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Issues

IN THIS ISSUE

J Immunol (2019) 203 (5): 1091–1092.

PILLARS OF IMMUNOLOGY

J Immunol (2019) 203 (5): 1093–1094.

BRIEF REVIEWS

J Immunol (2019) 203 (5): 1095–1103.

CUTTING EDGE

J Immunol (2019) 203 (5): 1105–1110.

  • Platelets alter frequency, phenotype, and function of tumor-infiltrating lymphocytes.

  • Inhibition of platelet activation improves CD8+ T cell–dependent tumor control.

  • Pretreatment with antiplatelet therapy enhances responsiveness to PD-1 blockade.

ALLERGY AND OTHER HYPERSENSITIVITIES

J Immunol (2019) 203 (5): 1111–1121.

  • The Il9 CNS-25 is required for IL-9 production in mast cells and basophils.

  • There is differential control of the Il9 gene between mast cells and T cells.

  • Intestinal mast cell expansion requires Il9 CNS-25–dependent IL-9.

J Immunol (2019) 203 (5): 1122–1130.

  • SP-A aids in the resolution of allergic airway inflammation.

  • SP-A promotes eosinophil clearance through chemotaxis and apoptosis.

  • Genetic variation alters the ability of SP-A to induce eosinophil apoptosis.

ANTIGEN RECOGNITION AND RESPONSES

J Immunol (2019) 203 (5): 1131–1141.

  • Shrimp MD-2 homologue ML1 recognizes a lipid component of white spot syndrome virus.

  • Shrimp ML1 activates NF-κB signaling.

  • ML1 induces the expression of Vago, which is a functional analogue of IFN.

AUTOIMMUNITY

J Immunol (2019) 203 (5): 1142–1150.

  • IL-11+CD4+ cells accumulate in the CSF and active brain RRMS lesions.

  • IL-11 increased the numbers of CNS-infiltrating IL-17+CD4+ cells in RREAE.

  • Passive transfer of IL-11–induced encephalitogenic CD4+ T cells induced severe RREAE.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2019) 203 (5): 1151–1159.

  • Biliary epithelial cells secrete Th17-polarizing cytokines.

  • Biliary epithelial cells chemoattract AhR+CCR6+CD4 T cells.

  • Th17 cells promote local Th17 expansion and bile duct proliferation.

J Immunol (2019) 203 (5): 1160–1171.

  • Only 14% of CD4 or CD8 T cells of young adult Malawians were naive (CCR7+CD45RA+).

  • There is little age-associated accumulation of differentiated or senescent T cells.

  • There are robust T cell responses to viral Ags and mitogens from early 20s to late 60s.

IMMUNE REGULATION

J Immunol (2019) 203 (5): 1172–1188.

  • mTORC1 regulates teleost T cell activation, proliferation, and effector function.

  • mTORC1 links immune signals to metabolic programs in teleost T cells.

  • Primordial T cells in teleost have evolved sophisticated regulatory strategies

J Immunol (2019) 203 (5): 1189–1197.

  • Vitamin A negatively regulates iNKT cell population.

  • P2X7 upregulation by retinoic acid makes iNKT cells sensitive to cell death.

  • Tissue-resident iNKT cells are preferentially controlled by P2X7 activation.

J Immunol (2019) 203 (5): 1198–1207.

  • LPS downregulates 11β-HSD2 through inhibiting PPARγ in placental trophoblasts.

  • LPS promotes interaction between NF-κB p65 and PPARγ in the cytoplasm and nucleus.

  • Pretreatment with PPARγ agonist RSG partially alleviates LPS-induced fetal IUGR.

J Immunol (2019) 203 (5): 1208–1217.

  • CD4Cre efficiently recombines in alveolar macrophages and lung epithelial cells.

  • Constitutively active KRas causes T cell hyperactivation and autoimmune diseases.

  • CD4Cre-mediated KRas expression causes fatal hyperproliferative pneumonitis.

J Immunol (2019) 203 (5): 1218–1229.

  • PPE2 protein of M. tuberculosis inhibits ROS production.

  • PPE2 protein interact with p67phox, inhibiting NADPH oxidase complex formation.

  • W236 in PPE2–SH3 domain is crucial for PPE2–p67phox interaction and ROS inhibition.

J Immunol (2019) 203 (5): 1230–1241.

  • PLZF-deficient mice have reduced numbers of basophil progenitors and mature basophils.

  • PLZF-deficient basophils respond poorly to the protein allergen papain.

