Pseudomonas bacterial lung infection leads to pulmonary ACE2 dynamic variation.

  • The ACE2 dynamic alteration is critical in regulating neutrophilic lung inflammation.

  • ACE2 modulates IL-17–mediated neutrophil influx by impacting STAT3 activity.

J Immunol (2019) 203 (11): 3013–3022.

  • Exercise enhances resolution of acute inflammation and RvD1 biosynthesis.

  • Epinephrine stimulates macrophage production of RvD1 through α1-AR.

  • α1-AR blockade in vivo abrogates exercise-enhanced resolution.

MOLECULAR AND STRUCTURAL IMMUNOLOGY

J Immunol (2019) 203 (11): 3023–3036.

  • Ubc9 interacts with and SUMOylates the immune adaptor SLP-76 in T cells.

  • Synergy of SLP-76–Ubc9 on IL-2 transcription is SLP-76 SUMOylation dependent.

  • SLP-76 SUMOylation is required for Ubc9-NFAT complex assembly for IL-2 transcription.

J Immunol (2019) 203 (11): 3037–3044.

  • Recognition of monomeric Lex by 1G5F6 using a panel of Lex analogues was studied.

  • Anti-Lex mAbs bind in different ways; the hydrophobic patch of β-d-Gal is essential.

MUCOSAL IMMUNOLOGY

J Immunol (2019) 203 (11): 3045–3053.

  • Uhrf1-mediated DNA methylation represses Tnf-α expression in macrophages.

  • Uhrf1 deficiency augments Tnf-α expression, resulting in aggravated colitis.

  • Tnf-α triggers macrophage activation through destabilizing Uhrf1 protein.

J Immunol (2019) 203 (11): 3054–3067.

  • A mucosally associated lymphoid tissue is identified in teleost pharyngeal cavity.

  • Trout pharyngeal bacteria are mainly coated with secretory IgT.

  • Teleost IgT plays a vital role in protecting the PC from invading pathogens.

J Immunol (2019) 203 (11): 3068–3077.

  • Inhibitory receptors are upregulated on peripheral Tregs of DC-deficient mice.

  • Tregs from DC-deficient mice are functionally impaired.

  • Tregs require DCs for inhibition of T cell transfer-induced colitis.

TUMOR IMMUNOLOGY

J Immunol (2019) 203 (11): 3078–3085.

  • STAT3 induces the expression of Wnt5a in CLL cells.

  • Wnt5a provides CLL cells with survival advantage.

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