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J Immunol (2020) 204 (12): 3061–3062.

BRIEF REVIEWS

J Immunol (2020) 204 (12): 3063–3069.

CUTTING EDGE

J Immunol (2020) 204 (12): 3071–3076.

  • Siglec-E is expressed on IRMs.

  • In vivo, ST8Sia6 generates ligands for Siglec-E.

  • Overexpression of ST8Sia6 preserves β cells upon diabetes induction.

ALLERGY AND OTHER HYPERSENSITIVITIES

J Immunol (2020) 204 (12): 3077–3085.

  • Ag-induced MC degranulation is enhanced by P2X4 receptor activation.

  • P2X4 receptor activation augments Ag-induced Syk phosphorylation.

  • Passive anaphylaxis responses are reduced in P2X4 receptor–deficient mice.

J Immunol (2020) 204 (12): 3086–3096.

  • IL-13 is indispensable for the production of IgE Abs to peanuts.

  • Subsets of lung ILC2s produce IL-13 upon airborne exposure to peanut flour.

  • Mice deficient in ILC2s produce lower titers of peanut-specific IgE Abs.

J Immunol (2020) 204 (12): 3097–3107.

  • sPLA2-X serves as an effective adjuvant for a T2 immune response in the lungs.

  • The adaptive immune response requires the enzymatic activity of sPLA2-X.

  • The innate immune response is not fully dependent upon sPLA2-X enzymatic activity.

ANTIGEN RECOGNITION AND RESPONSES

J Immunol (2020) 204 (12): 3108–3116.

  • Hemizygous MHCI expression impacts CD8+ T cell maintenance but not generation.

  • MHCI hemizygous mice show selective retention of high-quality T cells.

  • CD8+ T cells from hemizygous mice are functionally superior after virus infection.

AUTOIMMUNITY

J Immunol (2020) 204 (12): 3117–3128.

  • A focused hepatic BCR repertoire is generated during cholestatic liver disease.

  • Blockade of BAFF reshapes BCR repertoire and reduces autoantibody production.

  • Depletion of B cells reduces both the hepatic fibrosis and autoantibody production.

J Immunol (2020) 204 (12): 3129–3138.

  • Costimulation blockade reduces the loss of β-cell function in type 1 diabetes.

  • CB affects peripheral regulatory and conventional CD4+ but not CD8+ T cell subsets.

  • CB blunts relationship between disease progression and CD4+ memory T cell subsets.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2020) 204 (12): 3139–3148.

  • Thymic-derived Tregs are the most attractive cell type for adoptive cell therapy.

  • Tregs that express the surface marker GPA33 can stably be expanded with high purity.

  • Developing Tregs become GPA33+ around thymic exit, but TGF-β–induced Tregs are GPA33.

J Immunol (2020) 204 (12): 3149–3159.

  • Term pregnancy dNK generate distinct cytolytic responses to K562, PMA/I, and HCMV.

  • Unlike first trimester dNK, term pregnancy dNK are not skewed to recognize HLA-C.

  • Protein and mRNA profiles suggest term pregnancy dNK are a distinct type of NK cell.

IMMUNE REGULATION

J Immunol (2020) 204 (12): 3160–3170.

  • TH17 cells show distinct metabolic and epigenetic states in vitro and in vivo.

  • A miR-21Peli1–c-Rel pathway controls glycolysis of pathogenic TH17 cells.

J Immunol (2020) 204 (12): 3171–3181.

  • TGF-β drives the conversion of human circulating NK cells to an ILC1-like phenotype.

  • CyTOF profiling was used to elucidate heterogeneity in the stages of conversion.

  • TGF-β–mediated conversion is driven by MAPK signaling and is enhanced by IL-15.

J Immunol (2020) 204 (12): 3182–3190.

  • Whole-genome bisulfite sequencing distinguishes between resistant and susceptible O. niloticus.

  • Promoter methylation regulates gene expression in immune-related genes.

J Immunol (2020) 204 (12): 3191–3204.

  • Tupaia STING has two alternative splicing isoforms, tSTING-FL and tSTING-mini.

  • tSTING-mini is critical for RNA virus-induced antiviral signaling transduction.

  • tSTING-mini enhances MDA5–LGP2-mediated antiviral response and IRF3 phosphorylation.

J Immunol (2020) 204 (12): 3205–3216.

  • Cortisol strongly decreases porcine adaptive immune cells and increases neutrophils.

  • Catecholamines exert acute effects on porcine immune cell numbers and function.

  • All stress hormones promote innate over adaptive immune functionality in pigs.

J Immunol (2020) 204 (12): 3217–3226.

  • CD4+ T cell–expressed CD83 regulates T cell responses in vitro and in vivo.

  • CD83+CD4+ T cells control CD40 expression and IL-12 production of DCs.

J Immunol (2020) 204 (12): 3227–3235.

  • Naive CD4 T cells are impaired in lymphopenia-induced proliferation.

  • Limited availability of IL-2Rβ impedes homeostatic IL-15 signaling in CD4 T cells.

  • Forced IL-2Rβ expression permits effective LIP of naive CD4 T cells.

J Immunol (2020) 204 (12): 3236–3247.

  • Xbp1s inhibits BCR tonic signaling, causing rapid death of FOB cells but not MZB cells.

  • Among many UPR-activated molecules, Xbp1s is the only one that causes FOB cell death.

  • BCR-mediated survival and clonal expansion responses are independently regulated.

