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IN THIS ISSUE

J Immunol (2019) 203 (2): 309–310.

BRIEF REVIEWS

J Immunol (2019) 203 (2): 311–320.

CUTTING EDGE

J Immunol (2019) 203 (2): 323–327.

  • BCL6 is dispensable for the maintenance of memory CD8+ T cells.

  • BCL6 is required for the generation of CD8+ memory precursors.

  • BCL6 promotes TCF-1 expression in CD8+ memory precursors.

ALLERGY AND OTHER HYPERSENSITIVITIES

J Immunol (2019) 203 (2): 329–337.

  • β-Chain receptor cytokines produce a proinflammatory and survival phenotype.

  • IL-3 stimulation yields a distinct eosinophil gene expression program.

  • IL-3–upregulated hub genes may have implications in future asthma therapeutics.

AUTOIMMUNITY

J Immunol (2019) 203 (2): 338–348.

  • Metformin affects gene expression in HC and SLE patient CD4 T cells.

  • Metformin reduces activation of T1 IFN–stimulated genes in CD4 T cells.

  • Inhibition of ETC activity reduces T1 IFN response.

J Immunol (2019) 203 (2): 349–359.

  • A novel model of autoimmunity against elastin resulted in emphysema.

  • Elastin-specific TCR sequences identified autoreactive T cell clones in the lung.

J Immunol (2019) 203 (2): 360–369.

  • Soluble CD13 (sCD13) is a potent angiogenic factor in vitro and ­­­in vivo.

  • sCD13 induces acute inflammatory arthritis in mice and induces MN migration via GPCR.

  • sCD13 increases cytokine secretion and phosphorylation of signaling molecules.

IMMUNE REGULATION

J Immunol (2019) 203 (2): 370–378.

  • Mice with a deficiency of Helios in all T cells do not develop autoimmunity.

  • Although Ag-specific Helios−/− CD4+ T cells prime normally, they become tolerant.

  • pTreg cells are generated in the absence of Helios and mediate the tolerant state.

J Immunol (2019) 203 (2): 379–388.

  • C3ar1/C5ar1 signaling supports B2 cell activation, IL-6, AID/Bcl-6, and CSR.

  • B2 cells locally produce factor I as well as C3 enabling autocrine CD21 signaling.

  • Ab production and CSR are augmented in the absence of DAF (CD55).

J Immunol (2019) 203 (2): 389–399.

  • DC-ASGPR induces IL-10 expression mainly through the activation of ERK/p90RSK/CREB.

  • DC-ASGPR–induced Akt/GSK-3/β-catenin activation contributes to IL-10 induction.

  • DC-ASGPR can play an important role in controlling host immune responses.

J Immunol (2019) 203 (2): 400–407.

  • Skint8 shares sequence and structural similarity to existing B7 family members.

  • Skint8-Ig fusion protein inhibits T cell functions in vitro.

  • Skint8-Ig alleviates experimental autoimmune encephalomyelitis in mice.

IMMUNE SYSTEM DEVELOPMENT

J Immunol (2019) 203 (2): 408–417.

  • In vivo, T cell maturation entails increasing resistance to complement proteins.

  • In vitro, MBL2 is required for complement deposition on immature thymocytes.

  • NKAP-deficient T cells that fail maturation die by ferroptosis, not by complement.

J Immunol (2019) 203 (2): 418–428.

  • Tonic BCR signaling is not sufficient for optimal development of any B cell lineage.

  • Ag recognition is required for development not only of B1a, but also of B2 cells.

  • The minimal threshold for Ag recognition is higher for MZ than for Fo B2 cells.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2019) 203 (2): 429–440.

  • FMDV infection activates two UPR branches: PERK-eIF2α and ATF6 signaling.

  • FMDV infection suppresses the IRE1α-XBP1 pathway of the UPR.

  • Sec62 suppresses FMDV replication by promotion of IRE1α–RIG-I antiviral signaling.

J Immunol (2019) 203 (2): 441–452.

  • PAR-2–activating peptide can act as an adjuvant when delivered to lung.

  • PAR-2–activating peptide plus flu virosomes protect from influenza infection.

  • PAR-2–activating peptide increases the frequency of memory CD8+ T cells in lung.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2019) 203 (2): 453–464.

  • Lactic acid suppresses LPS-mediated mast cell function.

  • Suppression required the MCT-1 transporter and reduced NF-κB function.

  • Lactic acid suppresses LPS-induced glycolysis; these effects are linked to suppression.

J Immunol (2019) 203 (2): 465–475.

  • A stat2−/−Oncorhynchus tshawytscha cell line was isolated.

  • STAT2 is required for type I but not type II signaling in salmonid cells.

J Immunol (2019) 203 (2): 476–484.

  • Eosinophils are prominent in quadriceps lesions of dystrophin-deficient mdx mice.

  • Muscle damage was evaluated quantitatively in mdx, mdx.PHIL, and mdx.IL5tg mice.

  • In these models, eosinophil infiltration is not driving acute muscle pathology.

J Immunol (2019) 203 (2): 485–492.

  • Nicotine can attenuate joint inflammation and pain in experimental OA via α7-nAChRs.

  • Nicotine inhibits MMP-9 production by macrophages through the PI3K/Akt/NF-κB pathway.

J Immunol (2019) 203 (2): 493–499.

  • Polyphosphate released from platelets induces fibrocyte differentiation.

  • Polyphosphate can act as a chemoattractant for neutrophils.

J Immunol (2019) 203 (2): 500–510.

  • Resting FMs induce low levels of neutrophil cytokine secretion and vital NET release.

  • LPS-stimulated FMs augment neutrophil activation and vital NET release via TNF-α.

  • NET release induced by LPS-stimulated FMs was ROS and p38 MAP kinase dependent.

J Immunol (2019) 203 (2): 511–519.

  • Wnt4 is a noncanonical Wnt protein that is expressed in stroma and cDC.

  • Wnt4 is both necessary and sufficient for maintenance of cDC1.

  • Lack of DC-derived Wnt4 accelerates type 2 immunity.

J Immunol (2019) 203 (2): 520–531.

  • Eosinophils are heterogeneous with natural variations in cytokine content.

  • Eosinophil IL-16 content varies dramatically among normal donors (CV = 103%).

  • Eosinophil IL-16 content may correlate directly with donor BMI (R2 = 0.60).

MUCOSAL IMMUNOLOGY

J Immunol (2019) 203 (2): 532–543.

  • The presence of CRTAM impacts the gut microbiota during homeostasis and infection.

  • CRTAM-mediated responses enhance Salmonella gut infection.

  • Transplanted gut microbiota modulates CRTAM expression in ex–germ-free mice.

J Immunol (2019) 203 (2): 544–556.

  • The differentiation of naive T cells into Th1 cells induces the expression of Nlrp6.

  • The expression of Nlrp6 by Th1 cells depends on the microbiota.

  • Nlrp6 deficiency in T cells activates caspase-1 associated with cell death.

TRANSPLANTATION

J Immunol (2019) 203 (2): 557–568.

  • Notch signals in conventional CD4+ T cells are essential for GVHD pathogenesis.

  • Notch induces a unique molecular signature during priming of alloreactive T cells.

NOVEL IMMUNOLOGICAL METHODS

J Immunol (2019) 203 (2): 569–579.

  • pLckCre inefficiently deletes floxed genes in γδ T cells generated in the adult.

  • pLckCre expression mainly effects γδ T cells developing early in ontogeny.

  • Endogenous Lck expression is diminished in developing γδ compared with αβ T cells.

CORRECTIONS

J Immunol (2019) 203 (2): 580.
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