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J Immunol (2019) 203 (12): 3089–3090.

LETTERS TO THE EDITOR

J Immunol (2019) 203 (12): 3091.
J Immunol (2019) 203 (12): 3091–3092.
J Immunol (2019) 203 (12): 3092–3093.
J Immunol (2019) 203 (12): 3093.

BRIEF REVIEWS

J Immunol (2019) 203 (12): 3095–3104.

CUTTING EDGE

J Immunol (2019) 203 (12): 3107–3111.

  • CD300c2 exacerbates BLM-induced pulmonary fibrosis.

  • CD300c2 on alveolar macrophages enhances neutrophil recruitment.

  • CD300c2 amplifies HMGB-1–mediated TLR4 signaling.

ALLERGY AND OTHER HYPERSENSITIVITIES

J Immunol (2019) 203 (12): 3113–3125.

  • Pglyrp1 enhances allergic asthma in mice through its effect on the intestinal microbiome.

  • This effect is strong in asthma-prone mice and weak in asthma-resistant outbred mice.

  • This effect requires germ-free mice before colonization with the Pglyrp1 microbiome.

ANTIGEN RECOGNITION AND RESPONSES

J Immunol (2019) 203 (12): 3126–3135.

  • IgG fucosylation status and target cell Ag density determine NK cell ADCC.

  • Aspecific serum IgG bound to FcγRIIIa and target cell glycocalyx limit NK cell ADCC.

  • NK cell FcγRIIIa is preferentially occupied by high-affinity afucosylated serum IgG.

AUTOIMMUNITY

J Immunol (2019) 203 (12): 3136–3147.

  • Anti-C3d mAb 3d-8b blocks in vivo CR2-dependent Ab production to foreign Ags.

  • Anti-C3d mAb 3d-8b is capable of blocking in vivo iC3b/C3d from CR1/CR2.

  • Disruption of the B cell–CR2 costimulatory signal reduces autoantibody production.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2019) 203 (12): 3148–3156.

  • TNF-producing CD4+ T cells in patients with AIH are significantly expanded.

  • Most TNF-producing T cells also produce IFN-γ and have an inflammatory phenotype.

  • Autoantigen-specific stimulation results in expansion of these inflammatory T cells.

J Immunol (2019) 203 (12): 3157–3165.

  • Chemokine ligand CCL2 is cleared from the blood in a CCR2-dependent manner.

  • CCR2-dependent clearance of CCL2 is G protein (Gαi, Gαs, or Gαq/11) independent.

  • Equilibrium between secretion of CCL2 and its uptake by CCL2 determines blood levels.

J Immunol (2019) 203 (12): 3166–3178.

  • CRISPR gene disruption in CD4+ T cells is enhanced by donor DNA template delivery.

  • Disruption of key signaling proteins in human CD4+ T cells mimics murine data.

  • Hyperactive signaling in human T cells can drive compensatory regulatory responses.

J Immunol (2019) 203 (12): 3179–3189.

  • CXCR3 identifies human naive CD8+ T cells with biased effector potential.

  • Human naive CD8+ T cell subsets are functionally and transcriptionally distinct.

  • Effector potential correlates with the physicochemical attributes of expressed TCRs.

J Immunol (2019) 203 (12): 3190–3198.

  • Circulating intermediate monocytes are enriched in AH patients.

  • AH intermediate monocytes are functionally activated.

  • AH intermediate monocytes induce CD4+ T cell IL-17 and are enriched in the liver.

IMMUNE REGULATION

J Immunol (2019) 203 (12): 3199–3208.

  • A high-fiber diet attenuates arthritis in a microbiota-dependent manner.

  • Butyrate attenuates arthritis in an iNKT cell–dependent manner.

  • Butyrate inhibits cytokine production of iNKT cells in an HDAC-dependent manner.

J Immunol (2019) 203 (12): 3209–3215.

  • RORα deficiency leads to a reduction in ILC2 and ILC3 subsets during infection.

  • Residual Rorasg/sg ILC3s have lower expression of Rorc and lineage-specific receptors.

  • RORα conserves ILC3 function by modulating integration of environmental cues.

J Immunol (2019) 203 (12): 3216–3224.

  • FcγR activation in human monocytes regulates the localization and expression of CD31.

  • FcγR-mediated CD31 downregulation is mediated mainly through FcγRIIa and PI3K.

  • CD31 negatively regulates FcγR-mediated phagocytosis but not cytokine production.

J Immunol (2019) 203 (12): 3225–3236.

  • OX40L-JAG1 induced Treg proliferation mediated via noncanonical NF-κB signaling.

  • OX40L-JAG1 expanded epigenetically stable and suppressive Tregs to ameliorate EAT.

  • OX40L-JAG1 induced TCR-independent selective proliferation of human thymic Tregs.

J Immunol (2019) 203 (12): 3237–3246.

  • Western diet feeding increases Nrp1 on Foxp3 CD4 T cells in ApoE−/− mice.

  • Nrp1+Foxp3 CD4 T cells are highly proliferative and atherogenic.

  • Nrp1+Foxp3 CD4 T cells preferentially migrate to the aorta and PaLN.

J Immunol (2019) 203 (12): 3247–3255.

  • Adenosine targets both PKA and Epac pathways to suppress dendritic cell activation.

  • Adenosine/cAMP increases the expression of negative regulators of NF-κB signaling.

IMMUNE SYSTEM DEVELOPMENT

J Immunol (2019) 203 (12): 3256–3267.

