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J Immunol (2019) 203 (9): 2353–2354.

LETTERS TO THE EDITOR

J Immunol (2019) 203 (9): 2355.
J Immunol (2019) 203 (9): 2355–2356.

BRIEF REVIEWS

J Immunol (2019) 203 (9): 2357–2367.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2019) 203 (9): 2369–2376.

  • TCR-γδ tetramer identified ligand expression by flow cytometry.

  • TCR-γδ ligands were induced on activated monocytes or T cells.

  • Bioinformatics combined with mass spectrometry produced an overlapping list of 16 candidate ligands.

IMMUNE REGULATION

J Immunol (2019) 203 (9): 2377–2387.

  • Flot1−/− CD8+ T cells have altered cell morphology and speeds in vivo.

  • Flot1−/− CD8+ T cells show robust expansion and infiltration of peripheral tissues.

J Immunol (2019) 203 (9): 2388–2400.

  • The mRNA encoding for USP11 is preferentially translated in TREG cells.

  • USP11 modulates TGF-β signaling in murine CD4+ T cells.

  • The USP11/TGF-β axis favors TREG and TH17 cell development.

J Immunol (2019) 203 (9): 2401–2414.

  • Mice lacking Grk2 B cell expression develop a severe immune phenotype.

  • Grk2 expression in B cells limits S1PR1 signaling but augments CXCR5 signaling.

  • An S1PR1 antagonist partially normalizes the signaling defects and immune phenotypes.

J Immunol (2019) 203 (9): 2415–2424.

  • E. muris infection causes major changes in spleen morphology.

  • The changes in lymphoid tissue organization were in part due to TNF-α.

  • Neutralization of TNF-α resulted in an increase in GC-phenotype T-bet+ B cells.

IMMUNOGENETICS

J Immunol (2019) 203 (9): 2425–2442.

  • BTLA–HVEM checkpoint axis regulates hepatic homeostasis and inflammation.

  • Engagement of BTLA by HVEM triggers inhibitory signals for CD8+ T cell tolerization.

  • A potential BTLA–HVEM–LIGHT modulatory network is involved in hepatitis.

IMMUNOTHERAPY AND VACCINES

J Immunol (2019) 203 (9): 2443–2450.

  • Topical CpG adjuvant with s.c. Ag vaccination promotes skin CD8 TRM.

  • Topical CpG adjuvant activity depends on TLR9 expression by hematopoietic cells.

  • Topical CpG adjuvant promotes global protection against dermal tumor challenge.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2019) 203 (9): 2451–2458.

  • Mice can control Mycobacterium avium infections independently of MΦ activation by IFN-γ.

  • TNF compensates for the lack of MΦ activation by IFN-γ.

  • Granulomas form without MΦ activation by IFN-γ.

J Immunol (2019) 203 (9): 2459–2471.

  • NKp44+ ILCs not only diminish SIV acquisition risk but also affect viremia control.

  • Δγ NKp44+ and Δγ DN cells impact viremia control and disease course, respectively.

  • Rectal SIV gp120-specific Ab-mediated ADCC is correlated with rectal CD16+NKp44+ ILCs.

J Immunol (2019) 203 (9): 2472–2484.

  • Intestinal ILCs protect against enteric L. monocytogenes infection.

  • STAT4 signaling directs the protective ILC response to infection.

J Immunol (2019) 203 (9): 2485–2496.

  • The mechanism of anemia in infection is unknown and differs according to infectious agent.

  • M. avium infection causes reticulocytosis and enhanced liver erythrophagocytosis.

  • IFN-γ is necessary for M. avium–induced anemia, but sensing by macrophages is not.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2019) 203 (9): 2497–2507.

  • A caspase-1 biosensor was generated to monitor spatiotemporal dynamics of inflammation.

  • Biosensors allow the tracking of inflammatory events in living animals.

J Immunol (2019) 203 (9): 2508–2519.

  • Interaction of RV with TLR2 regulates RV-induced IFN expression via SIRT-1.

  • SIRT-1 regulates RV-induced IFN expression via inhibition of JAK-STAT pathway.

  • RV-induced excessive IFNs in COPD is associated with defective TLR2 signaling.

J Immunol (2019) 203 (9): 2520–2531.

  • House dust mites (HDM) may harbor a long dsRNA species (HDM-dsRNA).

  • HDM-dsRNA induces an innate immune response that can attenuate type 2 inflammation.

J Immunol (2019) 203 (9): 2532–2544.

  • DUOX2 mRNA expression is associated with poor prognosis in pancreatic cancer.

  • IL-4 and IL-17A synergize to upregulate DUOX2 in pancreatic and colon cancer lines.

  • DUOX2 upregulation increases the production of H2O2 and DNA damage.

MOLECULAR AND STRUCTURAL IMMUNOLOGY

J Immunol (2019) 203 (9): 2545–2556.

  • The structure of mite Der p 2 in complex with murine IgG mAb 7A1 was determined.

  • Human IgE construct identified from phage-display library overlaps with mAb 7A1.

  • Epitope mutagenesis analysis contributes to designing hypoallergens for therapy.

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