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Issues
1 May 2020
ISSN 0022-1767
EISSN 1550-6606
In this Issue
IMMUNOLOGY2020™ had been scheduled to take place May 8-12, 2020, in Honolulu, HI. Due to the COVID-19 pandemic, it was cancelled.
Antigen Processing and Presentation 2
Identification of dendritic cell precursors in the culture of bone marrow with hematopoietic cytokines
Hyunju In; Hye Young Na; Seul Hye Ryu; Moah Sohn; Wanho Choi; Hyun Soo Shin; Ji Soo Park; Sejung Park; Chae Gyu Park
J Immunol (2020) 204 (1_Supplement): 140.10.
Butyrophilin molecules govern γδ T cell reactivity against phosphoantigens
Marc Rigau; Simone Ostrouska; Tom Fulford; Darryl Neil Johnson; Katherine Woods; Zheng Ruan; Hamish McWilliam; Christopher Hudson; Candani Tutuka; Adam K Wheatley; Stephen J Kent; Jose A Villadangos; Bhupinder Pal; Christian Kurts; Jason Simmonds; Matthias Pelzing; Andrew D Hammet; Anne M Verhagen; Gino Vairo; Eugene Maraskovsky; Con Panousis; Nicholas Anthony Gherardin; Jonathan Cebon; Dale Ian Godfrey; Andreas Behren; Adam Peter Uldrich
J Immunol (2020) 204 (1_Supplement): 140.12.
Activation of Dendritic Cells Alters the Mechanism of MHC Class II Antigen Presentation to CD4 T Cells
J Immunol (2020) 204 (1_Supplement): 140.14.
Determining the impact of HLA type and chronic viral infection on peripheral T-cell receptor sharing between unrelated individuals
J Immunol (2020) 204 (1_Supplement): 140.16.
Reevaluating HLA-A2-restricted Lassa epitopes in human Lassa fever survivors
Brian Martin Sullivan; Saori Sakabe; Jessica N Hartnett; Nhi Nho; Augustine Goba; Mambu Momoh; John Demby Sandi; Lansana Kanneh; Beatrice Cubitt; Selma D Garcia; Brian C Ware; Dylan Kotliar; Refugio Robles-Sikisaka; Karthik Gangavarapu; Juan Carlos de la Torre; Pardis C Sabeti; Kristian G Andersen; Robert F Garry; Donald S Grant; John S Schieffelin; Michael B Oldstone
J Immunol (2020) 204 (1_Supplement): 140.17.
Activation of virtual memory CD8+ T cells specific for self antigens requires antigen presentation by CD11c+ cells
J Immunol (2020) 204 (1_Supplement): 140.19.
TGF-β downregulates MHC I surface expression through a Smad3-dependent mechanism
J Immunol (2020) 204 (1_Supplement): 140.2.
Classical splenic dendritic cell subsets, cDC1 and cDC2, from C57BL/6 mice are more potent in stimulating the Th1 immune response than those from BALB/c mice during mousepox
J Immunol (2020) 204 (1_Supplement): 140.20.
Illuminating the Mechanism of MHC-I Folding and Antigen Repertoire Selection Using Deep Mutational Scanning and Biophysical Studies
J Immunol (2020) 204 (1_Supplement): 140.21.
Targeted protein degradation via NEDD8 conjugation does not enhance direct MHC class I antigen presentation
J Immunol (2020) 204 (1_Supplement): 140.7.
The (tremendous) gap between predicted epitopes and those actually recognized by CD8 T cells
J Immunol (2020) 204 (1_Supplement): 140.8.
Structural Insights into the Mechanism(s) of Peptide Loading in MHC-I dependent Antigen Presentation
Jiansheng Jiang; Kannan Natarajan; Ellen Kim; Javeed A. Dhobi; Michael G. Mage; Lisa F. Boyd; David H. Margulies
J Immunol (2020) 204 (1_Supplement): 140.9.
Microorganisms: Friend or Foe in Autoimmunity
Single cell RNA sequence analysis reveals novel clusters unique to post-infectious myocarditis in the mouse model of Coxsackievirus infection
Ninaad Lasrado; Rajkumar Arumugam; Sabarirajan Jayaraja; Sandra Thibivilliers; Marc Libault; Timothy K. Starr; Jay Reddy
J Immunol (2020) 204 (1_Supplement): 141.10.
Microbiota-driven regulatory T cells suppress experimental autoimmune encephalomyelitis (EAE) in interleukin-17A deficient HLA class-II transgenic mice model of multiple sclerosis (MS)
Shailesh K Shahi; Samantha N Freedman; Alexandra C Murra; Nicole Cady; Arnav Gupta; Natalya V Guseva; Katherine N Gibson-Corley; Aaron D Bossler; Sukirth M Ganesan; Nitin J Karandikar; Ashutosh K Mangalam
J Immunol (2020) 204 (1_Supplement): 141.11.
Isoflavone Rich Diet Ameliorates Experimental Autoimmune Encephalomyelitis (EAE) through Modulation of Gut Bacteria Depleted in Multiple Sclerosis Patients
Samantha N Freedman; Shailesh K Shahi; Kasra Zarei; Arnav Gupta; Natalya V Guseva; Aaron D Bossler; Kevin L Legge; Ashutosh K Mangalam
J Immunol (2020) 204 (1_Supplement): 141.12.
Maturation of dendritic cells derived from type 1 diabetes-susceptible NOD mice is differentially regulated by two strains of generally regarded as safe (GRAS) Lactobacillus
Joseph Larkin; Zaynab Sidi Mohamed; Alexandria Ardissone; Simone Bedoya; Erin Collins; Clive Wasserfall; Graciela Lorca; Eric W. Triplett; Mark Atkinson
J Immunol (2020) 204 (1_Supplement): 141.14.
Virus-mediated dysbiosis alters immune populations to promote type 1 diabetes onset
J Immunol (2020) 204 (1_Supplement): 141.15.
Bacterially-derived indole modulates murine arthritis through alteration of B cell glycosylation enzymes
J Immunol (2020) 204 (1_Supplement): 141.16.
Prevotella histicola treatment reduces arthritic pain and partially normalizes gut microbiota and metabolites
J Immunol (2020) 204 (1_Supplement): 141.17.
Targeting both IL-17 and CXCR2 in the gut leads to the suppression of arthritis and joint inflammation in the autoimmune arthritis mice driven by a mycoplasma superantigen
J Immunol (2020) 204 (1_Supplement): 141.18.
Understanding the role of hnRNPA1 on T cell differentiation and function in the Gut
J Immunol (2020) 204 (1_Supplement): 141.19.
Latency III gene products of Epstein-Barr Virus (EBV) are associated with Systemic Lupus Erythematosus (SLE) genetic risk loci
Viktoryia Laurynenka; Xiaoting Chen; Martha Carter; Sreeja Parameswaran; Shruti Eswar; Kenneth M. Kaufman; Bahram Namjou; Matthew T. Weirauch; Leah C. Kottyan; John B. Harley
J Immunol (2020) 204 (1_Supplement): 141.2.
Genetics but not intestinal microbiota determines the onset of systemic autoimmune disease in BXD2 mice
Huixian Hong; Qi Wu; PingAr Yang; Wayne Duck; Casey D. Morrow; Jeremy B. Foote; Trenton R. Schoeb; Charles O. Elson; Hui-Chen Hsu; John D. Mountz
J Immunol (2020) 204 (1_Supplement): 141.3.
TLR9 stimulation by the gut microbiota promotes tissue-specific immunosuppression in autoimmune-prone MRL/lpr mice
Michael Richard Edwards; Qinghui Mu; Brianna Swartwout; Xavier Cabana-Puig; Jiangdi Mao; Christopher M. Reilly; Xin M. Luo
J Immunol (2020) 204 (1_Supplement): 141.4.
Characterizing the role of Lactobacillus spp. in systemic lupus erythematosus
Xavier Cabana Puig; Qinghui Mu; Brianna Swartwout; Leila Abdelhamid; Meeta B. Prakash; Christopher M. Reilly; Xin M. Luo
J Immunol (2020) 204 (1_Supplement): 141.5.
The Effect of Dietary Fiber Intake on Systemic Lupus Erythematosus (SLE) Disease in NZB/W Lupus Mice
Eric James Panther; Jingjing Ren; Xavier Cabana-Puig; Leila Abdelhamid; Brianna Swartwout; Xin M. Luo; Christopher M. Reilly
J Immunol (2020) 204 (1_Supplement): 141.6.
Inhibition of autoimmune enteritis in IFABP-Ova mice by LCMV infection
J Immunol (2020) 204 (1_Supplement): 141.8.
Single cell RNA sequence analysis reveals novel clusters unique to post-infectious myocarditis in the mouse model of Coxsackievirus infection
Jay Reddy; Ninaad Lasrado; Rajkumar Arumugam; Sabarirajan Jayaraja; Sandra Thibivilliers; Marc Libault; Timothy K Starr
J Immunol (2020) 204 (1_Supplement): 141.9.
T Cells in Autoimmunity
Cardiac myosin-specific TCR transgenic mouse models for studying dilated cardiomyopathy
Jay Reddy; Chandirasegaran Massilamany; Rajkumar Arumugam; Ninaad Lasrado; Arunkumar Gangaplara; Sabarirajan Jayaraja; David Steffen; Channabasavaiah Gurumurthy
J Immunol (2020) 204 (1_Supplement): 142.1.
A newly discovered dual expresser lymphocyte that clonally expanded in Type 1 diabetes (T1D) patients secretes a public antibody that recognize public TCR in T1D
Rizwan Ahmed; Zahra Omidian; Adebola Giwa; Kagan E Karakus; Neha Majety; Angela Yang; Hao Zhang; Hamid Rabb; Chunfa Jie; Thomas Donner; Abdel R.A. Hamad
J Immunol (2020) 204 (1_Supplement): 142.10.
Genetic and pharmaceutical targeting of OCA-B/Pou2af1 blocks T1D in mouse models
Heejoo Kim; Arvind Shakya; Jelena Perovanovic; Andrea Ibarra; Brian Evavold; Danny H.-C. Chou; Xiao He; Peter E Jensen; Dean R Tantin
J Immunol (2020) 204 (1_Supplement): 142.11.
Analysis of the nonobese diabetic mouse islet MHC-II peptidome reveals posttranslationally modified autoantigens
J Immunol (2020) 204 (1_Supplement): 142.12.
Single-cell RNA sequencing of pancreatic islets reveals the complexity of autoimmune diabetes throughout its initiation and development
J Immunol (2020) 204 (1_Supplement): 142.13.
Characterization and use of human insulin transgenic mouse models for type 1 diabetes
J Immunol (2020) 204 (1_Supplement): 142.14.
Expression of the lupus associated Pbx1-d isoform induces pro-inflammatory phenotypes in mesenchymal stem cells (MSCs) in a mouse model of lupus
J Immunol (2020) 204 (1_Supplement): 142.16.
Lupus susceptibility gene Pbx1 promotes atherosclerosis via dysfunctional T cells in a mouse model
Wei Li; Ahmed Elshikha; Xiangyu Teng; Georges Abboud; Josephine Michelle Brown; Seung-Chul Choi; Kristianna Fredenburg; Amy S Major; Laurence Morel
J Immunol (2020) 204 (1_Supplement): 142.17.
CD6 modulation ameliorates immune complex-mediated glomerulonephritis
Samantha A. Chalmers; Sayra J Garcia; Leal Herlitz; Jeanette Ampudia; Cherie Ng; Stephen Connelly; Chaim Putterman
J Immunol (2020) 204 (1_Supplement): 142.18.
Follicular helper T cells express a metabolic and cell signaling gene signature in a lupus-prone murine model
J Immunol (2020) 204 (1_Supplement): 142.19.
T cell cooperation in the induction of autoimmunity in a murine model of multiple sclerosis
J Immunol (2020) 204 (1_Supplement): 142.20.
Investigating the antigen-specific T cell response to MHC variant peptide 45D
J Immunol (2020) 204 (1_Supplement): 142.21.
Differential effects of Flavipin on Ahr and Arid5a: A new therapeutic strategy for autoimmune encephalomyelitis
J Immunol (2020) 204 (1_Supplement): 142.27.
Functions and mechanisms of chondroitin disaccharide-induced miRNAs in the regulation of CD44 expression involved in the development of experimental autoimmune encephalomyelitis
J Immunol (2020) 204 (1_Supplement): 142.28.
Gata3 regulates the pathogenicity of Tbet-expressing Th17 cells in EAE
J Immunol (2020) 204 (1_Supplement): 142.29.
Noncoding RNAs modify GATA3-driven transcription, leading to the immune profiles seen in psoriasis and atopic dermatitis
J Immunol (2020) 204 (1_Supplement): 142.3.
Induced lymphatic circulation decreases IL-17 expression in the lymph nodes of rats in adjuvant-induced arthritis
Michael V Volin; Brian Zanotti; Denver Hager; LinhChi Lai; Calley Gober; Paul Anthony Pulpulaan; Ryan Incrocci; Michelle Anne Swanson-Mungerson
J Immunol (2020) 204 (1_Supplement): 142.30.
Genetic Interactions of the Transcription Factor Ets1 and IL17RA Signaling in Autoimmunity and Immunodeficiency
Michael Battaglia; Alex Sunshine; Wei Luo; Richard M Jin; Matthew Garis; Alifa Stith; Matthew Lindemann; Lloyd S Miller; Satrajit Sinha; Elizabeth A Wohlfert; Lee Ann Garrett-Sinha
J Immunol (2020) 204 (1_Supplement): 142.31.
The gut as a potential licensing site for central nervous system (CNS)-specific autoimmune lymphocytes
J Immunol (2020) 204 (1_Supplement): 142.33.
Exhausted CD8 T cells exhibit phenotypic and functional heterogeneity in type I diabetes (T1D)
J Immunol (2020) 204 (1_Supplement): 142.34.
The effects of germline STAT3-activating mutations from autoimmunity and lymphoid malignancy on mouse and human T cells
Etienne Masle-Farquhar; Kathryn Payne; Mandeep Singh; Geetha Rao; Ghamdan Al-Eryani; Christopher Jara; Katherine Jackson; Robert Adrian Brink; Stuart Tangye; Joanne Reed; Christopher C Goodnow
J Immunol (2020) 204 (1_Supplement): 142.35.
Aberrant expression of β5t in the periphery induces a self-reactive T-cell response
J Immunol (2020) 204 (1_Supplement): 142.37.
More roles of IL-4 than being as an antagonist of IFN-γ in experimental autoimmune uveitis
J Immunol (2020) 204 (1_Supplement): 142.4.
A novel self-regulatory mechanism of Th17 cells controls autoimmune uveitis through interleukin-24
Wai Po Chong; Mary Mattapallil; Kumarkrishna Raychaudhuri; Phyllis B. Silver; Yingyos Jittayasothorn; Chi-Chao Chan; Jun Chen; Reiko Horai; Rachel R Caspi
J Immunol (2020) 204 (1_Supplement): 142.5.
GM-CSF mediates development of eosinophil-dominant autoimmune uveitis in the absence of both IFN-γ and IL-17A
J Immunol (2020) 204 (1_Supplement): 142.6.
Sjögren’s syndrome minor salivary gland CD4+ T cells associate with glandular disease features and have a germinal center T follicular helper transcriptional profile
A. Darise Farris; Michelle L Joachims; Kerry M Leehan; Mikhail G Dozmorov; Constantin Georgescu; Zijian Pan; Astrid Rasmussen; Lida Radfar; David M Lewis; Donald U Stone; Kiely Grundahl; R. Hal Scofield; Christopher J Lessard; Jonathan D Wren; Linda F Thompson; Kathy L Sivils; Jacen S Moore
J Immunol (2020) 204 (1_Supplement): 142.7.
Delineating T cell autoreactivity in autoimmune diabetes by assessing the MHC-II-bound peptidome
J Immunol (2020) 204 (1_Supplement): 142.8.
LAG3 limits the diabetogenicity of intra-islet CD8 T cells
Stephanie J Grebinoski; Qianxia Zhang; Anthony R Cillo; Andrea Szymczak-Workman; Creg Workman; Dario Vignali
J Immunol (2020) 204 (1_Supplement): 142.9.
Tolerance and Tregs in Autoimmunity
Dissection of T-cell tolerance induction by dendritic cell surface glycoproteins
Michael Dustin; Ahmed Saadawi; Viveka Mayya; Pablo Cespedes; Salvatore Valvo; Lina Chen; Philippos Demetriou
J Immunol (2020) 204 (1_Supplement): 143.1.
Treg-restricted deletion of TRAIL (Tnfsf10) reduces autoimmune diabetes
Rebekah Dadey; Stephanie J Grebinoski; Qianxia Zhang; Angela Gocher; Erin Brunazzi; Lawrence Peter Andrews; Amanda Burton; Creg Workman; Dario Vignali
J Immunol (2020) 204 (1_Supplement): 143.10.
UVB light exposure promotes IgE autoantibody production and skin autoreactivity in mice that express a lupus-associated isoform of Foxp3
J Immunol (2020) 204 (1_Supplement): 143.11.
Characterization of Aire-expressing DCs using a novel Aire-reporter strain
Mitsuru Matsumoto; Minoru Matsumoto; Ryuichiro Miyazawa; Junko Morimoto; Koichi Tsuneyama; Hitoshi Nishijima
J Immunol (2020) 204 (1_Supplement): 143.13.
Androgens may mediate protection through an effect on immunoregulation in lupus-prone mice
J Immunol (2020) 204 (1_Supplement): 143.15.
Pathogenic role of plasmacytoid dendritic cells in the development and onset of Sjögren’s syndrome-like exocrinopathy in non-obese diabetic mice
J Immunol (2020) 204 (1_Supplement): 143.16.
A lifestyle-educational program improves depression levels of those with autoimmune disease
J Immunol (2020) 204 (1_Supplement): 143.18.
Impact of age-associated decrease in thymic B cell expression of Aire and self-antigen genes on T cell tolerance
J Immunol (2020) 204 (1_Supplement): 143.2.
Zfp36 family members redundantly protect against T cell-mediated autoinflammation and premature mortality
Melissa Erin Cook; Tara R Bradstreet; Andrea Santeford; Jongshim Kim; Ashlee Webber; Elizabeth A Schwarzkopf; Nicholas N Jarjour; Chih-Chung Lin; Deborah J Stumpo; Rajendra S Apte; Perry J Blackshear; Brian T Edelson
J Immunol (2020) 204 (1_Supplement): 143.3.
Melanocyte-specific CD8+ T cells demonstrate tolerance characterized by an impaired ability to differentiate into a highly proliferative population
Emily Nestor Truckenbrod; Kristin R Renkema; Kristina S Burrack; Henrique Borges da Silva; Stephen C Jameson
J Immunol (2020) 204 (1_Supplement): 143.4.
The novel role of signal transducer and activator of transcription 5B (STAT5B) in mediating T cell differentiation and regulatory functions
J Immunol (2020) 204 (1_Supplement): 143.5.
Helminth-induced modulation of neuroinflammation in a mouse model of multiple sclerosis
J Immunol (2020) 204 (1_Supplement): 143.6.
Foxp3+ regulatory T cells play an indispensable role during glucocorticoid-induced treatment of autoimmune inflammation
J Immunol (2020) 204 (1_Supplement): 143.7.
Aged T cells shape neuronal autoimmune disease in a model of late-onset multiple sclerosis (Supported by NIH/NIAID R01AI121147)
J Immunol (2020) 204 (1_Supplement): 143.8.
The Role of Aire in the selection of Regulatory T cells in Diabetes
Jennifer Anne Bridge; Jared Balolong; Shen Dong; Nathan Cramer; Cody Mowery; Frances Crawford; Jimmie Ye; John W Kappler; Jeffrey A Bluestone; Mark S Anderson
J Immunol (2020) 204 (1_Supplement): 143.9.
Antioxidants and Metabolic Regulation of Inflammation
Influenza infection exacerbates disease symptoms in relapsing models of multiple sclerosis
J Immunol (2020) 204 (1_Supplement): 144.10.
Regulation of necroptosis by targeting tumor suppressor death-associated protein kinase 1
Ming-Zong Lai; Yung-Hsuan Wu; Ting-Fang Chou; Leslie Young; Fu-Yi Hsieh; Hsuan-Yin Pan; Shu-Ting Mo; Shani Bialik Brown; Ruey-Hwa Chen; Adi Kimchi
J Immunol (2020) 204 (1_Supplement): 144.11.
LPS elevates ceramide levels through regulating ORMDL3 expression in macrophages and acute respiratory distress syndrome model
J Immunol (2020) 204 (1_Supplement): 144.13.
Peripherally-induced brain tissue resident memory CD8 T cells mediate protection against CNS infections
J Immunol (2020) 204 (1_Supplement): 144.15.
Inflammation associated weight cycling contributes to an obesogenic memory phenotype in adipose tissue
Sierra J McDonald; Alexander T Sougiannis; Brandon Vanderveen; Taryn Cranford; Reilly T Enos; Kandy Velazquez; Ioulia Chatzistamou; Daping Fan; Angela E Murphy
J Immunol (2020) 204 (1_Supplement): 144.17.
DAMP-mediated cardiac dysfunction: cardiomyocytes as actors and target of innate immune response
J Immunol (2020) 204 (1_Supplement): 144.18.
Imaging neuroinflammation in murine endotoxemia: a dual-tracer microPET evaluation
Lauren Turecki; Santhoshi P Palandira; Hui Liu; Meghan Addorisio; Tea Tsaava; Eric Chang; Yilong Ma; Joseph Carrion; Kevin J Tracey; Valentin A Pavlov
J Immunol (2020) 204 (1_Supplement): 144.19.
How safe is the application of nanotitania when it can induce inflammatory response, affect liver function or body weight in animal models?
J Immunol (2020) 204 (1_Supplement): 144.2.
The kinase activity of IRAK4 controls sterile autoinflammation and manifestations of Murine Lupus
Federica Agliano; Antoine Ménoret; Keaton S. Karlinsey; Michael Ragazzi; Timofey Karginov; Anthony T. Vella
J Immunol (2020) 204 (1_Supplement): 144.21.
STAT3 modulates metabolic programming of inflammation-induced macrophages
J Immunol (2020) 204 (1_Supplement): 144.22.
The actin-bundling protein L-plastin regulates NLRP3 inflammasome activation in macrophages
Hemant Joshi; Edgar Anaya; Alison Almgren-Bell; Talyor P. Szasz; Elizabeth M. Todd; Sharon Celeste Morley
J Immunol (2020) 204 (1_Supplement): 144.24.
IEX-1 deficiency in hematopoietic cells mitigates high fat diet-induced obesity and glucose intolerance
J Immunol (2020) 204 (1_Supplement): 144.25.
Somatostatin receptor subtype 4 protects against indomethacin-induced gastrointestinal mucosal injury in mouse
Kata Cseko; Viktória Kormos; Ádám István Horváth; Angéla Kecskés; Balázs Gaszner; Maria Sudalina; Natalia Iarushkina; Dóra Zelena; Ludmila Filaretova; Zsuzsanna Helyes
J Immunol (2020) 204 (1_Supplement): 144.26.
Validation of a chronic imiquimod-induced psoriasiform dermatitis model in Balb/c mice
J Immunol (2020) 204 (1_Supplement): 144.27.
Endocannabinoid hydrolysis inhibition unmasks that unsaturated fatty acids induce a robust synthesis of 2-arachidonoyl-glycerol and its congeners in human myeloid leukocytes
Anne-Sophie Archambault; Caroline Turcotte; Elizabeth Dumais; Cyril Martin; Marie-Renée Blanchet; Elyse Bissonnette; Nami Ohashi; Keiko Yamamoto; Toshimasa Itoh; Michel Laviolette; Alain Veilleux; Louis-Philippe Boulet; Vincenzo Di Marzo; Nicolas Flamand
J Immunol (2020) 204 (1_Supplement): 144.28.
Lymphangiogenesis near the Cribriform Plate after Cerebral Ischemia
J Immunol (2020) 204 (1_Supplement): 144.30.
Increased neuroinflammation and atherosclerosis in sleep fragmented mice
Alina K Moriarty; W. Coles Keeter; Tayab Waseem; Shelby Ma; Phillip Joseph Gauronskas; Matthew J Butcher; Laurie Wellman; Larry Sanford; Elena Galkina
J Immunol (2020) 204 (1_Supplement): 144.31.
Phosphatase SHP2-mediated mitochondrial homeostasis for the resolution of inflammation
J Immunol (2020) 204 (1_Supplement): 144.32.
Inhibition of thrombin signalling on the surface of monocytes reduces inflammation in oxazolone-induced delayed type hypersensitivity
J Immunol (2020) 204 (1_Supplement): 144.4.
Macrophage-restricted tyrosine phosphatase SHP2 is a novel anti-atherosclerotic regulator
J Immunol (2020) 204 (1_Supplement): 144.5.
Sleep-loss activates NLRP3 inflammasome-activity in astrocytes by increasing electroencephalogram slow-waves and activates microglia to increase NREM sleep amounts
J Immunol (2020) 204 (1_Supplement): 144.6.
Anti-inflammatory effects of β-cry on 5FU-induced cytokine production in hOMF
Fumishige Oseko; Toshiro Yamamoto; Yoshiki Sato; Kenta Yamamoto; Keiji Adachi; Mitsunori Akane; Masaru Nishigaki; Narisato Kanamura
J Immunol (2020) 204 (1_Supplement): 144.9.
Human Immunology in Health and Disease
Epigenetic Regulation of Notch1/2 Signaling Modulates CD4+ T cell Phenotype and Impairs Diabetic Wound Healing
Frank M Davis; Sonya Wolfe; Aaron Dendekker; Amrita Joshi; Christopher Audu; Bethany B Moore; Nicholas W Lukacs; Steven L Kunkel; Katherine Gallagher
J Immunol (2020) 204 (1_Supplement): 145.10.
Progressive immunosenescence in diabetic chronic kidney disease
J Immunol (2020) 204 (1_Supplement): 145.12.
The growth regulator human proliferation-associated 2G4 (PA2G4) protein interacts with NLRP7 which is involved in recurrent hydatidiform molar pregnancy
J Immunol (2020) 204 (1_Supplement): 145.14.
M2-polarized macrophages as a potential cell therapy to mitigate inflammation-induced preterm birth
Valeria Garcia-Flores; Roberto Romero; Yi Xu; Derek Miller; Rebecca Slutsky; Sarah A Robertson; Nardhy Gomez-Lopez
J Immunol (2020) 204 (1_Supplement): 145.15.
The effect of N-butyl benzyl phthalate, a common plasticizer, on endometriosis development
J Immunol (2020) 204 (1_Supplement): 145.16.
A potential association of an interferon gene signature with RBC alloimmunization in sickle cell disease
J Immunol (2020) 204 (1_Supplement): 145.18.
NFkB mediated sustained inflammation promotes hepatobiliary injury in Sickle Cell Disease
J Immunol (2020) 204 (1_Supplement): 145.19.
A circulating population of CD4+ cutaneous resident memory T cells is diminished in humans with fibrotic disease
Peter A Morawski; Mitch Fahning; Suraj Varkhande; Emma Beale; Maria Klicznik; Iris Gratz; Daniel J. Campbell
J Immunol (2020) 204 (1_Supplement): 145.21.
Characterization of immune cells found in keloid versus normal skin tissue
Jaclyn B Anderson; Alexander B Harrant; Nalu Navarro-Alvarez; Zhaohui Wang; Adrie van Bokhoven; Whitney High; Tae W Chong; Christene A Huang
J Immunol (2020) 204 (1_Supplement): 145.23.
PD-L1 expression at the single cell level in Myeloid Derived Suppressor Cells using a stimulatory functional assay to evaluate immunotherapy strategies in multiple myeloma
Jolene A Bradford; Laura G. Rico; Jordi Junca; Jorge Bardina; Angel Bistue-Rovira; Michael D. Ward; Jordi Petriz
J Immunol (2020) 204 (1_Supplement): 145.25.
Differential Activity of Key Super-Enhancers Drives Disease-Defining Oncogenes in B Cell Cancers
Jacqueline Payton; Jared Andrews; Sarah Pyfrom; Jennifer Schmidt; Hannah Marcy; Olivia Koues; Amanda F. Cashen; Eugene M. Oltz
J Immunol (2020) 204 (1_Supplement): 145.27.
Longitudinal Immune and Genomic Monitoring Reveals Signatures of Immune-related Adverse Events in Cancer Patients Receiving Checkpoint Inhibitor Therapy
Shaheen Khan; Angela Moses; Marjaan Imam; Edward K Wakeland; Carlos Arana; Farjana Fattah; Quan-Zhen Li; Mitch von Itzstein; David Hsieh; Vinitha Popat; Spencer Barnes; Yang Xie; Saad Khan; David Gerber
J Immunol (2020) 204 (1_Supplement): 145.28.
Epigenetic drivers of Cutaneous T Cell Lymphoma revealed at single cell resolution
J Immunol (2020) 204 (1_Supplement): 145.29.
Disease-associated dominant negative CARD11 mutations interfere with the CARD11 Opening Step during antigen receptor signaling to NF-κB and JNK2
J Immunol (2020) 204 (1_Supplement): 145.3.
T-cells dysregulate hematopoiesis in Myeloproliferative Neoplasm through increased interferon-gamma production
J Immunol (2020) 204 (1_Supplement): 145.30.
Cervical Cancer induces NLRP3 inflammasome activation in human peripheral blood monocytes
J Immunol (2020) 204 (1_Supplement): 145.31.
A Physiologically-Relevant Three-Dimensional In Vitro Model of Human Myeloma Bone Disease
J Immunol (2020) 204 (1_Supplement): 145.32.
Developing & Validating an Approach for Diagnosing and Prognosticating Cancer from Biochemical Motifs in T-cell Receptors
J Immunol (2020) 204 (1_Supplement): 145.33.
The IgM and IgG subclass distribution of anti-Galactose-alpha-1,3-galactose and anti-N-glycolylneuraminic acid antibodies in healthy adults
J Immunol (2020) 204 (1_Supplement): 145.35.
Connecting GWAS SNPs to Target Genes in primary human immune cell types
Vivek Chandra; Sourya Bhattacharyya; Benjamin J. Schmiedel; Ariel Madrigal; Cristian Gonzalez-Colin; Stephanie Fotsing; Mitchell Kronenberg; Bjoern Peters; Ferhat Ay; Pandurangan Vijayanand
J Immunol (2020) 204 (1_Supplement): 145.36.
Obesity contributes to a dysfunctional regulatory T Cell phenotype within adipose tissue
J Immunol (2020) 204 (1_Supplement): 145.38.
Inflammatory Response to Chronic Opioid Exposure in Humans
Kavita Mathi; Sylvie D Dobrota; Timothy J Lee; Zahra N Sayyid; Dara Rouholiman; Jamison G Gamble; Ellen M Encisco; Tom Rico; Holden T Maecker; Larry F Chu
J Immunol (2020) 204 (1_Supplement): 145.39.
Characterization of DOCK8 as a novel gene associated with hemophagocytic lymphohistiocytosis
J Immunol (2020) 204 (1_Supplement): 145.4.
Cell-specific transcriptional signature of human immune cells in GESTALT
Mary Kaila; Benj Shapiro; Christopher Dunn; Amit Singh; Arsun Bektas; Jaekwan Kim; Yulan Piao; William Wood; Cuong Nguyen; Tonya Wallace; Julia Mckelvey; Linda Zukley; Alexis Battle; Supriyo De; Nan-Ping Weng; Ranjan Sen
J Immunol (2020) 204 (1_Supplement): 145.40.
Regulatory T cells suppress novel skeletal muscle macrophages identified by single-cell RNA sequencing
Gerald COULIS; Jenna Kastenschmidt; Ali Mannaa; Quy Nguyen; Nicholas Pervolarakis; Jorge Duarte; Melissa Emami; Catherine Yang; Kai Kessenbrock; Armando VILLALTA
J Immunol (2020) 204 (1_Supplement): 145.41.
A triple “no” to the enrichment of immune genes at X files
Irene Meester; Edgar Manilla-Muñoz; Juan Manuel Solís-Soto; Gustavo A. Paniagua-Frausto; Diego Carrión-Alvarez; Ximena Rodríguez-Rangel; C. Orelli Ruiz-Rodríguez
J Immunol (2020) 204 (1_Supplement): 145.43.
Anti-CD3 Mono-Fab co-potentiates TCR antigen recognition in human T cells
Laura R Becher; Wendy Nevala; Shari Sutor; Megan Abergel; Michele Hoffmann; Christopher Parks; Larry R Pease; Adam G Schrum; Svetomir N Markovic; Diana Gil Pages
J Immunol (2020) 204 (1_Supplement): 145.44.
Noncanonical NF-κB signaling is suppressed through the negative regulation of the essential kinase NIK and attenuation is associated with eosinophilic esophagitis pathogenesis
J Immunol (2020) 204 (1_Supplement): 145.46.
Absence of SIRPα signaling drives TLR9-induced hemophagocytic lymphohistiocytosis-like disease independent of IFN-γ in mice
J Immunol (2020) 204 (1_Supplement): 145.5.
The ImmunoGenetic Theory of Cancer Survival: Insights from the analysis of 200+ unselected breast cancer patients followed for over 8 years
J Immunol (2020) 204 (1_Supplement): 145.50.
A clinical trial comparing aliskiren with enalapril for the treatment of C3 glomerulopathy
J Immunol (2020) 204 (1_Supplement): 145.52.
Functional studies to understand class II MHC as a gene modifier in cystic fibrosis
J Immunol (2020) 204 (1_Supplement): 145.53.
Single-center report of antibody deficiencies in Azerbaijan
J Immunol (2020) 204 (1_Supplement): 145.6.
A Type I interferon response is associated with increased mTOR activation in idiopathic multicentric Castleman disease
Ruth-Anne Langan Pai; Alberto Sada Japp; Michael Gonzalez; Rozena F Rasheed; Mariko Okumura; Daniel Arenas; Sheila K Pierson; Awo Akosua Kesewa Layman; Charlly Kao; Hakon Hakonarson; Frits van Rhee; Michael R Betts; Taku Kambayashi; David C Fajgenbaum
J Immunol (2020) 204 (1_Supplement): 145.7.
The role of Thymic Stromal Lymphopoietin (TSLP) in protection from Type II diabetes
Ruth Choa; Shogo Wada; Hu Meng; Ruth-Anne Langan Pai; Mariko Okumura; Junichiro Tohyama; Arben Nace; Christian Hopkins; Malay Haldar; Patrick Seale; George Cotsarelis; John Seykora; Garret Fitzgerald; Zoltan Arany; Taku Kambayashi
J Immunol (2020) 204 (1_Supplement): 145.8.
Epigenetic Regulation of the COX-2 Pathway Modulates Macrophage Inflammation in Diabetic Wound Repair
Frank M Davis; Aaron Dendekker; Amrita Joshi; Carol Wilke; Hongping Deng; Andrew Smith; Andrea Obi; Steve Huang; Scott Robinson; William J Melvin; Jaime Fuentes; Steven L Kunkel; Bethany B Moore; Katherine Gallagher
J Immunol (2020) 204 (1_Supplement): 145.9.
Human Respiratory and Cardiovascular Disease
Single cell multiplex mass cytometry reveals differential abundance of specific cytotoxic memory and regulatory T cell populations in human hypertension
Matthew Alexander; Bethany L Dale; Fernando Elijovich; Cara E Wogsland; Jonathan M Irish; Meena S Madhur
J Immunol (2020) 204 (1_Supplement): 146.1.
Differentiated immunoglobulins and neutrophil-related proteins in bronchoalveolar lavage fluid exosomes of acute respiratory distress syndrome
J Immunol (2020) 204 (1_Supplement): 146.10.
The expression and function of complement inhibitory protein CD55 in chronic rhinosinusitis with nasal polyp
J Immunol (2020) 204 (1_Supplement): 146.11.
Repeated exposures to the environmental allergen methylisothiazolinone reduce viability of fibroblasts derived from allergic sites in response to allergen challenge in vitro
J Immunol (2020) 204 (1_Supplement): 146.14.
MAIT cell function in response to airway epithelial cells is dysregulated in the context of cigarette smoke and COPD
J Immunol (2020) 204 (1_Supplement): 146.16.
Wildfire smoke exposure is associated with decreased methylation of the PDL2 gene
Mary Prunicki; Sarah Miller; Austin Hopkins; Matthew Poulin; Hesam Movassagh; Liying Yan; Kari Christine Nadeau
J Immunol (2020) 204 (1_Supplement): 146.17.
Understanding Genetic and Immune Cellular-Signaling Defects in Common Variable Immunodeficiency with Granulomatous Lymphocytic Interstitial Lung Disease
J Immunol (2020) 204 (1_Supplement): 146.18.