  • PLZF-deficient basophils are refractory to activation and produce less IL-4.

IMMUNE SYSTEM DEVELOPMENT

J Immunol (2019) 203 (5): 1242–1251.

  • Our study shows that IL-21 plays a pleiotropic role in thymic T cell development.

  • IL-21 is involved in the differentiation of DN subsets as early as the DN1 stage.

  • Furthermore, IL-21 seems to be implicated in the emigration of SP CD4 CD8 T cells.

IMMUNOGENETICS

J Immunol (2019) 203 (5): 1252–1264.

  • Somatic mutations in close proximity exhibit high linkage disequilibrium.

  • Pairs of somatic mutations within 8 bp are templated from IgHV gene segments.

  • Pairs of somatic mutations in non-Ig genes at the IgH locus are similarly templated.

J Immunol (2019) 203 (5): 1265–1275.

  • Ig-TCRδ rearrangement expression is equivalent to canonical TCRδ in the nurse shark.

  • Novel lineage of TCR-associated Ig-like V segments is found in shark TCRδ locus.

  • Ig-TCRδ receptors are produced by intralocus and interlocus VDJ events and pair with TCRγ.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2019) 203 (5): 1276–1287.

  • Primary EBV infection drives highly cytotoxic virus-specific CD4+ T cell responses.

  • EBV-specific memory CD4+ T cells are polyfunctional but lack cytotoxic activity.

  • Acute EBV-specific CD4-CTLs differ transcriptionally from classical memory CD4-CTLs.

J Immunol (2019) 203 (5): 1288–1297.

  • Viral infection downregulates GNAQ expression.

  • GNAQ deficiency increases host antiviral immunity both in vitro and in vivo.

  • GNAQ negatively regulates IFN-I production in a calcineurin-dependent manner.

J Immunol (2019) 203 (5): 1298–1312.

  • Memory reactivation to priming Ags induces real-time immune resetting in sepsis.

  • Sepsis response shifts from pathogen-driven to one driven by memory reactivation.

  • Resetting in sepsis increases survival by a new hypoinflammatory T cell response.

J Immunol (2019) 203 (5): 1313–1324.

  • PGE2 induces immune exhaustion and promotes disease progression of BLV infection.

  • Dual blockade of PGE2 and PD-L1 invigorates antiviral immune response in cattle.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2019) 203 (5): 1325–1337.

  • MDSCs were identified as CD11b+Gr1lo-int in HSV1-infected mice.

  • In vitro–generated MDSCs controlled the severity of HSK lesions.

  • MDSCs promoted endogenous Treg response that also included a de novo conversion.

J Immunol (2019) 203 (5): 1338–1347.

  • PPM1L prevents excessive inflammation and cardiac dysfunction after MI.

  • PPM1L binds IKKβ, inhibits its phosphorylation, and impairs NF-κB activation.

J Immunol (2019) 203 (5): 1348–1355.

  • IFNs induce RIPK3-dependent cell death in the absence of RIPK1.

  • The IFN-stimulated gene product ZBP1 drives cell death in Ripk1−/− cells.

  • ZBP1 and IFN signaling contribute to perinatal lethality of Ripk1−/− mice.

J Immunol (2019) 203 (5): 1356–1368.

  • The mice with constitutively activated MDA5 exhibit SMS-like bone abnormalities.

  • Bone resorption and bone formation are attenuated in MDA5 G821S mutant mice.

  • The pathogenesis is dependent on type I IFN induced by MDA5/MAVS signaling.

J Immunol (2019) 203 (5): 1369–1382.

  • Tongue sole GSDME is cleaved mainly by CASP1 and induces pyroptosis.

  • CASP3/7 also cleave tongue sole GSDME and switch apoptosis to secondary pyroptosis.

  • CASP1-dependent cleavage of GSDME is preserved in a large number of teleost species.

MOLECULAR AND STRUCTURAL IMMUNOLOGY

J Immunol (2019) 203 (5): 1383–1391.

  • Integrin α5β1 binds to monomeric CD40L through the trimeric interface of CD40L.

  • CD40L mutants defective in integrin binding act as antagonists.

  • Functional defects in HIGM1 mutations may be due to defective integrin binding.

TRANSPLANTATION

J Immunol (2019) 203 (5): 1392–1403.

  • Postoperative portal hypertension enhances alloimmune responses after LDLT.

  • Immune-suppression capacity of LSECs is impaired by portal hypertension.

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