  • miR-183C expression dynamically changes during iNKT cell development.

  • The deletion of miR-183C interferes with iNKT cell development and function.

  • Multiple target molecules are involved in miR-183C–mediated iNKT cell regulation.

J Immunol (2019) 203 (12): 3268–3281.

  • 2F5 BCR B cells are tolerized primarily by reactivity to kynureninase, not lipid.

  • Extensive receptor editing occurs in 2F5 BCR knock-in mice.

  • Mature and anergic B cells often express identical BCRs in 2F5 knock-in mice.

IMMUNOTHERAPY AND VACCINES

J Immunol (2019) 203 (12): 3282–3292.

  • VLP enhances antinorovirus IgA recall responses in humanized mice.

  • Particulate structure is required for IgA enhancement.

  • VLP-driven IgA responses are functionally superior to IgG responses.

J Immunol (2019) 203 (12): 3293–3300.

  • Live pertussis vaccine BPZE1 protects against B. pertussis infection within days.

  • Early protection induced by BPZE1 does not depend on adaptive immune responses.

  • Early protection induced by BPZE1 depends on TLR4-mediated innate immune responses.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2019) 203 (12): 3301–3312.

  • CVB3 infection induces a transient IL-17A expression in the pancreas of mice.

  • Pancreatic IL-17A is mainly produced by Vγ4γδ T cells.

  • IL-23/γδT17/neutrophil axis is critically involved in the onset of CVB3 pancreatitis.

J Immunol (2019) 203 (12): 3313–3324.

  • Chronic EtOH consumption alters the existing memory T cell compartment.

  • EtOH-induced changes in existing memory T cells increase susceptibility to IAV.

  • Chronic EtOH alters memory T cell–mediated killing and recruitment into the lungs.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2019) 203 (12): 3325–3338.

  • An IBD genetic risk variant increases expression of both STAT3 and STAT5 in MDMs.

  • Inflammatory cytokines increase once STAT3/STAT5 expression falls below a threshold.

  • Various STAT3/STAT5-dependent inhibitory cytokines cooperate to reduce inflammation.

J Immunol (2019) 203 (12): 3339–3348.

  • Mice with sJIA show aberrant NK cell phenotype and defective NK cell cytotoxicity.

  • NK cells have a regulatory role in the development of sJIA disease.

  • NK cell defects are associated with more activated monocytes and dendritic cells.

J Immunol (2019) 203 (12): 3349–3360.

  • FPR2-specific PSMα peptides are not chemotactic but activate the NADPH oxidase.

  • PSMα peptides induce ERK1/2 phosphorylation but not β-arrestin recruitment.

J Immunol (2019) 203 (12): 3361–3373.

  • We established an exhaustive list of larval zebrafish ISGs.

  • Orthologous ISGs in fish and humans identify a large ancestral ISG repertoire.

J Immunol (2019) 203 (12): 3374–3385.

  • The cleavage determinants of duSTING by NS2B3 are the R84 and G85 residues.

  • The interaction region is essential for the cleavage of duSTING by NS2B3.

MOLECULAR AND STRUCTURAL IMMUNOLOGY

J Immunol (2019) 203 (12): 3386–3394.

  • The β2m-free HLA-G1 isoform tends to dimerize and further multimerize.

  • The β2m-free HLA-G1 isoform specifically binds to LILRB2 with avidity effects.

  • The crystal structure of LILRB1/HLA-G1 complex showed a flexible binding manner.

J Immunol (2019) 203 (12): 3395–3406.

  • TCR β variable gene 4-1 (TRBV4-1) is overrepresented among CD1b-specific T cells.

  • The association between TRBV4-1 usage and CD1b is independent of lipid Ag.

  • CD1b residue E80 is essential for binding of TRBV4-1–utilizing TCRs.

MUCOSAL IMMUNOLOGY

J Immunol (2019) 203 (12): 3407–3415.

  • NLRX1 activation induces immunometabolic mechanisms to reduce effector CD4+ T cells.

  • NX-13 is a novel NLRX1-targeting therapeutic for IBD.

  • NX-13 is effective in three mouse models of IBD and primary human cells from UC.

J Immunol (2019) 203 (12): 3416–3426.

  • Bone marrow GM-CSF culture gives rise to four distinct populations.

  • GM-CSF MΦ can produce IFN-β.

  • GBS-stimulated GM-CSF MΦ have the ability to adapt their phenotype to be more DC like.

J Immunol (2019) 203 (12): 3427–3435.

  • Diet-induced obese mice exhibit reduced αβ and γδ IEL persistence within 7 wk.

  • Obese mice are more susceptible to dextran sulfate sodium–induced colitis.

  • Diet-induced weight loss restores IEL number and improves outcome in colitis.

TRANSPLANTATION

J Immunol (2019) 203 (12): 3436–3446.

  • Luteolin suppresses allograft rejection by regulating alloimmune responses.

  • Luteolin reduces effector T cell frequency while inducing CD4+Foxp3+ Tregs.

  • It also inhibits T cell proliferation by downregulating AKT/mTOR signaling.

TUMOR IMMUNOLOGY

J Immunol (2019) 203 (12): 3447–3460.

  • Breast tumor MSC-derived exosomes elicit differentiation of M-MDSC to TAM.

  • MSC exosome–educated myeloid cells exacerbate immunosuppression in the breast TME.

  • In vivo PD-L1 blockade neutralizes MSC exosome–driven breast cancer progression.

CORRECTIONS

J Immunol (2019) 203 (12): 3461.
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