Microarray analysis of human abdominal aortic aneurysm (AAA) detected altered gene expression profiles including H19
Song Lu; Liping Li; John V White; Xiaoying Zhang; Ifeyinwa Nwaneshiudu; Nectaria Ntaoula; Wanlu Lin; Charalambos Solomides; John Gaughan; Dimitri Monos; Emilia Oleszak; Chris D Platsoucas
J Immunol (2020) 204 (1_Supplement): 146.19.
Chronic Colitis Impairs Heart Function by Inducing Epigenetic Remodeling in the Adult Heart
J Immunol (2020) 204 (1_Supplement): 146.2.
Gamma/delta (γδ) T-cell receptor (TCR)-expressing T cells are clonally expanded in aneurysmal lesions of patients with abdominal aortic aneurism (AAA)
Ifeyinwa Nwaneshiudu; John V White; Song Lu; Adaobi Nwaneshiudu; Charalambos Solomides; John Gaughan; Dimitri Monos; Emilia L Oleszak; Chris D Platsoucas
J Immunol (2020) 204 (1_Supplement): 146.20.
The hematopoietic transcription factor GATA2 is a novel regulator of apoptotic cell clearance by macrophages in atherosclerosis
Charles Yin; Angela M Vrieze; James Akingbasote; Emily N Pawlak; Rajesh A Jacob; Jonathan Hu; Neha Sharma; Garth Blackler; Jimmy D Dikeakos; Lillian Barra; Dave Nagpal; Bryan Heit
J Immunol (2020) 204 (1_Supplement): 146.3.
Cholesterol crystals use both extracellular and intracellular complement to increase NLRP3 signalling pathways in atherosclerosis
Terje Espevik; Nathalie Niyonzima; Siril Skaret Bakke; Erin West; Jubayer Rahman; Pål Aukrust; Claudia Kemper; Tom Eirik Mollnes; Bente Halvorsen
J Immunol (2020) 204 (1_Supplement): 146.4.
Myeloid-derived suppressor cells modulate aortic aneurysm formation via CXCR2 and IL-17 signaling
Ashish Kumar Sharma; Craig Elder; Gang Su; Guanyi Lu; Xiaoyan Qi; Zhihua Jiang; Lyle Leonard Moldawer; Philip Efron; Gilbert R Upchurch
J Immunol (2020) 204 (1_Supplement): 146.5.
Over-expression of Chitotriosidase Modulates ECM Distribution in Atherosclerotic Plaques of Mice
J Immunol (2020) 204 (1_Supplement): 146.6.
Investigating the role of B cell signaling in atherosclerosis
J Immunol (2020) 204 (1_Supplement): 146.7.
A natural mouse model reveals genetic determinants of Systemic Capillary Leak Syndrome (Clarkson disease)
Zhihui Xie; Abbas Raza; Eunice Chan; Wei-Sheng Chen; Linda M Scott; A. Robin Eisch; Dimitry N Krementsov; Helene F Rosenberg; Samir M Parikh; Elizabeth P Blankenhorn; Cory Teuscher; Kirk M Druey
J Immunol (2020) 204 (1_Supplement): 146.8.
Soluble B7H3 induction in pulmonary fibrosis is associated with disease severity
J Immunol (2020) 204 (1_Supplement): 146.9.
Regulatory Mechanisms in Type 2 Disease
Aerosolized Toll-like Receptor Agonists Suppress Allergic Inflammation
David Goldblatt; Adrienne Fouts; Shradha M Wali; Gabriella Valverde-Ha; Margarita Moczygemba-Martinez; David P Huston; Michael J Tuvim; Burton Dickey; Scott Evans
J Immunol (2020) 204 (1_Supplement): 147.10.
Reduced BDCA3+ dendritic cells in nasal mucosa induce severe inflammation in patients with allergic rhinitis and chronic rhinosinusitis
J Immunol (2020) 204 (1_Supplement): 147.12.
The Role of Circadian Clock Period 2 (per 2) gene and the expression of per2 related gene in atopic dermatitis animal model
J Immunol (2020) 204 (1_Supplement): 147.13.
8-iso prostaglandin E2 causes nasal congestion in allergic rhinitis of mice
J Immunol (2020) 204 (1_Supplement): 147.14.
Modulated MAPK signaling during mast cell differentiation promotes an impaired inflammatory phenotype
J Immunol (2020) 204 (1_Supplement): 147.16.
Cul5 E3 ubiquitin ligase limits Th2 and Th9 differentiation by regulating IL4 receptor level in CD4 T cells
J Immunol (2020) 204 (1_Supplement): 147.17.
Resolvin D2 Promotes the Resolution of Allergen-Induced Lung Inflammation
Hong Yong Peh; Thayse R Bruggemann; Wanxing Eugene Ho; Chang Cheng; WS Daniel Tan; WS Fred Wong; Bruce D Levy
J Immunol (2020) 204 (1_Supplement): 147.19.
Biomarker prediction of pediatric atopic dermatitis severity
Mark H Kaplan; Sarah Engle; Ching-Yun Chang; Allyson Satterwhite; Benjamin Ulrich; Tristan Hayes; Robert Tepper; Jonathan Sims
J Immunol (2020) 204 (1_Supplement): 147.20.
Defining mechanisms of semaphorin 4A stimulatory action on human Treg cells
J Immunol (2020) 204 (1_Supplement): 147.21.
Hyperglycemia impairs tolerance and promotes allergic inflammation in mouse models of asthma
Ashley Queener; Brian M Jeong; Mackenzie Coden; Ton Doan; Matthew Walker; Reina Nagasaka; Sergejs Berdnikovs
J Immunol (2020) 204 (1_Supplement): 147.23.
A critical period of innate-immune development: Fetal origins of allergic asthma susceptibility
J Immunol (2020) 204 (1_Supplement): 147.24.
E3 Ubiquitin Ligase Cbl-b Inhibits Type 2 Innate Lymphoid Cell Development by Targeting ST2 for Ubiquitination
J Immunol (2020) 204 (1_Supplement): 147.25.
Mast cell activation enhances the TLR4-mediated antigen-specific CD4 T cell response
J Immunol (2020) 204 (1_Supplement): 147.26.
Establishment of airway tolerance in early life to inhaled house dust mite involves mitochondrial H2O2
J Immunol (2020) 204 (1_Supplement): 147.27.
Evaluation of the skin sensitizing potential of gold nanoparticles and the impact of established dermal sensitivity on the pulmonary immune response to various forms of gold
J Immunol (2020) 204 (1_Supplement): 147.28.
Autophagy is critical for group 2 innate lymphoid cell metabolic homeostasis and effector function
Lauriane Galle; Benjamin P Hurrell; Gavin Lewis; Emily Howard; Pedram Shafiei Jahani; Homayon Banie; Babak Razani; Pejman Soroosh; Omid Akbari
J Immunol (2020) 204 (1_Supplement): 147.3.
Altered natural killer cell responses linked to allergen sensitization in patients with atopic dermatitis
David E Ohayon; Stanley B. DeVore; Jocelyn M. Biagini Myers; John Kroner; Mariana Stevens; Stephen N Waggoner; Gurjit K Khurana Hershey
J Immunol (2020) 204 (1_Supplement): 147.33.
Diuretics combined with captopril modulate macrophage-induced humoral and contact hypersensitivity responses in mice
J Immunol (2020) 204 (1_Supplement): 147.34.
Immune Sensing of Aeroallergen-Associated Double-Stranded RNA Triggers an IFN Response and Modulates Type 2 Lung Inflammation
Hamad Alanazi; Li She; Liping Yan; Yilun Sun; Yi Zou; Peter Dube; Edward Brooks; Gema Barrera; Zhao Lai; Yidong Chen; Yong Liu; Xin zhang; Xiao-Dong Li
J Immunol (2020) 204 (1_Supplement): 147.35.
Investigation of cytokine levels after dupilumb treatment in adults with acute atopic dermatitis
J Immunol (2020) 204 (1_Supplement): 147.36.
IQ motif-containing GTPase-activating protein 1 is essential for the optimal maintenance of lung ILC2s
Shunichi Tayama; YUKO OKUYAMA; HAI THE PHUNG; ATSUKO ASAO; SHUHEI KOBAYASHI; TAKESHI KAWABE; SO TAKANORI; NAOTO ISII
J Immunol (2020) 204 (1_Supplement): 147.4.
IL-33 and allergen exposure promote development of “memory-like” ILC2s in the Airways
J Immunol (2020) 204 (1_Supplement): 147.5.
Nrf2 suppresses allergic lung inflammation by attenuating the type2-innate lymphoid cell response
J Immunol (2020) 204 (1_Supplement): 147.8.
The Role of Tyrosine Kinase Itk in T helper 17 and T regulatory cells in Hypersensitivity Pneumonitis
Jessica Elmore; Chavez Carter; Nicholas Koylass; Amelia Bennett; Max Mead; Alexia Kim; Weishan Huang; Avery August
J Immunol (2020) 204 (1_Supplement): 147.9.
Cellular Mechanisms of Innate Immunity: NK Cells, ILCs, and Other Non-Macrophages
Defense mechanisms during respiratory infections in hosts with underlying asthma
J Immunol (2020) 204 (1_Supplement): 148.1.
Neutrophils are actively involved in the regulation of inflammation and the maintenance of surfactant homeostasis during cigarette smoke exposure
Nadia Milad; Marie Pineault; Ariane Lechasseur; Joanie Routhier; Marie-Josée Beaulieu; Sophie Aubin; Mathieu Morissette
J Immunol (2020) 204 (1_Supplement): 148.10.
COX inhibition enhances allergen-induced IL-33 release and ILC2 responses in mouse lungs
Weisong Zhou; Jian Zhang; Shinji Toki; Kasia Goleniewska; Allison E. Norlander; Dawn C. Newcomb; Kelli L. Boyd; Hirohito Kita; R. Stokes Peebles, Jr.
J Immunol (2020) 204 (1_Supplement): 148.11.
The emerging roles of neutrophils and macrophages during experimental acute pyelonephritis
J Immunol (2020) 204 (1_Supplement): 148.12.
Plasmacytoid dendritic cells (pDCs) and IFN-α production in aged squirrel monkeys (Saimiri boliviensis boliviensis) stimulated with Class C CpG Oligodeoxynucleotides
Pramod N Nehete; Sriram Chitta; Bharti P Nehete; Lawrence E Williams; Thomas Wisniewski; Henrieta Scholtzova
J Immunol (2020) 204 (1_Supplement): 148.13.
Single-cell TCR analysis of mouse lung Vγ4 γδ T cells reveals a link between TCR clonotypes, SLAM family receptor expression, and effector function
J Immunol (2020) 204 (1_Supplement): 148.14.
Plasmactoid dendritic cells express EphA2 to negatively regulate type I interferon production in response to viral infection
J Immunol (2020) 204 (1_Supplement): 148.15.
CD71+ erythroid cells inhibit inflammatory cytokines secretion of monocytes during extracorporeal membrane oxygenation
J Immunol (2020) 204 (1_Supplement): 148.16.
Differences in NK and Memory CD8 T cell responses to antigen-nonspecific stimulation by interleukin-15
Sean J Judge; Cordelia Dunai; Catherine T. Le; Lam T. Khuat; Logan V. Vick; Kevin M. Stoffel; Arta M. Monjazeb; Robert J. Canter; William J. Murphy
J Immunol (2020) 204 (1_Supplement): 148.17.
Enhancement of vitamin C on PMN function in healthy individuals
Laongthip Ruknarong; Rujira Nonsa-ard; Nisa Chuangchot; Amonrat Jumnainsong; Naruemon Leelayuwat; Apinya Jusakul; Chanvit Leelayuwat
J Immunol (2020) 204 (1_Supplement): 148.18.
Identification of N-formylated peptides as the neutrophilic chemotactic factors of Mycobacterium tuberculosis
J Immunol (2020) 204 (1_Supplement): 148.19.
NK cells support host survival and release IL-10 following polymicrobial sepsis
J Immunol (2020) 204 (1_Supplement): 148.21.
STAT4 promotes critical neutrophil functions and is required for antimicrobial immunity in mice
W. Coles Keeter; Alina Moriarty; Pegah Mehrpouya-Baharami; Paulo Melo; Jerry Nadler; Carlos H Serezani; Mark H Kaplan; Elena Galkina
J Immunol (2020) 204 (1_Supplement): 148.22.
The TRPM2 ion channel regulates the inflammatory response of neutrophils during Listeria monocytogenes infection
J Immunol (2020) 204 (1_Supplement): 148.23.
CD1d-dependent NKT cells establish Th1-polarity to promote resolution of dengue virus infection
J Immunol (2020) 204 (1_Supplement): 148.24.
Peripheral blood MAIT cell response to enterotoxigenic E. coli strains H10407 and B7A after controlled human infection models (CHIMs)
J Immunol (2020) 204 (1_Supplement): 148.25.
The role of Toll-like receptor 2 and 9 in osteoclast responses to Staphylococcus aureus osteomyelitis
J Immunol (2020) 204 (1_Supplement): 148.26.
Potential role of thioredoxin-interacting protein in non-IgE mast cell degranulation
J Immunol (2020) 204 (1_Supplement): 148.27.
Nox2 deficiency in neutrophils promotes excessive and sustained inflammatory responses at local and distal sites of inflammation
J Immunol (2020) 204 (1_Supplement): 148.28.
Immune fibroblasts are unconventional antigen presenting cells and nonprofessional phagocytes in Lyme arthritis
J Immunol (2020) 204 (1_Supplement): 148.29.
M2-like, dermal macrophages are maintained via IL-4/CCL24 mediated cooperative interaction with eosinophils in cutaneous leishmaniasis
Sang Hun Lee; Mariana M. Chaves; Olena Kamenyeva; Pedro H. Gazzinelli-Guimaraes; Byung Hyun Kang; Gabriela Pessenda; Passelli Kaiuska; Fabienne M Tacchini-Cottier; Juraj Kabat; Elizabeth A Jacobsen; Thomas B Nutman; David Sacks
J Immunol (2020) 204 (1_Supplement): 148.3.
Role of invariant nature killer T cell in dysbiosis of gut microbiota among Mycobacterium tuberculosis infected patients
J Immunol (2020) 204 (1_Supplement): 148.34.
Suppression of Inflammation of the Cytokine Storm Following Francisella Tularensis Infection is Mediated by Natural Killer T Cell Subsets
J Immunol (2020) 204 (1_Supplement): 148.35.
Low density neutrophils as a potential biomarker of leprosy severity
Isabella Forasteiro Tavares; Jessica Brandão dos Santos; Fabiana dos Santos Pacheco; Mariana Gandini; Rafael Mariante Meyer; Milton Ozório Moraes; Veronica Schmitz
J Immunol (2020) 204 (1_Supplement): 148.37.
The PB1-F2 virulence protein regulates host ILC2 responses during influenza
J Immunol (2020) 204 (1_Supplement): 148.38.
Transcriptional reprogramming drives neutrophil phenotype and function in chronic lung disease
Camilla Margaroli; Diego Moncada Giraldo; Dalia Arafat-Gulick; Brian Dobosh; Vincent Giacalone; Haydn Kissick; Osric A Forrest; Chunhui Gu; Gregory Gibson; Rabindra M Tirouvanziam
J Immunol (2020) 204 (1_Supplement): 148.39.
β-1,3-glucan induces natural killer cell memory-like immunity
J Immunol (2020) 204 (1_Supplement): 148.40.
CALCIUM MOBILIZATION AND EXPRESION OF TRPM2 AND CRAC CHANNELS ARE ALTERED IN HUMAN NEUTROPHILS WITH AGING
Adriana Sumoza-Toledo; María de los Ángeles Vázquez-Prieto; Nallely Lascurais-Santamaría; Nilda Belén Fernández-Eufrasio; Dvorak Montiel-Condado; Adriana Garibay-Escobar
J Immunol (2020) 204 (1_Supplement): 148.41.
High dimensional cellular profiling of the myeloid compartment in the geriatric mouse model
J Immunol (2020) 204 (1_Supplement): 148.42.
Evidence for serial antibody-dependent cell-mediated cytotoxicity (ADCC) by primary unstimulated human natural killer (NK) lymphocytes
Alexander P Sung; Lydia T Navarrete-Galvan; Michael Guglielmo; Julie Smith-Gagen; Douglas D Redelman; Rebecca Merica; Dorothy Hudig
J Immunol (2020) 204 (1_Supplement): 148.44.
The expression of NKG2D ligand is induced in the cutaneous ischemia-reperfusion injury and mitigates pressure ulcer via NKG2D-NKG2D ligand interaction
J Immunol (2020) 204 (1_Supplement): 148.45.
Human influenza-specific adaptive NK cells mediate potent HLA-E-restricted responses against antigenically distinct influenza strains
J Immunol (2020) 204 (1_Supplement): 148.5.
Accumulation and activation of group 2 innate lymphoid cells in the aged brain alleviate aging associated cognitive decline
Ivan Ting Hin Fung; Poornima Sankar; Yuanyue Zhang; Lisa S. Robison; Xiuli Zhao; Shanti D’Souza; Abigail E. Salinero; Yue Wang; Jiang Qian; Marcy Kuentzel; Sridar V. Chittur; Sally Temple; Kristen L. Zuloaga; Qi Yang
J Immunol (2020) 204 (1_Supplement): 148.8.
Protective role of lung mesenchymal stem cells in pneumonia caused by the Carbapenem-resistant Klebsiella Pneumoniae.
J Immunol (2020) 204 (1_Supplement): 148.9.
Cellular Mechanisms of Innate Immunity: Macrophages
Activation-induced cell protrusions and vesicle secretion of human lung macrophages revealed by super-resolution microscopy
Susanne Dechantsreiter; Ashley Ambrose; Edith M Hessel; Soren Beinke; Gillian Tannahill; Daniel M Davis
J Immunol (2020) 204 (1_Supplement): 149.1.
Differences in the M1 and M2 macrophage subtypes between the sexes determine susceptibility to Francisella tularensis infection
J Immunol (2020) 204 (1_Supplement): 149.10.
Role of CD34+CD10+CD19−Pax5+ cells on M2b macrophage polarization
J Immunol (2020) 204 (1_Supplement): 149.12.
Inverse relationship between LPS concentration and monocyte and DC inflammatory response
J Immunol (2020) 204 (1_Supplement): 149.13.
Regulation of human macrophage phenotype and GPBAR1 expression by cell seeding density and glucocorticosteroids
Christopher Hammerbeck; Christine Goetz; Li Peng; Megan Constans; Ryan Peterson; Brian Astry; Andrew Hudacek; Jody L Bonnevier
J Immunol (2020) 204 (1_Supplement): 149.14.
Type III interferons are expressed in tuberculosis granulomas and promote an inflammatory phenotype in macrophages that differs from type I interferon
J Immunol (2020) 204 (1_Supplement): 149.15.
Effect of temperature on functional activity of macrophages in three different species
J Immunol (2020) 204 (1_Supplement): 149.17.
Early innate interactions drive alveolar macrophage localization and effector function during Mycobacterium tuberculosis infection
J Immunol (2020) 204 (1_Supplement): 149.18.
Leishmania donovani metacyclic promastigotes colonize inflammatory monocytes by impairing phagosome function
J Immunol (2020) 204 (1_Supplement): 149.19.
Temporal transcriptional, metabolic, and functional re-programming of THP-1 macrophages by the Lactobacillus rhamnosus R0011 secretome
J Immunol (2020) 204 (1_Supplement): 149.20.
Cross-reactive dengue immune complexes modulate innate antiviral responses to Zika virus infection in human placental macrophages
Matthew G Zimmerman; Devon Eddins; Ali Muhammad; Emery Register; Robert Kauffman; Sarah Cordes; Valerie Jean; Lisa Haddad; Jens Wrammert; Mehul S Suthar
J Immunol (2020) 204 (1_Supplement): 149.23.
A rho GDP dissociation inhibitor produced by a subset of T-regulatory cells enhances mitophagy in Mycobacterium tuberculosis infected human macrophages
Padmaja Paidipally; Ramya Sivangala Thandi; Rajesh Kumar Radhakrishnan; Madeline K McAllister; Buka Samten; Ramakrishna Vankayalapati; Deepak Tripathi
J Immunol (2020) 204 (1_Supplement): 149.24.
Activation of TREM1 Signaling in Kupffer Cells Following HIV and HCV Stimulation Augments Hepatic Inflammatory Responses
J Immunol (2020) 204 (1_Supplement): 149.26.
Elucidation of the respective roles of itaconate and nitric oxide in the nuclear accumulation and activation of Nrf2 in activated macrophages
J Immunol (2020) 204 (1_Supplement): 149.28.
Innate immune response changes during the progression of Alzheimer’s disease
J Immunol (2020) 204 (1_Supplement): 149.29.
Nerve associated lung resident interstitial macrophage subset exhibits distinct localization and polarization
Stephen T Yeung; Basak Burcu Ural; Payal Damani-Yokota; Joseph C. Devlin; Maren De Vries; Tasleem Samji; Geunhyo Jang; P’ng Loke; Meike Dittmann; Boris Reizis; Kamal M Khanna
J Immunol (2020) 204 (1_Supplement): 149.3.
Selective killing of proinflammatory human M1 macrophages by SMAC mimetics and anti-inflammatory M2 macrophages by SMAC mimetics and caspase inhibitors
J Immunol (2020) 204 (1_Supplement): 149.30.
Hippocampal damage and seizure severity during acute viral encephalitis are determined by the intensity of the infiltrating inflammatory monocyte response
J Immunol (2020) 204 (1_Supplement): 149.31.
IL-4R signaling mediated polarization of neutrophils promoted monocytes derived alveolar macrophages function
Fei Chen; Darine W. El-Naccache; Wenhui Wu; Juan M. Inclan-Rico; John J. Ponessa; Vanessa Espinosa; Katherine E Lothstein; Ameriliz rivera-Medina; Mark C Siracusa; William Gause
J Immunol (2020) 204 (1_Supplement): 149.4.
Characterization of renal macrophage (RM) fate, dynamics, and niches: embryonic RMs are more sensitive to immune challenges than bone marrow-derived RMs
J Immunol (2020) 204 (1_Supplement): 149.5.
A genome-wide CRISPR/Cas9 screen identifies novel regulators of GSDMD pore formation in engineered macrophages
J Immunol (2020) 204 (1_Supplement): 149.7.
Immune profiles in experimental two-Kidney-one-cuff (2K-1C) model of renovascular hypertension that predicts reversible versus irreversible renal injury
J Immunol (2020) 204 (1_Supplement): 149.8.
Exosomes secreted from microglia during chronic virus infection can induce demyelinating disease
J Immunol (2020) 204 (1_Supplement): 149.9.
T Cell Activation and Autoimmunity
Simplified size-based immune cell monitoring using a hand-held particle counting device
J Immunol (2020) 204 (1_Supplement): 150.10.
Functional responses of salivary gland resident T cells are suppressed by extracellular adenosine
J Immunol (2020) 204 (1_Supplement): 150.11.
CD6-ALCAM signaling regulates multiple effector/memory T cell functions
Jeanette Ampudia; William W. Young-Greenwald; Jana Badrani; Sole Gatto; Adam Pavlicek; Taylor Doherty; Stephen Connelly; Cherie T Ng
J Immunol (2020) 204 (1_Supplement): 150.13.
Antigen presenting group 3 innate lymphoid cells control neuroinflammation
John B Grigg; Arthi Shanmugavadivu; Tommy Regen; Christopher Parkhurst; Gerard Eberl; Ari Waisman; Gregory F Sonnenberg
J Immunol (2020) 204 (1_Supplement): 150.14.
Cyclic GMP-AMP synthase Regulates the Development of experimental autoimmune encephalomyelitis
J Immunol (2020) 204 (1_Supplement): 150.15.
PRMT5 has roles in thymic/peripheral T cell development and EAE
Shouvonik Sengupta; Lindsay M Webb; Janiret NarvaezMiranda; Stephanie A Amici; Claudia Edell; Mireia Guerau-de-Arellano
J Immunol (2020) 204 (1_Supplement): 150.17.
Laquinimod arrests development of experimental autoimmune uveitis (EAU) and inhibits related immune processes, in the context of altered gut microbiota
J Immunol (2020) 204 (1_Supplement): 150.18.
C-Type Lectin Receptor Dectin-1 Suppresses the Development of Experimental Autoimmune Encephalomyelitis
J Immunol (2020) 204 (1_Supplement): 150.19.
Basal TCR signaling drives the functional heterogeneity of naïve CD4+ T cells
J Immunol (2020) 204 (1_Supplement): 150.2.
CNS lymphangiogenesis regulates fluid homeostasis and immunity during neuroinflammation
J Immunol (2020) 204 (1_Supplement): 150.20.
In Silico Modeling of Metabolic State in Single Th17 Cells Reveals Novel Regulators of Inflammation and Autoimmunity
Allon Wagner; Chao Wang; David DeTomaso; Julian Avila Pacheco; Sarah Zaghouani; Johannes Fessler; Elliot Akama-Garren; Kerry Pierce; Noga Ron-Harel; Marcia Haigis; Raymond A Sobel; Clary Clish; Aviv Regev; Vijay K Kuchroo; Nir Yosef
J Immunol (2020) 204 (1_Supplement): 150.22.
T cell-intrinsic C5L2 activation protects against uncontrolled inflammatory Th responses and autoimmunity
Erin E West; Simon Freeley; Martin Kolev; Nathalie Niyonzima; Trine Hyrup Mogensen; Trent M Woodruff; Peter Monk; Knut Lappegard; Terje Espevik; Tom Eirik Mollnes; Mette Christiansen; Claudia Kemper
J Immunol (2020) 204 (1_Supplement): 150.23.
Enhanced N-glycan branching on CD8 T cells exacerbates autoimmune diabetes in non-obese diabetic mice
J Immunol (2020) 204 (1_Supplement): 150.25.
A road map of memory CD8+ T cell functional imprinting and fitness
Shu Shien Chin; Laurent Chorro; Sooraj Achar; Dietmar Zehn; Grergoire Altan-Bonnet; Fabien Delahaye; Gregoire Lauvau
J Immunol (2020) 204 (1_Supplement): 150.26.
Ssu72 phosphatase directly binds to ZAP-70, thereby providing fine-tuning of TCR signaling and preventing autoimmunity
jaesung ko; Dongjin Jeong; Jaemoon Koh; Hyeryeon Jung; Kyeong Cheon Jung; Yoon Kyung Jeon; Hye Young Kim; Eugene C Yi; Ho Lee; Chang Woo Lee; Doo Hyun Chung
J Immunol (2020) 204 (1_Supplement): 150.27.
Toll like receptor 4 ligation promotes B7 family costimulatory molecules expression in a time and cytokine dependent fashion
J Immunol (2020) 204 (1_Supplement): 150.28.
Modulation of Epidermal γδ T Cell Functionality by Obesity due to Acute versus Chronic TNF-α Reception
J Immunol (2020) 204 (1_Supplement): 150.3.
The C3-like molecule CD109 controls Th1 versus Th17 induction in CD4+ T cells
Nicolas S Merle; Martin Kolev; Jubayer Rahman; Erin West; Bingyu Yan; Majid Kazemian; Behdad Afzali; Claudia Kemper
J Immunol (2020) 204 (1_Supplement): 150.4.
Selenoprotein I is important for phosphatidylethanolamine synthesis and autophagy during T cell activation
J Immunol (2020) 204 (1_Supplement): 150.8.
Enhanced ER stress responses accompany greater effector T cell functions with deficiency of PSGL-1
Eun-ah Bae; Jennifer L Hope; Dennis C Otero; Christopher J Stairiker; Hannah A Faso; Ashley B Palete; Linda M Bradley
J Immunol (2020) 204 (1_Supplement): 150.9.
B Cell Signaling and Immune Responses
Investigating nuclear organization of the inactive X in female lymphocytes
J Immunol (2020) 204 (1_Supplement): 151.12.
Cytoskeletal control of the developing and mature B cell antigen receptor repertoire
J Immunol (2020) 204 (1_Supplement): 151.13.
H3K9 dimethyltransferase G9a is an important epigenetic modulator of B cell differentiation
J Immunol (2020) 204 (1_Supplement): 151.14.
Co-expression network analysis identified cell cycle signaling hub genes associated with progression and prognosis of multiple myeloma
J Immunol (2020) 204 (1_Supplement): 151.15.
Impact of Epstein-Barr Virus LMP2A-dependent BTK/STAT3 activation on resting and activated murine B cells
J Immunol (2020) 204 (1_Supplement): 151.18.
B cell-intrinsic STAT3 regulates the germinal center dark zone
J Immunol (2020) 204 (1_Supplement): 151.20.
The Notch-Myc signaling axis sets the division-differentiation clock in marginal zone B cells
J Immunol (2020) 204 (1_Supplement): 151.21.
Molecular mechanisms by which interferon regulatory factor 5 (IRF5) transduces signaling downstream of BCR and BCR/TLR9 pathways
J Immunol (2020) 204 (1_Supplement): 151.22.
A germinal center B cell-specific long non-coding RNA regulates the germinal center response
J Immunol (2020) 204 (1_Supplement): 151.23.
Downstream effectors of BCR signaling control transcription of autoimmunity-associated transcription factor Ets1
J Immunol (2020) 204 (1_Supplement): 151.24.
TLR adaptors MyD88 and TRIF are critical for extrafollicular B cell responses to influenza
J Immunol (2020) 204 (1_Supplement): 151.25.
IRF4 regulates the proliferative capacity of activated B cells during B cell differentiation
J Immunol (2020) 204 (1_Supplement): 151.26.
SHARPIN constrains IL-21-induced apoptosis in CD40-activated B cells to mediate the germinal center reaction and T-dependent antibody response
J Immunol (2020) 204 (1_Supplement): 151.27.
Human B cells respond more strongly to membrane-associated antigen than soluble antigen with the help of mechanosensors
J Immunol (2020) 204 (1_Supplement): 151.29.
Mechanisms of Activation-Induced Chromatin Decondensation in the Lymphoid Lineage
J Immunol (2020) 204 (1_Supplement): 151.3.
PI3K-dependent Reprogramming of Hexokinase Isoforms Regulates B Lymphocyte Metabolism
J Immunol (2020) 204 (1_Supplement): 151.30.
Desmosterol, an intermediate of cholesterol biosynthesis, modulates B cell activation and functions
J Immunol (2020) 204 (1_Supplement): 151.5.
Activation-dependent post-transcriptional regulation of CD40L mediates B cell development and survival in germinal centers
J Immunol (2020) 204 (1_Supplement): 151.6.
A histone code for inducible transcription in immune responses
Alexia Martinez de Paz; Wendy Beguelin; Merve Sahin; Christina S. Leslie; Ari M. Melnick; Steven Z. Josefowicz
J Immunol (2020) 204 (1_Supplement): 151.8.
TLR7/8 and TLR9 ligands induce phenotypic and transcriptional changes in human transitional B cells
J Immunol (2020) 204 (1_Supplement): 151.9.
Molecular Control of Innate Immunity
Transient Receptor Potential Vanilloid 4 (TRPV4) Protects the Lung from Bacterial Pneumonia via MAPK Molecular Switching
Rachel Greenberg Scheraga; Susamma Abraham; Lisa M Grove; Brian D Southern; James Crish; Jeffrey D Hasday; Christine McDonald; Mitchell A Olman
J Immunol (2020) 204 (1_Supplement): 152.1.
Expression of microglia-specific transcriptional signatures correlates with the severity of behavioral deficits in systemic lupus erythematosus
J Immunol (2020) 204 (1_Supplement): 152.10.
Surfactant protein receptor SP-R210 isoforms play a role in regulating macrophage immune response in conjunction with epigenetic changes during Influenza A infection
J Immunol (2020) 204 (1_Supplement): 152.11.
Circulating classical monocytes share a common transcriptional signature with skin macrophages in Systemic Sclerosis
Hadijat M Makinde; Salina T Dominguez; Carla M Cuda; Gaurav Gadhvi; Kathleen Aren; Chang Zeng; Garrett J Eickelberg; Dinesh Khanna; Shervin Assassi; Tracy Frech; Deborah R Winter; Harris Perlman; Monique Hinchcliff
J Immunol (2020) 204 (1_Supplement): 152.12.
Sts-1 and Sts-2 regulate the anti-fungal immune response
J Immunol (2020) 204 (1_Supplement): 152.13.
Cardiolipin dynamics regulate proinflammatory cytokine production in methicillin-resistant Staphylococcus aureus--infected macrophages
J Immunol (2020) 204 (1_Supplement): 152.14.
Therapeutic hypothermia rescues severe acute lung injury (ALI) by IL-1β-induced neutrophil extracellular traps (NETs) formation through down-regulation of Gasdermin D
J Immunol (2020) 204 (1_Supplement): 152.15.
Protein tyrosine phosphatase SHP-1 modulates microtubule organization in later stages of mast cell activation
Pavel DRABER; Anastasiya Klebanovych; Vladimira Sladkova; Tetyana Sulimenko; Vera Vosecka; Zuzana Rubikova; Eduarda Draberova; Vadym Sulimenko
J Immunol (2020) 204 (1_Supplement): 152.16.
Electrophilic properties of itaconate regulating macrophage activation
Monika Bambouskova; Laurent Gorvel; Vicky Lampropoulou; Alexey Sergushichev; Ekaterina Loginicheva; Marko Jovanovic; Eynav Klechevsky; Kelly M. Stewart; Gwendalyn J. Randolph; Maxim N. Artyomov
J Immunol (2020) 204 (1_Supplement): 152.17.
Production of leukotriene signaling mediators is limited by ORMDL3/serine palmitoyltransferase/5-lipoxygenase crosstalk
Petr Draber; Tomas Paulenda; Pavol Utekal; Ivana Halova; Ladislav Kuchar; Ondrej Kuda; Petra Vavrova; Bjoern Schuster; Lucie Potuckova; Sara Cernohouzova; Lubica Draberova; Monika Bambouskova; Viktor Bugajev
J Immunol (2020) 204 (1_Supplement): 152.18.
Assessment of function of neutrophil-derived properdin in a novel functional assay
J Immunol (2020) 204 (1_Supplement): 152.19.
Transcriptional regulation of IL10 gene in human macrophages
J Immunol (2020) 204 (1_Supplement): 152.21.
The Role of Phosphodiesterase (Pde) 3B in the Inflammatory Response of Macrophages to LPS
Yusen Liu; Xiaomei Meng; Xiantao Wang; Ali Snedden; Sean G. Kirk; Charles J. Cash; Parker R. Murphy; Markus Hafner; Leif D. Nelin; Bernadette Chen
J Immunol (2020) 204 (1_Supplement): 152.23.
Immune Tolerance Induction by the Exopolysaccharide from the Probiotic Bacillus subtilis
J Immunol (2020) 204 (1_Supplement): 152.24.
MDA-5 mediated RNA sensing signaling responds to the cellular RNAs escaped from RNA surveillance causing apoptotic cell death
J Immunol (2020) 204 (1_Supplement): 152.25.
Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression
Li Yu; Bin Zhang; Dinesh Deochand; Maria A. Sacta; Maddalena Coppo; Yingli Shang; Ziyi Guo; David A. Rollins; Bowranigan Tharmalingam; Rong Li; Yurii Chinenov; Inez Rogatsky; Xiaoyu Hu
J Immunol (2020) 204 (1_Supplement): 152.28.
TPL2 kinase action and control of inflammation
Daqi Xu; Youngsu Kwon; Kate Senger; Victoria Pham; Eugene Varfolomeev; George Francis; Jason Hackney; Brendan Parr; Nisha Rathore; Francesca Setiadi; Gladys Boenig; Seth Harris; Patrick Lupardus; Marissa Matsumoto; Yuanyuan Wang; Jesse Hanson; Jonathan Maher; Kai Wu; Andrey Shaw; Alexis Scherl; Jiansheng Wu; Cheng Lu; Zhiyu Huang; Juan Zhang; Summer Park; Swathi Sujatha-Bhaskar; Alice Almazan; Min Xu; Patrick Caplazi; Hans Brightbill; Nico Ghilardi; Michael Townsend; Wyne Lee; Adam Johnson; Brent McKenzie; Ali A Zarrin; Mark Wilson
J Immunol (2020) 204 (1_Supplement): 152.3.
Distinct Changes in the Chromatin Landscape Regulate Maturation of the Alveolar Macrophage Immune Response In Vivo
Asami Yamamura; Marten A. Hoeksema; Mashito Sakai; Sean J. Lund; Lindsay D. Butcher; Omar Lakhdari; Gertrude O. Oppong-Nonterah; Eniko Sajti; Christopher K. Glass; Lawrence S. Prince
J Immunol (2020) 204 (1_Supplement): 152.4.
CARD19 interacts with MICOS complex proteins and protects against mitochondrial dysfunction in macrophages
J Immunol (2020) 204 (1_Supplement): 152.6.
Epigenetic regulation of C-Kitlo FcɛR1a+ mast cells by cannabidiol during staphylococcal enterotoxin B-induced liver injury
J Immunol (2020) 204 (1_Supplement): 152.7.
