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Issues

IN THIS ISSUE

J Immunol (2019) 203 (8): 2027–2028.

LETTERS TO THE EDITOR

J Immunol (2019) 203 (8): 2029.
J Immunol (2019) 203 (8): 2029–2030.

BRIEF REVIEWS

J Immunol (2019) 203 (8): 2031–2041.

CUTTING EDGE

J Immunol (2019) 203 (8): 2043–2048.

  • Aberrant ROR1 expression correlates with a lack of cell response to BTK inhibition.

  • ROR1 associates and forms an active signaling complex with the CD19 receptor.

  • ROR1/CD19 signaling substitutes for BCR/BTK signaling in promoting cell growth.

J Immunol (2019) 203 (8): 2049–2054.

  • USP27X promotes deubiquitination and stabilization of cGAS.

  • USP27X deficiency impairs cGAS-mediated innate signaling.

  • USP27X positively regulates innate antiviral immunity to DNA viruses.

AUTOIMMUNITY

J Immunol (2019) 203 (8): 2055–2062.

  • The AM14 Vκ8 BCR recognizes a B6-derived cross-reactive Ag.

  • This B6 self-antigen induces anergy, receptor editing, and MZ B cell development.

  • Anergic AM14 Vκ8 B cells can be fully activated by nucleic acid containing ICs.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2019) 203 (8): 2063–2075.

  • We report (to our knowledge) novel CMV-specific KLRG1+CD27+ CD57+/− CD8+ TAEFF in primary infection.

  • KLRG1+ TAEFF correlates with CMV function and control in lung transplant patients.

J Immunol (2019) 203 (8): 2076–2087.

  • Reduced GPx4 and increased lipid peroxidation are exhibited in IPF lung fibroblasts.

  • Lipid peroxidation is involved in lung fibrosis development through TGF-β signaling.

  • GPx4-regulated lipid peroxidation can be a therapeutic target for IPF.

J Immunol (2019) 203 (8): 2088–2099.

  • IL-10 inhibition increases T cell IFN-γ and monocyte TNF-α in septic patients.

  • rhIL-10 increases T cell production of IFN-γ in septic patient PBMCs.

  • rhIL-10 decreases monocyte TNF-α production and HLA-DR expression in sepsis.

J Immunol (2019) 203 (8): 2100–2109.

  • JAK inhibitors momelotinib and ruxolitinib show differential effects on CLL cells.

  • JAK inhibitors may be a promising addition for CLL therapy.

IMMUNE REGULATION

J Immunol (2019) 203 (8): 2110–2120.

  • CD24hiCD27+ Bregs and TBs represent major Bregs in humans.

  • CD24hiCD27+ Bregs express IL-10 and increased levels of granzyme B and TGFβ1.

  • CD24hiCD27+ Bregs are more efficient than TBs at suppressing T cell responses.

J Immunol (2019) 203 (8): 2121–2129.

  • A fix/permeabilization approach allows isolation of Ag- and isotype-specific ASC.

  • IgM, IgG, and IgA ASC have shared and distinct transcriptome components.

  • Each ASC isotype displays distinct, expanded CDR3 regions.

J Immunol (2019) 203 (8): 2130–2140.

  • RMϕs inhibit alternative Mϕ activation.

  • Inhibition of alternate activation by RMϕs was not entirely dependent on IL-10.

  • RMϕ attenuated alternative activated Mϕ-mediated pathological conditions in peritoneal fibrosis.

J Immunol (2019) 203 (8): 2141–2149.

  • This study reveals the first (to our knowledge) known biological function of Foxo3 isoform2 in bone.

  • Foxo3 isoform2 is an activator for IFN-I response and an osteoclastic inhibitor.

  • Foxo3 isoform2 mice exclusively expressing isoform2 show osteopetrosis phenotype.

J Immunol (2019) 203 (8): 2150–2162.

  • PLZF expression in CD8αα Tunc distinguishes them from conventional CD8 T cells.

  • CD8αα Tunc express NK cell markers and are dependent upon IL-2Rβ signaling.

  • CD8αα Tunc use perforin in a negative feedback mechanism to control autoimmunity.

IMMUNE SYSTEM DEVELOPMENT

J Immunol (2019) 203 (8): 2163–2170.

  • Thymocyte GR deficiency enhances Ag-specific negative selection.

  • GCs antagonize negative selection by repressing Helios and Nur77 expression.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2019) 203 (8): 2171–2182.

  • PGRN decreases postinfluenza susceptibility to S. pneumoniae coinfection in mice.