IMMUNE SYSTEM DEVELOPMENT

J Immunol (2020) 204 (12): 3248–3261.

  • The loss of UHRF1 impairs the commitment to αβ T cell lineage.

  • UHRF1 deficiency promotes development of the Tγδ17.

  • UHRF1 mediates the epigenetic regulation of EGR1.

J Immunol (2020) 204 (12): 3262–3272.

  • Bmi1 regulates self-renewal ability of B-1a cells via Ink4-Arf and possibly Kdm5b.

  • Bmi1 may be involved in the developmental process of B-1 progenitors to B-1a cells.

  • FALCs, the niche for B-1a cells, are not altered in Bmi1−/− mice.

IMMUNOGENETICS

J Immunol (2020) 204 (12): 3273–3282.

  • Distinct peptide-binding motifs for HLA-DP alleles were identified.

  • Binding motifs are associated with structural differences across HLA-DP molecules.

  • New functional hierarchies were demonstrated among HLA-DP alleles.

IMMUNOTHERAPY AND VACCINES

J Immunol (2020) 204 (12): 3283–3295.

  • Select NulOs displayed on gonococcal LOS render bacteria susceptible to complement.

  • CMP-NulOs show promise against multidrug-resistant gonorrhea in preclinical studies.

  • CMP-Leg5,7Ac2 and CMP-Kdn are the current lead candidates.

J Immunol (2020) 204 (12): 3296–3306.

  • IL-17A is critical for GCP-rCpa1 vaccine–mediated protection against Coccidioides.

  • GCP-rCpa1 is recognized by macrophages expressing Dectin-1 and Dectin-2.

  • GCP-rCpa1 activates CLR-CARD9 signaling to induce protective Th17 immunity.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2020) 204 (12): 3307–3314.

  • Treg-boosting IL-2 complexes induce inflammatory factors systemically and in lungs.

  • Treg-boosting IL-2 complexes reduce immunopathology following IAV infection.

  • Treg-boosting IL-2 complexes promote CD4 T cell fitness to survive to form memory.

J Immunol (2020) 204 (12): 3315–3328.

  • SAMT-247 microbicide induces robust SIV protection in female rhesus macaques.

  • Strong vaccine-induced mucosal and systemic immunity did not delay SIV acquisition.

  • SAMT-247/vaccine combination enhanced protection compared with vaccine-only regimen.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2020) 204 (12): 3329–3338.

  • IL-1R signaling is not necessary to control acute or chronic T. gondii burden.

  • IL-1R signaling limits cell death in liver and adipose tissue at acute infection.

  • IL-1R prevents recovery from acute weight loss and drives chronic cachexia.

J Immunol (2020) 204 (12): 3339–3350.

  • Δ9-THC increases IL-10 and reduces IL-6 and CCL2 in endotoxemic mice via CB1R.

  • Δ9-THC decreases lung inflammation and organ injury in endotoxemic mice.

  • Monocytic-MDSCs mediate Δ9-THC–induced IL-10 upregulation in endotoxemic mice.

MOLECULAR AND STRUCTURAL IMMUNOLOGY

J Immunol (2020) 204 (12): 3351–3359.

  • αβ TCRs, A11 and B12A, recognize CD155 independent of MHC presentation.

  • CDR3 of α- or β-chain alone is insufficient to discriminate against MHC binding.

  • This study reports the structure of αβ TCR in complex with a non-MHC ligand.

J Immunol (2020) 204 (12): 3360–3374.

  • Cullin 3 is identified as a novel CD22 interacting protein.

  • Cullin 3 binds to CD22 and regulates CD22 surface expression and internalization.

  • Cullin 3 controls pro-B cell proliferation and is important for B cell signaling.

SYSTEMS IMMUNOLOGY

J Immunol (2020) 204 (12): 3375–3388.

  • The auxoGTU vaccine and EP triggered different components of innate immunity.

  • The auxoGTU vaccine with EP induces a local release of IL-15 and activation of LC.

  • AIM-2 seems to be a sensor of the auxoGTU vaccine.

J Immunol (2020) 204 (12): 3389–3399.

  • Neutrophils express robust transcriptional profiles following cytokine stimulation.

  • Myeloid cell gene signatures can stratify patients and predict disease outcomes.

TUMOR IMMUNOLOGY

J Immunol (2020) 204 (12): 3400–3415.

  • Suppression of Wdr5/Ash2l/Ml11 promotes PMN-MDSCs’ accumulation and function.

  • Stat3/Cebpβ downregulate Wdr5/Ash2l/Ml11 by upregulating miR–21a/21b/181b.

J Immunol (2020) 204 (12): 3416–3424.

  • Radiation fails to promote cDC1 maturation in poorly radioimmunogenic tumors.

  • Impaired cDC1 activation following radiation limits the response to treatment.

  • Adjuvants that drive cDC1 maturation improve tumor responses to radiation.

NOVEL IMMUNOLOGICAL METHODS

J Immunol (2020) 204 (12): 3425–3433.

  • Correction for batch and nonspecific binding enhances Luminex data.

  • Our novel R utility automates these corrections.

  • Utility can uncover undetected biological patterns in Luminex data.

J Immunol (2020) 204 (12): 3434–3444.

  • PacBio Iso-Seq enables generation of immune repertoire C region references.

  • Full-length CCS reads benchmark targeted immune repertoire assay efficiencies.

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