Autophagy-related protein VPS34 controls the homeostasis and function of macrophages
J Immunol (2020) 204 (1_Supplement): 152.9.
B Cell Subsets and Their Differentiation
Immunoglobulin gene rearrangement and BAFF responsive maturation defines a novel B cell population undergoing extra-BM development
Wasif N Khan; Cassandra A Bazile; Emily S Clark; Jennifer Magee; Justin C Boucher; Gianluca Carlesso; Christopher Morehouse; Akritee Shrestha; Oliver Umland; Daria Salyakina; Duane R Wesemann; Eden Kleiman
J Immunol (2020) 204 (1_Supplement): 153.1.
Templated mutagenesis in B cell non-Ig genes
Karla Navarrete; Gordon A. Dale; Matthew C. Woodruff; Christopher D. Scharer; Jeremy M. Boss; Ignacio Sanz; Joshy Jacob
J Immunol (2020) 204 (1_Supplement): 153.10.
The BCMA:Tomato Mouse – a new reporter to characterize long-lived plasma cells
Sebastian R Schulz; Jens Wittner; Andrew J. Kueh; Martin Pal; Marko J Herold; Wolfgang Schuh; Hans-Martin Jäck
J Immunol (2020) 204 (1_Supplement): 153.11.
RIP Kinase death pathways regulate B cell homeostasis and splenic architecture
Alexandra L. McLennan; Raksha Parthasarathy; Thomas Hägglöf; Aiden Mattke; Elizabeth Dudley; Elizabeth A. Leadbetter
J Immunol (2020) 204 (1_Supplement): 153.12.
Fc receptor-like 6 (FCRL6) delineates innate-like B cell progenitors that undergo pre-BCR dependent and independent pathways of natural antibody selection
Randall S Davis; Kazuhito Honjo; Woong-Jai Won; Rodney G King; Lara Ianov; David K Crossman; Juliet L Easlick; Mikhail Shakhmatov; Mohamed Khass; Andre M Vale; Robert P Stephan; Ran Li
J Immunol (2020) 204 (1_Supplement): 153.13.
Myocardial associated B cells are a dynamic subgroup of circulating B cells, in equilibrium with splenic and circulating B cells, but with organ specific features
J Immunol (2020) 204 (1_Supplement): 153.14.
Robust serum-free expansion of human B cells with an animal component-free cell culture supplement
J Immunol (2020) 204 (1_Supplement): 153.16.
Epigenetic control of the protocadherin-gamma locus provides a potential source of cell surface codes in B cell differentiation
Nicole L McDermott; Amel Saadi; Mario Cocco; Matthew Care; Ruth de Tute; Roger Owen; Gina Doody; Reuben Tooze
J Immunol (2020) 204 (1_Supplement): 153.17.
The class II peptide editor, H2-M, affects the development and repertoire of B-1 cells
Debopam Ghosh; Tho D Pham; Xiao He; Mary E O’mara; Aaron B Kantor; Khoa Nguyen; Deepanwita Sengupta; Laurence C Eisenlohr; Peter E Jensen; Leonore A Herzenberg; Scott D Boyd; Eliver E.B. Ghosn; Elizabeth D Mellins
J Immunol (2020) 204 (1_Supplement): 153.2.
Antigen Receptor Specificity and Cell Location Influence the Diversification and Selection of the B-1a Cell Pool with Age
J Immunol (2020) 204 (1_Supplement): 153.3.
The E3 ubiquitin ligase Fbw7 controls survival pathways to prevent apoptosis in mature B cells
J Immunol (2020) 204 (1_Supplement): 153.4.
Differentiation of antibody-secreting cells in the thymus of human neonates
Hector Cordero; Rodney G King; Pranay Dogra; Chloe Dufeu; Sarah B. See; Alexander M. Chong; Anne-Catrin Uhlemann; Siu-Hong Ho; Donna L Farber; John F Kearney; Emmanuel Zorn
J Immunol (2020) 204 (1_Supplement): 153.5.
Single cell transcriptomics of in vivo differentiating antibody-secreting cells reveals a divergent activated B cell program dependent on IRF4
J Immunol (2020) 204 (1_Supplement): 153.6.
T-bet regulates T cell-independent plasmablast responses during intracellular bacterial infection
J Immunol (2020) 204 (1_Supplement): 153.7.
Alteration in TNFα mediates impaired antigen-specific humoral responses in sepsis survivors
Minakshi Rana; Andrea La Bella; Rivka Lederman; Mahendar Ochani; Bruce T. Volpe; Barbara Sherry; Betty Diamond
J Immunol (2020) 204 (1_Supplement): 153.8.
Lymphocyte Effector Functions
Differential survival requirements for Lck- and CD3e-dependent signaling defines two populations of ATMKO thymic T cell lymphomas
J Immunol (2020) 204 (1_Supplement): 154.1.
Characterization of immune anomalies caused by the ptpn6Ala457Thr mutation associated with a specific form of pulmonary emphysema
Marie Pineault; Nadia Milad; Ariane Lechasseur; Marie-Josée Beaulieu; Joanie Routhier; Sophie Aubin; François Maltais; Mathieu Morissette
J Immunol (2020) 204 (1_Supplement): 154.10.
Malt1 Protease Is Critical in Maintaining Function of Regulatory T Cells and May Be a Therapeutic Target for Antitumor Immunity
J Immunol (2020) 204 (1_Supplement): 154.11.
Characterization of the cross reactive T cell repertoire in the context of heterosubtypic influenza A virus infection
J Immunol (2020) 204 (1_Supplement): 154.12.
2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Gimap5 Expression to Ameliorate Concanavalin-Induced T Cell-Mediated Liver Injury
J Immunol (2020) 204 (1_Supplement): 154.13.
IL-4 modulates reconstituted human T cells as a regulatory factor to mitigate GVHD in humanized mice model
J Immunol (2020) 204 (1_Supplement): 154.14.
Senescence-associated β-galactosidase activity and other markers of senescence are present in human peripheral blood mononuclear cells during healthy aging
Hannah K Dewald; Ricardo Iván Martínez-Zamudio; Themistoklis Vasilopoulos; Utz Herbig; Patricia Fitzgerald-Bocarsly
J Immunol (2020) 204 (1_Supplement): 154.15.
Cellular Phenotypes in Cancer Patient Spleen and Peripheral Blood
James E Talmadge; Kathryn Cole; Quan Ly; Tony Hollingsworth; Jesse Cox; Ingunn M Stromnes; James Padussis; Jason Foster; Luciano Vargus
J Immunol (2020) 204 (1_Supplement): 154.16.
T lymphocytes characterization and systemic inflammation after hypoxic ischemia in naturel-resuscitation newborn rats
J Immunol (2020) 204 (1_Supplement): 154.18.
Defining heterogeneity and biological signature in human effector memory CD8+ T cells expressing different levels of IL-7 receptor alpha by high-dimensional analysis
J Immunol (2020) 204 (1_Supplement): 154.19.
Homeostatic maintenance of human T cells in bioengineered secondary lymphoid organoids – a model for studying age-related immune decline
J Immunol (2020) 204 (1_Supplement): 154.2.
Development of regulatory IL-10-producing ILCs during type 2 inflammation
Natalie F. Nidetz; Michael C McGee; Candice B Limper; Kaixiong Ye; Rezwanul Islam; Avery August; Weishan Huang
J Immunol (2020) 204 (1_Supplement): 154.4.
Dietary fats directly impact viral immunity by modifying membrane flexibility and how T cells see antigen
J Immunol (2020) 204 (1_Supplement): 154.5.
Dysregulated TGF-β Signaling Leads to Cell-Intrinsic Changes in T cell Development that Promote Allergic Inflammation
J Immunol (2020) 204 (1_Supplement): 154.6.
SATB1 as a novel therapeutic target for methyltransferase inhibitors against Cutaneous T Cell Lymphoma
Carly Harro; Jairo Perez-Sanz; Tara Lee Costich; Kyle K Payne; Carmen Maria Anadon Galindo; Ricardo A Chaurio Gonzalez; Subir Biswas; Gunjan Mandal; Kristen E Rigolizzo; Jessica A Mine; Louise C Showe; Kebin Liu; Paulo C Rodriguez; Javier Lee Pinilla-Ibarz; Lubomir Sokol; Jose R Conejo-Garcia
J Immunol (2020) 204 (1_Supplement): 154.8.
Molecular and Metabolic Regulation of Lymphocyte Maintenance and Differentiation
Translational regulation directs fate decisions involved in memory CD8 T cell differentiation
J Immunol (2020) 204 (1_Supplement): 155.1.
ABCB7 is required to prevent ferroptosis in peripheral T cells
J Immunol (2020) 204 (1_Supplement): 155.10.
The role of ERK2 in regulating germinal center B cell fate decisions
Austin Joseph Negron; Sean Jeffreys; Nawal Abdul-Baki; Rebecca Perez; Christina Perez; Thomas G Forsthuber
J Immunol (2020) 204 (1_Supplement): 155.11.
Novel roles for Cullin 3 in T cell-mediated immune responses
J Immunol (2020) 204 (1_Supplement): 155.13.
CD8 T cell fate is programmed by a miRNA-mediated mechanism
J Immunol (2020) 204 (1_Supplement): 155.16.
Single-cell metabolic analysis by mass cytometry reveals distinct transitional states of CD8 T cell differentiation
Lauren Levine; Kamir J. Hiam; Diana M. Marquez; Iliana Tenvooren; Diana C Contreras; Jeffrey Charles Rathmell; Matthew H Spitzer
J Immunol (2020) 204 (1_Supplement): 155.18.
Utilization of Stable Isotope Tail-Vein Infusion to Assess Glutamine Utilization by Physiologically Activated CD8+ T cells in vivo
Eric H Ma; Mark J Verway; Dominic G Roy; Mya Steadman; Takla Griss; Bozena Sambroska; Victor Chubukov; Thomas P Roddy; Russell G Jones
J Immunol (2020) 204 (1_Supplement): 155.2.
T cell-intrinsic expression of HIC1 links retinoic acid to tissue residency
J Immunol (2020) 204 (1_Supplement): 155.3.
Integrative characterization of the coding and non-coding transcriptome in human memory B cells
J Immunol (2020) 204 (1_Supplement): 155.4.
Essential respiratory chain subunits encoded by mitochondrial DNA control plasma cell development
Sophia Urbanczyk; Olivier Baris; Dimitrios Mougiakakos; Rudolf Wiesner; Hans-Martin Jäck; Dirk Mielenz
J Immunol (2020) 204 (1_Supplement): 155.5.
Bnip3/Nix-mediated mitophagy protects memory B cells by restricting de novo fatty acid synthesis
J Immunol (2020) 204 (1_Supplement): 155.7.
The role of microRNA-142 in B cell activation and effector functions
J Immunol (2020) 204 (1_Supplement): 155.8.
H3K27me3 demethylases are important epigenetic regulators of B cell differentiation
J Immunol (2020) 204 (1_Supplement): 155.9.
Microbial, Parasitic, and Fungal Immunity 1
Iron in infection and immunity in C. elegans
Malini Rajan; Cole P Anderson; Steven Joshua Romney; Maria Carolina Ferreira Dos Santos; Jason Gertz; Elizabeth A Leibold
J Immunol (2020) 204 (1_Supplement): 156.1.
S. aureus persister cells have increased survival to components of innate immunity, leading to persistence within a catheter-associated biofilm infection
J Immunol (2020) 204 (1_Supplement): 156.11.
Interferon regulatory factor 5 expression in myeloid cells and T cells negatively impacts the outcome of visceral leishmaniasis
J Immunol (2020) 204 (1_Supplement): 156.13.
Candida tropicalis infection dramatically affects the gut microbiome in DSS-induced colitis
Luca Di Martino; Ludovica Buttò; Mahmoud Ghannoum; Cristopher Hager; Abdullah Osme; Kristine-Ann Buela; Carlo De Salvo; Theresa Pizarro; Fabio Cominelli
J Immunol (2020) 204 (1_Supplement): 156.14.
Mda5/MAVS are essential for host resistance against Aspergillus fumigatus
Xi Wang; Alayna Katherine Caffrey; Vanessa Espinosa; Cristina Cunha; Walburga Croteau; João Lacerda; António Campos; Katrien Lagrou; Johan Maertens; Amariliz Rivera; Agostinho Carvohlo; Robert A Cramer; Joshua J Obar
J Immunol (2020) 204 (1_Supplement): 156.15.
Nonencapsulated Streptococcus pneumoniae causes Bacteremia in C1q-Deficient Mice
J Immunol (2020) 204 (1_Supplement): 156.16.
Specific Cell-Surface Glycans on Phagocytes Mediate Binding of Pseudomonas aeruginosa
Hector Felipe Sanchez; Daniel Hopkins; Sally Demirdjian; Cecilia Gutierrez; George O’Toole; Brent Berwin
J Immunol (2020) 204 (1_Supplement): 156.17.
Proteomic analysis of exosomes released from Leishmania infected macrophages
J Immunol (2020) 204 (1_Supplement): 156.19.
IL-15 complex modulates the Plasmodium-specific CD4 T cell response in mice
J Immunol (2020) 204 (1_Supplement): 156.2.
Mice infected with the hypervirulent Mycobacterium tuberculosis HN878 strain develop lung lesions resembling human tubercle granulomas
Suhas Bobba; José Alberto Choreño-Parra; Javier Rangel-Moreno; Mushtaq Ahmed; Smriti Mehra; Bruce Rosa; John Martin; Makedonka Mitreva; Deepak Kaushal; Joaquin Zúñiga; Shabaana A Khader
J Immunol (2020) 204 (1_Supplement): 156.20.
The Function of Brain Th1-like regulatory T cells in Suppressing Lethal Immune Pathology and Neurological Deterioration during Cryptococcus neoformans Meningoencephalitis
Jintao Xu; Jessica Zhao; Michael Ivey; Rafael Lopez; Brandon McClellan; Steven Do; Akanksha Malepati; Samantha Kroon; Alexa Mysel; Michal A Olszewski
J Immunol (2020) 204 (1_Supplement): 156.21.
Expression of virulence factors and pro-inflammatory cytokines by Candida species associated with Vulvovaginal Candidiasis in Eastern Nigeria
J Immunol (2020) 204 (1_Supplement): 156.22.
Bacterial Extracellular Vesicle Mediated Host-Pathogen Interactions in Pneumococcal Infections
Saigopalakrishna S Yerneni; Sarah Werner; Juliana H Azambuja; Nils Ludwig; Surya Aggarwal; Rory Eutsey; Peter C Lucas; Phil G Campbell; Luisa Hiller
J Immunol (2020) 204 (1_Supplement): 156.23.
Screening of biological biomarker for distinguishing latent and active tuberculosis by proteome microarray
J Immunol (2020) 204 (1_Supplement): 156.27.
Investigating Staphylococcus aureus tolerance to innate immunity
J Immunol (2020) 204 (1_Supplement): 156.28.
An unconventional T cell population is critical for protection from repeat pulmonary infection with Klebsiella pneumoniae
J Immunol (2020) 204 (1_Supplement): 156.29.
Distinct host immune programs in lung macrophages elicit cell-type specific Mycobacterium tuberculosis transcriptional responses
Jared L Delahaye; Sara B Cohen; Eliza Peterson; Kristin Adams; Courtney R Plumlee; Christopher Plaisier; Nitin Baliga; Kevin B Urdahl
J Immunol (2020) 204 (1_Supplement): 156.3.
Subchronic inhalation of Aspergillus versicolor conidia leads to sustained innate immune responses and is associated with irreversible remodeling of pulmonary arterial tissue following recovery
Mark A Barnes; Tara L. Croston; Angela R. Lemons; Rachael E. Rush; Donald H Beezhold; Brett J. Green
J Immunol (2020) 204 (1_Supplement): 156.32.
Dispensable role of chemokine receptors in migration of mycobacterial antigen-specific CD4+ T cells into mycobacteria-infected lung
J Immunol (2020) 204 (1_Supplement): 156.34.
Neonatal Deficiencies in NK cell-Activating Cytokines in the Context of Bordetella pertussis Infection
J Immunol (2020) 204 (1_Supplement): 156.35.
Differential immune cell response to Mycobacterium intracellulare colony morphotypes
J Immunol (2020) 204 (1_Supplement): 156.4.
Polymicrobial sepsis impairs antigen-specific memory CD4 T cell-mediated immunity
Frances V Sjaastad; Tamara A Kucaba; Thamotharampillai Dileepan; Whitney Swanson; Cody S Dail; Javier Cabrera-Perez; Katherine A Murphy; Vladimir P Badovinac; Thomas S Griffith
J Immunol (2020) 204 (1_Supplement): 156.6.
Intrinsic Impairment of CD8 T Cells Induced by Helminth Coinfection
J Immunol (2020) 204 (1_Supplement): 156.8.
Identification of a phagosomal F-actin structure that evades dendritic cell immunity to Cryptococcus gattii
Khusraw Jamil; Maria J Polyak; David D Feehan; Philip Surmanowicz; Shushun Li; Henry Ogbomo; Danuta Stack; Michal A Olszewski; Anutosh Ganguly; Christopher H Mody
J Immunol (2020) 204 (1_Supplement): 156.9.
Immunity in the Skin, Female Reproductive Tract, and Liver
Neonatal Tregs Suppress the Development of a Stromal Niche for Th2 Cells in Skin
J Immunol (2020) 204 (1_Supplement): 157.1.
Staphylococcus epidermidis facilitates intracellular pathogen clearance through upregulation of antimicrobial protein perforin-2 (P-2) in the human skin gamma delta T cells
Natasa Strbo; Katelyn E. O’Neill; Cheyanne R. Head; Laura Padula; Olivera Stojadinovic; Irena Pastar; Marjana Tomic-Canic
J Immunol (2020) 204 (1_Supplement): 157.10.
Antigen-Specific CD4 T cells Protect Against Reproductive Pathology by Subverting Chlamydia-specific CD8 T cell Response
Weidang Li; Katerina Warda; Lindsay N Moy; Tarakarama Musunuri; Nhi Bui; Erika Wright-McAfee; Ashlesh K. Murthy
J Immunol (2020) 204 (1_Supplement): 157.11.
Activation of skin-resident group 2 innate lymphoid cells by cold-sensing TRPM8+ neuron-derived signals in thermo-homeostatic regulation and tissue inflammation
J Immunol (2020) 204 (1_Supplement): 157.12.
Increased cervical neutrophil survival during bacterial vaginosis in Canadian women from the THRIVE study
Christina Farr; Laura Noel-Romas; Kenzie Birse; Marlon De Leon; Kateryna Kratzer; Michelle Perner; Hossaena Ayele; Cobi Wiwchar; Helen Pymar; Alicia R Berard; Vanessa Poliquin; Adam Burgener
J Immunol (2020) 204 (1_Supplement): 157.13.
Crosstalk between skin homing innate T cells and epithelial cells via cholesterol byproduct messengers is required for tissue immunity
Michela Frascoli; Bing Miu; Enxhi Ferraj; Jisu Lee; Kelsey Esposito; Nicholas Spidale; Jennifer Cowan; Avinash Bhandoola; Joonsoo Kang; Andrea Reboldi
J Immunol (2020) 204 (1_Supplement): 157.14.
Skin-resident natural killer T cells induce cutaneous allergic inflammation in atopic dermatitis
J Immunol (2020) 204 (1_Supplement): 157.15.
CD8 T cell immunosurveillance and elimination of HIV target cells in the female reproductive tract
J Immunol (2020) 204 (1_Supplement): 157.3.
Migratory memory CD4 T cells surveilling the lower reproductive tract direct rapid clearance of Chlamydia muridarum following vaginal challenge
Alison Kohlmeier; Tiger Li; Jenna Lobby; Kirsten Kost; Paul Dunbar; Anice Lowen; HaoQiang Zheng; Jacob E Kohlmeier
J Immunol (2020) 204 (1_Supplement): 157.4.
The role of CCL27 in the establishment, maintenance, and homeostasis of skin-resident CCR10+ lymphocytes
J Immunol (2020) 204 (1_Supplement): 157.5.
Targeting CD49a+PBX1+ NK cells in recurrent spontaneous abortion immunotherapy
J Immunol (2020) 204 (1_Supplement): 157.6.
Human liver CD69+CD103−CD8+ memory T cells are regulated by HIF-2α
Jong Hoon Kim; Ji Won Han; Young Joon Choi; Min-Seok Rha; June-Young Koh; Jun Yong Park; Su-Hyung Park; Dong Jin Joo; Eui-Cheol Shin
J Immunol (2020) 204 (1_Supplement): 157.7.
Transcriptomic, phenotypical, and functional characterization of human liver sinusoidal CD69+CD4+ T cells
June-Young Koh; Ji Won Han; Min-Seok Rha; Jun Yong Park; Dong Jin Joo; Su-Hyung Park; Eui-Cheol Shin
J Immunol (2020) 204 (1_Supplement): 157.8.
IL17 and Candida albicans colonization in the vaginal mucosa
Bianca M Coleman; Brian M Peters; Hubertine M.E. Willems; Katherine S. Barker; Felix E.Y. Aggor; Ellyse Cipolla; Akash H Verma; Srinivas Bishu; Anna H Huppler; Vincent M Bruno; Erin E Childs; Heather Conti; Sarah L Gaffen
J Immunol (2020) 204 (1_Supplement): 157.9.
Gastrointestinal Immunity
Myeloid cells recruit colonic TCRab+ Intraepithelial Lymphocytes through Sphingosine-1-phosphate
J Immunol (2020) 204 (1_Supplement): 158.1.
Immunosuppressive therapy of immune-mediated GI damage may impair epithelial regeneration
Viktor Arnhold; Shuichiro Takashima; Paola Vinci; Jason Kuttiyara; Anastasiya Egorova; Marco Calafiore; Alan Hanash
J Immunol (2020) 204 (1_Supplement): 158.11.
IL-2 signals promote acute and selective apoptosis of B cells in Peyer’s Patches
J Immunol (2020) 204 (1_Supplement): 158.12.
Dissecting the role of endogenous epithelial IL-10 using a small intestinal organoid model
J Immunol (2020) 204 (1_Supplement): 158.16.
Dissecting the cellular responses of immune cells and Lgr5+ stem cells in the inflamed mouse colon with the RNAscope in situ hybridization technology
J Immunol (2020) 204 (1_Supplement): 158.17.
The role of glutamate-NMDA-receptor in mice alpha beta T cells from intestinal mucosa
Marília Garcia De Oliveira; Rafaela Andreoni; Wesley Brandao; Beatriz Peixinho; Carolina Manganeli Polonio; Nagela Ghabdan Zanluqui; Lilian Oliveira; Jean Pierre S Peron
J Immunol (2020) 204 (1_Supplement): 158.18.
Role of Granzyme B in mucosal immune responses
Kristen L Hoek; Ali Nazmi; Kshipra Singh; M. Blanca Piazuelo; Keith Wilson; Danyvid Olivares-Villagómez
J Immunol (2020) 204 (1_Supplement): 158.19.
Th17 cell production of amphregulin contributes to the intestinal homeostasis
J Immunol (2020) 204 (1_Supplement): 158.2.
Physiologic expression of AhR regulates CX3CR1+ resident intestinal macrophages and promotes diabetes in NOD mice
J Immunol (2020) 204 (1_Supplement): 158.21.
Temporal changes in cellular sources of CXC chemokines control neutrophil recruitment during Citrobacter rodentium infection
Baiyi Cai; Carlene L. Zindl; Daniel J. Silberger; David A. Figge; Jeffery R. Singer; Simon F Merz; Matthias Gunzer; Casey T. Weaver
J Immunol (2020) 204 (1_Supplement): 158.22.
Immune Activation of the Blood Brain Barrier and Implications for Neuroinflammation in Schizophrenia
Alexis Mary Crockett; Sean K. Ryan; Adriana Hernandez Vasquez; Caroline Canning; Nickole Kanyuch; Guadalupe Ceja; James Gesualdi; Hania Kebir; Richa Kapoor; Nail Benallegue; Stewart A. Anderson; Jorge I. Alvarez
J Immunol (2020) 204 (1_Supplement): 158.23.
Th17 immunity in the colon is controlled by two novel subsets of colon-specific mononuclear phagocytes
J Immunol (2020) 204 (1_Supplement): 158.3.
CCR9+ dendritic cells promote the differentiation of Foxp3+ regulatory CD4 T cells
J Immunol (2020) 204 (1_Supplement): 158.4.
Roles for Leukemia-inhibitory factor receptor signaling in intestinal immunity
Laura Maria Kahn; Haiyan S. Li; Taylor T. Chrisikos; Yifan Zhou; Yusra B. Medik; Bhakti Patel; Rachel Lauren Babcock; Kathryn Newton; Stephanie S Watowich
J Immunol (2020) 204 (1_Supplement): 158.5.
GPR120 regulates neutrophil functions and intestinal homeostasis
J Immunol (2020) 204 (1_Supplement): 158.6.
The role of JAML-CAR costimulation in gamma delta T cell-mediated repair of the intestinal epithelium
J Immunol (2020) 204 (1_Supplement): 158.7.
Analysis of tissue specific mechanisms that control the maintenance of Foxp3+ regulatory T cells in the intestine
J Immunol (2020) 204 (1_Supplement): 158.8.
Technological Innovations in Immunology 2
Novel fluorochrome development enables 34-color high-content flow cytometry
J Immunol (2020) 204 (1_Supplement): 159.1.
Quantitative immune profiling of human tumor tissues with multiplexed ChipCytometry
J Immunol (2020) 204 (1_Supplement): 159.10.
Curated, multi-omic, ML-driven single-cell atlas for characterizing the human immune system across disease states
Evgeny Kiner; Hila Sharim; Antonino Montalbano; Tali Raveh-Sadka; Uri Yanover; Daniel K. Wells; Ansuman Satpathy
J Immunol (2020) 204 (1_Supplement): 159.11.
ImmuneSpace enables multicohort immune correlates analysis
J Immunol (2020) 204 (1_Supplement): 159.12.
Advancing Compensation into the Future with the Next Generation of Comp Beads
J Immunol (2020) 204 (1_Supplement): 159.13.
Organ-on-Chip Meets Immunology: Let’s Start with the Lungs
J Immunol (2020) 204 (1_Supplement): 159.14.
Demonstration of High Gain mode in combination with Imaging Flow Cytometry for improved EV analysis
J Immunol (2020) 204 (1_Supplement): 159.15.
Standardized Approach for Monitoring Plasma Cell Disorders
J Immunol (2020) 204 (1_Supplement): 159.16.
Expanding the capabilities of the Maxpar Direct Immune Profiling Assay with additional markers, and customization of the analysis model in Maxpar Pathsetter
J Immunol (2020) 204 (1_Supplement): 159.17.
Immune phenotypic analysis using pre-designed BD® AbSeq pan immune-response panel
J Immunol (2020) 204 (1_Supplement): 159.18.
A Novel IL2-based Immunotherapeutic Protein Prevents the Development of Atherosclerosis in ApoE−/− mice and LDLR−/− mice
Qiongzhen li; Xiaoyun Zhu; Catherine Spanoudis; Kristine Ravelo; Mike Dee; Bai Liu; Caitlin Prendes; Lijing You; Hing Wong
J Immunol (2020) 204 (1_Supplement): 159.19.
Infinity Flow: comprehensive single-cell protein profiling via massively parallel flow cytometry and machine learning
J Immunol (2020) 204 (1_Supplement): 159.2.
Biological Evaluation of the MILLIPLEX® Human Cytokine/Chemokine/Growth Factor Panel A for Disease Profiling of 48 Immune Factors
J Immunol (2020) 204 (1_Supplement): 159.20.
Using super-resolution microscopy to detect and resolve the distribution of biomarkers that are relevant in a range of immuno-oncology studies
J Immunol (2020) 204 (1_Supplement): 159.22.
Deep characterization of in vitro chronically stimulated T cells via single-cell multiomic analysis
Mirko Corselli; Suraj Saksena; Margaret Nakamoto; Woodrow E Lomas; Ian Taylor; Pratip K Chattopadhyay
J Immunol (2020) 204 (1_Supplement): 159.23.
A novel radio-pharmaceutical to image activation of the innate immune system in vivo
J Immunol (2020) 204 (1_Supplement): 159.26.
Detection and Quantification of Extracellular Vesicles with Cargo Protein and RNA Using the Amnis® CellStream® Flow Cytometer
J Immunol (2020) 204 (1_Supplement): 159.28.
CRISPR Cas9 ribonucleoprotein-mediated genomic editing in primary innate immune cells
Andrew D Hildreth; Luke Riggan; Marion Rolot; Yung-Yu Wong; Will Satyadi; Ryan Sun; Chris Huerta; Timothy E. O’Sullivan
J Immunol (2020) 204 (1_Supplement): 159.3.
High throughput subpopulation signaling analysis: protocol considerations for multiplexed intracellular flow cytometry
J Immunol (2020) 204 (1_Supplement): 159.30.
EVALUATION OF A MULTIPLEX ARBOVIRUS SEROLOGY ASSAY AS A TOOL FOR SEROSURVEILLANCE
J Immunol (2020) 204 (1_Supplement): 159.31.
Microfluidic generation of lipid nanoparticles to facilitate DNA entry into human mast cells
J Immunol (2020) 204 (1_Supplement): 159.33.
A universal multiplex assay format for ultra-sensitive cytokine quantification in human serum and plasma
J Immunol (2020) 204 (1_Supplement): 159.35.
Development of a novel model: Using songbirds to elucidate the pro-neurogenic role of microglia in healthy and natural neurodegenerative states
J Immunol (2020) 204 (1_Supplement): 159.38.
CD34 count using Image based-immunofluorescence cell counter with filterpaper imbeded microchip
J Immunol (2020) 204 (1_Supplement): 159.39.
Biomarker Trends: Luminex & Olink, Dried Blood Spots & Plasma
Yael Rosenberg-Hasson; Tiffany C. Ho; Tamara D. Simon; Jing Liang; Serena Chang; Iris Herschmann; Ian H. Gotlib; Holden T. Maecker
J Immunol (2020) 204 (1_Supplement): 159.4.
A cloud-based bioinformatic and analytic infrastructure for the Expanded Program on Immunization Consortium
J Immunol (2020) 204 (1_Supplement): 159.40.
Global targeting of functional (phospho)tyrosines using sulfur-triazole exchange chemistry
Ku-Lung Hsu; Adam L Borne; Jeffrey W Brulet; Heung S Hahm; Emmanuel K Toroitich; Adam H Libby; Kun Yuan; Timothy B Ware; Rebecca L McCloud; Anthony M Ciancone
J Immunol (2020) 204 (1_Supplement): 159.44.
Evaluation of intrahepatic macrophages in patients with non-alcoholic steatohepatitis using multispectral imaging
Omar A Saldarriaga; Jingjing Jiao; Laura Beretta; Benjamin Freiberg; Santhoshi Krishnan; Arvind Rao; Adam L. Booth; Heather L. Stevenson
J Immunol (2020) 204 (1_Supplement): 159.45.
Adarza’s ZIVA multiplex protein detection platform offers format for ultra-high sensitivity
J Immunol (2020) 204 (1_Supplement): 159.46.
Regulation of body temperature in Canadian beef cattle of various immune response phenotypes when the temperature humidity index is above normal
J Immunol (2020) 204 (1_Supplement): 159.47.
Protein- and sequencing-based massively parallel single-cell approaches to immune profiling asthma-specific cell subtypes and related gene expression biomarkers
Xuhuai Ji; Swati Acharya; Igor Goncharov; Shu-Chen Lyu; Molly Miranda; Gilly Padalon-Brauch; Kari Christine Nadeau; Holden T. Maecker
J Immunol (2020) 204 (1_Supplement): 159.49.
Whole-body immunoPET imaging to monitor immune activation status in situ
Heather Gibson; Justin Hackett; Jordan White; Josh Mandella; Brian Zeglis; Outi Keinanen; Jhansi Kalluri; Stephen Barr; Claire McCarthy; Wendy Wiesend; Nerissa Viola
J Immunol (2020) 204 (1_Supplement): 159.5.
A Performance-Optimized Multicolor Flow Cytometry Dried-Reagent Cocktail for Memory T-Cell Analysis
Mary Hanley; Mamatha Bharadwaj; Chip Lomas; Scott Bornheimer; Suraj Saksena; Elena Afonina; Erika Barboza Prado Lopes
J Immunol (2020) 204 (1_Supplement): 159.51.
Development of a competition ELISA (cELISA) for specific detection of Zika virus antibodies in human sera
David Katz; Dan He; Irina Patrusheva; G Maria Clara Echevery; Carolina Ortiz; Holly R Hughes; Alberto Moreno; Vishakh Walia; Julia Hilliard
J Immunol (2020) 204 (1_Supplement): 159.52.
Single B cell isolation and cloning from rabbits to generate recombinant antibodies
Bryce Alves; Mary Anne Jelinek; Yanan Lu; Melissa Ritland; Patricia Velasco; Xi Zhao; Eddie Adams; Joseph Fernandez
J Immunol (2020) 204 (1_Supplement): 159.53.
Early cancer detection using ctDNA technology – what is the relevance for Pacific Communities?
J Immunol (2020) 204 (1_Supplement): 159.54.
Antibody-Immobilized <wbr>Nanofiber Scaffolds for the Delivery of Human Tumor Antigen-Specific Cytotoxic T Lymphocytes
EUNJU LEE; Joann Ng Pei Jia; Tae-Jin Kim; Siyoung Lim; Jiyoung Kim; Jungwon Kim; Jeongsoo Kim; Junghee Kim; Sunghee Park; Kyung-mi Lee
J Immunol (2020) 204 (1_Supplement): 159.55.
A comparison of single cell capture methods and amplification strategies to pair alpha and beta
Brittany E Brown; Wenjing Pan; Miranda Byrne-Steele; Mary Eisenhower; Song Li; Xiaohong Hou; Mollye M Depinet; Jian Han
J Immunol (2020) 204 (1_Supplement): 159.56.
Complete multi-chain adaptome amplification from whole blood and PBMC via novel dam-PCR technology
Mollye M Depinet; Wenjing Pan; Xiaohong Hou; Brittany E Brown; Mary Eisenhower; Daniel Weber; Miranda Byrne-Steele; Jian Han
J Immunol (2020) 204 (1_Supplement): 159.57.
Development of an in vivo model to assess immune and angiogenic responses to metallic implants using Humanized TLR-4 mice
J Immunol (2020) 204 (1_Supplement): 159.58.
Housing laboratory mice deficient for Nod2 and Atg16l1 in a natural environment uncovers genetic and environmental contributions to immune variation
Jian-Da Lin; Joseph C. Devlin; Frank Yeung; Caroline McCauley; Jacqueline M. Leung; Ying-Han Chen; Alex Cronkite; Christina Hansen; Charlotte Drake-Dunn; Kelly V. Ruggles; Ken Cadwell; Andrea L. Graham; P’ng Loke
J Immunol (2020) 204 (1_Supplement): 159.6.
The EPIC data analytics platform for clinical mass cytometry
Martin Wasser; Joo Guan Yeo; Pavanish Kumar; Valerie Chew; Chun Jye Lim; Thaschawee Arkachaisri; Su Li Poh; Jing Yao Leong; Kee Thai Yeo; Salvatore Albani
J Immunol (2020) 204 (1_Supplement): 159.7.
A robust and interpretable, end-to-end deep learning model for cytometry data
J Immunol (2020) 204 (1_Supplement): 159.8.
Therapeutic Approaches in Autoimmune Neurologic Disease
Eukaryotic Translation Initiation Factor 4E (eIF4E) is Required for Development of T Follicular Helper Cells and Pathogenesis of Autoimmune Encephalitis
Preeyam S Patel; Beth Walters; Margo Orlen; Angelina Volkova; Kelly Ruggles; Christopher Park; Robert Schneider
J Immunol (2020) 204 (1_Supplement): 160.1.
Schisandrin B and Alantolactone ameliorates experimental autoimmune encephalomyelitis in mice
J Immunol (2020) 204 (1_Supplement): 160.12.
A Phase 1 study comparing subcutaneous and intramuscular routes of administration of peginterferon beta-1a: macrophage-producing neopterin levels as biomarker
J Immunol (2020) 204 (1_Supplement): 160.13.
Farnesol reduces T cell infiltration in murine CNS inflammatory demyelination
Christina C Ramelow; Lacey B. Sell; Kevin D. Strawn; Theresa Hevrin; Trevor O. Kirby; K. Michael Gibson; Jean-Baptiste Roullet; Javier Ochoa-Repáraz
J Immunol (2020) 204 (1_Supplement): 160.14.
Small molecule prevents inflammation in microglia by targeting the NLRP3 inflammasome
J Immunol (2020) 204 (1_Supplement): 160.15.
Alpha-synuclein specific regulatory T cells expanded with bee venom phospholipase A2 improves the neuroprotective effects in MPTP-induced mouse model of Parkinson’s disease
J Immunol (2020) 204 (1_Supplement): 160.16.
