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CLINICAL AND HUMAN IMMUNOLOGY
Detection of Cell Surface Ligands for Human Synovial γδ T Cells
TCR-γδ tetramer identified ligand expression by flow cytometry.
TCR-γδ ligands were induced on activated monocytes or T cells.
Bioinformatics combined with mass spectrometry produced an overlapping list of 16 candidate ligands.
IMMUNE REGULATION
In Vivo Function of the Lipid Raft Protein Flotillin-1 during CD8+ T Cell–Mediated Host Surveillance
Flot1−/− CD8+ T cells have altered cell morphology and speeds in vivo.
Flot1−/− CD8+ T cells show robust expansion and infiltration of peripheral tissues.
The Deubiquitinating Enzyme Ubiquitin-Specific Peptidase 11 Potentiates TGF-β Signaling in CD4+ T Cells to Facilitate Foxp3+ Regulatory T and TH17 Cell Differentiation
The mRNA encoding for USP11 is preferentially translated in TREG cells.
USP11 modulates TGF-β signaling in murine CD4+ T cells.
The USP11/TGF-β axis favors TREG and TH17 cell development.
Biased S1PR1 Signaling in B Cells Subverts Responses to Homeostatic Chemokines, Severely Disorganizing Lymphoid Organ Architecture
Mice lacking Grk2 B cell expression develop a severe immune phenotype.
Grk2 expression in B cells limits S1PR1 signaling but augments CXCR5 signaling.
An S1PR1 antagonist partially normalizes the signaling defects and immune phenotypes.
TNF-α Contributes to Lymphoid Tissue Disorganization and Germinal Center B Cell Suppression during Intracellular Bacterial Infection
E. muris infection causes major changes in spleen morphology.
The changes in lymphoid tissue organization were in part due to TNF-α.
Neutralization of TNF-α resulted in an increase in GC-phenotype T-bet+ B cells.
IMMUNOGENETICS
BTLA–HVEM Checkpoint Axis Regulates Hepatic Homeostasis and Inflammation in a ConA-Induced Hepatitis Model in Zebrafish
BTLA–HVEM checkpoint axis regulates hepatic homeostasis and inflammation.
Engagement of BTLA by HVEM triggers inhibitory signals for CD8+ T cell tolerization.
A potential BTLA–HVEM–LIGHT modulatory network is involved in hepatitis.
IMMUNOTHERAPY AND VACCINES
Topical Adjuvant Application during Subcutaneous Vaccination Promotes Resident Memory T Cell Generation
Topical CpG adjuvant with s.c. Ag vaccination promotes skin CD8 TRM.
Topical CpG adjuvant activity depends on TLR9 expression by hematopoietic cells.
Topical CpG adjuvant promotes global protection against dermal tumor challenge.
INFECTIOUS DISEASE AND HOST RESPONSE
TNF-Mediated Compensatory Immunity to Mycobacterium avium in the Absence of Macrophage Activation by IFN-γ
Mice can control Mycobacterium avium infections independently of MΦ activation by IFN-γ.
TNF compensates for the lack of MΦ activation by IFN-γ.
Granulomas form without MΦ activation by IFN-γ.
Differential Effect of Mucosal NKp44+ Innate Lymphoid Cells and Δγ Cells on Simian Immunodeficiency Virus Infection Outcome in Rhesus Macaques
NKp44+ ILCs not only diminish SIV acquisition risk but also affect viremia control.
Δγ NKp44+ and Δγ DN cells impact viremia control and disease course, respectively.
Rectal SIV gp120-specific Ab-mediated ADCC is correlated with rectal CD16+NKp44+ ILCs.
STAT4 Directs a Protective Innate Lymphoid Cell Response to Gastrointestinal Infection
Intestinal ILCs protect against enteric L. monocytogenes infection.
STAT4 signaling directs the protective ILC response to infection.
IFN-γ–Dependent Reduction of Erythrocyte Life Span Leads to Anemia during Mycobacterial Infection
The mechanism of anemia in infection is unknown and differs according to infectious agent.
M. avium infection causes reticulocytosis and enhanced liver erythrophagocytosis.
IFN-γ is necessary for M. avium–induced anemia, but sensing by macrophages is not.
INNATE IMMUNITY AND INFLAMMATION
A Caspase-1 Biosensor to Monitor the Progression of Inflammation In Vivo
A caspase-1 biosensor was generated to monitor spatiotemporal dynamics of inflammation.
Biosensors allow the tracking of inflammatory events in living animals.
Rhinovirus-Induced SIRT-1 via TLR2 Regulates Subsequent Type I and Type III IFN Responses in Airway Epithelial Cells
Interaction of RV with TLR2 regulates RV-induced IFN expression via SIRT-1.
SIRT-1 regulates RV-induced IFN expression via inhibition of JAK-STAT pathway.
RV-induced excessive IFNs in COPD is associated with defective TLR2 signaling.
Immune Sensing of Aeroallergen-Associated Double-Stranded RNA Triggers an IFN Response and Modulates Type 2 Lung Inflammation
House dust mites (HDM) may harbor a long dsRNA species (HDM-dsRNA).
HDM-dsRNA induces an innate immune response that can attenuate type 2 inflammation.
IL-4 and IL-17A Cooperatively Promote Hydrogen Peroxide Production, Oxidative DNA Damage, and Upregulation of Dual Oxidase 2 in Human Colon and Pancreatic Cancer Cells
DUOX2 mRNA expression is associated with poor prognosis in pancreatic cancer.
IL-4 and IL-17A synergize to upregulate DUOX2 in pancreatic and colon cancer lines.
DUOX2 upregulation increases the production of H2O2 and DNA damage.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
A Human IgE Antibody Binding Site on Der p 2 for the Design of a Recombinant Allergen for Immunotherapy
The structure of mite Der p 2 in complex with murine IgG mAb 7A1 was determined.
Human IgE construct identified from phage-display library overlaps with mAb 7A1.
Epitope mutagenesis analysis contributes to designing hypoallergens for therapy.
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Cover Image
Cover Image
On the cover: Conformational changes of dust mite allergen Der p 2 (ribbon) upon recognition by the IgE-overlapping mAb 7A1 (dark red) were observed in two x-ray crystal structures (allergen alone or in complex with mAb-Fab) and confirmed with nuclear magnetic resonance probes of methyl residues in the allergen (sticks). Glesner, J., A. B. Kapingidza, M. Godzwon, L. R. Offermann, G. A. Mueller, E. F. DeRose, P. Wright, C. M. Richardson, J. A. Woodfolk, L. D. Vailes, S. Wünschmann, R. E. London, M. D. Chapman, M. Ohlin, M. Chruszcz, and A. Pomés. 2019. A human IgE antibody binding site on Der p 2 for the design of a recombinant allergen for immunotherapy. J. Immunol. 203: 2545–2556.
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