  • PGRN increases survival of mice in lethal influenza/S. pneumoniae coinfection.

  • PGRN suppresses lung inflammation and ERS-mediated apoptosis in coinfection.

J Immunol (2019) 203 (8): 2183–2193.

  • H. pylori induces IL-18 through the NLRC4 inflammasome in gastric epithelial cells.

  • IL-18 blocks β-defensin 1 expression via NF-κB activation.

  • NLRC4 contributes to H. pylori immunoescape.

J Immunol (2019) 203 (8): 2194–2209.

  • IFN-γ dominates the CD4+-dependent M. tuberculosis–induced BAL cell gene signature in LTBI.

  • Nevertheless, CD4+ BAL cells in LTBI display polyfunctional responses to M. tuberculosis.

  • This signature may provide a means to assess vaccine-induced local immunity to M. tuberculosis.

J Immunol (2019) 203 (8): 2210–2221.

  • Chronic HIV-1 is associated with increased levels of FcγRIIIA+ CD8 T cells.

  • FcγRIIIA+ CD8 T cells display an innate transcriptomic profile akin to NK cells.

  • ADCC is mediated by FcγRIIIA+ CD8 T cells at levels comparable with NK cells.

J Immunol (2019) 203 (8): 2222–2238.

  • JEV infection elicits miR-301a upregulation in microglial cells.

  • miR-301a upregulation reduces NKRF abundance, thus amplifying NF-κB signaling.

  • Inhibiting miR-301a reduces microglia-mediated bystander killing of neurons.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2019) 203 (8): 2239–2251.

  • Gsr−/− mice exhibited markedly increased susceptibility to C. albicans challenge.

  • Gsr−/− neutrophils display defects in fungicidal activity.

  • Gsr−/− macrophages exhibit an enhanced inflammatory response.

J Immunol (2019) 203 (8): 2252–2264.

  • This study identified two distinct alveolar macrophage populations in old mice.

  • A CD11c+ CD11b alveolar macrophage population is immune regulatory.

  • CD11c+ CD11b+ macrophages are more inflammatory and permissive for M. tuberculosis.

J Immunol (2019) 203 (8): 2265–2275.

  • IL-37 is expressed in alveolar epithelial cells and macrophages.

  • IL-37 levels are decreased in lung and blood obtained from IPF patients.

  • IL-37 attenuates lung fibrosis by inducing autophagy and inhibiting TGF-β1 signaling.

J Immunol (2019) 203 (8): 2276–2290.

  • LL-37 antimicrobial peptides promote macrophage uptake of NETs.

  • NETs modulate LPS-induced cytokine responses in macrophages and DCs.

  • NETs are digested intra- and extracellularly by TREX1 and DNase1L3.

J Immunol (2019) 203 (8): 2291–2300.

  • MK2/3 are the only LPS-induced kinases for S52 and S178 of TTP.

  • TNF regulation by MK2/3 is not restricted to TTP phosphorylation at S52 and S178.

  • The MK2/3/TTP signaling axis contributes to sepsis in vivo.

J Immunol (2019) 203 (8): 2301–2309.

  • KIR polymorphism crucially influences NK cell responses to HCMV.

  • The size of NKG2C expansions correlates with loss of KIR repertoire diversity.

  • These NKG2C expansions correlated with the HCMV-specific Ab concentration.

MUCOSAL IMMUNOLOGY

J Immunol (2019) 203 (8): 2310–2318.

  • MjGCTL provides functional evidence of immune defense in shrimp gills.

  • Gill defense by MjGCTL reveals primitive mucosal immunity in shrimp.

J Immunol (2019) 203 (8): 2319–2327.

  • IL-25 contributes to specific disease phenotypes in chronic HDM-induced asthma.

  • Lung remodeling is partly dependent on IL-25 signaling in cDCs and in Th cells.

  • IL-25 induces clustering of Th9 T cells next to IL-25–activated cDCs in airways.

TRANSPLANTATION

J Immunol (2019) 203 (8): 2328–2338.

  • TSAd knockout mice mount accelerated rejection responses following transplantation.

  • TSAd is a potent regulator of cellular activation in CD4+ Tregs.

  • TSAd knockout CD4+ Tregs fail to shuttle Lck from the cytoplasm to mitochondria.

NOVEL IMMUNOLOGICAL METHODS

J Immunol (2019) 203 (8): 2339–2350.

  • Lymph carries the “omic,” vesicular, and immune cell signature of the draining organs.

  • Lymph analysis provides precise and “undiluted” biochemical and cellular information.

  • A protocol for lymph collection from mouse and rat lymphatics is reported.

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