Inhibition of CSF-1R curtails inflammation during experimental autoimmune encephalomyelitis
J Immunol (2020) 204 (1_Supplement): 160.18.
Immunotherapy in Probable autoimmune encephalitis without detected autoantibody
Woo-Jin Lee; Soon-Tae Lee; Sang Bin Hong; Hyoshin Son; Yoonhyuk Jang; Jun-Sang Sunwoo; Kyung-Il Park; Kon Chu; Sang Kun Lee
J Immunol (2020) 204 (1_Supplement): 160.19.
B Cell Maturation Antigen deficiency increases inflammatory B-cell functions in multiple sclerosis
J Immunol (2020) 204 (1_Supplement): 160.2.
Deficiency in B Cell Maturation Antigen reveals sex differences in Experimental Autoimmune Encephalomyelitis
J Immunol (2020) 204 (1_Supplement): 160.20.
Identification of markers of relapse in EAE using high-resolution quantitative mass spectrometry
J Immunol (2020) 204 (1_Supplement): 160.21.
Immunomodulatory networks in multiple sclerosis
Achillefs Ntranos; Brian Lee; Hui Xie; Jonathan Rockoff; Rachel Brandstadter; Seunghee Kim-Schulze; Fred Lublin
J Immunol (2020) 204 (1_Supplement): 160.22.
Case study: mepolizumab prevents progression of eosinophilic granulomatosis with polyangiitis with involvement of the central nervous system which is refractory to conventional immunotherapy
Hyoshin Son; Sang Bin Hong; Yoonhyuk Jang; Woo-Jin Lee; Jun-Sang Sunwoo; Daejong Jeon; Soon-Tae Lee; Kyung-Il Park; Sang Kun Lee; Kon Chu
J Immunol (2020) 204 (1_Supplement): 160.23.
Cognitive deficit and neuroinflammation were abolished by a single adoptive transfer of Regulatory T cells in 3xTg mouse model of Alzheimer’s disease
J Immunol (2020) 204 (1_Supplement): 160.24.
Taurodeoxycholate, a master key locking both priming and activation signal necessary for inflammasomal activation of microglia by Amyloid beta in Alzheimer’s diseases
MD JAHIRUL ISLAM; Jong-Ah Cho; Tae-Joo Kim; Bong Jik Kim; Sung-Yoon Moon; Eun-Young Lee; Song-Jin Lee; Seung-Yong Seong
J Immunol (2020) 204 (1_Supplement): 160.25.
Gypenosides attenuate lipopolysaccharide-induced neuroinflammation and anxiety-like behaviors in rats
J Immunol (2020) 204 (1_Supplement): 160.26.
Human neural stem cells induce central nervous system specific regulatory T cells from the exTreg pool and promote repair in models of multiple sclerosis
Scott A Greilach; Laura L McIntyre; Jonathan Hasselmann; Shivashankar Othy; Quy Ngyuen; Ilse Sears-Kraxberger; Oswald Steward; Kai Kessenbrock; Michael D Cahalan; Mathew Blurton-Jones; Thomas E Lane; Craig M Walsh
J Immunol (2020) 204 (1_Supplement): 160.3.
Molecular patterns expressed by a human gut commensal strain of Lactobacillus suppress neuroinflammation
John Michael Sison Sanchez; Daniel Jason Doty; Ana Beatriz DePaula-Silva; Jane E. Libbey; Robert S Fujinami
J Immunol (2020) 204 (1_Supplement): 160.4.
HMGB1 A Box prevents neuronal injury from PD via restricting activation of microglia and inhibiting differentiation and infiltration of Th17 cells
J Immunol (2020) 204 (1_Supplement): 160.6.
Alpha-synuclein (αS) functions as an alarmin to promote inflammatory and immune responses by activating dendritic cells and macrophages
Md Masud Alam; De Yang; Xiao-Qing Li; Jia Liu; Timothy Carrel Back; Anna Trivett; Baktiar Karim; Michael Zasloff; Joost J Oppenheim
J Immunol (2020) 204 (1_Supplement): 160.7.
Photobiomodulation (PBM) regulates nitric oxide (NO) production by peripheral blood mononuclear cells (PBMC) isolated from Multiple Sclerosis (MS) patients
J Immunol (2020) 204 (1_Supplement): 160.8.
Dimethyl Itaconate, an Itaconate Derivative, Exhibits Immunomodulatory Effects on Neuroinflammation in Experimental Autoimmune Encephalomyelitis
Ping-Chang Kuo; Wen-Tsan Weng; Barbara A. Scofield; Hallel C. Paraiso; Dennis A. Brown; I-Chen Yu; Jui-Hung Yen
J Immunol (2020) 204 (1_Supplement): 160.9.
Immunology of Organ Transplantation
Allo and autoimmune response following cardiac progenitor cells transplantation in rat myocardial infarction model
Muthukumar Gunasekaran; Rachana Mishra; Sudhish Sharma; Progyapramita Saha; Lina Wang; Lauren Davidson; Aakash Shah; Mir Yasir Arfat; Xuebin Fu; Mohamed Abdullah; Deqiang Li; Sunjay Kaushal
J Immunol (2020) 204 (1_Supplement): 161.1.
Characterization of Immune Phenotypes in Peripheral Blood of Adult Renal Transplant Recipients using Mass Cytometry (CyTOF)
J Immunol (2020) 204 (1_Supplement): 161.10.
B cell-derived IL-1β and IL-6 drive homeostatic T cell recovery following lymphoablation
J Immunol (2020) 204 (1_Supplement): 161.11.
Recipient expression of C-type lectin receptor Mincle promotes rapid T cell homeostatic recovery following antibody mediated lymphoablation
J Immunol (2020) 204 (1_Supplement): 161.12.
Immunosuppressive activity of cyclosporin A in vivo via NFAT-independent inhibition of TCR signaling
J Immunol (2020) 204 (1_Supplement): 161.13.
B Cell derived IL-4 promotes IL-10 secreting TIM-1+ regulatory B cell expansion and regulates Th2 T cell responses
J Immunol (2020) 204 (1_Supplement): 161.16.
IL-10 signaling in T cells is essential for induction of transplant tolerance
J Immunol (2020) 204 (1_Supplement): 161.17.
Novel insights into high alloantibody production in CCR5 KO recipient mice
Jing Light Han; Jason M Zimmerer; Qiang Zeng; Bryce A Ringwald; Clarissa Cassol; Robert T Warren; Mahmoud Abdel-Rasoul; Christopher K Breuer; Ginny L Bumgardner
J Immunol (2020) 204 (1_Supplement): 161.18.
Recipient LAG3 deficiency results in antibody-mediated rejection of mouse renal allografts
Michael Nicosia; Juyeun Lee; Ran Fan; Victoria Gorbacheva; Ashley Beavers; Nina Dvorina; William Baldwin; Robert L Fairchild; Booki Min; Anna Valujskikh
J Immunol (2020) 204 (1_Supplement): 161.2.
IFNAR signaling augments T cell and plasmacytoid dendritic cell activation during costimulation blockade resistant rejection
J Immunol (2020) 204 (1_Supplement): 161.21.
Mechanisms of transplant rejection after the establishment of donor-specific tolerance
Christine McIntosh; Michelle Miller; Ying Wang; Luqiu Chen; Zheng Jenny Zhang; Jiao-Jing Wang; Jennifer Allocco; Anita S F Chong; Maria-Luisa Alegre
J Immunol (2020) 204 (1_Supplement): 161.22.
DNA-PKcs Inhibition Extends Allogeneic Skin Graft Survival and Suppresses EGR1 and NFκB-mediated IL6 Production
J Immunol (2020) 204 (1_Supplement): 161.23.
Formation and function of resident memory t cells in renal allografts
J Immunol (2020) 204 (1_Supplement): 161.24.
Marginal zone B cells induce T cell homeostatic proliferation following antibody-mediated lymphoablation
J Immunol (2020) 204 (1_Supplement): 161.25.
The alarmin HMGB1 in cell cytoplasm can modulate the apoptosis to autophagy switch of pancreatic beta cells under stress
J Immunol (2020) 204 (1_Supplement): 161.28.
The effect of SLA expression on genetically-engineered pig renal cells on the human T cell xenoresponse
Zheng-Yu Wang; Joseph M. Ladowski; Juan Li; Gregory R. Martens; Luz M. Reyes; Jose L. Estrada; A. Joseph Tector
J Immunol (2020) 204 (1_Supplement): 161.29.
Identification of immunologic factors associated with allograft rejection using NGS T cell receptor repertoire data
Julia Vetter; Constantin Aschauer; Andreas Heinzel; Roman Reindl-Schweighofer; Kira Jelencsics; Karin Hu; Rainer Oberbauer; Stephan Winkler; Susanne Schaller
J Immunol (2020) 204 (1_Supplement): 161.3.
Out-of-the-black-box: Standardisation of the EliSpot Method for immunomonitoring in personalized Immunosupression after solid organ tranplantation
J Immunol (2020) 204 (1_Supplement): 161.4.
Salvia miltiorrhiza inhibits allospecific memory CD8+ T cell generation and allograft rejection in mice
J Immunol (2020) 204 (1_Supplement): 161.6.
Role of non-HLA antigens in cardiac transplant rejection
Anjali Jacob Panicker; Katherine V Gates; Sherri M Biendarra-Tiegs; Nikolai G Vetr; Manuela Lopera Higuita; Timothy J Nelson; Naveen L Pereira; Leigh G Griffiths
J Immunol (2020) 204 (1_Supplement): 161.7.
Immunoproteomic identification of in vivo response toward residual antigenic proteins in xenogeneic heart valve biomaterials
J Immunol (2020) 204 (1_Supplement): 161.9.
Central Signaling Pathways Regulating Innate Immunity and Cellular Stress and Immune Dysfunction
The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity and promotes natural killer cell memory by regulating c-Myc and mitochondrial respiration
Han Dong; Nicholas Adams; Yichi Xu; Jin Cao; Xi Chen; Rizwan Romee; Joseph Chai-Yuen Sun; Laurie H Glimcher
J Immunol (2020) 204 (1_Supplement): 162.11.
Autophagy Induced due to Moderate Endoplasmic Reticulum Stress in T Cells Enhances Immunotherapeutic Tumor Control
Paramita Chakraborty; Shilpak Chatterjee; Danh T. Tran; Dariusz Pytel; Dosung Kim; Satish N. Nadig; Carl Atkinson; Hongjun Wang; J. Alan Diehl; Vamsi Gangaraju; Viswanathan Palanisamy; Shikhar Mehrotra
J Immunol (2020) 204 (1_Supplement): 162.14.
Peroxiredoxin 1 controls β-catenin activity and Epstein-Barr Virus-encoded MicroRNA in Nasopharyngeal Carcinoma
Minhye Noh; Eun-Yeung Gong; Temitope Michael Akinleye; Lata Rajbongshi; Yeong Seok Kim; Dea Young Hur
J Immunol (2020) 204 (1_Supplement): 162.15.
STING pathway mediated immunologic consequences of DNA damage repair gene losses in high-grade serous ovarian tumors
Noor E. Shakfa; Elizabeth Lightbody; Afrakoma Afriyie-Asante; Deyang Li; Stephen Chenard; Ali Hamade; Madhuri Koti
J Immunol (2020) 204 (1_Supplement): 162.4.
TREX1-induced chromosome fragmentation at the interface of innate immunity and genomic instability
J Immunol (2020) 204 (1_Supplement): 162.5.
Exploiting cancer cell metabolism with stimuli-responsive toll-like receptor agonists
Rock Mancini; Austin Ryan; Anunay Pulukri; Maryam Davaritouchaee; Armina Abbasi; Aaron Hendricksen; Larissa Opp; Anthony Burt; Amy Nielsen
J Immunol (2020) 204 (1_Supplement): 162.6.
Too Much of a Good Thing: IFN-I, Dendritic Cells, and Cancer
J Immunol (2020) 204 (1_Supplement): 162.7.
cGAS-STING pathway mediates antitumor immunity of tumor cryoablation in syngeneic murine Rhabdomyosarcoma
J Immunol (2020) 204 (1_Supplement): 162.8.
Regulation of ultraviolet radiation-induced cutaneous DNA damage by type I interferons
J Immunol (2020) 204 (1_Supplement): 162.9.
Hematologic Malignancies
BRD4 inhibitors synergize with anti-PD1 in rescuing T cell exhaustion in acute myeloid leukemia by increasing TCF1 expressing CD8+ T cells
J Immunol (2020) 204 (1_Supplement): 163.10.
Nanoparticles as potential therapeutics for acute myeloid leukemia
J Immunol (2020) 204 (1_Supplement): 163.13.
The Ikaros1, IKZF1, risk locus for Acute Lymphoblastic Leukemia (ALL) at chromosome 7p12.2 regulates the expression of the FIGNL1 gene
Viktoryia Laurynenka; Danielle Ho; Yongbo Huang; Sreeja Parameswaran; Leah C. Kottyan; Matthew T. Weirauch; John Perentesis; Kenneth M. Kaufman; Benjamin Mizukawa; John B. Harley
J Immunol (2020) 204 (1_Supplement): 163.15.
Treg dysregulation contributes to pathogenesis of Myelodysplastic syndrome
Virginia Camacho; Victoria Matkins; Sweta Patel; Ashlyn Anderson; Ashley E Landuy; Paul Brent Ferrell; Craig L Maynard; Laurie E Harrington; Heth Roderick Turnquist; Robert S Welner
J Immunol (2020) 204 (1_Supplement): 163.16.
Developing a novel biologic for the treatment of high-risk B cell acute lymphoblastic leukemia
Caleb Ruiz-Jiménez; Jacqueline Coats; Xianmei Meng; Cornelia Stoian; Ineavely Baez; Hossam AlKashgari; Andy Paz-Aldana; Sarah Doublet; Hannah Choi; Roland Williams; Shadi Farzin-Gohar; Sinisa Dovat; Kimberly J Payne
J Immunol (2020) 204 (1_Supplement): 163.17.
Innate immune populations contribute to effective immune responses against B lymphoblastic leukemia cells
J Immunol (2020) 204 (1_Supplement): 163.18.
B cell transcription factors define a novel tumor suppressor gene network In ALL
Lynn M Heltemes Harris; Gregory Hubbard; Rebecca LaRue; Sarah A. Munro; Rendong Yang; Christine Henzler; Aaron Sarver; Michael A Farrar
J Immunol (2020) 204 (1_Supplement): 163.19.
Multivariate Gene Expression Analysis Identifies Novel Signatures and Therapeutic Targets for CLL Relapse
Tiara L Griffen; Eric D Dammer; Courtney D Dill; Kaylin M Carey; Corey D Young; Sha’Kayla K Nunez; James W Lillard
J Immunol (2020) 204 (1_Supplement): 163.2.
Overexpression of LLT1 (CLEC2D) in childhood Acute Lymphoblastic Leukemia (ALL)
Stephen O Mathew; Sheila Powers; Steffi Daniel; Roslin Jose; Subhash Aryal; W. Paul Bowman; Porunelloor Mathew
J Immunol (2020) 204 (1_Supplement): 163.20.
Tumor-associated myeloid cells provide critical support for T-ALL in vivo
Aram Lyu; Todd A. Triplett; Wesley H. Godfrey; Seo Hee Nam; Rachel Y. Ames; Zicheng Hu; Adviti Sarang; Hilary J. Selden; Chang-Han Lee; George Georgiou; Terzah M. Horton; Lauren I. R. Ehrlich
J Immunol (2020) 204 (1_Supplement): 163.5.
The role of the splenic microenvironment in Chronic Lymphocytic Leukemia
Subbarao Bondada; James P. Collard; Mary Kathryn McKenna; Sunil K. Noothi; Sara S. Alhakeem; Jacqueline R. Rivas; Shelbi Broeking
J Immunol (2020) 204 (1_Supplement): 163.6.
A novel Cullin 4A/BCereblon E3 Ligase Modulator, FPFT-2216, offers protective effect against Myelodysplastic syndrome
J Immunol (2020) 204 (1_Supplement): 163.7.
Insights into Myeloid cell, Macrophage and Dendritic Cell-mediated Immune Dysfunction within the Tumor Microenvironment
Modified culture protocol for differentiation of human promyelocytic leukaemia PLB-985 cell-line into mature neutrophil-like granulocytes
J Immunol (2020) 204 (1_Supplement): 164.1.
Autocrine IL6 activates the STAT3-DNMT axis to silence the TNFa-RIP1 necroptosis pathway to sustain myeloid-derived suppressor cell survival and accumulation
Alyssa D. Smith; Chunwan Lu; Daniela Payne; Amy V Paschall; John David Klement; Priscilla S Redd; Mohammed Ibrahim; Dafeng Yang; Qimei Han; Zhuoqi Liu; Huidong Shi; Thomas Hartney; Asha Nayak-Kapoor; Kebin Liu
J Immunol (2020) 204 (1_Supplement): 164.10.
Circulating Low Density Neutrophils In Advanced Lung Cancer Patients Exhibit Unique Immune Signatures and affect prognosis
J Immunol (2020) 204 (1_Supplement): 164.11.
Neutral ceramidase regulates ferroptosis in myeloid-derived suppressor cells
huabin zhu; Chunwan Lu; Dafeng Yang; Priscilla S Redd; Mohammed L. Ibrahim; John D. Klement; Alyssa D. Smith; Thomas Albers; Iryna Lebedyeva; Nicolas Coant; Yusuf Hannun; Kebin Liu
J Immunol (2020) 204 (1_Supplement): 164.12.
Myeloid-derived suppressor cell subset heterogeneity drives glioblastoma progression in a sex-dependent manner
Defne Bayik; Yadi Zhou; Chihyun Park; Changjin Hong; Daniel Vail; Daniel J Silver; Adam J Lauko; Gustavo A Roversi; Dionysios C Watson; Alice Lo; Tyler J Alban; Mary McGraw; Mia D Sorensen; Matthew M Grabowski; Balint Otvos; Michael A Vogelbaum; Craig M Horbinski; Ahmad M Khalil; Tae Hyun Hwang; Manmeet S Ahluwalia; Feixiong Cheng; Justin D Lathia
J Immunol (2020) 204 (1_Supplement): 164.14.
Hedgehog signaling induced metabolic reprogramming is essential for M2 polarization of macrophages in breast cancer
J Immunol (2020) 204 (1_Supplement): 164.16.
Dynamic regulation of TRIM37 expression in macrophages facilitates pancreatic cancer development
J Immunol (2020) 204 (1_Supplement): 164.17.
Regulation of macrophages in tumor microenvironment by microRNA in T cell lymphoma-bearing mice
J Immunol (2020) 204 (1_Supplement): 164.18.
Metabolic barriers imposed on tumor associated macrophages
J Immunol (2020) 204 (1_Supplement): 164.19.
Arginase-1 production by myeloid cells in tumor microenvironment induce inflammasome activation and activate PI3K pathway in tumor-associated macrophages in head and neck cancer
J Immunol (2020) 204 (1_Supplement): 164.20.
cDC1 prime and receive help from CD4 T cells to promote anti-tumor responses
J Immunol (2020) 204 (1_Supplement): 164.21.
Altering the dendritic cell signature in the lung: a new adjuvant to immune checkpoint inhibitor therapies?
Julyanne Brassard; Emilie Bernatchez; Meredith Elizabeth Gill; Philippe Joubert; Marie-Renée Blanchet
J Immunol (2020) 204 (1_Supplement): 164.22.
Circular RNA AEBP2 modulates dendritic cells by the hnRNP/pP65 signaling pathway
Qinfeng Zhou; Bowen Wang; James Koropatnick; Weiping Min; Vivian McAlister; Adam Greasley; Xiufen Zheng
J Immunol (2020) 204 (1_Supplement): 164.24.
Depletion of tumor-associated macrophages by melittin-dKLA enhances anti PD-L1 mediated anti-tumor effects in breast cancer models
J Immunol (2020) 204 (1_Supplement): 164.27.
CARD9 Induces Metabolic Reprogramming and Mediates the Immune Cascades in Dendritic Cell Against Pancreatic Cancer Progression
J Immunol (2020) 204 (1_Supplement): 164.29.
Targeting AXL-JAK1 in tumor and immune ecosystem of lung cancer
Josephine Amalia Taverna; Chia-Nung Hung; Daniel Dearmond; Meizhen Chen; Chun-Lin Lin; Pawel Osmulski; Maria Gaczynska; Chiou-Miin Wang; Nicholas Daniel Lucio; Chih-Wei Chou; Chun-Liang Chen; David Bearss; Steve Warner; Clifford Whatcott; Lars Mouritsen; Mark Wade; Steven Weitman; Ruben Mesa; Nameer Kirma; Tim Huang
J Immunol (2020) 204 (1_Supplement): 164.4.
Immune landscape of genetically-engineered murine models of glioma relative to human glioma by single-cell sequencing
J Immunol (2020) 204 (1_Supplement): 164.5.
PD-L1+PD-L2+ monocytes from patients with hepatocellular carcinoma may be associated with a poor prognosis
Hidetaka Yasuoka; Akira Asai; Masahiro Matsui; Norio Okamoto; Tomohiro Nishikawa; Hideko Ohama; Yusuke Tsuchimoto; Shinya Fukunishi; Kazuhide Higuchi
J Immunol (2020) 204 (1_Supplement): 164.6.
LncRNA AK036396/FcnB regulating polymorphonuclear myeloid-derived suppressor cells in tumor bearing mice
J Immunol (2020) 204 (1_Supplement): 164.7.
STAT3 induces the expression of fatty acid transport proteins (FATP2 and FATP4) to promote myeloid-derived suppressor cells function in tumor
Adeleye Oluwatosin Adeshakin; Dehong Yan; Mengqi Zhang; Lukman Olalekan Afolabi; Funmilayo Oladunni Adeshakin; Xiaochun Wan
J Immunol (2020) 204 (1_Supplement): 164.9.
Molecular and Cellular Mediators of T Cell Dysfunction within the Tumor Microenvironment
CD4 T cell phenotypes differentially modulate the CD8 T cell response in kidney cancer
J Immunol (2020) 204 (1_Supplement): 165.1.
Antibody targeting tumor-derived soluble NKG2D ligand sMIC provides dual co-stimulation of CD8 T cells and enables sMIC tumors respond to PD1/PD-L1 blockade therapy
J Immunol (2020) 204 (1_Supplement): 165.12.
Unsuccessful checkpoint blockade and vaccination therapy despite expansion of tumor neoantigen-specific CD8 T cells in the Lewis Lung Carcinoma (LLC) model
Shamin Li; Yannick Simoni; Summer Zhuang; Shaokang Ma; Jonathan Chee; Alec Redwood; Bruce Robinson; Evan Newell
J Immunol (2020) 204 (1_Supplement): 165.13.
Distributions of non-expressed MHC class I chain related A (MICA) and NKG2D receptor polymorphism in cholangiocarcinoma
J Immunol (2020) 204 (1_Supplement): 165.14.
IRF4 overexpression in therapeutic anti-tumor CD8 T cells inhibits tumor growth by driving functional state transition of therapeutic and endogenous CD8 T cells in tumors
hui yan; Hedong Zhang; Dawei Zou; Jinfei Fu; Xiaolong Zhang; Xiang Xiao; Yang Guo; Guohua Wang; Anze Yu; Xian C. Li; Wenhao Chen
J Immunol (2020) 204 (1_Supplement): 165.15.
Identification of novel ligands that alter the function of type II NKT cells
Kumiko Nishio; Kaddy Camara; Lise Pasquet; Anja C Bloom; Stewart K Richardson; Susanna L Cardell; Amy R Howell; Masaki Terabe; Purevdorj Olkhanud; Jay A Berzofsky
J Immunol (2020) 204 (1_Supplement): 165.16.
Distinct responses to αPD-1, αPD-L1 and αPD-L2 immunotherapy in aged versus young hosts includes T-cell stem cell effects and PD-L2 expression differences
Myrna G Garcia; Alvaro S Padron; Yilun Deng; Aravind Kancharla; Ryan M Reyes; Harshita B Gupta; Tyler J Curiel
J Immunol (2020) 204 (1_Supplement): 165.17.
Antigen-presenting cells lead to severe T cell exhaustion in glioblastoma
J Immunol (2020) 204 (1_Supplement): 165.18.
Lymphoma mutations in HVEM (TNFRSF14) disrupt bi-directional activation of BTLA and CD160 singaling within the tumor microenvironment
J Immunol (2020) 204 (1_Supplement): 165.19.
Antigen-cross presentation promotes development of terminally differentiated CD8 T cells in young individuals
Ardiana Moustaki; Jeremy Chase Crawford; Shanta Alli; Anthony E Zamora; Yiping Fan; Shannon Boi; Natalie MN McDonald; Paul Glyndwr Thomas; Alberto Pappo; Michael Dyer; Elizabeth Stewart; Sara Federico; Benjamin A Youngblood
J Immunol (2020) 204 (1_Supplement): 165.2.
Blockade of CD80 interaction with PD-L1 between T and tumor cells augments effector T expansion and tumor immunity in a PD-1-dependent manner
J Immunol (2020) 204 (1_Supplement): 165.20.
DNA Hypomethylation of PDCD1 Gene in Korean Colorectal Cancer Patients
J Immunol (2020) 204 (1_Supplement): 165.22.
Elucidating the Role of HDACs in T Cell Biology and Comparing Distinct HDAC Inhibitors in Augmenting Responses to Cancer Immunotherapy
J Immunol (2020) 204 (1_Supplement): 165.23.
Adipocyte PD-L1 suppresses anti-tumor immune response and promotes breast cancer progression
Bogang Wu; Xiujie Sun; Harshita B. Gupta; Bin Yuan; Huai-Chin Chiang; Yanfen Hu; Tyler J Curiel; Rong Li
J Immunol (2020) 204 (1_Supplement): 165.24.
Intracranial tumors lead to sequestration of T cells in the bone marrow
J Immunol (2020) 204 (1_Supplement): 165.26.
Upregulated 4-1BB (CD137) expression on skin T cells from a mouse model of precancerous skin
J Immunol (2020) 204 (1_Supplement): 165.27.
Granuloma in tumor-draining lymph nodes impairs tumor-reactive CD8+ T cell trafficking in immune-checkpoint therapy
J Immunol (2020) 204 (1_Supplement): 165.3.
Inhibition of PI3Kδ improves tumor specific T cell immunity and metabolic fitness
Guillermo O Rangel Rivera; Connor Dwyer; Dimitrios Arthontoulis; Hannah Knochelmann; Aubrey S Smith; Amalia Rivera Reyes; Megan Wyatt; Chrystal M Paulos
J Immunol (2020) 204 (1_Supplement): 165.30.
A phosphotyrosine switch controls antitumor activity of estrogen receptor b
J Immunol (2020) 204 (1_Supplement): 165.31.
NF-kB1 induces T cell dysfunction to promote colon tumorigenesis
Chunwan Lu; John D. Klement; Wei Xiao; Mohammed L. Ibrahim; Alyssa D. Smith; Dafeng Yang; Daren Browning; David H. Munn; Kebin Liu
J Immunol (2020) 204 (1_Supplement): 165.32.
Glial TIM-3 shows distinct expression patterns and functions in brain tumor microenvironment
J Immunol (2020) 204 (1_Supplement): 165.33.
PD1 and LAG3 converge to limit polyfunctionality and systemic immunity
J Immunol (2020) 204 (1_Supplement): 165.34.
CD28 and glycogen synthase kinase-3 (GSK-3) inhibitor combination therapy generates tumor infiltrating T-cells (TILs) with a reversal of markers for T-cell exhaustion
J Immunol (2020) 204 (1_Supplement): 165.35.
Adrenergic stress regulates the exhausted phenotype of T cells in the tumor microenvironment
Guanxi Qiao; Minhui Chen; Hemn Mohammadpour; Mark Bucsek; Cameron MacDonald; Bonnie Hylander; Elizabeth Repasky
J Immunol (2020) 204 (1_Supplement): 165.36.
Illuminating the onco-GPCRome: targeting the prostaglandin receptor-Gαs signaling axis as a novel immune checkpoint in cancer
J Immunol (2020) 204 (1_Supplement): 165.37.
Detailing the mechanism of CDK5-mediated PD-L1 regulation in Medulloblastoma
J Immunol (2020) 204 (1_Supplement): 165.38.
Evaluation of immune checkpoints in small cell lung cancer: implications for immunotherapy
J Immunol (2020) 204 (1_Supplement): 165.39.
Pembrolizumab treatment increases K+ channel function and calcium fluxes in cytotoxic T cells of head and neck cancer patients
Hannah Newton; Vaibhavkumar S Gawali; Ameet A Chimote; Maria Lehn; Sarah Palackdharry; David Hildeman; Edith Janssen; Trisha Wise-Draper; Laura Conforti
J Immunol (2020) 204 (1_Supplement): 165.41.
Targeting TNFR2 to overcome acquired adaptive resistance to immune checkpoint blockade
Lena Sophie Mayer; Robert J. Orlowski; Josephine Giles; Joseph L. Benci; Gavin Ellis; Guoping Deng; John Attanasio; Zeyu Chen; Bertram Bengsch; Omar Kahn; Sasikanth Manne; Ramin S. Herati; Shin Ngiow; Sangeeth M. George; Denise L. Faustman; Gary Gilliland; Rosemarie Mick; Wei Xu; Suzanne McGettigan; Xiaowei Xu; Ravi K. Amaravadi; Giorgos C. Karakousis; Lynn M. Schuchter; Tara C. Mitchell; James L. Riley; Alexander C. Huang; Andy Minn; Vesselin Tomov; E. John Wherry
J Immunol (2020) 204 (1_Supplement): 165.42.
A peptide presentation by an MHC tetramer reduces the expansion of the peptide-specific T cells and the reduced expansion is reversible by PD-1 blockades
J Immunol (2020) 204 (1_Supplement): 165.44.
Effects of aging on immunosenescence and checkpoint inhibitor efficacy in a C57BL/6J syngeneic model
J Immunol (2020) 204 (1_Supplement): 165.46.
T cell intrinsic DNA damage and repair response as a novel marker associated with clinical response to PD-1 blockade
Yuki Muroyama; Alexander C. Huang; Sasikanth Manne; Ramin S. Herati; Divij Mathew; Caiyue Xu; Lakshmi Chilukuri; Dmitriy Zamarin; Claire F Friedman; E John Wherry
J Immunol (2020) 204 (1_Supplement): 165.47.
Tumor-specific CD8 T cell activation in draining lymph nodes supports the anti-tumor CD8 T cell response
Nataliya Prokhnevska; Maria Cardenas; Caroline Jansen; Rajesh Valanparambil; Viraj Master; Martin Sanda; Haydn Kissick
J Immunol (2020) 204 (1_Supplement): 165.5.
Protein Phosphatase 2A (PP2A) is essential for CD8+ T cell mediated anti-tumor immunity
J Immunol (2020) 204 (1_Supplement): 165.6.
ANT2 (SLC25A5) balances the pro-apoptotic vs. effector signals of Bim in CD8 T cells
Joanina K Gicobi; Xiatong Yu; Roxana S. Dronca; Xin Liu; Whitney Barham; Ti Wen; Henan Zhang; Mojun Zhu; Susan M. Harrington; Vianca Vianzon; Jacob Hirdler; Haidong Dong
J Immunol (2020) 204 (1_Supplement): 165.7.
Identification of a core miRNA signature unique to exhausted cytotoxic CD8+ T cells
Caoimhe H. Kiernan; Jennifer L Hope; Leticia G. Leon; Manzhi Zhao; Marjan van Meurs; Inge Brouwers-Haspels; Paulette van Strien; Erik Bindels; Remco M. Hoogenboezem; Yunlei Li; Andrew P. Stubbs; Dietmar Zehn; Yvonne M Mueller; Stefan J. Erkeland; Peter D Katsikis
J Immunol (2020) 204 (1_Supplement): 165.9.
Novel Nano/Microparticles, Delivery systems, and Adjuvants
Oral administration of a self-assembling nanofiber-based vaccine generates neutralizing antibodies against HIV and expands CD8+ memory T cell populations
J Immunol (2020) 204 (1_Supplement): 166.1.
Novel non-segmented negative-sense RNA virus-based vaccine platforms for Zika virus
Anzhong Li; Mijia Lu; Jingyou Yu; Olivia Harder; Zayed Attia; Chao Shan; Xueya Liang; Miaoge Xue; Pei-Yong Shi; Mark E. Peeples; Shan-Lu Liu; Prosper N Boyaka; Stefan Niewiesk; Jianrong Li
J Immunol (2020) 204 (1_Supplement): 166.10.
Bacteria-like particle bead complexes as an immunostimulatory platform for high-throughput vaccine antigen capture and delivery
Sharon Jan; Jiin Felgner; Rafael Assis; Jenny Davies; Tyler Albin; Rie Nakajima; Algis Jasinskas; David Huw Davies; Philip Felgner
J Immunol (2020) 204 (1_Supplement): 166.11.
Mucosal Vaccination with a Novel Live Attenuated Brucella melitensis Mutant Protects via IFN-γ-producing Memory CD8+ T Cells in Concert with B Cells
J Immunol (2020) 204 (1_Supplement): 166.13.
Novel lipid A mimetics, BECC438 and BECC470, act as potent adjuvants in bacterial and viral subunit vaccines
J Immunol (2020) 204 (1_Supplement): 166.14.
Adjuvant combinations activate dendritic cells and contribute to antigen-specific CD4 T cell expansion
J Immunol (2020) 204 (1_Supplement): 166.15.
Vaccine adjuvant choice regulates antigen-specific B cell activation and phenotype
J Immunol (2020) 204 (1_Supplement): 166.16.
Vaccine-elicited T cells rely on a distinct transcriptional program from infection-elicited T cells
J Immunol (2020) 204 (1_Supplement): 166.18.
Precision immunology for discovery and development of the Precision Vaccines Program (PVP)-037 small molecule series: imidazopyrimidine adjuvants identified via age-specific human in vitro modeling
Dheeraj Soni; Francesco Borriello; David A Scott; Al Ozonoff; Spencer Brightman; Jennifer Smith; Caroline Shamu; Juan C Ramirez; Lindsey Robert Baden; Wing Ki Cheng; Simon Daniel van Haren; Matthew Pettengill; David J Dowling; Ofer Levy
J Immunol (2020) 204 (1_Supplement): 166.19.
Endogenous dendritic cell subset cDC1 mediates DC vaccine immunity against gamma herpesvirus in syngeneic BMT recipients
Xiaofeng Zhou; Matthew M. Chadwick; Paul R. Chan; James J. Buonavolonta; Carol A. Wilke; Bethany B. Moore
J Immunol (2020) 204 (1_Supplement): 166.20.
The quality of heat shock protein-mediated responses is determined by the antigen presenting cell
J Immunol (2020) 204 (1_Supplement): 166.21.
Effect of ontogeny and vaccination on plasma adenosine deaminase (ADA)-1 and -2 levels across the first week of human life
Kinga Smolen; Alec Plotkin; Jensen Pak; Oludare Odumade; Olubukola Idoko; Matthew Pettengill; Al Ozonoff; Tobias Kollmann; Beate Kampmann; Ofer Levy
J Immunol (2020) 204 (1_Supplement): 166.22.
Differential recruitment and activation of mucosal and systemic ILC for improved vaccine design
J Immunol (2020) 204 (1_Supplement): 166.24.
Development of a reverse genetics system to generate vaccine strain of Hepatitis A virus
J Immunol (2020) 204 (1_Supplement): 166.25.
Vaccine and abscopal effects result from in situ vaccination with nanosecond electric pulse treatment for breast cancer in mice
J Immunol (2020) 204 (1_Supplement): 166.27.
Aluminum hydroxide and calcium phosphate adjuvants in adsorbed tetanus and diphtheria vaccines: Immunologic vs histopathologic effects
J Immunol (2020) 204 (1_Supplement): 166.28.
Programming effective respiratory immunity to influenza with combination microparticle adjuvants
Brock Bakke; Chandranaik Marinaik; Randall Toy; Autumn Larsen; Woojong Lee; Yoshihiro Kawaoka; Krishnendu Roy; Marulasiddappa Suresh
J Immunol (2020) 204 (1_Supplement): 166.29.
Polyanhydride-based RSV prefusion F nanoparticle vaccine establishes lasting protection mediated by humoral and cellular immune responses
Laura Stephens; Kathleen A. Ross; Stacey M. Hartwig; Jason S. McLellan; Balaji Narasimhan; Kevin L. Legge; Steven M. Varga
J Immunol (2020) 204 (1_Supplement): 166.3.
Single-Cycle Adenoviruses (SC-Ads) as Platforms for Immunostimulation
J Immunol (2020) 204 (1_Supplement): 166.30.
A microneedle vaccination with glycoprotein E of Varicella Zoster Virus elicits antibody production and polyfuctional T cells in mice
J Immunol (2020) 204 (1_Supplement): 166.31.
Corn based nanoparticle delivered inactivated influenza virus vaccine intranasally augments mucosal immune response in pigs
Renukaradhya J Gourapura; Ninoshkaly Feliciano-Ruiza; Sankar Renu; Fangjia Lu; Yi Han; Jennifer Schrock; Santosh Dhakal; Veerupaxagouda Patil; Harm HogenEsch
J Immunol (2020) 204 (1_Supplement): 166.4.
IRF5 Drives Potentiated IFN-beta and IL-12 production by dendritic cells in response to combinatorial CpG- and MPLA- delivery on microparticles
Navdeep Jhita; Randall Toy; Pallab Pradhan; Emmeline Blanchard; Neha Narang; Gabriela Cortes; Mark Cole Keenum; Philip J Santangelo; Dmitry M Shayakhmetov; Krishnendu Roy
J Immunol (2020) 204 (1_Supplement): 166.6.
Utilising nanoparticles to enhance the vaccine induced T cell immune response
Kirsty L Wilson; Liam Powles; Peter Tsirikis; Sue D Xiang; Cordelia Selomulya; Edward Henderson; Simon Corrie; Magdalena Plebanski
J Immunol (2020) 204 (1_Supplement): 166.8.
Vaccines and Immunotherapies for HIV, Ebola, and Other Viral Infections
The potential role of HLA-I associated adaptation in elevated risk of infection among HIV-1 STEP study vaccine recipients
J Immunol (2020) 204 (1_Supplement): 167.1.
Neonatal vaccination primes persistent HIV Env-specific antibodies that are augmented by a single booster immunization in late infancy
Alan Dale Curtis; Maria Dennis; Joshua Eudailey; Kenneth Cronin; Justin Pollara; Guido Ferrari; Michael Hudgens; Koen Van Rompay; Sallie Permar; Kristina De Paris
J Immunol (2020) 204 (1_Supplement): 167.10.
DNA priming vaccination to induce T cell responses to subdominant conserved HIV epitopes
Barbara K. Felber; Zhongyan Lu; Xintao Hu; Antonio Valentin; Margherita Rosati; James I. Mullins; George N Pavlakis
J Immunol (2020) 204 (1_Supplement): 167.11.
Vaccine-induced protection against intrarectal AIDS virus transmission in the absence of anti-Env antibodies mediated by trained innate immunity
J Immunol (2020) 204 (1_Supplement): 167.12.
Development of alternative vaccination strategies to overcome Tc1 vaccine failure caused by chronic schistosomiasis
J Immunol (2020) 204 (1_Supplement): 167.13.
Understanding the early steps of the adaptive immune response to differentially-effective vaccines during chronic schistosomiasis
J Immunol (2020) 204 (1_Supplement): 167.14.
Generation of clinically-relevant vaccine vectors for use in schistosome-endemic areas
J Immunol (2020) 204 (1_Supplement): 167.15.
An Ebola virus vaccine that leverages helper T cells induced by prior BCG immunization
Tony W Ng; Ariel A Wirchnianski; John Chan; William R Jacobs, Jr.; Kartik Chandran; Andrea Marzi; Steven A Porcelli
J Immunol (2020) 204 (1_Supplement): 167.16.
Utilizing defined structural subunits to elucidate antibody populations elicited by a recombinant subunit Ebola virus vaccine
J Immunol (2020) 204 (1_Supplement): 167.18.
Structural and functional analysis of cooperativity in a potent human antibody cocktail against Ebola virus
Pavlo Gilchuk; Charles D Murin; Jacob C Milligan; Robert W Cross; Chad E Mire; Philipp A Ilinykh; Kai Huang; Natalia Kuzmina; Pilar X Altman; Sean Hui; Bronwyn M Gunn; Aubrey L Bryan; Edgar Davidson; Benjamin J Doranz; Hannah L Turner; Tanwee Alkutkar; Robin Flinko; Chiara Orlandi; Robert Carnahan; Rachel Nargi; Robin G Bombardi; Megan E Vodzak; Sheng Li; Adaora Okoli; Morris Ibeawuchi; Benjamin Ohiaeri; George K Lewis; Galit Alter; Alexander Bukreyev; Erica Ollmann Saphire; Thomas W Geisbert; Andrew B Ward; James E Crowe
J Immunol (2020) 204 (1_Supplement): 167.19.
Dendritic cell targeting anti-CD40 antibody-CD40L-HIV-1 vaccines are adjuvant intrinsic
Valentina Ceglia; Sandy Zurawski; Monica Montes; Aurelie Bouteau; Zhiqing Wang; Jerome Ellis; Mitchell Kroll; Botond Z Igyarto; Yves Levy; Gerard Zurawski
J Immunol (2020) 204 (1_Supplement): 167.2.
Antibody therapeutics for emerging infectious diseases: Ebola virus and others
John M Dye; Kartik Chandran; Anna Wec; Laura Walker; Larry Zeitlin; Zachary Bornholdt; Andrew Herbert
J Immunol (2020) 204 (1_Supplement): 167.21.
Comparison of antibody responses in mice generated by different multivalent Filovirus vaccines based on recombinant glycoprotein subunits
J Immunol (2020) 204 (1_Supplement): 167.22.
Characterization of a protective antibody against dengue virus non-structural protein 1 (NS1) reveals critical domains required for NS1-triggered pathogenesis
Marcus P Wong; Scott B Biering; David L Akey; Nicholas TN Lo; W. Clay Brown; Francielle Tramontini Gomes de Sousa; Henry Puerta-Guardo; Chunling Wang; Jamie Konwerski; Diego Espinosa; Jeffery Li; Sophie Blanc; P. Robert Beatty; Janet L Smith; Eva Harris
J Immunol (2020) 204 (1_Supplement): 167.23.
The prevention and augmentation of tetravalent recombinant measles-vectored dengue vaccine in dengue-2 infected AG129 mice
J Immunol (2020) 204 (1_Supplement): 167.24.
Neutralizing monoclonal antibodies against Venezuelan equine encephalitis virus envelope glycoprotein E2 protect from lethal encephalitis
J Immunol (2020) 204 (1_Supplement): 167.26.
Characterization of immune response in mice vaccinated with highly efficacious vaccine 0ΔNLS against HSV-1
J Immunol (2020) 204 (1_Supplement): 167.28.
Differential protection of Mayaro virus antigen-antibody binding by various inactivation approaches: Implication in vaccine development
J Immunol (2020) 204 (1_Supplement): 167.29.
Cervicovaginal and Alveolar Macrophage responses of Rhesus Macaques following Mucosal Adenovirus-SIV recombinant priming and systemic SIV envelope boosting
Ruth Hunegnaw; Sabrina Helmold Hait; Mohammad Arif Rahman; Gospel M Enyindah-Asonye; Tanya Hoang; Marjorie Robert-Guroff
J Immunol (2020) 204 (1_Supplement): 167.3.
A recombinant subunit Lassa virus vaccine elicits strong antibody responses
J Immunol (2020) 204 (1_Supplement): 167.30.
The effective immunization of plasmid DNA vaccine targeted for smallpox virus
Wonrak Son; Nayoung Kim; Minhoon Lee; Euni Sim; Donghyun Song; Chiho Yu; YoungJo Song; GyeungHaeng Hur; SeongTae Jeong; Sungyoul Hong; YoungKee Shin; Sungho Shin; JunYoung Choi
J Immunol (2020) 204 (1_Supplement): 167.32.
Development of a DNA vaccine for SFTSV that confers complete protection against lethal infection in ferrets
Jeong-Eun Kwak; Young-Il Kim; Su-Jin Park; Moonsup Jeong; Joel N. Maslow; Min-Suk Song; Jae U. Jung; Eui-Cheol Shin; Young Ki Choi; Su-Hyung Park
J Immunol (2020) 204 (1_Supplement): 167.33.
Suppression of HBV replication in mice using stem cell-derived viral antigen-specific T lymphocytes
J Immunol (2020) 204 (1_Supplement): 167.34.
Immunogenicity of a Purified Inactivated Zika Virus Vaccine Candidate in Humans is Diminished by Priming with a Yellow Fever or Japanese Encephalitis Virus Vaccine: Elucidating Immunologic Interference between Flavivirus Vaccines
Kayvon Modjarrad; Michael Koren; Leyi Lin; Erica Sondergaard; Rafael De La Barrera; Kenneth Eckels; Shelly Krebs; Michael Eller; Margaret Costanzo; Gordon Joyce; Vincent Dussupt; Gregory D Gromowski; Casey Storme; Mihret Amare; Richard G Jarman; Stephen Thomas; Nelson Michael
J Immunol (2020) 204 (1_Supplement): 167.35.
Chimeric VP1-PCV2bCap protein as antigen for construction of recombinant vaccine against porcine circovirus type 2
Alena Vrablikova; Renata Hezova; Jan Kotoucek; Pavel Kulich; Pavlina Turanek-Knotigova; Jan Gebauer; Martina Fojtikova; Ivan Psikal; Jaroslav Turanek
J Immunol (2020) 204 (1_Supplement): 167.36.
Lymph node and circulating TFH cells support SIV-specific antibody responses in peripheral blood and genital tract of vaccinated female rhesus macaques
J Immunol (2020) 204 (1_Supplement): 167.4.
Exploration of roles of CD4 T cell help in recruitment of rare B cells to germinal centers
J Immunol (2020) 204 (1_Supplement): 167.5.
Trispecific antibody against HIV-1 demonstrate anti-viral activity in vivo and have potent Fc-dependent effector functions
Cassandra Almasri; Ling Xu; Joana Dias; Wanwisa Promsote; Ronnie Wei; Dana M Lord; Ercole Rao; Jochen Beninga; Zhi-yong Yang; Amarendra Pegu; John R. Mascola; Gary J. Nabel
J Immunol (2020) 204 (1_Supplement): 167.6.
Therapeutic vaccination with Ad48/MVA and TLR7 stimulation in SIV-infected, ART-treated infant rhesus macaques
Katherine M Bricker; Veroncia Obregon-Perko; Ferzan Uddin; Brianna Williams; Joseph Hesselgesser; Merlin Robb; Nelson Michael; Dan H Barouch; Ann Chahroudi
J Immunol (2020) 204 (1_Supplement): 167.9.
Vaccines against Bacteria and Parasites
Glycolipid-peptide vaccination induces liver-resident memory CD8+ T cells that protect against malaria
Lauren Holz; Yu Cheng Chua; Regan Anderson; Sarah Draper; Benjamin Compton; Susanna Chan; Juby Mathew; Maria de Menezes; Anton Cozijnsen; Vanessa Mollard; Geoffrey McFadden; Gavin Painter; William R Heath
J Immunol (2020) 204 (1_Supplement): 168.1.
Adjuvanted bacteriophage vaccine targeting Pseudomonas aeruginosa
Valery Cristina Román-Cruz; Shannon Miller; Cassandra Buhl; Roman Schooner; Lois Walsh; Patrick Secor; David J Burkhart; Jay T Evans
J Immunol (2020) 204 (1_Supplement): 168.10.
Isotype-specific outcomes in Fc gamma receptor targeting of PspA using fusion proteins as a vaccination strategy against Streptococcus pneumoniae infection
J Immunol (2020) 204 (1_Supplement): 168.11.
Role of antibody in vaccine-mediated protection against pneumonic tularemia in the rabbit model
J Immunol (2020) 204 (1_Supplement): 168.12.
Human B cell responses to a live attenuated cholera vaccine
J Immunol (2020) 204 (1_Supplement): 168.13.
Increased immune cell infiltration contribute to enhanced protective immunity following co-delivery of VCG Chlamydia vaccine with Flt3L
J Immunol (2020) 204 (1_Supplement): 168.15.
gdT cells stimulated by a novel vaccine confer protection to the naïve mice against S. aureus challenge
J Immunol (2020) 204 (1_Supplement): 168.16.
Identification of toxicity and efficacy against new staphylococcal enterotoxin B subunit vaccine
J Immunol (2020) 204 (1_Supplement): 168.17.
An outer membrane vesicle-adjuvanted oral vaccine protects against lethal, oral Salmonella infection
J Immunol (2020) 204 (1_Supplement): 168.19.
Secreted heat shock protein gp96-Ig vaccine induces malaria specific intrahepatic CD8 T cell responses
Natasa Strbo; Laura Padula; Eva Fisher; Wathsala Wijayalath; Noelle B. Patterson; Jun Huang; Harini Ganeshan; Katelyn O’Neill; Denisse Garcia; Irina V. Etobayeva; Kimberly A. Edgel; Eckhard R Podack; Martha Sedegah; Eileen F. Villasante
J Immunol (2020) 204 (1_Supplement): 168.2.
Application of a Campylobacter jejuni mouse infection model to test efficacy of a C. jejuni capsule conjugate vaccine delivered with a potent liposome adjuvant containing monophosphoryl lipid A and QS-21
Renee M Laird; Christina L Gariepy; Heather Eggleston; Nina M Shoemaker; Mario A Monteiro; Patricia Guerry; Zoltan Beck; Gary R Matyas; Frédéric Poly
J Immunol (2020) 204 (1_Supplement): 168.20.
Vaccination with a Live Attenuated Brucella abortus Mutant Stimulates Cytotoxic CD8+ T Cell Responses
J Immunol (2020) 204 (1_Supplement): 168.23.
A small molecule based immunotherapy targeting IL-10/STAT3 praxis to augment the potential of rBCG30 vaccine against experimental tuberculosis
J Immunol (2020) 204 (1_Supplement): 168.24.
Immunization with a subunit of housekeeping proteins provide partial protection against experimental necrotic enteritis in broiler chickens
J Immunol (2020) 204 (1_Supplement): 168.25.
Intranasal vaccination induces complete protection against multidrug resistant A. baumannii pneumonia and sepsis
J Immunol (2020) 204 (1_Supplement): 168.26.
Bacillus Calmette-Guérin (BCG) vaccine reprograms human neonatal metabolism in vivo and in vitro
Joann Diray Arce; Kristoffer Jarlov Jensen; Asimenia Angelidou; Maria Giulia Conti; Rachel S. Kelly; Matthew Pettengill; Mark Liu; Simon D. van Haren; Christine Stabell Benn; Al Ozonoff; Hanno Steen; Jessica Lasky-Su; Ofer Levy
J Immunol (2020) 204 (1_Supplement): 168.3.
Vaccine-Elicited T cells are Important for Intravenous BCG Mediated Protection in a Rhesus macaque Model of Tuberculosis
Joseph John Zeppa; Patricia A Darrah; Matthew Sutton; Supriya Pokkali; Chuck A Scanga; Pauline Maiello; Philana L Lin; Mario Roederer; Robert A Seder; JoAnne L Flynn
J Immunol (2020) 204 (1_Supplement): 168.4.
Identifying mediators of STING-dependent TB vaccine immunity
Robyn MY Jong; Erik Van Dis; Alexander Baltodano; Xammy Nguyenla; Bianca Blackshire; Kiran Magee; Sarah Stanley
J Immunol (2020) 204 (1_Supplement): 168.5.
Systemic BCG Vaccination in “Dirty Mice” induces Protective Trained Immunity against TB
J Immunol (2020) 204 (1_Supplement): 168.6.
Two for one: Identification of P. aeruginosa and B. pertussis Cross-species Antigens
Catherine B Blackwood; Emel Sen Kilic; Kelly Weaver; Dylan T Boehm; Jesse Hall; Ting Wong; Aaron Malkowski; William T Witt; F. Heath Damron; Mariette Barbier
J Immunol (2020) 204 (1_Supplement): 168.7.
Identifying mechanistic correlates of protection against Pseudomonas aeruginosa in an acute lung pneumonia model
Emel Sen Kilic; Catherine B Blackwood; Alexander M Horspool; Annalisa B Huckaby; Kelly Weaver; Aaron Malkowski; William T Witt; Justin R Bevere; Michael T Winters; F. Heath Damron; Mariette Barbier
J Immunol (2020) 204 (1_Supplement): 168.8.
Th17 responses to Pseudomonas aeruginosa vaccines are defective in cystic fibrosis mice
J Immunol (2020) 204 (1_Supplement): 168.9.
Therapeutic Antibodies and Vaccines for Cancer Immunotherapy 1
Pairwise interactions govern the effects of complex immune adjuvant combinations
J Immunol (2020) 204 (1_Supplement): 169.1.
The regulation of transcription factor T cell factor 1 (TCF1) in vaccine-elicited CD8+ T cells
J Immunol (2020) 204 (1_Supplement): 169.12.
Arenavirus vectors for massive tumor self-antigen-specific CD8 T cell attack
Daniel D. Pinschewer; Weldy V. Bonilla; Sandra Kallert; Nicole Kirchhammer; Anna-Friederike Marx; Magdalena Krzyzaniak; Sarah Schmidt; Josipa Raguz; Ursula Berka; Stephan Günther; Carsten Magnus; Klaus Orlinger; Alfred Zippelius
J Immunol (2020) 204 (1_Supplement): 169.13.
The efficacy and mechanism of CD020 on the induction of specific immune responses against HPV-related cancer
J Immunol (2020) 204 (1_Supplement): 169.14.
Combination immunotherapy of αPD-1 and extended half-life IL-2 clears established GL261 gliomas in an MHC class I independent fashion
Zachariah Peter Tritz; Kathy Ayasoufi; Courtney Malo; Benjamin Himes; Roman Khadka; Lila Yokanovich; Emma Goddery; Cori Fain; Michael Hansen; Fang Jin; Chensu Wang; Darrell J Irvine; K. Dane Wittrup; Ian F Parney; Aaron J Johnson
J Immunol (2020) 204 (1_Supplement): 169.15.
CD103+ cDC1 vaccine efficacy in murine breast cancer is inhibited by STAT3
Taylor T Chrisikos; Yifan Zhou; Haiyan S Li; Rachel Lauren Babcock; Xianxiu Wan; Bhakti Patel; Kathryn Newton; James Mancuso; Stephanie S Watowich
J Immunol (2020) 204 (1_Supplement): 169.16.
Network-guided bioengineering of oncolytic immunovirotherapies for glioblastoma
J Immunol (2020) 204 (1_Supplement): 169.17.
In silico design of a universal carrier protein: A potential solution to the variable immunogenicity observed in past vaccines against drugs of abuse
J Immunol (2020) 204 (1_Supplement): 169.2.
Impact of viral sensitizer-enhanced oncolytic virus immunotherapy on the anti-tumor immune response
Nouf N. Alluqmani; Anabel Bergeron; Andrew Chen; Sarwat Khan; Nicole Forbes; Rozanne Arulanandam; Christiano Souza; Debbi C. Crans; Jean-Simon Diallo
J Immunol (2020) 204 (1_Supplement): 169.21.
Promoting anti-tumor immunity via bispecific T cell engaging cytokine (biteokine) therapy
J Immunol (2020) 204 (1_Supplement): 169.22.
Immunomodulatory effects of topotecan augment the effectiveness of chemotherapy-immunotherapy combination
Jeongmi Lee; Kwang-Soo Shin; Choong-Hyun Koh; Insu Jeon; Tae-Seung Kang; Boyeong Song; Chang-Yuil Kang
J Immunol (2020) 204 (1_Supplement): 169.23.
N2 / Ar plasma acts as a switch from apoptosis to necroptosis by degradation of MAVS aggregates
J Immunol (2020) 204 (1_Supplement): 169.26.
Immunogenicity comparison of neoantigen vaccines through different delivery platform
J Immunol (2020) 204 (1_Supplement): 169.27.
Characterization of T cell responses induced following checkpoint inhibition therapy across multiple malignancies with a high tumor mutational burden
J Immunol (2020) 204 (1_Supplement): 169.28.
Agonistic anti-ICOS antibodies promote unexpected elimination of tumor infiltrating effector T cells in a FcγR-independent manner
Dafne Sofia Franz Demane; Kroopa Joshi; Cristóbal Costoya; Dimitrios Zervas; Isabelle Solomon; Karl S. Peggs; Sergio A. Quezada
J Immunol (2020) 204 (1_Supplement): 169.29.
Cyclooxygenase-2 dependent prostaglandin E2 signaling through the EP3 receptor is required for cell-mediated immunity to Listeria monocytogenes
J Immunol (2020) 204 (1_Supplement): 169.3.
Modulation of interleukin 4 signaling increases the efficacy of vaccines against opioid use disorders and overdose
J Immunol (2020) 204 (1_Supplement): 169.30.
Tri-functional T-cell engagers target immune checkpoint inhibitors PD-1 and TIGIT to enhance CD8 effector T-cell functions in chronically SHIV-infected rhesus macaques
Wanwisa Promsote; David Ambrozak; Cassandra Almasri; Catherine Liu; Megan DeMouth; Jason Hataye; Amarendra Pegu; John R. Mascola; Richard Koup
J Immunol (2020) 204 (1_Supplement): 169.31.
Pharmacological inhibition of protein kinase C-eta inactivates the contact-dependent suppressive activity of regulatory T cells (Tregs): A novel approach for cancer immunotherapy?
J Immunol (2020) 204 (1_Supplement): 169.32.
Amplifying an abscopal effect of radiation therapy with a novel immunotherapeutic agent
J Immunol (2020) 204 (1_Supplement): 169.35.
Novel minigene vaccine stimulates CD8+ memory inflation to control growth of murine colorectal tumor
Jonathan Kwok; Anna Maria Theresa Kroon; Senthil Chinnakannan; Cathy de Lara; Uzi Gileadi; Vincenzo Cerundolo; Paul Klenerman; Lian Ni Lee
J Immunol (2020) 204 (1_Supplement): 169.36.
Reduced T cell priming to vaccination in microbially-experienced (‘dirty’) mice
Frances V Sjaastad; Matthew A Huggins; Whitney Swanson; Tamara A Kucaba; Sara E. Hamilton; Thomas S Griffith
J Immunol (2020) 204 (1_Supplement): 169.4.
A trifunctional bispecific antibody mediates efficient killing of B-cell lymphoma cells
J Immunol (2020) 204 (1_Supplement): 169.6.
A new checkpoint receptor targets for cancer immunotherapy
J Immunol (2020) 204 (1_Supplement): 169.7.
Application of individual HLA-binding prediction thresholds increases the detection of target cell surface-presented HPV16 E6- and E7-derived epitopes as a basis for therapeutic HPV vaccine design
Maria Bonsack; Nitya Mohan; Kathrin Öhlenschläger; Catharina Lotsch; Julia M. Heinze; Janika Schmitt; Stephanie Hoppe; Jonas Förster; Renata Blatnik; Angelika B. Riemer
J Immunol (2020) 204 (1_Supplement): 169.8.
Development of a prophylactic vaccine for lung squamous cell carcinoma
J Immunol (2020) 204 (1_Supplement): 169.9.
Cytokine and T Cell-Based Therapies 2
Effect of CRISPR/Cas9-mediated PD-1-disrupted primary human third-generation CAR-T cells targeting EGFRvIII on human glioblastoma cell growth
Tsutomu Nakazawa; Atsushi Natsume; Fumihiko Nishimura; Ryosuke Matsuda; Mitsutoshi Nakamura; Ichiro Nakagawa; Yasushi Motoyama; Young Soo Park; Takahiro Tsujimura; Toshihiko Wakabayashi; Hiroyuki Nakase
J Immunol (2020) 204 (1_Supplement): 170.1.
Enhanced functional properties of in vitro expanded lymph node derived human NK cells
Pranay Dogra; Athena Chin; Masaru Kubota; Rei Matsumoto; Puspa Thapa; Peter Szabo; Maya M.L. Poon; Donna L. Farber
J Immunol (2020) 204 (1_Supplement): 170.11.
Exploring γδ T cells for use in non-MHC restricted immunotherapy
Kalyn Schriefer; Dan Chang; Phillip Garett-Engele; Lixia Li; Ed Spooner; Morgan Monslow; Jason Killough; Linda Lieberman; Sina Mohammadi; Theodore Sana; Thomas Wyche; Amanda Guo; Bonnie Howell; Vanessa Peterson; Roberta Martinelli
J Immunol (2020) 204 (1_Supplement): 170.12.
The alarmin cytokine IL-1a drives a feedback-amplification loop between dying tumor cells and inflammatory monocyte-lineage dendritic cells
J Immunol (2020) 204 (1_Supplement): 170.13.
Reprogramming T Cell Specificity to Suppress Autoreactive T Cells in Type 1 Diabetes
J Immunol (2020) 204 (1_Supplement): 170.14.
Preclinical studies of the off-target reactivity of AFP158-specific TCR engineered T cells
J Immunol (2020) 204 (1_Supplement): 170.15.
Macrophages genetically engineered to secrete IL-12 induce tumor killing and immune activation in human tumor slice cultures
Shannon A Kreuser; Katherine J Brempelis; Kevin P Ladabie; Courtney M Cowan; Harrison K Chinn; Amira Davis; Venu G Pillarisetty; Courtney A Crane
J Immunol (2020) 204 (1_Supplement): 170.18.
The length of the intracellular domain conditions the antitumor efficacy of CAR-T cells
J Immunol (2020) 204 (1_Supplement): 170.20.
Characterization of a novel type NK cell line KHYG-1 carrying EGFRvIII-specific CAR in glioblastoma cells
Takayuki Morimoto; Tsutomu Nakazawa; Atsushi Natsume; Fumihiko NIshimura; Ryosuke Matsuda; Toshiharu Murakami; Mitsutoshi Nakamura; Ichiro Nakagawa; Yasushi Motoyama; Young-Soo Park; Takahiro Tsujimura; Toshihiko Wakabayashi; Hiroyuki Nakase
J Immunol (2020) 204 (1_Supplement): 170.22.
Exploring mechanisms of tumor resistance to CAR T cell therapy in immunocompetent mouse models
J Immunol (2020) 204 (1_Supplement): 170.24.
Optimization of CAR T cell co-stimulation reduces to MDSC suppression
J Immunol (2020) 204 (1_Supplement): 170.3.
Cytokine Pre-activated γδT cells in Cancer Adoptive Immunotherapy
J Immunol (2020) 204 (1_Supplement): 170.4.
Phosphatidylserine targeting antibody enhances anti-tumor activity of adoptive cell therapies in a mouse melanoma model
Sara Schad; Daniel Hirschhorn-Cymerman; Sadna Budhu; Hong Zhong; Xia Yang; Taha Merghoub; Jedd D Wolchok
J Immunol (2020) 204 (1_Supplement): 170.5.
T-cells modified with CD70 as an alternative cellular vaccine for antitumor immunity
J Immunol (2020) 204 (1_Supplement): 170.6.
CD4 depletion potentiates anti-tumor immunity in adoptive immunotherapy by increasing IL-18Rαhi endogenous CD8+ T cells
J Immunol (2020) 204 (1_Supplement): 170.7.
Improved trafficking and tumor control with regional, pressure-enabled drug delivery of anti-CEA CAR-T cells for colorectal liver metastases in a murine model
Louis F. Chai; John C. Hardaway; Kara R. Heatherton; Kyle P. O’Connell; Jason P. LaPorte; Prajna Guha; Abdul Saied; Robert Knight; David Jaroch; Bryan F. Cox; Steven C. Katz
J Immunol (2020) 204 (1_Supplement): 170.8.
Engineering CAR T cells with a GM-CSF:IL-18 cytokine switch receptor results in potent antitumor activity in solid tumors
J Immunol (2020) 204 (1_Supplement): 170.9.
Interferons and Virus Control
Human cytomegalovirus preferentially infects early gestation placental macrophages and evades their antiviral immunogenicity through evasion of the type I IFN response
J Immunol (2020) 204 (1_Supplement): 171.10.
Comparison of Interferons and Other Biomarkers in Influenza and Healthy Donor Samples
J Immunol (2020) 204 (1_Supplement): 171.11.
Activation of the hypoxia-inducible factor 1 alpha is necessary for type 1 interferon and IFN stimulatory gene expression during gammaherpesvirus infection
J Immunol (2020) 204 (1_Supplement): 171.13.
B cell-intrinsic expression of Interferon Regulatory Factor 1 supports chronic gammaherpesvirus infection
J Immunol (2020) 204 (1_Supplement): 171.14.
Conspiring with the enemy: IRF-3 supports latent gammaherpesvirus infection of germinal center B cells
J Immunol (2020) 204 (1_Supplement): 171.15.
Interferon gamma promotes long term retention of tissue resident memory T cells in the brain following alphavirus clearance in mice
J Immunol (2020) 204 (1_Supplement): 171.2.
Type I interferons mediate pathogenic reactive oxygen species during neonatal influenza virus infection
J Immunol (2020) 204 (1_Supplement): 171.4.
A commensal Clostridium species restricts systemic alphavirus dissemination through a type I interferon signaling axis
Emma S Winkler; Larissa B Thackray; Barry L Hykes; Scott A Handley; Lindsay Droit; Prabhakar Andhey; Matthias Mack; Swathi Shrihari; Amanda Swain; Marina Cella; Marco Colonna; Maxim Artyomov; Thaddeus S Stappenbeck; Michael S Diamond
J Immunol (2020) 204 (1_Supplement): 171.5.
Investigating the pathogenesis of chronic chikungunya virus infection
J Immunol (2020) 204 (1_Supplement): 171.6.
Maternal interferon lambda signaling limits transplacental transmission and mediates fetal pathology during congenital Zika virus infection in mice
J Immunol (2020) 204 (1_Supplement): 171.7.
Interferon gamma signaling regulates the generation of influenza-specific memory B cells
J Immunol (2020) 204 (1_Supplement): 171.8.
Early IFN-I limits virus-specific immunity
Nicole M Palacio; Tanushree Dangi; Young Rock Chung; Yidan Wang; Juan Loredo; Zhongyao Zhang; Pablo Penaloza-MacMaster
J Immunol (2020) 204 (1_Supplement): 171.9.
Antigen Processing and Presentation 1
Lysosomal Protease Creation of Chimeric Epitopes for Diabetogenic CD4 T cells via Transpeptidation
Brendan Kearney Reed; Frances Crawford; Ryan Hill; Niyun Jin; Sai Harsha Krovi; Janice White; Philippa Marrack; Kirk Hansen; John Kappler
J Immunol (2020) 204 (1_Supplement): 217.11.
Loss of the Class II Accessory Molecule HLA-DO leads to presentation of lower abundance of DM-resistant epitopes
J Immunol (2020) 204 (1_Supplement): 217.13.
Differential of I-Ab Immunopeptidome of Thymus, Splenic B cells, and Splenic DCs from C57BL/6 mice
J Immunol (2020) 204 (1_Supplement): 217.14.
Sirt1 is a requisite for the antigen presentation by B cells
J Immunol (2020) 204 (1_Supplement): 217.15.
Proteogenomics and de novo sequencing based approach for neoantigen discovery from the immunopeptidomes of patient CRC liver metastases using Mass Spectrometry
J Immunol (2020) 204 (1_Supplement): 217.16.
Destabilization of exotoxin A diminishes serum antibody titer and affinity maturation by reducing peptide-MHCII abundance
Daniel L Moss; Kejing Song; Alanna G Wanek; Qingbo Shu; Tony Hu; Jay K Kolls; Ramgopal R Mettu; Samuel J Landry
J Immunol (2020) 204 (1_Supplement): 217.17.
Lipid dysregulation and antigen presentation during intestinal inflammation
J Immunol (2020) 204 (1_Supplement): 217.18.
The Outer Face of the IgV Domain of Butyrophilin 3A1 is Critical for the Sensing of Prenyl Pyrophosphates by Human Vγ2Vδ2 T cells: A New Paradigm for γδ T Cell Recognition
Craig T Morita; David A. Rhodes; Mohanad Hameed Nada Al-Janabi; Yoshimasa Tanaka; Shun Sakuraba; Hong Wang
J Immunol (2020) 204 (1_Supplement): 217.19.
Molecular requirements for B cell receptor engagement and activation
J Immunol (2020) 204 (1_Supplement): 217.20.
Oral feeding as well as intravenous administration of biodegradable nanoparticles containing antigen and dexamethasone induces antigen-specific immune tolerance
J Immunol (2020) 204 (1_Supplement): 217.22.
GILT in thymic epithelial cells facilitates central CD4 T cell tolerance to a tissue-restricted, melanoma-associated self antigen
Karen Hastings; Matthew P. Rausch; Lydia R. Meador; Todd C. Metzger; Handong Li; Shenfeng Qiu; Mark S Anderson
J Immunol (2020) 204 (1_Supplement): 217.4.
B cell-intrinsic MHCII expression restricts bacterial dissemination from the gut and maintains metabolic tone
J Immunol (2020) 204 (1_Supplement): 217.6.
B Cells and Antibodies in Autoimmunity
The E3 Ubiquitin Ligase Itch Restricts the Magnitude of Antigen-Driven B Cell responses
Emily K Moser; Jennifer Roof; Joseph Dybas; Lynn Spruce; Stephen Seeholzer; Michael P Cancro; Paula M Oliver
J Immunol (2020) 204 (1_Supplement): 218.1.
Serine phosphorylation of the STAT1 transactivation domain promotes autoreactive B cell and systemic autoimmunity development
Adam J Fike; Sathi Babu Chodisetti; Phillip P Domeier; Harinder Singh; Stephanie L Schell; Taryn E Mockus; Nicholas M Choi; Chelsea Corradetti; Yuka Imamura Kawasawa; Baidong Hou; Hannah M Atkins; Roberto Caricchio; Thomas Decker; Aron E Lukacher; Nancy J Olsen; Ziaur S.M. Rahman
J Immunol (2020) 204 (1_Supplement): 218.10.
TLR7/8 agonist accelerates lupus development with heart disease in lupus-prone mice
Ahmed Samir Elshikha; Xiangyu Teng; Wei Li; Josephine Michelle Brown; Georges Abboud; Seung-Chul Choi; Nathalie Kanda; Xueyang Zou; Laurence Morel
J Immunol (2020) 204 (1_Supplement): 218.11.
Isoform repertoire of Blood mononuclear cells from SLE patients
Silvina del Carmen; Prashant Singh; Pulak Nath; Yuqi Zhao; Richie Huynh; Cheng-Han Chung; Robert Rossi; Virginia Pascual; Jacques Banchereau
J Immunol (2020) 204 (1_Supplement): 218.12.
Genetic contribution to loss of B cell anergy during development of autoimmunity
Mia J Smith; Marynette Rihanek; Zachary Stensland; Virginia Sarapura; Peter Gottlieb; John C Cambier
J Immunol (2020) 204 (1_Supplement): 218.14.
TLR9 dependent regulation of AXL expression impacts migration of autoreactive B cells
Kerstin (Kiefer) Nundel; Stephanie Moses; Jillian M Richmond; Carla V. Rothlin; Ann Marshak-Rothstein
J Immunol (2020) 204 (1_Supplement): 218.15.
Food allergens could promote the Th2 mediated autoantibody development in an autoimmune skin disease bullous pemphigoid
J Immunol (2020) 204 (1_Supplement): 218.16.
Novel B cell-dependent multiple sclerosis model using extracellular domains of myelin proteolipid protein
J Immunol (2020) 204 (1_Supplement): 218.18.
Expansion of polyreactive and autoreactive IgG B cells in NOD.H-2h4 mice, a model of Sjögren’s Syndrome
Pablo Engel; Rebeca Gutiérrez-Cózar; Joan Puñet-Ortiz; Jorge Carrillo; Julìa Blanco; Manuel Sáez Moya
J Immunol (2020) 204 (1_Supplement): 218.19.
Ikaros regulates gene expression programs required for proper BCR-activation in mature B cells
J Immunol (2020) 204 (1_Supplement): 218.2.
Novel shared antibody specificities in anti-Ro/ La antibody negative Sjögren’s Syndrome
Sherri Longobardi; Constantin Georgescu; Christina Lawrence; Charmaine Moya; Jonathan Wren; Judith A James; Kathy L Sivils; A. Darise Farris
J Immunol (2020) 204 (1_Supplement): 218.20.
Identification and characterization of adipose tissue-derived human antibodies with “anti-self” specificity
Daniela Frasca; Alain Diaz; Maria Romero; Denisse Garcia; Diya Jayram; Seth Thaller; Bonnie Blomberg
J Immunol (2020) 204 (1_Supplement): 218.21.
Single Cell RNA Sequencing of Human Liver Infiltrating B Cells in Primary Biliary Cholangitis (PBC)
Weici Zhang; Xunyao Wu; Ying Sun; Weijia Duan; Sandeep Dhaliwal; Patrick S.C. Leung; Christopher Bowlus; Xuan Zhang; M Eric Gershwin
J Immunol (2020) 204 (1_Supplement): 218.23.
Autoantibodies targeting apolipoprotein A-I are associated with cardiovascular disease outcomes
J Immunol (2020) 204 (1_Supplement): 218.24.
Autoantibodies targeting components of neutrophil extracellular traps are elevated in cystic fibrosis
J Immunol (2020) 204 (1_Supplement): 218.25.
Expression of ANA patterns by Indirect Fluorescent Assay in a local Hong Kong population from private sector
Kwun Hung Lau; Marco Hing-Lam Hung; Po-Yi Kwan; Tsoi-Hin Lam; Cheuk-Him Kai; Ho-Hin Lai; Peter Kin-Nam Yau
J Immunol (2020) 204 (1_Supplement): 218.26.
Autoantibody Prevalence in Cerebrospinal Fluid in Autoimmune Encephalitis and Related Disorders: The Need for a More Targeted Screening Approach
J Immunol (2020) 204 (1_Supplement): 218.27.
Defects in lysosome acidification are evident in active, but not inactive, systemic lupus erythematosus (SLE)
J Immunol (2020) 204 (1_Supplement): 218.29.
Autoreactive B cells have a specific metabolic response during humoral responses
J Immunol (2020) 204 (1_Supplement): 218.3.
MHCII density only weakly impacts autoreactive germinal center B cell fitness
J Immunol (2020) 204 (1_Supplement): 218.30.
Defining the mechanisms of B cell initiated autoimmune disease
Cassandra A Bazile; Jacqueline A Wright; Emily S Clark; Gianluca Carlesso; Linlin Gao; Tamer Mahmoud; Justin Boucher; Eden Kleiman; Anne B Satterthwaite; Edward Harhaj; Wasif N Khan
J Immunol (2020) 204 (1_Supplement): 218.5.
Defining altered regulome structured in response to antigen co-receptors, toll-like receptors, and cytokine receptors stimuli to predispose early developing B cells for pathogenic fate in Systemic lupus erythematosus
Ankur Saini; Meixue Duan; Tian Mi; Sakeenah Hicks; Eun-Hyung Lee; Christopher D. Scharer; Jeremy M Boss; Greg Gibson; Ignacio Sanz
J Immunol (2020) 204 (1_Supplement): 218.6.
Longitudinal Phenotyping Studies of MRL/MpJ-Faslpr/J and NZBWF1/J Mouse Lupus Models
J Immunol (2020) 204 (1_Supplement): 218.7.
IL-4 synergizes with low-dose IL-2 to restore systemic lupus erythematosus B cells at the resting naive status
J Immunol (2020) 204 (1_Supplement): 218.8.
Multiple tolerance checkpoints suppress low-affinity germline precursor B cells of high affinity anti-dsDNA antibody-producing cells in BCR knock-in mice
J Immunol (2020) 204 (1_Supplement): 218.9.
Innate Immunity in Autoimmune Diseases
Effects of NLRP1 risk polymorphisms on IL-18 levels and gene expression
J Immunol (2020) 204 (1_Supplement): 219.1.
Lupus-like disease in B6.Nba2 mice shows a biphasic disease progression
J Immunol (2020) 204 (1_Supplement): 219.10.
Interferon alpha promotes extrinsic apoptosis of keratinocytes following exposure to ultraviolet B radiation
J Immunol (2020) 204 (1_Supplement): 219.11.
Dysregulation of type I IFN and IL-4R signaling regulates the development of BCR VH and VL repertoire encoding anti-Sm autoantibodies in SLE
John D. Mountz; Min Gao; Shanrun Liu; Zechen Chong; Qi Wu; PingAr Yang; W. Winn Chatham; Hui-Chen Hsu
J Immunol (2020) 204 (1_Supplement): 219.12.
Interferon lambda promotes immune dysregulation and tissue inflammation in TLR7-induced lupus
Xinghao Wang; Rishi R. Goel; Liam J. O’Neil; Shuichiro Nakabo; Kowser Hasneen; Sarthak Gupta; Gustaf Wigerblad; Luz P. Blanco; Jeffrey B. Kopp; Maria I. Morasso; Sergei V. Kotenko; Zu-Xi Yu; Carmelo Carmona-Rivera; Mariana J. Kaplan
J Immunol (2020) 204 (1_Supplement): 219.13.
AIM2 deficient mice develop severe Systemic Lupus Erythematosus pathogenesis due to elevated type I interferon signaling
J Immunol (2020) 204 (1_Supplement): 219.15.
Metformin enhances the immunomodulatory potential of adipose-derived mesenchymal stem cells through STAT1 in an animal model of lupus
J Immunol (2020) 204 (1_Supplement): 219.16.
Dnase1L3 levels from macrophages in providing protection against SLE development
J Immunol (2020) 204 (1_Supplement): 219.18.
Type 1 interferons promote allo-antibody responses to RBC transfusion in a lupus mouse model
J Immunol (2020) 204 (1_Supplement): 219.19.
Single Cell RNA-sequencing Identifies Distinct Fibroblast Subsets in a Human 3D Skin Model of Systemic Sclerosis
Noelle Noreen Kosarek; Tamar Wheeler; Diana Maria Toledo; Mengqi Huang; Patricia A Pioli; Michael Whitfield
J Immunol (2020) 204 (1_Supplement): 219.21.
Critical role of macrophages in checkpoint blockade induced autoimmune diabetes in the NOD mouse
J Immunol (2020) 204 (1_Supplement): 219.3.
Complement C1q synergizes with PTX3 in promoting NLRP3 inflammasome over-activation and pyroptosis in rheumatoid arthritis
J Immunol (2020) 204 (1_Supplement): 219.4.
Human gingiva-derived mesenchymal stem cells ameliorate rheumatoid arthritis through directly targeting of rheumatoid arthritis synovial fibroblasts
J Immunol (2020) 204 (1_Supplement): 219.6.
Organic compound farnesol as possible inhibitor of inflammasome complex, in murine macrophages and mouse model of multiple sclerosis
Lacey B Sell; Christina C. Ramelow; Kevin D. Strawn; Theresa Hevrin; Trevor O. Kirby; K. Michael Gibson; Jean-Baptiste Roullet; Javier Ochoa-Repáraz
J Immunol (2020) 204 (1_Supplement): 219.7.
Distinct chromatin modifications at the Il33 locus in mast cells contribute to sex dimorphic susceptibility to EAE, an autoimmune CNS demyelinating disease
J Immunol (2020) 204 (1_Supplement): 219.8.
Mechanisms of Leukocyte Entry during Inflammation
Kindlin-3 organizes a ring of clustered high affinity β2 integrins during human neutrophil spreading under flow
Zhichao Fan; Lai Wen; Yi-Ting Yeh; William B Kiosses; Edgar Gutierrez; Alex Groisman; Joshua Francois; Juan C Lasheras; Juan C del Alamo; Shu Chien; Mark H Ginsberg; Brian G Petrich; Klaus Ley
J Immunol (2020) 204 (1_Supplement): 220.1.
Epithelial cytokine IL-33 and sub-epithelial matrix protein tenascin C compartmentalize eosinophil phenotype and function
J Immunol (2020) 204 (1_Supplement): 220.11.
Formin-like-1 mediates effector T cell extravasation through restrictive endothelial barriers enabling T cell entry into peripheral tissues and autoimmunity induction
Jordan Jacobelli; Scott B. Thompson; Adam M. Sandor; Victor Lui; Jeffrey W. Chung; Monique M. Waldman; Rachel S. Friedman
J Immunol (2020) 204 (1_Supplement): 220.12.
Unraveling the role of β2 integrins in neutrophil migration to the lung and subsequent acute lung injury in sepsis
J Immunol (2020) 204 (1_Supplement): 220.13.
BCG-Infected Dendritic Cells Induce TNF-alpha Dependent Cell Cluster Formation that Damage Brain Endothelial Cells in an In Vitro Model of the Blood Brain Barrier
J Immunol (2020) 204 (1_Supplement): 220.14.
Combining RNA in situ hybridization and spectral flow cytometry to investigate the leukocyte glycocalyx in autoimmunity
Payton L Marshall; Gernot Kaber; Miles H Linde; Graham L Barlow; Naomi L Haddock; Lisa Wagar; Nadine Nagy; Paul L Bollyky
J Immunol (2020) 204 (1_Supplement): 220.15.
Combined blockade of α4β7 and αEβ7 integrins leads to a greater reduction of gut proinflammatory T lymphocytes over either pathway alone
Bingbing Dai; Jason Hackney; Ryan Ichikawa; Justin Elstrott; Kai-Hui Sun; Zora Modrusan; Alvin Gogineni; Jacqueline McBride; Mary E Keir; Tangsheng Yi
J Immunol (2020) 204 (1_Supplement): 220.17.
The pathogenic role of choroid plexus infiltrating T cells in Neuropsychiatric Lupus
J Immunol (2020) 204 (1_Supplement): 220.18.
Effects of using nanogel-cross-linked porous gel with cell adhesion factor for cell transplantation
Yoshiki Sato; Kenta Yamamoto; Shigeta Takizawa; Keiji Adachi; Fumishige Oseko; Takeshi Amemiya; Tsunao Kishida; Toshiro Yamamoto; Osam Mazda; Narisato Kanamura
J Immunol (2020) 204 (1_Supplement): 220.2.
Complement protein C1q modulates endothelial cell functions in atherosclerosis
J Immunol (2020) 204 (1_Supplement): 220.20.
Effects of mechanical stress on cells derived from human oral mucosa
J Immunol (2020) 204 (1_Supplement): 220.21.
GPR56 inhibits chemotaxis of human Natural Killer and TEMRA lymphocytes
J Immunol (2020) 204 (1_Supplement): 220.22.
Functional differences in behavior of monocyte/macrophage from HIV+ patients versus healthy subjects
Javier Lozano; Dominic C Chow; Lishomwa C Ndhlovu; Chathura Siriwardhana; Jocelyn Liu; Jason Irei; Lorna Nagamine; Cecilia Shikuma; William A Boisvert
J Immunol (2020) 204 (1_Supplement): 220.23.
Oxysterols induce proinflammatory response via Focal Adhesion Kinase (FAK) signaling
J Immunol (2020) 204 (1_Supplement): 220.24.
The α7 nicotinic acetylcholine receptor is an important determinant of monocyte-derived macrophage migration
J Immunol (2020) 204 (1_Supplement): 220.25.
In vivo tracking: Using a photoconvertible system to probe immune cell entry and exit in the context of inflammation
J Immunol (2020) 204 (1_Supplement): 220.26.
Follicular dendritic cell migration is facilitated by the expression of matrix metalloproteinase 3 through TNFα-ERK1/2-AP-1 signaling
J Immunol (2020) 204 (1_Supplement): 220.27.
Human eosinophils and neutrophils biosynthesize novel 15-lipoxygenase metabolites from 1-linoleoyl-glycerol and N-linoleoyl-ethanolamine
Anne-Sophie Archambault; Francesco Tinto; Cyril Martin; Elizabeth Dumais; Volatiana Rakotoarivelo; Michel Laviolette; Cristoforo Silvestri; Magdalena Kostrzewa; Alessia Ligresti; Louis-Philippe Boulet; Vincenzo Di Marzo; Nicolas Flamand
J Immunol (2020) 204 (1_Supplement): 220.28.
CD103 promotes the proinflammatory response of gastric resident CD4+ T cell in Helicobacter pylori- positive gastritis
J Immunol (2020) 204 (1_Supplement): 220.30.
Autologous intraoperative cell salvage ameliorates suppression of transfusion-related monocyte and dendritic cell inflammatory responses
Melinda M Dean; Maheshi P Obeysekera; Thu V Tran; David Sturgess; Kerstin Wyssusek; Andrea Van Zundert; Louisa G Gordon; D Da Silva; J Punnasseril; John-Paul Tung; Robert L Flower; Michelle Roets
J Immunol (2020) 204 (1_Supplement): 220.31.
Constitutive TGFβ signaling prevents inflammation-induced Langerhans cell migration
J Immunol (2020) 204 (1_Supplement): 220.33.
Bactericidal activity of transendothelial neutrophils based the endothelial IL-1α crosstalk during neutrophil–endothelial interaction
J Immunol (2020) 204 (1_Supplement): 220.34.
Mechanism of Microvascular Endothelial Cells Protected by Pulsatillae Decoction Activated Neutrophils to Kill Bacteria
J Immunol (2020) 204 (1_Supplement): 220.35.
Full-length gasdermin-B (GSDMB) regulates epithelial adhesion and migration, and is increased in patients with IBD
Nitish Rana; Rebecca Maywald; Hannah Kondolf; Derek W Abbott; Jason Heaney; Andrei Ivanov; Theresa Pizarro
J Immunol (2020) 204 (1_Supplement): 220.5.
Spatiotemporal Dynamics of Regulatory T Cells and Th17 Cells in the Leptomeninges During Autoimmune Neuroinflammation
Shivashankar Othy; Amit Jairaman; Joseph Dynes; Tobias X Dong; Cornelia Tune; Andriy V Yeromin; Angel Zavala; Chijioke Akunwafo; Fangyi Chen; Ian Parker; Michael D Cahalan
J Immunol (2020) 204 (1_Supplement): 220.6.
Recruitment of kindlin-3 to plasma membrane through its PH domain precedes high affinity β2 integrin activation and neutrophil arrest
Lai Wen; Alex Marki; Payel Roy; Sara McArdle; Hao Sun; Zhichao Fan; Alexandre R. Gingras; Mark H Ginsberg; Klaus Ley
J Immunol (2020) 204 (1_Supplement): 220.7.
CXCL10+ perivascular clusters nucleate Th1 cell tissue entry and activation in the inflamed skin
Hen Prizant; Nilesh Patil; Seble Negatu; Alexandra Livingston; Scott Leddon; Andrew D Luster; Deborah J Fowell
J Immunol (2020) 204 (1_Supplement): 220.9.
Novel Insights in Common Gamma Chain Family Cytokines
Chemical modification strategies for photo-induced control of immune cell signaling
Lacey A Perdue; Priscilla Do; Andrew Chyong; Emma Costanza; Hye Ryong Kim; Camille David; Anna Kellner; Khalid Salaita; Gregory Lesinski; Christopher C. Porter; Erik C. Dreaden
J Immunol (2020) 204 (1_Supplement): 221.1.
Limited application of IL-2/CD25 leads to persistent IL-2R signaling that promotes gene expression for Treg expansion
J Immunol (2020) 204 (1_Supplement): 221.11.
Inflammation impairs IL-2R signaling in regulatory T cells
J Immunol (2020) 204 (1_Supplement): 221.13.
Interleukin 7 regulates naive T cell metabolism to promote motility of T cells
Judy L Cannon; Janie Rae Byrum; Rebekah Gridley; Paulus Mrass; Miriam Valenzuela; David J Torres; Matthew Fricke; Melanie E Moses
J Immunol (2020) 204 (1_Supplement): 221.2.
IL-9 Represses Intestinal Granzyme A Positive CD4 T Cells in Mice with Allergic Airway Inflammation
J Immunol (2020) 204 (1_Supplement): 221.3.
Rapid protocol for in vitro induction of cytokine associated with Th2 and Th17 cells from PBMC
J Immunol (2020) 204 (1_Supplement): 221.4.
IL-13 promotes precancerous epithelial cell changes during autoimmune gastritis
J Immunol (2020) 204 (1_Supplement): 221.5.
IL-4 regulates resident memory CD8+ T cell formation and persistence
J Immunol (2020) 204 (1_Supplement): 221.6.
An engineered IL-2 partial agonist promotes CD8+ T cell stemness and anti-tumor efficacy
Fei Mo; Zhiya Yu; Peng Li; Jangsuk Oh; Rosanne Spolski; Liang Zhao; Caleb R. Glassman; Tori N. Yamamoto; Yun Chen; Filip M. Golebiowski; Dalton Hermans; Sonia S. Marjri; Lora Picton; Wei Liao; Min Ren; Xiaoxuan Zhuang; Suman Mitra; Jian-Xin Lin; Luca Gattinoni; Jonathan D. Powell; Nicholas P. Restifo; K. Christopher Garcia; Warren J Leonard
J Immunol (2020) 204 (1_Supplement): 221.7.
Autocrine and paracrine IL-2 signals collaborate to regulate distinct phases of CD8 T cell memory
J Immunol (2020) 204 (1_Supplement): 221.8.
Immunology Education
The Use of Moodle Apps and Khan Academy Short Videos to Engage Students to Learn Microbiology/Immunology
J Immunol (2020) 204 (1_Supplement): 222.1.
Training Next-Generation Immunologists on GuavaÒ MuseÒ Cell Analyzer Platform
J Immunol (2020) 204 (1_Supplement): 222.10.
Active learning about the dynamic and complex nature of CD4+ T cell differentiation with computer network modeling and simulations
J Immunol (2020) 204 (1_Supplement): 222.11.
In-class activities as formative assessments in immunology: student buy-in and utilization
J Immunol (2020) 204 (1_Supplement): 222.13.
Development of a 4-year, comprehensive curriculum model for undergraduate immunology education
J Immunol (2020) 204 (1_Supplement): 222.14.
Building Foundations for First Year Medical Students: Integration of Immunology, Microbiology, Pharmacology, and Infectious Disease Using Active Teaching and Self-Directed Learning
J Immunol (2020) 204 (1_Supplement): 222.15.
Development of a CURE course aimed at characterization of bacterial Toll/interleukin 1 receptor (TIR) domain-containing proteins
J Immunol (2020) 204 (1_Supplement): 222.16.
Development of Curriculum Guidelines for Undergraduate Immunology Education –a Report by a Task Force on Undergraduate Immunology Curriculum Guidelines
Louis B Justement; Heather A. Bruns; Samantha Elliott; Sarah Sletten; Rebecca Sparks-Thissen; Danielle Condry; Brian Wisenden; Archana Lal; Timothy Paustian; Philip F Mixter; Rebekah Taylor; Rachel Pritchard; Thiru Vanniasinkam; Glenn Dorsam; David Freier; Sumali Pandey
J Immunol (2020) 204 (1_Supplement): 222.17.
Using IF-AT strategy in the dental immunology curriculum has a beneficial impact on performance and long term retrieval
J Immunol (2020) 204 (1_Supplement): 222.18.
Implementing participatory immunology education in a diverse Latin American student population
Leonardo Ferreira; Giovanni A. Carosso; Natalia Montellano Duran; Soad Bohorquez-Massud; Gustavo Vaca-Diez; Laura Ines Rivera-Betancourt; Yara Rodriguez; Dalila G. Ordonez; Diana K. Alatriste-Gonzalez; Aldo Fabian Vacaflores; Lilian Gonzalez Auza; Christian Schuetz; Lucia Elena Alvarado-Arnez; Carolina Alexander-Savino; Omar Gandarilla; Mohammed A. Mostajo-Radji
J Immunol (2020) 204 (1_Supplement): 222.19.
Learning outcomes of using animated video podcasts as a tool for teaching immunology physiology and pharmacology courses in pharmacy curriculum
J Immunol (2020) 204 (1_Supplement): 222.20.
Human subjects research as part of immunology education
J Immunol (2020) 204 (1_Supplement): 222.24.
Improving the computational reproducibility of immunological research
Brooke Anderson; Michael Lyons; Marcela I Henao-Tamayo; Mercedes Gonzalez Juarrero; Gregory Robertson
J Immunol (2020) 204 (1_Supplement): 222.25.
Use of crossword puzzles: Filling the rows and columns to promote student engagement in an Immunology class
J Immunol (2020) 204 (1_Supplement): 222.26.
Open Discovery in an Undergraduate Immunology Course Lab: Testing Anti-Inflammatory Drugs
J Immunol (2020) 204 (1_Supplement): 222.27.
Immunology that supports STEM participation for High School students
J Immunol (2020) 204 (1_Supplement): 222.28.
Contextualisation of Immunology related STEM examples to support Youth interest and engagement
J Immunol (2020) 204 (1_Supplement): 222.29.
The importance of cultural context in supporting STEM related Immunology content for High School students
J Immunol (2020) 204 (1_Supplement): 222.30.
The utility and appropriate contextualisation of Immunology based cancer related teaching examples within Medical Sciences Education
Dianne Sika-Paotonu; Patricia Baltazar; Joshua dudley; Alana Gilespie; Monica Logan; Terrence Su; Victoria Tam; Michaela Walton
J Immunol (2020) 204 (1_Supplement): 222.31.
Appropriate Contextualisation of Immunology based STEM and Health teaching for undergraduate Medical Sciences Education
Dianne Sika-Paotonu; Pratik Chandra; Hashini De Silva; Zsófia Hermann; Fionnuala Lowry; Sophie Papalii; Priyanka Rajakumaran; Emma Simpson; Michaela Walton; Maxine Mitchell
J Immunol (2020) 204 (1_Supplement): 222.32.
Immunology based STEM outreach education efforts that support Knowledge Translation for Pacific College students
J Immunol (2020) 204 (1_Supplement): 222.33.
Graduate training in T cell immunotherapy and CAR-T cell therapy
Rosalie Sterner; Karen E. Hedin; Richard E. Hayden; Grzegorz S. Nowakowski; Saranya P. Wyles; Alexandra J. Greenberg-Worisek; Andre Terzic; Saad S. Kenderian
J Immunol (2020) 204 (1_Supplement): 222.4.
Bridging statistics and life sciences education for immunologists: Exploring a significantly impactful collaboration
J Immunol (2020) 204 (1_Supplement): 222.6.
Optimization of a T cells education protocol to treat hematological cancers
Cedric MATHIEU; Annabelle MINGUY; Jessica TROTTIER; Jaime SANCHEZ-DARDON; Vibhuti DAVE; Denis-Claude ROY
J Immunol (2020) 204 (1_Supplement): 222.7.
The Use of Interactive Educational Tools to Engage Students in Microbiology and Immunology Classroom
J Immunol (2020) 204 (1_Supplement): 222.8.
H5P as an active learning tool builds content-based critical thinking skills in Biological Sciences and student confidence in problem-based learning
J Immunol (2020) 204 (1_Supplement): 222.9.
Hematopoiesis and Lymphocyte Development
Conditional deletion of the actin-regulatory protein hematopoietic protein-1 alters B cell maturation, migration and antibody production
J Immunol (2020) 204 (1_Supplement): 223.1.
Neonatal exposure to commensal bacteria-derived antigens directs polysaccharide-specific B-1 B cell repertoire development
James Stewart New; Brian L.P. Dizon; Christopher Fucile; Alexander F. Rosenberg; John F Kearney; Rodney G King
J Immunol (2020) 204 (1_Supplement): 223.10.
Elucidating the Role of NEMO and SpiC in DNA Double Strand Break Induced Inhibition of V(D)J Recombination
J Immunol (2020) 204 (1_Supplement): 223.12.
Characterization of new circular RNA products from the Pax-5 gene in B-cells
J Immunol (2020) 204 (1_Supplement): 223.14.
Deletion of von-Hippel Lindau in Dmp1-expressing cells impairs B cell development
J Immunol (2020) 204 (1_Supplement): 223.15.
Altered 3D chromatin structure permits inversional recombination at the IgH locus
J Immunol (2020) 204 (1_Supplement): 223.16.
Missense mutation in non-recombinase domain of RAG1 results in B-cell developmental defect
J Immunol (2020) 204 (1_Supplement): 223.17.
Conditional abrogation of Ddx3x reveals its essential role in lymphocyte development and partial compensation by Y chromosome
J Immunol (2020) 204 (1_Supplement): 223.19.
Early AID expression in developing B cells marks a population with a restricted IgH repertoire favoring D-proximal VH gene usage
J Immunol (2020) 204 (1_Supplement): 223.2.
Depletion of SCFA-fermenting gut bacteria alters the epigenome of hematopoietic stem and progenitor cells
Michael R Hughes; Alissa Cait; Misha Bilenky; Michelle M. Moksa; William Yip; Kristen Li; Diana Canals-Hernaez; Martin Hirst; William W Mohn; Kelly M McNagny
J Immunol (2020) 204 (1_Supplement): 223.21.
A single-cell multiomics approach to study tumor-driven perturbations during hematopoiesis in mice
J Immunol (2020) 204 (1_Supplement): 223.22.
Enhanced development of functional human innate immune cells in a novel mouse FLT3null NSG mouse strain expressing human FLT3L
Shantashri Vaidya; Pamela St. Louis; Lisa Burzenski; Dale L Greiner; Michael A Brehm; Leonard D Shultz
J Immunol (2020) 204 (1_Supplement): 223.24.
Metabolic pathways that mediate expansion and homeostasis of hematopoietic lineages
Hannah A Pizzato; Yahui Wang; Wing Y. Lam; Michael J. Wolfgang; Brian N. Finck; Gary J. Patti; Deepta Bhattacharya
J Immunol (2020) 204 (1_Supplement): 223.4.
E protein support of Zeb2 expression regulates development of multiple hematopoietic lineages
J Immunol (2020) 204 (1_Supplement): 223.5.
PU.1 mediates hematopoietic stem cell self-renewal during cellular stress by non-canonical Wnt signaling
Robert S Welner; Deepak Bararia; Elena Levantini; Virginia Camacho; Sweta Patel; Victoria R. Matkins; Daniel G Tenen
J Immunol (2020) 204 (1_Supplement): 223.6.
The Transcription Factors Thpok And Runx3 Identify Two Distinct CD4−CD8− Double Negative T Cell Populations And Respectively Define Their Commitment In The Helper Or Cytotoxic Fate
Nicolas Thiault; Greet Verstichel; Gregory Seumois; Pandurangan Vijayanand; Mitchell Kronenberg; Hilde Cheroutre
J Immunol (2020) 204 (1_Supplement): 223.7.
A divergent transcriptional landscape underpins the development and functional branching of MAIT cells
Hui Fern Koay; Shian Su; Daniela Amann-Zalcenstein; Stephen R Daley; Iain Comerford; Carly E Whyte; Igor E Konstantinov; Yves d’Udekem; Tracey Baldwin; Peter F Hickey; Stuart P Berzins; Jeffrey Y.W. Mak; Axel Kallies; Zhenjun Chen; Simone Nussing; Katherine Kedzierska; Laura K Mackay; Shaun R McColl; Elissa K Deenick; David P Fairlie; James McCluskey; Christopher C Goodnow; Matthew E Ritchie; Gabrielle T Belz; Shalin H Naik; Daniel G Pellicci; Dale I Godfrey
J Immunol (2020) 204 (1_Supplement): 223.8.
Quantitative Expression of GATA3 Specifies Lineage Fates and Functions of Innate Lymphoid Cells
Mingzhu Zheng; Chao Zhong; Kairong Cui; Andrew Martins; Gangqing Hu; Dan Li; Lino Tessarollo; Serguei Kozlov; Jonathan Keller; John Tsang; Keji Zhao; Jinfang (Jeff) Zhu
J Immunol (2020) 204 (1_Supplement): 223.9.
Autoimmunity and Inflammation in Human Disease
Inflammation-Induced Tumorigenesis: Diminished Noncanonical NF-κB Signaling is Associated with Pathogenesis of Colitis-associated Colorectal Cancer
Holly Morrison; Christina Mounzer; Kristin Eden; Katherine Baumgarner; Stephan Brown; Eda Holl; Irving C Allen
J Immunol (2020) 204 (1_Supplement): 224.1.
Human TLR8 Adversely Affects Placental Development and Induces Spontaneous Pregnancy Loss in a model of Systemic Lupus Erythematosus
J Immunol (2020) 204 (1_Supplement): 224.10.
Exploring the transcriptional impact of ERα in the B cell response of systemic lupus erythematosus
J Immunol (2020) 204 (1_Supplement): 224.12.
Immunological characteristics and clinical significance of urinary CD11c+ macrophages in lupus nephritis
J Immunol (2020) 204 (1_Supplement): 224.13.
TNIP1/ABIN1 mutation contributes to lupus nephritis via chemokine IP-10 induction
J Immunol (2020) 204 (1_Supplement): 224.14.
Type III interferon networks in systemic lupus erythematosus
Jennifer L Barnas; Jennifer Albrecht; Nida Meednu; Neha D Nandedkar-Kulkarni; Mary O’Connell; R John Looney; Jennifer H Anolik
J Immunol (2020) 204 (1_Supplement): 224.16.
Activation of AIM2 inflammasome in salivary gland epithelial cells of patients with primary Sjögren’s syndrome
J Immunol (2020) 204 (1_Supplement): 224.17.
Influence of proton pump inhibitor or rebamipide use on gut microbiota of rheumatoid arthritis patients
J Immunol (2020) 204 (1_Supplement): 224.18.
New classification of CD4+CD8a+ double positive cells in Crohn’s disease patients
Shun Tanemoto; Tomohisa Sujino; Yuya Hagihara; Yoshiaki Takada; Yusuke Yoshimatsu; Satoko Umeda; Ena Nomura; Keiko Ono; Yohei Mikami; Makoto Naganuma; Takanori Kanai
J Immunol (2020) 204 (1_Supplement): 224.2.
High dimensional single cell characterization of autoreactive CD8 T-cells reveals heterogeneous phenotypes that play a role in disease progression in Type 1 Diabetes
J Immunol (2020) 204 (1_Supplement): 224.20.
Role of ICOS expressing CXCR5+PD-1+ T helper cells in pemphigus vulgaris
A Reum Kim; Dawoon Han; Ji Young Choi; Joon Seok; Song-Ee Kim; Seong-Hoon Seo; Su-Hyung Park; Soo-Chan Kim; Eui-Cheol Shin; Jong Hoon Kim
J Immunol (2020) 204 (1_Supplement): 224.22.
Role of 2B4 on dermal γδ T cells in the development of psoriasis-like skin inflammation
J Immunol (2020) 204 (1_Supplement): 224.23.
Comparative Profiling of the Immune System in Sarcoidosis via CITE-Seq and Flow Cytometry
Roman E. Magallon; Jennifer R. Knapp; Laura D. Harmacek; Ting-Hui Clair Tu; Brian Vestal; May Gillespie; Kristyn MacPhail; LI Li; Jill Elliot; Briana Barkes; Lisa Maier; Anne Sommer; Pineet Grewal; Laura Koth; Nicholas Arger; Brenda Werner; Linda Powers; Nabeel Hamzeh; Linda Breslin; Edward Chen; Thomas Danhorn; Sonia M Leach; Tasha E. Fingerlin; Brian P. O’Connor
J Immunol (2020) 204 (1_Supplement): 224.24.
Identification of molecules associated with disease progression of autoimmune myocarditis to dilated cardiomyopathy
J Immunol (2020) 204 (1_Supplement): 224.25.
Upregulated autophagy in antigen-presenting splenic cells hints at promotion of immune-mediated thrombotic thrombocytopenic purpura (iTTP)
J Immunol (2020) 204 (1_Supplement): 224.27.
Glucocorticoid receptor modulates myeloid-derived suppressor cell function via mitochondria respiration and metabolism in immune thrombocytopenia
J Immunol (2020) 204 (1_Supplement): 224.28.
Anti-idiotypic network involved in restoring ADAMTS13 activity in immune-mediated thrombotic thrombocytopenic purpura (iTTP)
J Immunol (2020) 204 (1_Supplement): 224.29.
Adipose Tissue-Derived Mesenchymal Stem Cells’ Acellular Product Extracellular Vesicles as a Potential Therapy for Crohn Disease
J Immunol (2020) 204 (1_Supplement): 224.3.
Landscape of bone marrow T cells in acquired aplastic anaemia revealed by single-cell sequencing
J Immunol (2020) 204 (1_Supplement): 224.31.
Platelet extracellular vesicles drive inflammasome-IL1β-dependent lung injury in Sickle Cell Disease
Prithu Sundd; Ravi Vats; Tomasz Brzoska; Margaret Bennewitz; Maritza Jimenez; Tirthadipa Pradhan-Sundd; Mark Gladwin
J Immunol (2020) 204 (1_Supplement): 224.32.
Pro-fibrotic Activation of Human Macrophages in Systemic Sclerosis
Rajan Bhandari; Michael S. Ball; Viktor Martyanov; Dillon Popovich; Evelien Schaafsma; Saemi Han; Mohamed Eltanbouly; Mary Carns; Esperanza Arroyo; Kathleen Aren; Monique Hinchcliff; Michael L Whitfield; Patricia A Pioli
J Immunol (2020) 204 (1_Supplement): 224.33.
IFNγ Contributes to Splenic B and T cell Activation and Cytopenia in STING Gain-of-Function Autoinflammation
J Immunol (2020) 204 (1_Supplement): 224.34.
Immunodietica: towards a data-driven approach to dissect interactions between diet and autoimmune disease
J Immunol (2020) 204 (1_Supplement): 224.35.
A novel mouse model of proteasome associated autoinflammatory syndromes
J Immunol (2020) 204 (1_Supplement): 224.36.
Connecting metabolism to inflammation: the role of LACC1 in inflammatory diseases
J Immunol (2020) 204 (1_Supplement): 224.37.
An amino acid change in IRF7 increases SLE risk through transcriptional regulation of type I interferons
Ellen F Javier; Katelyn Dunn; Omer Donmez; Carmy Forney; Margaret Roe; Hope Rowden; Daniel Miller; Jose Javier; Margaret M McDaniel; Chandrashekhar Pasare; Stephen N Waggoner; Matthew T Weirauch; Leah C Kottyan
J Immunol (2020) 204 (1_Supplement): 224.38.
Monovalent IgG4 autoantibodies require self-antigen driven affinity maturation to acquire pathogenic capacity
Miriam F L Fichtner; Casey Vieni; Rachel L. Redler; Ruoyi Jiang; Pablo Suarez; Richard Nowak; Steven J Burden; Gira Bhabha; Damian C Ekiert; Kevin C O’Connor
J Immunol (2020) 204 (1_Supplement): 224.39.
Understanding human Crohn’s disease: T cell immunoprofiling and in vitro primary intestinal epithelial monolayer models
J Immunol (2020) 204 (1_Supplement): 224.4.
Hemagglutinin as potential in vivo driver of DQ6-restricted clonal expansion of CD4+ T cells cross-reactive with hypocretin in narcolepsy
Wei Jiang; James R. Birtley; Shu-Chen Hung; Weiqi Wang; Shin-Heng Chiou; Mark M Davis; Lawrence J. Stern; Elizabeth D Mellins
J Immunol (2020) 204 (1_Supplement): 224.40.
Autoinflammatory Eye Disease Due to NLRP3 Inflammasome-Associated Mutations and Excessive IL-1β Responses may be Driven by Ocular Exposure to Commensals
Jay Siak; Anthony J St. Leger; Mary Mattapallil; M. Teresa Magone; Wadih Zein; Sara Alehashemi; Kumarkrishna Raychaudhuri; Guangxun Meng; Ivan Fuss; Warren Strober; Raphaela Goldbach-Mansky; Rachel R Caspi
J Immunol (2020) 204 (1_Supplement): 224.41.
Altered CD4+ T cell Transcriptional and Epigenetic Programming Define Changes in Sarcoidosis Disease Phenotypes
Ting-Hui Clair Tu; Jennifer Knapp; Laura Harmacek; Roman Magallon; Brian Vestal; Sonia Leach; Thomas Danhorn; Lily Li; May Gillespie; Kristyn MacPhail; Christina Riley; Briana Barkes; Jill Elliott; Nicholas Arger; Anne Sommer; Linda Powers; Brenda Werner; Tasha Fingerlin; Lisa Maier; Laura Koth; Nabeel Hamzeh; Brian O’Connor
J Immunol (2020) 204 (1_Supplement): 224.42.
Genetic immunodeficiency and autoimmune disease reveals a WRC-independent role for Hem1 in mTORC2 regulation
J Immunol (2020) 204 (1_Supplement): 224.43.
Prominent antibody mediated auto-immune response in idiopathic CD4 lymphopenic patients
Ainhoa Perez-Diez; Chun-Shu Wong; Xiangdong Liu; Harry Mystakelis; Jian Song; Virginia Sheikh; Megan Anderson; Andrea Lisco; Richard M Siegel; John Tsang; Irini Sereti
J Immunol (2020) 204 (1_Supplement): 224.44.
Detection of T cells Reactive to Hybrid Insulin Peptides in Subjects at Risk for Type 1 Diabetes
J Immunol (2020) 204 (1_Supplement): 224.45.
Inflammatory environments disrupt both bone formation and bone resorption
J Immunol (2020) 204 (1_Supplement): 224.46.
Role of eosinophils and MMP-9 in autoimmune blistering disease bullous pemphigoid
J Immunol (2020) 204 (1_Supplement): 224.47.
Effect of combined low dose IL-2 and polyclonal Tregs infusion in Type 1 Diabetes patients
Shen Dong; Cody Mowery; Kamir Hiam; Kevan C Herold; Stephen Gitelman; Jonathan Esensten; Weihong Liu; Angela Lares; Vinh Nguyen; Michael Lee; Ashley Leinbach; Jimmie Ye; Qizhi Tang; Jeffrey A Bluestone
J Immunol (2020) 204 (1_Supplement): 224.49.
Myasthenia gravis: From single cell signatures to cancer diagnosis
Florian Ingelfinger; Michael Kramer; Sebastian Utz; Sarah Mundt; Sinduya Krishnarajah; Edoardo Galli; Mirjam Lutz; Nicole Puertas Jurado; Corinne Widmer; Ina Camille Reichen; Luca Piccoli; Federica Sallusto; Didier Schneiter; Isabelle Opitz; Hans Heinrich Jung; Antonio Lanzavecchia; Bettina Schreiner; Burkhard Becher
J Immunol (2020) 204 (1_Supplement): 224.50.
Increased expression of EZH2 is mediated by higher glycolysis and mTORC1 activation in lupus CD4+ T cells
J Immunol (2020) 204 (1_Supplement): 224.51.
Telomere length predicts mortality in the Black Women’s Experiences Living with Lupus (BeWELL) Study
David H. Chae; Kara Chung; Connor D. Martz; Cristina M. Drenkard; S. Sam Lim; Jue Lin; Elissa S. Epel
J Immunol (2020) 204 (1_Supplement): 224.52.
CpG methylation in the TGFB1 and IL-6 gene promoters serve as surrogate biomarkers for diagnosis of IBD in children
Ali Ahmad; Suzanne Samarani; Claire-Lucas Dupont; Valerie Marcel; David Mack; Ernest Seidman; Colette Deslandres; Prevost Jantchou; Devendra Amre
J Immunol (2020) 204 (1_Supplement): 224.6.
HERV1-env dependent unfolded protein response activation is a potential initiator of autoreactivity in autoimmune liver disease
Udeme D Ekong; Jie Yao; James Knight; Sameet Mehta; Yaron Avitzur; Mercedes Martinez; Steve J Lobritto; Andrew Mason
J Immunol (2020) 204 (1_Supplement): 224.7.
Aryl hydrocarbon receptor inhibition and non-canonical signaling activation impact Treg function in autoimmune hepatitis
Marta Vuerich; Rasika Harshe; Luiza Abrahão-Frank; Samiran Mukherjee; Barbora Gromova; Alan Bonder; Vilas Patwardhan; Simon C. Robson; Maria Serena Longhi
J Immunol (2020) 204 (1_Supplement): 224.8.
Dietary tryptophan alters CD4+ T cell function in the lupus-prone B6. Sle1.Sle2.Sle3 (TC) mouse model
J Immunol (2020) 204 (1_Supplement): 224.9.
Human Infectious Disease
Genetic and infectious regulators of baseline and acute immunity across ancestrally distinct human populations
Aisha Souquette; Kaity Allen; Christine Oshansky; Li Tang; Sook-san Wong; Trushar Jeevan; Benson Ogunjimi; Stacey Schultz-Cherry; Richard Webby; Aubree Gordon; Richard Rothman; Andrew Pekosz; Paul Glyndwr Thomas
J Immunol (2020) 204 (1_Supplement): 225.1.
Similar cardiovascular disease histopathology and macrophages in heart tissues of younger adult SIV-infected and uninfected aged rhesus macaques
J Immunol (2020) 204 (1_Supplement): 225.11.
Single cell profiling illustrates down-regulation of GM42031 in macrophages and microglia as a potential mechanism of neuroinflammation in transgenic GFAP-gp120 mice
J Immunol (2020) 204 (1_Supplement): 225.12.
Effects of Morphine on Behavioral and CNS Inflammatory Responses in GP120 Mice Under Immunocompetent vs. Immunodeficient Conditions
J Immunol (2020) 204 (1_Supplement): 225.13.
Lack of Polyfunctional Cytomegalovirus-specific T cells in Hemodialysis Patients
J Immunol (2020) 204 (1_Supplement): 225.14.
Intracellular expression of IFN-λ4 leads to ER stress, enhanced IRF1 signaling and decreased proliferation in hepatic cells that might protect HCV+ patients from liver cirrhosis
Olusegun O Onabajo; Fang Wang; Mei-Hsuan Lee; Oscar Florez-Vargas; Adeola Obajemu; Mauro A Castro; Joselin Vargas; Shu-Fen Liao; Yu-Han Huang; Chen-Yang Shen; Rouf Banday; Thomas O’Brien; A. Gordon Robertson; Ludmila Prokunina-Olsson
J Immunol (2020) 204 (1_Supplement): 225.17.
Longitudinal immunomonitoring across the virome using a highly-multiplexed serological assay and citizen science
J Immunol (2020) 204 (1_Supplement): 225.2.
Defective macrophage mediated immune responses in HIV negative Mycobacterium avium complex (MAC) patients with pulmonary diseases
Bock-Gie Jung; Buka Samten; Barbara A Brown-Elliott; Richard J Wallace; Steven Idell; Carly Wadle; Julie V Philley; Ramakrishna Vankayalapati
J Immunol (2020) 204 (1_Supplement): 225.20.
Single cell transcriptomics of the T cell response to Mycobacterium Tuberculosis reveals phenotypic diversity within and between infected individuals
J Immunol (2020) 204 (1_Supplement): 225.21.
Prognostic value of autophagy markers in sepsis- a clinical case report
Chandra Shekar Mallarpu; Meenakshi Ponnana; Sudhir Prasad; Maneendra Singarapu; Lakshmi Kiran Chelluri; Charitha Madiraju
J Immunol (2020) 204 (1_Supplement): 225.22.
Phenotypic changes of mucosal-associated invariant T (MAIT) cells during and after acute human sepsis
Daniel Labuz; Shubhanshi Trivedi; Cole Anderson; Claudia Araujo; Toni Blair; Elizabeth Middleton; Robert A. Campbell; Scott Hale; Matthew T. Rondina; Daniel T. Leung
J Immunol (2020) 204 (1_Supplement): 225.23.
Activation of the innate immune response by IL-36 mediated inflammation during active ticks mediated ehrlichial transmission in mice
J Immunol (2020) 204 (1_Supplement): 225.24.
The nonreceptor tyrosine kinase SYK induces autoinflammatory osteomyelitis in a mouse model of chronic recurrent multifocal osteomyelitis
J Immunol (2020) 204 (1_Supplement): 225.25.
Ureaplasma parvum induces preterm birth by triggering immune responses in the fetus and at the maternal-fetal interface
Kenichiro Motomura; Roberto Romero; Kevin Theis; Andrew Winters; Yi Xu; Valeria Garcia-Flores; Chengrui Zou; Robert Para; Madison Ahmad; Rebecca Slutsky; Nardhy Gomez-Lopez
J Immunol (2020) 204 (1_Supplement): 225.26.
Synergic effect of combined intervention with clindamycin and PPARγ agonist in an HLA-II mouse model of Group A Streptococcal Necrotizing Fasciitis
J Immunol (2020) 204 (1_Supplement): 225.27.
Neutrophil Effector Responses to Cystic Fibrosis Clinical Isolates of Staphylococcus aureus and Pseudomonas aeruginosa
Kayla M Fantone; Arthur Miller; Rachel Fricker; Ruchi Yadav; Arlene Stecenko; Joanna Goldberg; Balazs Rada
J Immunol (2020) 204 (1_Supplement): 225.28.
The CF airway environment affects neutrophil antibacterial effector mechanisms: phagocytosis and NET formation
J Immunol (2020) 204 (1_Supplement): 225.29.
HIV-1 infection is associated with increased prevalence of immature neutrophils and alterations in total neutrophil phenotype and metabolic profile
Ashley N Connelly; Harish Pal; Marcus Davis; Krystle Ong; Valeriya Kuznetsova; Christian Fay; E. Turner Overton; Zdenek Hel
J Immunol (2020) 204 (1_Supplement): 225.32.
Mucosal correlates associated with natural regression of HPV-associated dysplasia
J Immunol (2020) 204 (1_Supplement): 225.33.
Complement-driven inflammasome activation on circulating blood monocytes in immune reconstitution inflammatory syndrome in TB-HIV coinfected patients
Silvia Lucena Lage; Chun-Shu Wong; Denise C HSU; Daniel Sturdevant; Maura Manion; Nuha S Naqvi; Andrea Lisco; Elizabeth Laidlaw; Yolanda Mejia; Eduardo Pinheiro Amaral; Irini Sereti
J Immunol (2020) 204 (1_Supplement): 225.34.
SIV and CD4 depletion distinctly reactivate latent Mycobacterium. tuberculosis infection
Collin R Diedrich; Tara Rutledge; Pauline Maiello; Tonilynn Baranowski; Alex White; H. Jacob Borish; Paul Karell; Forrest Hopkins; Jessica Brown; Sarah Fortune; JoAnne L Flynn; Zandrea Ambrose; Philana Ling Lin
J Immunol (2020) 204 (1_Supplement): 225.35.
Single-cell RNA-sequencing of leprosy skin lesions reveals a titin (TTN) expressing T cell subset associated with the progressive disease
Bruno Jorge de Andrade Silva; Travis K Hughes; Priscila R Andrade; Feiyang Ma; Rosane MB Teles; Alex K Shalek; Barry Bloom; Matteo Pellegrini; Robert L Modlin
J Immunol (2020) 204 (1_Supplement): 225.36.
The chemokine CCL17 is associated with protection against HIV-1 acquisition
Timothy R Powell; Rodrigo Duarte; Matthew Hotopf; Stephani Hatch; Miguel de Mulder; Daniela Marin Marín-Hernández; Gerome Breen; Cathryn Lewis; Douglas F. Nixon
J Immunol (2020) 204 (1_Supplement): 225.37.
Cytomegalovirus coinfection is associated with increased vascular-homing CD57+ CD4 T cells in HIV infection
Michael L Freeman; Bonnie Chen; Stephen R Morris; Soumya Panigrahi; Gillian M Michaelson; Jonathan M Wyrick; Alexey A Komissarov; Daria Potashnikova; Anna Lebedeva; Souheil Antoine Younes; Karem Harth; Vikram S Kashyap; Elena Vasilieva; Leonid Margolis; David A Zidar; Scott F Sieg; Carey L Shive; Nicholas T Funderburg; Sara Gianella; Michael M Lederman
J Immunol (2020) 204 (1_Supplement): 225.38.
Fc-bridged immune cell activation and its role in infectious diseases and autoimmune diseases
J Immunol (2020) 204 (1_Supplement): 225.4.
Defects in the Macrophage Galactose-type Lectin Pathway due to HIV Infection
Preeti Bharaj; Joshua Lisinicchia; Kubra Fatima Naqvi; Xiuzhen Fan; Matthew B. Huante; Sadhana Chahuan; Yazmin Martinez; Mark Endsley; Janice Endsley; Benjamin Gelman
J Immunol (2020) 204 (1_Supplement): 225.5.
Immune checkpoint dysregulation and immune activation in HIV-exposed uninfected children
J Immunol (2020) 204 (1_Supplement): 225.6.
NLRP3 inflammasome activation profile in CD4+ T and CD19+ B lymphocytes from HIV-infected patients
J Immunol (2020) 204 (1_Supplement): 225.8.
Studying platelet-HIV interactions and potential to promote viral spread
J Immunol (2020) 204 (1_Supplement): 225.9.
Innate Immune Sensing and Signaling
Expression of the Src-family kinase LynA tunes myeloid-cell signaling and function
J Immunol (2020) 204 (1_Supplement): 226.1.
Autocrine prostaglandin feedback determines the kinetics of bacterial type I interferon induction by restricting endosomal TLR4/TRIF complex assembly
J Immunol (2020) 204 (1_Supplement): 226.10.
MISTR: A conserved MItochondrial STress Response network revealed by signatures of evolutionary conflict
J Immunol (2020) 204 (1_Supplement): 226.11.
A host innate immune circuit licenses downregulation of Salmonella flagellin expression inside macrophages
J Immunol (2020) 204 (1_Supplement): 226.12.
The dual role of alkylated trehalose copolymers as C-Type Lectin Receptor agonists and excipients
J Immunol (2020) 204 (1_Supplement): 226.14.
Expression of Pattern Recognition Receptor mRNA in Pediatric Patients with Otitis Media with Effusion
J Immunol (2020) 204 (1_Supplement): 226.16.
6-Methyladenine may enhance immunostimulatory activity of bacterial genomic DNA
J Immunol (2020) 204 (1_Supplement): 226.17.
VAMP8 mediates TLR4-dependent TNF secretion in RBL-2H3 pro-inflammatory cells
J Immunol (2020) 204 (1_Supplement): 226.18.
Macrophage production and activity of innate immune proteins C1q, C1r, and C1s are modulated in response to molecular patterns
J Immunol (2020) 204 (1_Supplement): 226.19.
TLR2-Tpl2-dependent ERK Signaling Drives Opposite IL-12 Regulation in Dendritic Cells and Macrophages
J Immunol (2020) 204 (1_Supplement): 226.2.
MAP Kinase Phosphatase (Mkp)-1 Controls Type I Interferon (IFN) and PD-L1 Expression during Sepsis
Yusen Liu; Sean G. Kirk; Charles J. Cash; Abel J. Batty; Xiantao Wang; Parker R. Murphy; Jinhui Li; Williams E. Ackerman; Markus Hafner
J Immunol (2020) 204 (1_Supplement): 226.20.
The study of a dendritic cells-based standardized evaluation system for immunity-boosting functional foods
Jaeyul Kwon; Ye-Eun Kim; Pureum Sun; Eunbyeol Go; Bu Yeon Heo; In-Wook Choi; Bok Kyung Han; Bo-In Kwon; Young-Ha Lee; Seong Wook Kang
J Immunol (2020) 204 (1_Supplement): 226.21.
Extensive sex-dimorphism in age-related transcriptional remodeling in mouse peritoneal macrophages
J Immunol (2020) 204 (1_Supplement): 226.22.
Cytoplasmic labile zinc regulates IL-1β production in human monocytes/macrophages via mTORC1-induced glycolysis
J Immunol (2020) 204 (1_Supplement): 226.24.
The role of novel E3 ubiquitin ligase in the regulation of TLR3 signaling pathway
J Immunol (2020) 204 (1_Supplement): 226.26.
Activated platelet-mediated induction of CD16 expression and its role in human monocytes
Su Jeong Lee; Bo Reum Yoon; Bonah Kim; Ga Hye Lee; Yeon Jun Kang; Seong Wook Kang; Eun Bong Lee; Won-Woo Lee
J Immunol (2020) 204 (1_Supplement): 226.27.
Immune sensing of synthetic, bacterial and protozoan RNA by TLR8 requires coordinated processing of RNA substrates by RNaseT2 and RNase2
Eva Sarah Bartok; Thomas Ostendorf; Thomas Zillinger; Katarzyna Andryka; Thais Marina Guimaraes; Saskia Schmitz; Samira Marx; Kübra Bayrak; Rebecca Linke; Sarah Salgert; Tatjana Grasser; Sonja Baersachs; Marc Hübner; Leon Soltesz; Matthias Kettwig; Maximilian Nastaly; Ingo Roehl; Marco Henneke; Winfried Barchet; Jutta Gärtner; Martin Schlee; Gunther Hartmann
J Immunol (2020) 204 (1_Supplement): 226.30.
Direct effects of ethanol at relevant concentrations on conformation and ligand binding of Toll-like Receptor 3 (TLR3)
J Immunol (2020) 204 (1_Supplement): 226.31.
TLR3 co-localizes with LAMP1-labeled endosomes from the first minute following poly(I:C) stimulation of murine astrocytes
Matylda Barbara Mielcarska; Karolina Paulina Gregorczyk-Zboroch; Magdalena Bossowska-Nowicka; Lidia Szulc-Dąbrowska; Felix Ngosa Toka
J Immunol (2020) 204 (1_Supplement): 226.33.
Identifying critical immune effectors of the dermal wound healing response by innate cells using microporous-annealed-particle (MAP) hydrogel
J Immunol (2020) 204 (1_Supplement): 226.34.
Bacterial Polyphosphates Modulate Macrophage Responses to Infection
Markus Bosmann; Julian Roewe; Georgios Stavrides; Federico Marini; Stephanie A. Smith; Christoph Reinhardt; James H. Morrissey
J Immunol (2020) 204 (1_Supplement): 226.4.
The G9a methyltransferase inhibitor BIX01294 inhibits IFN-α production and regulates DNMT1 in virus-activated pDC
J Immunol (2020) 204 (1_Supplement): 226.5.
Macrophages activate a MLK3/MEK signaling axis to remove pore forming toxins by microvesicle shedding
J Immunol (2020) 204 (1_Supplement): 226.6.
Therapeutic targeting of intracellular Toll-like and interleukin-1/18 receptor (TIR) resistance domain containing proteins for protection against infection, inflammation and disease
Greg A Snyder; Wendy Lai; Lindsey Brown; Jorge Blanco; Robert Beadenkpf; Yajing wang; Stefanie Vogel; Kari Ann Shirey
J Immunol (2020) 204 (1_Supplement): 226.7.
Pathogen Control and Evasion—Bacterial/Fungal/Parasitic Infections
Mitochondrial Calcium Signaling Facilitates Bacterial Survival by Restraining LC3-associated Phagocytosis
J Immunol (2020) 204 (1_Supplement): 227.1.
Mechanistic investigations of Granzyme A-mediated TB protective effects
J Immunol (2020) 204 (1_Supplement): 227.10.
STING-dependent type-1 interferon restrains schistosome immunopathology via down-regulation of the CD209a lectin receptor
Parisa Kalantari; Ilana Shecter; Andrea Pilotta Gois; Jacob Hopkins; Yoelkys Morales; Shruti Sharma; Miguel Stadecker
J Immunol (2020) 204 (1_Supplement): 227.11.
Myeloid cells expressing CK2α modulates resistance to systemic Listeria monocytogenes infection
J Immunol (2020) 204 (1_Supplement): 227.13.
Novel Anti-bacterial and Anti-inflammatory Roles for the Macrophage Galactose-type Lectin in Pulmonary Immunity to Mycobacterium tuberculosis
J Immunol (2020) 204 (1_Supplement): 227.14.
Complement activation by C-reactive protein is essential for protection against pneumococcal infection
J Immunol (2020) 204 (1_Supplement): 227.15.
The transcription factor BACH1 promotes tissue damage and host susceptibility in Mycobacterium tuberculosis infection by reducing expression of Gpx4, a major negative regulator of ferroptosis
Eduardo Pinheiro Amaral; Sivaranjani Namasivayam; Diego L. Costa; Logan Fisher; Caio Cesar B. Bomfim; Bruno B. Andrade; Alan Sher
J Immunol (2020) 204 (1_Supplement): 227.16.
Lactoperoxidase-generated hypothiocyanite efficiently kills Streptococcus pneumoniae
Balazs Rada; Aaron Gingerich; Fayhaa Doja; Rachel Thomason; Eszter Toth; Jessica L Bradshaw; Larry S McDaniel
J Immunol (2020) 204 (1_Supplement): 227.17.
Mycobacterium tuberculosis ESX-1 induces eicosanoid mediated neutrophil influx to the lung during Tuberculosis
J Immunol (2020) 204 (1_Supplement): 227.18.
A naturally-occurring mutation in IL-17F reveals a protective role for the IL-17AF heterodimer in oropharyngeal candidiasis (OPC)
Chunsheng Zhou; Felix E.Y. Aggor; Leticia A Monin; Rachael A Gordon; Tara N Edwards; Daniel H Kaplan; Mark J Shlomchik; Sebastien Gingras; Sarah L Gaffen
J Immunol (2020) 204 (1_Supplement): 227.2.
Staphylococcus aureus biofilm-derived lactate inhibits HDAC11 to augment leukocyte IL-10 production and promote infection persistence
Cortney Heim; Megan E Bosch; Kelsey J Yamada; Amy L Aldrich; Sujata S Chaudhari; David Klinkebiel; Casey M Gries; Abdulelah A Alqarzaee; Yixuan Li; Edward Seto; Adam R Karpf; Tammy Kielian
J Immunol (2020) 204 (1_Supplement): 227.20.
Can Effector Molecules of Innate Immunity Target Microbial Motility?
J Immunol (2020) 204 (1_Supplement): 227.21.
Suppression of caspase-11-mediated cytosolic LPS sensing pathway by Shiga toxin
J Immunol (2020) 204 (1_Supplement): 227.22.
A LIVE ATTENUATED Brucella VACCINE POTENTIATES MACROPHAGE ALARMINS
J Immunol (2020) 204 (1_Supplement): 227.23.
Dual RNA-seq as an effective tool to simultaneously identify transcriptional changes in host macrophages and invading intracellular pathogens
J Immunol (2020) 204 (1_Supplement): 227.27.
Activation of the cGAS-STING pathway during Trypanosoma cruzi infection induces a type I interferon response that promotes parasite growth at the infection site
J Immunol (2020) 204 (1_Supplement): 227.29.
Vitamin D modulates innate immunity in pulmonary tuberculosis
J Immunol (2020) 204 (1_Supplement): 227.3.
Gasdermin D Promotes AIM2 Inflammasome Activation and Is Required for Host Protection against Francisella novicida
J Immunol (2020) 204 (1_Supplement): 227.30.
Phagocyte-derived SOCS1 disrupts Staphylococcus aureus skin host defense
J Immunol (2020) 204 (1_Supplement): 227.4.
Hypusination regulates the antibacterial response of macrophages
Alain P Gobert; Yvonne L Latour; Jordan K Finley; Mohammad Asim; Daniel P barry; Margaret M Allaman; Kristie K Lindsey-Rose; Maria B Piazuelo; Johanna C Sierra; Keith T Wilson
J Immunol (2020) 204 (1_Supplement): 227.5.
Genetic mechanisms contributing to IFNβ regulation of Lyme Arthritis: involvement of the Borrelia burgdorferi arthritis associated locus 1 (Bbaa1)
J Immunol (2020) 204 (1_Supplement): 227.6.
Inflammasome signalling is dynamically modulated during the course of a chronic infection by Salmonella Typhimurium
J Immunol (2020) 204 (1_Supplement): 227.7.
Cholesterol-dependent cytolysins promote immune evasion by clustering host membrane lipids
J Immunol (2020) 204 (1_Supplement): 227.8.
Less may be more for Brucella bacteriophage therapy due to immune suppressive effects
J Immunol (2020) 204 (1_Supplement): 227.9.
T Cell Regulation
LAG-3 expression on Foxp3+ regulatory T cells is critical for controlling homeostasis and autoimmune neuroinflammation
J Immunol (2020) 204 (1_Supplement): 228.12.
Regulatory T cells integrate combinatorial cytokine signaling to promote immune homeostasis
J Immunol (2020) 204 (1_Supplement): 228.13.
Sub-lethal Dose of Alcohol Modulates Innate Immune-Mediated Regulatory T-Cell Differentiation
J Immunol (2020) 204 (1_Supplement): 228.14.
The liver controls regulatory T cell populations by enclysis, a CD4+ T cell engulfment process
Zania Stamataki; Scott Davies; Gary Reynolds; Xiaoyan Li; Joe Grove; Nicholas Barnes; David Adams; Yuehua Huang; Omar Qureshi
J Immunol (2020) 204 (1_Supplement): 228.16.
Regulation of the immune response by ST8Sia6
Sydney B Crotts; David J Friedman; Zheng Wang; Michael J Shapiro; Matthew Rajcula; Shaylene McCue; Jie Sun; Virginia Smith Shapiro
J Immunol (2020) 204 (1_Supplement): 228.18.
Transcriptomic and Epigenomic Regulation of Leukocytes by the Polyamine Pathway
J Immunol (2020) 204 (1_Supplement): 228.19.
Drak2 contributes to autoimmunity by negatively regulating IL-2 signaling and altering regulatory T cell development
J Immunol (2020) 204 (1_Supplement): 228.20.
Self-originating CTL peptides induce the cross-activation of Treg cells to suppress the proliferation of self-reactive CD8+ T cells
J Immunol (2020) 204 (1_Supplement): 228.21.
A Neural Circuit for the Suppression of Peripheral Inflammation by Hunger
J Immunol (2020) 204 (1_Supplement): 228.23.
Pathogenic T cell subset Th17 is regulated by chromatin remodeling dependent manner to switch Th1 phenotype
J Immunol (2020) 204 (1_Supplement): 228.24.
Novel role for T-helper 17 signature cytokine, IL-17, in inducing CD4 effector resistance to immune suppression
Michael Patrick Crawford; Sushmita Sinha; Pranav S Renavikar; Nicholas Borcherding; Ashley Brate; Nitin Karandikar
J Immunol (2020) 204 (1_Supplement): 228.3.
Divergent roles of retinoic acid signaling in T regulatory cell function
Govindarajan Thangavelu; Gabriela Andrejeva; Michael Loschi; Ethan G Aguilar; Yu-Chi Lee; Scott N Furlan; Cameron McDonald-Hyman; Michael C Zaiken; Colby J Feser; Angela Panoskaltsis-Mortari; Leslie S Kean; Jeffrey C Rathmell; Hongbo Chi; Randolph J Noelle; Bruce R Blazar
J Immunol (2020) 204 (1_Supplement): 228.4.
Increased regulatory T cells suppress traumatic injury induced inflammation and control adaptive immune cell expansion in an experimental model of burn trauma
Laura Cahill; Fei Guo; Fan Zhang; Julie Ng; Alec Griffith; Kaitlyn Howard; Joshua Keegan; James Lederer
J Immunol (2020) 204 (1_Supplement): 228.5.
Anergy-derived Foxp3+ T regulatory cell differentiation in the neonatal mouse
J Immunol (2020) 204 (1_Supplement): 228.6.
CTLA-4-dependent trogocytosis promotes the interactions between Tregs and antigen-presenting cells
J Immunol (2020) 204 (1_Supplement): 228.8.
Dendritic Cell Activation and Function
BRAF-V600E causes intrinsic hyper-responsiveness of dendritic cells to TLR4 stimulus
J Immunol (2020) 204 (1_Supplement): 229.10.
Differential transcriptional response of plasmacytoid dendritic cells in mice with lupus
Carlos Wong Baeza; Albany Reséndiz Mora; Monserrat Figueroa Pensado; Giovanna Barrera Aveleida; Karen Sánchez Ángeles; Cinthya Portas Cortés; Eréndira Molina Gómez; Carla Landa Saldívar; Isabel Wong Baeza; Isabel Baeza
J Immunol (2020) 204 (1_Supplement): 229.11.
TAGLN2 is essential for both dendritic cell migration and dendritic cell-mediated T cell stimulation
J Immunol (2020) 204 (1_Supplement): 229.12.
Super-induction of immunosuppressive glioblastoma extracellular vesicles by IFN-g through PD-L1 and IDO1
J Immunol (2020) 204 (1_Supplement): 229.13.
Immunological function of Foxo6 in hypersensitive immune reaction
J Immunol (2020) 204 (1_Supplement): 229.14.
Lymphotoxin β receptor signaling and CD11c-positive dendritic cells form high endothelial venule-like vessels in the skin in murine atopic dermatitis model
J Immunol (2020) 204 (1_Supplement): 229.2.
Regulation of Id2 gene expression in plasmacytoid dendritic cells
J Immunol (2020) 204 (1_Supplement): 229.3.
The secretory pathway-resident SNARE Sec22b regulates nitric oxide and cytokine production in dendritic cells
Albert Descoteaux; Renaud Dion; Julien Descoteaux; Aymeric Fabié; Simona Stäger; Guillermo Arango Duque
J Immunol (2020) 204 (1_Supplement): 229.4.
MicroRNA-9 fine tunes dendritic cell function by suppressing negative regulators
Brendan Cordeiro; Peter Jeon; Giselle Boukhaled; Mario Corrado; Orsolya Lapohos; Dominic G Roy; Kelsey Williams; Russell G Jones; Samantha Gruenheid; Selena M. Sagan; Connie M. Krawczyk
J Immunol (2020) 204 (1_Supplement): 229.5.
Dissecting the molecular mechanisms underpinning T cell help for Dendritic Cell
J Immunol (2020) 204 (1_Supplement): 229.6.
Distinct roles of programmed cell death ligands 1 and 2, based on the type of immunity
J Immunol (2020) 204 (1_Supplement): 229.7.
miR-146a −/− deficiency in the DC compartment results in increased effector phenotype CD4+ and CD8+ T cells in response to LCMV infection
J Immunol (2020) 204 (1_Supplement): 229.9.
T Cell Homeostasis and Differentiation
PRMT5 controls pathogenicity and metabolic genes during Th17 polarization
Zayda L. Piedra-Quintero; Shouvonik Sengupta; Lindsay M Webb; Stephanie A Amici; Georgios Laliotis; Philip N Tsichlis; Mireia Guerau-de-Arellano
J Immunol (2020) 204 (1_Supplement): 230.1.
Dynamic changes in patterns of ganglioside expression characterize maturation of lymphoid lineage cells into effector cells and suggest a close relationship between CD8+ T cells and NK cells
Taylor Johnson; Mary-Peyton A. Knapp; Madison K. Ritter; Natalie D. King-Lyons; Jennifer T. Grier; Robert O Rainer; Terry D. Connell; Sergio Arce
J Immunol (2020) 204 (1_Supplement): 230.10.
RORγt-driven TH17 cell differentiation requires epigenetic control by the Swi/Snf chromatin remodeling complex
J Immunol (2020) 204 (1_Supplement): 230.14.
IFN-γ-induced nitric oxide leads to inhibition of Th17 differentiation via induction of iNOS and nitration of ROR-γ T
Rachel Robinson-Joern; Alina Dietz; Celeste Garza; Brian Moy; Neil Elijah S. Crisostomo; Dora Vukmirovic; Thomas Forsthuber
J Immunol (2020) 204 (1_Supplement): 230.15.
Lactoferrin and TGF-β1 synergize to enhance differentiation of OVA-specific Foxp3+ iTregs
J Immunol (2020) 204 (1_Supplement): 230.17.
Lactoferrin modulates BMDCs to be tolerogenic leading to enhancement of Foxp3+iTreg differentiation as well as suppression of T cell proliferation
J Immunol (2020) 204 (1_Supplement): 230.18.
Serine phosphorylation of CREB-binding protein (CBP) is critical to intestinal homeostasis but not CD4 T cell differentiation
J Immunol (2020) 204 (1_Supplement): 230.19.
A specific microbial metabolite influences the development of peripheral intraepithelial lymphocytes
J Immunol (2020) 204 (1_Supplement): 230.2.
Identification of splice isoforms in T helper cells using Nanopore-based cDNA sequencing
J Immunol (2020) 204 (1_Supplement): 230.20.
Foreign epitope-specific regulatory T cells respond robustly to vaccination and limit Th1 differentiation by conventional T cells specific for the same epitope
J Immunol (2020) 204 (1_Supplement): 230.21.
How do CD8+ T cells complete DNA replication in less than 4 hours?
Norie Sugitani; Tatiana Moiseeva; Yiyan Wang; Drake Palmer; Rhodes Ford; Sandra Schamus; Ankita Singh; Kathryn Lemon; Udai Kammula; Frank P Vendetti; Amanda Poholek; Hatice Osmanbeyoglu; Greg M. Delgoffe; Christopher J Bakkenist
J Immunol (2020) 204 (1_Supplement): 230.22.
Dissecting the mechanisms responsible for the generation of regulatory versus pathogenic human CD4+ T cells by TLR9-activated plasmacytoid dendritic cells
J Immunol (2020) 204 (1_Supplement): 230.3.
Temporal, TCR signal strength, and Notch signaling requirements for γδ T-cell functional programming and execution in vivo
J Immunol (2020) 204 (1_Supplement): 230.4.
Bile acid metabolites control Th17 and Treg cell differentiation
Saiyu Hang; Donggi Paik; Lina Yao; Trinath Jamma; Jingping Lu; Soyoung Ha; Brandon N Nelson; Samantha P Kelly; Lin Wu; Ye Zheng; Randy S Longman; Fraydoon Rastinejad; A Sloan Devlin; Michael R Krout; Michael A Fischbach; Dan R Littman; Jun R Huh
J Immunol (2020) 204 (1_Supplement): 230.6.
High-affinity tonic TCR:self-pMHC interactions inhibit T follicular helper cell development
J Immunol (2020) 204 (1_Supplement): 230.7.
T cell receptor repertoire features display universal rules for selection and plasticity in the functional CD4 T cell subsets
J Immunol (2020) 204 (1_Supplement): 230.9.
Microbial, Parasitic, and Fungal Immunity 3
Gut microbial composition and expression of host immune-related genes are tightly linked in the model teleost system, Gasterosteus aculeatus (three-spined stickleback)
J Immunol (2020) 204 (1_Supplement): 231.1.
Transcriptomic approaches elucidate novel aspects of the host immune response to candidemia
J Immunol (2020) 204 (1_Supplement): 231.10.
Pathogen-elicited memory γδ T cells express a broadly reactive canonical TCR or a pathogen-specific non-canonical TCR
Camille F Khairallah; Julie Bettke; Jessica Nancy Imperato; Yue Zhang; Zhijuan Qiu; Oleksandr Gorbatsevych; Kyungjin Cho; Kwang Soon Kim; Lynn Puddington; Charles D Surh; James B Bliska; Adrianus WM Van der Velden; Brian S Sheridan
J Immunol (2020) 204 (1_Supplement): 231.11.
IRF8 regulated interferon beta production drives Gram-negative bacteria-mediated NLRP3 inflammasome activation
J Immunol (2020) 204 (1_Supplement): 231.13.
Differential dynamics of the Jersey ruminal microbiome and immune response in the heat stress environment
J Immunol (2020) 204 (1_Supplement): 231.14.
Characterization of a potential Escherichia coli virulence factor identified in a screen using the social amoeba phagocyte, Dictyostelium discoideum
J Immunol (2020) 204 (1_Supplement): 231.15.
Molecular Mechanisms of Immune Dysregulation during Acute Orientia tsutsugamushi Infection in Mice
J Immunol (2020) 204 (1_Supplement): 231.16.
NOD2 promotes protective responses and recovery from Candida tropicalis infection in dextran sodium sulfate (DSS) colitic mice
Kristine-Ann G. Buela; Carlo De Salvo; Hannah Havran; Christopher Hager; Luca Di Martino; Fabio Cominelli; Mahmoud Ghannoum; Theresa Pizarro
J Immunol (2020) 204 (1_Supplement): 231.17.
Interferon Receptor 2 (IFNAR2) is involved in regulation of host damage responses and fungal clearance during Aspergillus fumigatus pulmonary infection
Kelly Shepardson; Laura Logan Johns; Zeynep Malkoc; Emiliano Hernandez; Clyde Schulein; Agnieszka Rynda-Apple
J Immunol (2020) 204 (1_Supplement): 231.18.
IFN-γ signaling is essential for the clearance of C. neoformans in the brain and survival of the infected mice
J Immunol (2020) 204 (1_Supplement): 231.2.
Controlled human infection with Neisseria lactamica induces B-cell responses that are cross-reactive with Neisseria meningitidis
Adam P Dale; Anastasia A Theodosiou; Jay R Laver; Eleanor F Roche; Alison R Hill; Andrew Gorringe; Marta E Polak; Andrew T Vaughan; Robert C Read
J Immunol (2020) 204 (1_Supplement): 231.21.
Vaccine elicited ASGM1+ CD8+ T cells are essential for protective immunity against Toxoplasma gondii infection
J Immunol (2020) 204 (1_Supplement): 231.22.
Immunity to Invasive Infection by Intestinal Commensal Microbes
J Immunol (2020) 204 (1_Supplement): 231.23.
Immune respones against Trypanosoma cruzi infection by oral route in cynomolgus macaques (Macaca fascicularis)
Pramod N Nehete; Sriram Chitta; Bharti P Nehete; Christian R Abee; Sarah A Hamer; Carolyn L Hodo; Gregory K Wilkerson
J Immunol (2020) 204 (1_Supplement): 231.24.
Apparent sterilizing immunity in BCG-immunized mice challenged with an ultra-low dose of Mycobacterium tuberculosis
Courtney R Plumlee; Fergal J Duffy; Benjamin H Gern; Jared L Delahaye; Sara B Cohen; Tige R Rustad; John D Aitchison; David R Sherman; Daniel E Zak; Michael Y Gerner; Kevin B Urdahl
J Immunol (2020) 204 (1_Supplement): 231.25.
Glucuronoxylomannan in the Cryptococcus species capsule as a target for CAR+ T-cell therapy
J Immunol (2020) 204 (1_Supplement): 231.26.
Using wild mice to interrogate immunological mechanisms of asymptomatic malaria
Douglas Cornwall; Mellina Srey; Franklin Maloba; Birk Evavold; Adesola C Olatunde; Anne Jensen; Tracey Lamb; Brian Evavold
J Immunol (2020) 204 (1_Supplement): 231.27.
The tropic life forms of Pneumocystis alter alveolar macrophage responses to inflammatory stimuli
J Immunol (2020) 204 (1_Supplement): 231.28.
Temporal patterns in single cell immune profile of tuberculosis lung granulomas
Hannah Priyadarshini Gideon; Travis K. Hughes; Marc H. Wadsworth, II; Sarah Nyquist; Philana Ling Lin; Sarah Fortune; Alex K Shalek; JoAnne L Flynn
J Immunol (2020) 204 (1_Supplement): 231.29.
Continuous generation of effector (Teff) and effector memory (Tem) T cells with mouse cytomegalovirus (MCMV) vaccination to prolong malaria immunity
J Immunol (2020) 204 (1_Supplement): 231.3.
Developmental immaturity of sialic acid recognition mediates neonatal susceptibility to GBS pneumonia
Sean J Lund; Kathryn A Patras; Jacqueline M Kimmey; Asami Yamamura; Lindsay D Butcher; Pamela G B Del Rosario; Gilberto E Hernandez; Alyssa M McCoy; Omar Lakhdari; Victor Nizet; Lawrence S Prince
J Immunol (2020) 204 (1_Supplement): 231.31.
Alveolar macrophages provide an early Mycobacterium tuberculosis niche and initiate dissemination
Sara Beth Cohen; Benjamin H Gern; Jared L Delahaye; Courtney R Plumlee; Michael Y Gerner; Kevin B Urdahl
J Immunol (2020) 204 (1_Supplement): 231.32.
Correlation of DNA Methylation Status and Immune Function in the Cytotoxic Immune Cells of Tuberculosis Patients
Tomoki Nishiguchi; Godwin Mtetwa; Alexander Kay; Gugu Maphalala; Anna Mandalakas; Cristian Coarfa; Andrew DiNardo
J Immunol (2020) 204 (1_Supplement): 231.33.
Antibiotic resistant Pseudomonas aeruginosa upregulate iron piracy genes during macrophage infection and evade killing
J Immunol (2020) 204 (1_Supplement): 231.34.
Sensory afferent neurons coordinate in host immune responses to Citrobacter rodentium
J Immunol (2020) 204 (1_Supplement): 231.35.
Initial phospholipid recognition on Toxoplasma vacuoles elicits IFN-inducible GTPase-mediated host defense
J Immunol (2020) 204 (1_Supplement): 231.36.
T cell-derived interferon-γ is required for host defense to Toxoplasma gondii
J Immunol (2020) 204 (1_Supplement): 231.37.
Role of meningeal lymphatic vessels in the T cell response against Toxoplasma gondii
Michael Kovacs; Igor Smirnov; Samantha J. Batista; Maureen N. Cowan; Katherine M. Still; Ashley C. Bolte; Tajie H. Harris
J Immunol (2020) 204 (1_Supplement): 231.4.
A novel variant in ubiquinone biosynthesis highly prevalent in Papua New Guinea children increases mortality following bacterial pneumonia
Emma C Walker; Rashmi Ramani; Sarah Javati; Elizabeth Todd; Pallavi Chandra; John-Paul Matlam; Edgar Anaya; William Pomat; Sharon Celeste Morley
J Immunol (2020) 204 (1_Supplement): 231.5.
VAMP3 as a negative regulator of Leishmania amazonensis infection and antigen cross-presentation
J Immunol (2020) 204 (1_Supplement): 231.6.
Identification and characterization of Escherichia coli genes associated with grazing resistance to the social amoeba Dictyostelium discoideum
J Immunol (2020) 204 (1_Supplement): 231.7.
Association of gut microbiota with spontaneous autoimmune uveitis studied by human flora reconstitution of germ-free mice
Amy Zhang; Reiko Horai; Ryan S. Salvador; Colm O’hUigin; Jonathan Badger; Wuxing Yuan; Vishal Thovarai; Katsuko Sudo; Koji Atarashi; Kenya Honda; Rachel R. Caspi
J Immunol (2020) 204 (1_Supplement): 231.8.
CD4 T cells are important in protection against M. tuberculosis reinfection in cynomolgus macaques
J Immunol (2020) 204 (1_Supplement): 231.9.
Infection and Immunity in the Gastrointestinal Tract
Maternal EGF protects offspring from enterally acquired bloodstream infections by limiting bacterial translocation in the neonatal intestine
J Immunol (2020) 204 (1_Supplement): 232.1.
Epithelial STAT6 O-GlcNAcylation drives type 2 mucosal immunity against helminth infection
J Immunol (2020) 204 (1_Supplement): 232.11.
Differential phenotypes and localization of CD8 T cell responses to acute and chronic viral infections
J Immunol (2020) 204 (1_Supplement): 232.12.
IL–17 receptor signaling regulates Citrobacter rodentium growth
Yasuka Matsunaga; Alanna Wanek; Cathy Flemington; Kejing Song; Naoki Iwanaga; Trevon Clark; Jacob P. Bitoun; Misty Good; Jay K. Kolls
J Immunol (2020) 204 (1_Supplement): 232.14.
Addition of rexinoids during T cell activation enhances mucosal-homing receptor expression and migratory ability of effector cells in vitro
J Immunol (2020) 204 (1_Supplement): 232.16.
Effect of muscarine and atropine in the synthesis and secretion of IgA by T-dependent and T-independent mechanisms in small intestine of mice
Aldo Arturo Resendiz Albor; Xóchitl Abril Rebollar-Ruíz; Ivonne Maciel Arciniega-Martínez; Mónica Miguel Santamaría-Chávez; Rafael Campos-Rodríguez
J Immunol (2020) 204 (1_Supplement): 232.17.
Anti-Vibrio cholerae responses in the human periphery and intestine following a live-attenuated vaccine
Lindsay E Nyhoff; Oluwaseyi Adekunle; Robert C Kauffman; Steven Keilin; Nadine Rouphael; Jens Wrammert
J Immunol (2020) 204 (1_Supplement): 232.2.
Diverse dendritic cell subsets promote infection and induction of CD8 T cell responses after foodborne Listeria monocytogenes infection
Jessica Nancy Imperato; Daqi Xu; Pablo A Romagnoli; Zhijuan Qiu; Pedro Perez; Camille F Khairallah; Quynh-Mai Pham; Simon W.F. Milling; Leo Lefrancois; Kamal M Khanna; Lynn Puddington; Brian S Sheridan
J Immunol (2020) 204 (1_Supplement): 232.3.
Tbet-expressing Tregs protect against lethal immunopathology during T. gondii infection
J Immunol (2020) 204 (1_Supplement): 232.4.
Streptococcus pneumoniae coinfection dictates susceptibility to oral Listeria monocytogenes through suppressive Natural Killer (NK) cell activity
J Immunol (2020) 204 (1_Supplement): 232.5.
CD4+ T cells modulates efficacy of microbiome transplantation in treatment of Clostridiodes difficile infection
J Immunol (2020) 204 (1_Supplement): 232.6.
Metabolic utilization of propanediol by adherent-invasive E. coli regulates intestinal tissue immunity
Monica Viladomiu; Maeva L Metz; Svetlana F Lima; Lance Chou; Chun-Jun Guo; Kenneth W Simpson; Ellen J Scherl; Randy Longman
J Immunol (2020) 204 (1_Supplement): 232.7.
Lymph Node Priming Licenses Intestinal CD103+ CD8 Tissue-Resident Memory T Cell Development
Zhijuan Qiu; Camille Khairallah; Jessica Nancy Imperato; Timothy H Chu; Daqi Xu; Galina Romanov; Lynn Puddington; Brian S Sheridan
J Immunol (2020) 204 (1_Supplement): 232.8.
The Effects of Quantum Dots Nanoparticles on Caenorhabditis elegans infected with Microsporidia
J Immunol (2020) 204 (1_Supplement): 232.9.
Intestinal Inflammation
Lymphotoxin-beta receptor expression by neutrophils prevents metabolic activation and colitis pathogenesis
Thomas Riffelmacher; Daniel Giles; Sonja Zahner; Alexander Andreyev; Sara McArdle; Tamara Perez; E.T.I. van der Gracht; Venetia Morris; Alexei Tumanov; Mitchell Kronenberg
J Immunol (2020) 204 (1_Supplement): 233.1.
Vitamin C insufficiency aggravates dextran sulfate sodium (DSS)-induced colitis and colitis-associated colon cancer by regulating IL-6 and IL-22 production in Gulo(−/−) mice
J Immunol (2020) 204 (1_Supplement): 233.10.
MicroRNA-146a limits tumorigenic IL-17-mediated inflammation in colorectal cancer
J Immunol (2020) 204 (1_Supplement): 233.11.
2B4 controls gut immune homeostasis by promoting IL-1β expression in Ly6Chigh monocytes that trigger IL-22/IL-18-mediated epithelial regeneration
J Immunol (2020) 204 (1_Supplement): 233.12.
The inflammatory response after an intestinal inflammatory challenge affects in an opposite manner to the female and male offspring gestated in hypothyroxinemia
Juan Carlos Rivera; Barbara Gutiérrez; Máximo Díaz; Linda Chamorro; Matías Estrella; Reynaldo Guajardo; Ignacio Díaz; María Cecilia Opazo; Helene Boudin; Michel Neunlist; Susan M Bueno; Pablo González; Alexis M Kalergis; Claudia Riedel
J Immunol (2020) 204 (1_Supplement): 233.13.
The Wnt-β-catenin-IL-10 signaling axis in intestinal antigen-presenting cells protects mice from colitis-associated colon cancer in response to gut microbiota
Mohamed Ahmed Shawky Hussein; Daniel Swafford; Arulkumaran Shanmugam; Punithavathi Ranganathan; Santhakumar Manicassamy
J Immunol (2020) 204 (1_Supplement): 233.14.
Ingestion of subtoxic doses of cadmium induces persistent dysbiosis and enhances susceptibility to DSS-induced colitis long after exposure
J Immunol (2020) 204 (1_Supplement): 233.15.
Toll-like receptor 7 protects against intestinal inflammation and restricts the development of tissue-resident memory CD8+ T cells
Hussein Hamade; Jasmine Stamps; Lisa Thomas; Dalton Stamps; Masato Tsuda; Naoki Oshima; Michelle Wong; Brenda Salumbides; Caroline Jin; Jordan Nunnelee; Stephan R Targan; Kathrin S Michelsen
J Immunol (2020) 204 (1_Supplement): 233.16.
ECM1 is an essential factor for the determination of M1 macrophage polarization in inflammatory bowel disease in response to LPS stimulation
J Immunol (2020) 204 (1_Supplement): 233.17.
Cigarette smoke has opposite effects in murine models of ulcerative colitis and Crohn’s disease through mucosal immunity and gut environment
J Immunol (2020) 204 (1_Supplement): 233.19.
Formation of mesenteric tertiary lymphoid organs shapes the immune cell and lymph trafficking from the intestine in a Crohn’s disease-like mouse model
Rafael Sanguinetti Czepielewski; Emily J Onufer; Emma Erlich; Ki-Wook Kim; Brian Saunders; Shannon Young; Shashi Kumar; Bernd Zinselmeyer; Chyi-Song Hsieh; Michael J Davis; Gwendalyn J Randolph
J Immunol (2020) 204 (1_Supplement): 233.2.
B cells produce anti-inflammatory cytokine IL-27 in the gut upon induction by cyclic dinucleotides and to prevent murine colitis
Shuai Wu; Hui Yan; Carlos Eduardo Rivera; Jingwei Wang; Maria Fernandez; Xiaodong Li; Xiaoyan Wang; Zhenming Xu
J Immunol (2020) 204 (1_Supplement): 233.21.
Integrin β7 is required for B cell migration and regulation of the intestinal microbiota during colitis
J Immunol (2020) 204 (1_Supplement): 233.24.
Antagonists of chemokine receptor CCR9 synergize with anti-TNFα immunotherapy to reduce inflammation in the MDR1a−/− mouse model of colitis
James J Campbell; Linda S Ertl; Karen J Ebsworth; Jeffrey P McMahon; Penglie J Zhang; Vicky J Chhina; Israel F Charo; Thomas J Schall
J Immunol (2020) 204 (1_Supplement): 233.3.
Glucose promotes Treg differentiation and suppresses intestinal inflammation
J Immunol (2020) 204 (1_Supplement): 233.5.
Indole-3-carbinol prevents colitis and regulates microbial dysbiosis by induction of anti-microbial peptides and mucins in an IL-22 dependent manner
J Immunol (2020) 204 (1_Supplement): 233.6.
Intestinal colonization with IL-10 inducing adherent E. coli protects from intestinal inflammation and tumor development
Gretchen Diehl; Daniel Zegarra Ruiz; Dasom Kim; Kendra Norwood; Andrea A. Hill; Fatima Beatriz Saldana Morales
J Immunol (2020) 204 (1_Supplement): 233.7.
Microbial hydrogen economy alleviates colitis by reprogramming colonocyte metabolism and reinforcing intestinal epithelial barrier
Li Ge; Jie Qi; Xueqiang Sun; Shuman Liu; Pengfei Li; Hao Chen; Bo Shao; Shiyang Wang; Zhenzhen Ruan; Wengang Song
J Immunol (2020) 204 (1_Supplement): 233.9.
Airway Immunity
A novel lung DC(3) population potently induces Th17 responses to inhaled allergens
J Immunol (2020) 204 (1_Supplement): 234.1.
Exosomal miRNA19a from primary human nasal epithelial cells induce pro-inflammatory responses of macrophages via RORA
J Immunol (2020) 204 (1_Supplement): 234.10.
Efferocytosis mediated by TAM receptors maintains lung homeostasis and controls inflammation in a mouse model of silicosis
Kamila Guimaraes Pinto; Antonia Castro Ferreira; Monique Leandro; Marcela F Lopes; Estefania Vazquez; JianPing He; Brian L Kelsall; Alessandra Filardy
J Immunol (2020) 204 (1_Supplement): 234.11.
B cell-specific S1P1 deletion reshapes both B and T cell activation profiles in hypersensitivity pneumonitis
J Immunol (2020) 204 (1_Supplement): 234.12.
Inhibition of Acute Type-2 Lung Inflammation by 2′3′-cyclic Guanosine Monophosphate-Adenosine Monophosphate (2′3′-cGAMP)
Li She; Gema Barrera; Liping Yan; Hamad Alanazi; Edward Brooks; Peter Dube; Yilun Sun; Yong Liu; Nu Zhang; Xin zhang; Xiao-Dong Li
J Immunol (2020) 204 (1_Supplement): 234.13.
Do inflammasomes play a role in controlling cell damage/injury (ARDS) in order to initiate the cascade of healing and tissue repair?
Jenny May-Sim Lau; Emma McKay; Joseph Curran; Tara Bertholon; Anna Krasnodembskaya; Rebecca Ingram; Denise Fitzgerald; Cecilia O’Kane; Yvonne Dombrowski
J Immunol (2020) 204 (1_Supplement): 234.15.
Klebsiella Pneumoniae Mucosal Vaccination Elicits Lung CD4+ TRM cells that are resistant to CD4 depleting antibodies
J Immunol (2020) 204 (1_Supplement): 234.17.
Antifibrotics Modify B-cell Induced Fibroblast Migration and Activation in IPF Patients
Mohamed Ali; Ashley M Egan; Gaja F Shaughnessy; Harika Dasari; Virginia P. Van Keulen; Marie Christine Aubry; Andrew H Limper; Tobias Peikert; Eva M Carmona
J Immunol (2020) 204 (1_Supplement): 234.18.
Heterogeneity of regulatory T cells during lung inflammation
Weishan Huang; Kaixiong Ye; Natalie F Nidetz; Michael C McGee; Rezwanul Islam; Candice B Limper; Avery August
J Immunol (2020) 204 (1_Supplement): 234.19.
Distinct memory γδ T cell subsets are fine-tuned by TCR engagement and soluble signals to shape IFNγ and IL-17A responses
J Immunol (2020) 204 (1_Supplement): 234.2.
Anti-dsDNA specific antibody secreting cells are increased in both frequency and abundance in Chronic Rhinosinusitis with Nasal Polyps
J Immunol (2020) 204 (1_Supplement): 234.20.
Role of NFKB signaling in Respiratory Epithelial Cells in Vaccine-Induced T Cell Immunity to Influenza
Tracy NK Luu; Brock Kingstad-Bakke; Chandramaik Marinaik; Autumn Rose Larsen; Marulasiddappa R Suresh
J Immunol (2020) 204 (1_Supplement): 234.21.
IL-25-responsive migratory iILC2s require BATF and stably convert to tissue-resident nILC2s
J Immunol (2020) 204 (1_Supplement): 234.3.
IL-7 shapes a multifaceted CD8 T cell response to airway Influenza/A infection
J Immunol (2020) 204 (1_Supplement): 234.4.
Airway mucociliary dysfunction enhances antigen-specific nasal IgA immune responses to cholera toxin-based nasal vaccine
Huangwenxian Lan; Hidehiko Suzuki; Takahiro Nagatake; Koji Hosomi; Koji Ikegami; Mitsutoshi Setou; Jun Kunisawa
J Immunol (2020) 204 (1_Supplement): 234.6.
The role of RUBCN in exacerbating allergic airway inflammation
Jennifer Martinez; Thomas H Oguin; Joseph P Kolb; Gregory Whitehead; Seddon Y Thomas; Ginger W Muse; Laura Miller DeGraff; Donald N. Cook
J Immunol (2020) 204 (1_Supplement): 234.7.
Compartmentalized effects of aging on group 2 innate lymphoid cell development and function
Shanti D’Souza; Xiaofei Shen; Ivan T. H. Fung; Longyun Ye; Marcy Kuentzel; Sridar V. Chittur; Yoichi Furuya; Christian W. Siebel; Ivan P. Maillard; Dennis W. Metzger; Qi Yang
J Immunol (2020) 204 (1_Supplement): 234.8.
Reduced A20 expression in nasal epithelial cells correlates with disease severity in patients with chronic rhinosinusitis with nasal polyps
J Immunol (2020) 204 (1_Supplement): 234.9.
Development and Homeostasis of Mucosal Immunity
Krüppel-Like-Factor 2, a new player in mucosal IgA homeostasis
Jens Wittner; Sebastian R Schulz; Tobit Steinmetz; Andreas R Hutloff; Adam F Cunningham; Hans-Martin Jäck; Wolfgang Schuh
J Immunol (2020) 204 (1_Supplement): 235.10.
Eosinophil accumulation in postnatal lung is specific to the primary septation phase of development
Mackenzie Coden; Lucas F Loffredo; Brian M Jeong; Matthew Walker; Kishore Reddy Anekalla; Ton Doan; Raul Rodriguez; Mandy Browning; Kiwon Nam; James Lee; Hiam Abdala-Valencia; Sergejs Berdnikovs
J Immunol (2020) 204 (1_Supplement): 235.11.
Zom-biecoming: Single-Cell RNA-sequencing reveals senescence-like features of alveolar macrophages during aging
Yue Wu; Bibo Zhu; Ruixuan Zhang; Nicholas PJ. Goplen; Zheng Wang; Ying Li; Amber Cardani-Boulton; Thomas J Braciale; Jie Sun
J Immunol (2020) 204 (1_Supplement): 235.13.
ST2-expressing B1 B cells acquire an anti-inflammatory capacity during pregnancy in mice
J Immunol (2020) 204 (1_Supplement): 235.14.
Human Chorionic Gonadotropin acts as a central regulator of adaptive immune responses during early pregnancy safeguarding fetal survival
J Immunol (2020) 204 (1_Supplement): 235.17.
Lymphocytes in autoimmune-resistant mice may protect the islets through IL-10 production
Jennifer C Whitesell; Robin S Lindsay; Seth Yannacone; Jessica Olivas-Corral; Erin Lucas; Rachel S. Friedman
J Immunol (2020) 204 (1_Supplement): 235.18.
Baby’s First Macrophage: characterizing Hofbauer Cell phenotype through gestation using unsupervised dimensionality reduction
J Immunol (2020) 204 (1_Supplement): 235.19.
Early dynamic accumulation of tissue resident memory T cells in the human lung during infancy
Rei Matsumoto; Thomas Connors; Basak Burcu Ural; Rebecca Guyer; Emma Idzikowski; Maya M.L. Poon; Puspa Thapa; Donna L Farber
J Immunol (2020) 204 (1_Supplement): 235.2.
Age-related changes in the immune phenotype of human memory CD4 T cells differ between colon and peripheral blood
J Immunol (2020) 204 (1_Supplement): 235.20.
The role of old age on Mycobacterium bovis BCG vaccine-induced tissue immunity
Julia M Scordo; Tucker J Piergallini; Colwyn A Headley; Vida Hodara; Nicole Reuter; James F Papin; Joanne Turner
J Immunol (2020) 204 (1_Supplement): 235.22.
Oral administration of antigen mainly induces T helper lineage-negative CD200+ CTLA4+ anergic CD4+ T cells which tend to become regulatory T cells
J Immunol (2020) 204 (1_Supplement): 235.23.
Distinct contributions of CRAMP produced by epithelial cells and macrophages to colon mucosal homeostasis
J Immunol (2020) 204 (1_Supplement): 235.24.
Antigen recognition by CD8+ T cells in non-lymphoid tissues initiates a transcriptional program of tissue-resident memory differentiation
J Immunol (2020) 204 (1_Supplement): 235.3.
Genetic regulation of immune homeostatic lung leukocyte populations
Brea K Hampton; Kara Jensen; Alan C. Whitmore; Clayton R. Morrison; Kenneth S. Plante; Sarah R. Leist; Lisa E. Gralinski; Vineet D. Menachery; Alexander Schäfer; Fernando Pardo-Manuel de Villena; Ralph S. Baric; Mark T. Heise; Martin T. Ferris
J Immunol (2020) 204 (1_Supplement): 235.4.
Epithelial cell intrinsic IL-1R signaling regulates intestinal homeostasis and inflammation
J Immunol (2020) 204 (1_Supplement): 235.6.
Human T cell immunity in barrier sites is phenotypically distinct but clonally connected to other sites
Maya ML Poon; Wenzhao Meng; Pranay Dogra; Nora Lam; Peter A Szabo; Masaru Kubota; Rei Matsumoto; Adeeb Rahman; Eline T Luning Prak; Donna L Farber
J Immunol (2020) 204 (1_Supplement): 235.7.
Comparison of the therapeutic effects between topical 8-oxo-2′-deoxyguanosine and steroid in ocular chemical burn experimental model
J Immunol (2020) 204 (1_Supplement): 235.9.
Innovations in SLE Therapeutics
Verdinexor, a selective inhibitor of nuclear export, decreases plasma cell survival in human lupus
Neha D Nandedkar; Nida Meednu; Jennifer Albrecht; Javier Rangel-Moreno; Jennifer L Barnas; Douglas G Widman; Jennifer H Anolik
J Immunol (2020) 204 (1_Supplement): 236.1.
Targeting interferon regulatory factor 5 (IRF5) activation with a peptide inhibitor ameliorates clinical lupus in MRL/lpr mice
J Immunol (2020) 204 (1_Supplement): 236.10.
Retinoic acid exerts disease stage-dependent and tissue-specific effects on pristane-induced lupus
Leila Abdelhamid; Xavier Cabana-Puig; Brianna Swartwout; Jiyoung Lee; Song Li; Sha Sun; Yaqi Li; A. Catharine Ross; Thomas E. Cecere; Tanya LeRoith; Haifeng Wang; Christopher M. Reilly; Xin M. Luo
J Immunol (2020) 204 (1_Supplement): 236.11.
Human gingiva-derived mesenchymal stem cells are therapeutic in lupus nephritis through targeting of CD39-CD73 signaling pathway
J Immunol (2020) 204 (1_Supplement): 236.13.
Deletion of Dnase1L3 from Macrophages results in reduced serum Dnase activity in mice
J Immunol (2020) 204 (1_Supplement): 236.15.
Lupus pathogenesis and autoimmunity are exacerbated by high fat diet-induced obesity in mice
Xin Zhang; Juan Meng; Xuhua Shi; Hiba Ali; Linh Hellmers; Neeha Mathew; Talon Washington; Robert Quinet; William Davis; Jerald Zakem; Chandana Keshavamurthy; Zongbing You
J Immunol (2020) 204 (1_Supplement): 236.17.
Hydroxychloroquine enhances efferocytosis and inhibits IL-6 and TNF-α productions through upregulating both Gas6/Axl and MFG-E8/TG2 Signaling pathways in Pristine-induced lupus mice
Gregory J Tsay; Fei-Hung Hsieh; Ting-Yin Xue; Hsin-Yi Peng; Yan-Chi Tsao; Mei-Chin Yin; Jiunn-Horng Chen; Chung-Ming Huang; Der-Yuan Chen; Joung-Liang Lan
J Immunol (2020) 204 (1_Supplement): 236.18.
Male microbiota-associated metabolites restore macrophage apoptotic cell clearance function in female lupus-prone mice
J Immunol (2020) 204 (1_Supplement): 236.2.
Response Gene to Complement -32 facilitates local recruitment of IL-17-producing cells in immune complex mediated glomerulonephritis through the CCR6/CCL20 axis
Violeta Rus; Alexandru Tatomir; Vinh Nguyen; John Papadimitriou; Cinthia Drachenberg; Sun-Sang J Sung; Shu Man Fu; Irina G Luzina; Tudor Constantin Badea; Horea G Rus
J Immunol (2020) 204 (1_Supplement): 236.3.
Immune-phenotyping IRF5 genetic risk and in vivo targeting of Irf5 hyper-activation in mouse models of lupus
J Immunol (2020) 204 (1_Supplement): 236.4.
Fli-1 inhibitors reduce the production of inflammatory cytokines in human renal glomerular endothelial cells and ameliorate lupus nephritis in NZB/W F1 mice
J Immunol (2020) 204 (1_Supplement): 236.5.
Amelioration of skin and kidney disease in a spontaneous murine lupus model via CD6 modulation
Samantha A. Chalmers; Sayra J Garcia; Rajalakshmy Ayilam Ramachandran; Chandra Mohan; Leal Herlitz; Jeanette Ampudia; Cherie Ng, PhD; Stephen Connelly, PhD; Chaim Putterman
J Immunol (2020) 204 (1_Supplement): 236.6.
Therapeutic Benefit of Regulating Iron Metabolism in Spontaneous Lupus Nephritis
Yogesh Scindia; Ewa Wlazlo; Elizabeth Ghias; Valentina Voi; Sylvia Cechova; Joseph Leeds; Sundararaman Swaminathan
J Immunol (2020) 204 (1_Supplement): 236.7.
Neutralizing CXCL13 attenuates neuropsychiatric manifestations in lupus-prone mice
J Immunol (2020) 204 (1_Supplement): 236.8.
Cell therapy targeting follicular T cells as an innovative approach for treating autoimmune disease
Kelly M Rangel; Seth D Reighard; David E Ochayon; Durga Krishnamurthy; Wen-Hai Shao; Stephen N Waggoner
J Immunol (2020) 204 (1_Supplement): 236.9.
Novel Therapeutic Approaches in DM, IBD, Arthritis, and Autoimmune Skin Disease
Tumor necrosis factor like weak inducer of apoptosis (TWEAK) Promotes Inflammatory Activity in Keratinocytes with IL-17 and TNF to Drive Psoriasis
J Immunol (2020) 204 (1_Supplement): 237.1.
Augmentation of the Conversion of 25-hydroxyvitamin D into 1,25-Dihydroxyvitamin D Specifically in Inflamed Intestines for the Treatment of Inflammatory Bowel Disease
J Immunol (2020) 204 (1_Supplement): 237.10.
Prevention of Type 1 Diabetes via a lipid Nanoparticle-Based Oral Immunotherapy that Targets Selective Lymphoid Tissues
YICHUAN ZHANG; Jialu Wang; Xiomara Calderon-Colon; Olivia Tiburzi; Marcos Iglesias Lozano; Julia B. Patrone; Giorgio Raimondi
J Immunol (2020) 204 (1_Supplement): 237.11.
Endogenous antisense regulates CD39 in Crohn’s disease upon interaction with nucleolin and heterogeneous-nuclear-ribonucleoprotein-A1
Marta Vuerich; Rasika Harshe; Anyan Xie; Luiza Abrahão-Frank; Barbora Gromova; Haohai Zhang; Samiran Mukherjee; Rene’ J. Robles; Alan C. Moss; Simon C. Robson; Maria Serena Longhi
J Immunol (2020) 204 (1_Supplement): 237.12.
Endogenous IL-33 contributes to Treg expansion induced by IL-2/CD25, a novel IL-2 biologic developed for low-dose IL-2 therapy
J Immunol (2020) 204 (1_Supplement): 237.13.
Transferable Immune Reactive Microbiota Determine Clinical and Immunologic Outcome of FMT in UC
Svetlana Ferreira Lima; Lasha Gogokhia; Monica Viladomiu; Viola Woo; Andrew Marderstein; Gregory Putzel; Ellen J Scherl; Su-Ellen Brown; John Hambor; Melissa Rosenthal; Vinita Jacob; Carl Crawford; Lance Chou; Randy Longman
J Immunol (2020) 204 (1_Supplement): 237.14.
Impact of curcumin and its metabolites on the immune response of type 1 diabetes-prone mice
J Immunol (2020) 204 (1_Supplement): 237.15.
The VR23 anticancer proteasome inhibitor also exhibits anti-inflammatory activity through the downregulation of the IL-6-JAK-STAT pathway
J Immunol (2020) 204 (1_Supplement): 237.17.
Pharmacological activation of protein tyrosine phosphatase SHP-1 ameliorates autoimmune arthritis in mice
J Immunol (2020) 204 (1_Supplement): 237.18.
Mesenchymal stem cells derived exosomes promote the expansion of Bregs and alleviate the collagen-induced arthritis
J Immunol (2020) 204 (1_Supplement): 237.19.
Tolerogenic nanoliposomes for the treatment of Rheumatoid Arthritis
Jessica Kenison-White; Dominika J Nowakowska; Aditi Jhaveri; Nikita Khase; Sara Tezza; David Sherr; Francisco Javier Quintana
J Immunol (2020) 204 (1_Supplement): 237.2.
Saliva plebeia ameliorates articular carttilage degration of osteoarthritis induced rats
Sung Hyen Lee; Eun-Byeol Lee; Ji-Hye Choi; Sae-Kwang Ku; Beom-Rak Choi; Jung-Bong Kim; Hwan-Hee Jang; Kyung-Ah Hwang; Shin-Young Park
J Immunol (2020) 204 (1_Supplement): 237.20.
High-content screening assay for compounds that enhance or inhibit leukocyte superoxide production to identify drugs for treating immune-mediated diseases
J Immunol (2020) 204 (1_Supplement): 237.21.
Pneumocystis jiroveci pneumonia in rheumatoid arthritis patient treated with methotrexate but without prednisolone: A case report
J Immunol (2020) 204 (1_Supplement): 237.22.
ST8Sia6 overexpression in beta cells prevents onset of autoimmune diabetes in the murine NOD model
J Immunol (2020) 204 (1_Supplement): 237.24.
IL-35 producing antigen presenting cells in type 1 diabetes
J Immunol (2020) 204 (1_Supplement): 237.25.
Peptide fragments of cystatin protein from filarial parasite has potent anti-inflammatory effect on DSS-induced colitis in mouse
J Immunol (2020) 204 (1_Supplement): 237.28.
Blockade of the neurokinin-1 receptor in keratinocytes prevents neuroinflammation and decreases innate and adaptive immune responses in the skin
Mohna Bandyopadhyay; Adrian E Morelli; Geza Erdos; Tina L Sumpter; Olga Tkacheva; William Shufesky; Louis D Falo; Adriana T Larregina
J Immunol (2020) 204 (1_Supplement): 237.3.
Generation of islet antigen-specific engineered Treg for use in T1D therapy via homology-directed gene editing of conventional CD4+ T cells
Soo Jung Yang; Akhilesh Singh; Peter Cook; Yuchi Honaker; Tori Tappen; Kelsey Mauk; Jessica Smith; Karen Sommer; David J Rawlings; Jane H Buckner
J Immunol (2020) 204 (1_Supplement): 237.30.
CHOP depletion does not prevent gut inflammation in experimental spondyloarthritis
J Immunol (2020) 204 (1_Supplement): 237.4.
CD126 negative regulatory cells represents a superior Treg subset in treating autoimmune diseases
J Immunol (2020) 204 (1_Supplement): 237.5.
The Endocannabinoid System: a new anti-inflammatory target in rheumatoid arthritis
KYLE BOON CHIN TAN; Elaine K Murray; Steven Watterson; Denis Alexander; James Linden; David S Gibson
J Immunol (2020) 204 (1_Supplement): 237.7.
Defining the role for the gut microbiome in the clinical efficacy of sulfasalazine therapy for IBD associated spondyloarthritis
Svetlana Ferreira Lima; Randy Longman; Amanda Rupert; Monica Viladomiu; Andrew Marderstein; Gregory Putzel; Gabriela Funez-dePagnier; Viola Woo; Maeva L Metz; Ellen J Scherl; Lance Chou
J Immunol (2020) 204 (1_Supplement): 237.8.
Autoimmunity Therapeutics Potpourri
Chimeric antigen receptor signaling confers antitumor activity to human regulatory T cells
Leonardo Ferreira; Yannick D. Muller; Anupurna M. Kaul; Hashim Shaikh; Ryan Guerrero-Moreno; Lilian E. Yao; Daniel B. Goodman; Jeffrey A Bluestone; Qizhi Tang
J Immunol (2020) 204 (1_Supplement): 238.1.
Iloprost-treated dendritic cells promote antigen-specific regulatory T cell differentiation in mice
Tzu-Hsuan Wong; Rong-Jiun Gau; Yu-Fang Chen; Hsin-Hsin Shen; Carl Tsai-Yu Lin; Sen-Lu Chen; Jau-Ling Suen
J Immunol (2020) 204 (1_Supplement): 238.10.
Olfactory ecto-mesenchymal stem cells derived exosomes reverse the immunosuppressive capacity of myeloid-derived suppressor cells to ameliorates experimental Sjögren’s syndrome
J Immunol (2020) 204 (1_Supplement): 238.11.
IL-37 increases liver inflammation in Con A-induced hepatitis by increasing IFN-γ secretion of infiltrated NK Cells
J Immunol (2020) 204 (1_Supplement): 238.12.
Antigen-specific suppression of previously activated T cell responses via polymeric GalNAc antigen conjugation
J Immunol (2020) 204 (1_Supplement): 238.13.
Effect of Curcumin on pro-inflammatory cytokines in primary Sjögren’s Syndrome
J Immunol (2020) 204 (1_Supplement): 238.14.
Novel mRNA-based Therapeutics to Modulate T and B Cell Signaling and Function
J Immunol (2020) 204 (1_Supplement): 238.15.
Single-cell analysis of autoreactive B cells in patients with systemic sclerosis revealed that responses to therapy are determined by effector and regulatory B cell balance
J Immunol (2020) 204 (1_Supplement): 238.16.
Antigen targeted to the apoptotic pathway via dying erythrocytes leads to profound T cell exhaustion and tolerance
J Immunol (2020) 204 (1_Supplement): 238.17.
Combining tolerogenic agents with dexamethasone synergistically inhibits innate inflammatory responses
J Immunol (2020) 204 (1_Supplement): 238.18.
Improving Hematopoietic Stem Cell transplantation with Flonase for potential use in treating a novel mouse model of Idiopathic Thrombocytopenic Purpura
J Immunol (2020) 204 (1_Supplement): 238.19.
Antigen-specific B cell depletion with desmoglein 3 chimeric autoantibody receptor T cells (DSG3-CAART) for targeted therapy of mucosal pemphigus vulgaris
Daniel Kjell Lundgren; Jinmin Lee; Xuming Mao; Silvio Manfredo-Vieira; Baomei Wang; Selene Nunez-Cruz; Erik Williams; Joseph Fraietta; Michael Milone; Aimee Payne
J Immunol (2020) 204 (1_Supplement): 238.2.
Metabolite changes and anti-inflammatory effects of Astragalus membranaceus Radix by fermentation with Aspergilus strains
Sung Hyen Lee; Shin-Young Park; Da-Bin Lee; Eun-Jung Lee; Bit-Na Song; Bo-Ram Park; Ji-Ho Choi; Eun-Byeol Lee
J Immunol (2020) 204 (1_Supplement): 238.20.
JMJD3-deficient impair CD4 T cell trafficking in autoimmune disease models and adoptive immunotherapy models by targeting cytoskeleton genes
J Immunol (2020) 204 (1_Supplement): 238.21.
Lidocaine improves psoriasis by calming down inflammatory cells
J Immunol (2020) 204 (1_Supplement): 238.22.
BAFF-R: A new target for depletion of pathogenic B cells in experimental lupus
J Immunol (2020) 204 (1_Supplement): 238.4.
Contact-dependent suppression of FVIII-specific memory B cells by BAR-Tregs
J Immunol (2020) 204 (1_Supplement): 238.5.
Myelin-specific CD8 T cells require IFNγ responsiveness to optimally suppress CNS autoimmunity
J Immunol (2020) 204 (1_Supplement): 238.6.
In Vivo Generation of Autoantigen-specific Treg Cells in Treating Experimental Autoimmune Uveitis Without Compromising Anti-Tumor Immunity
J Immunol (2020) 204 (1_Supplement): 238.7.
Use of CART cells to selectively target autoantigen-specific T cells for the treatment of autoimmune diabetes
Hua Yu; Maria Bettini; Gavin Ellis; James L Riley; Jesse Collins; Paula Preston-Hurlburt; Maria Korah; Roberto Mallone; Songyan Deng; Xiaoli Wang; Daved H. Fremont; David Spiegel; Peter Cresswell; Kevan C Herold
J Immunol (2020) 204 (1_Supplement): 238.8.
Chloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases
J Immunol (2020) 204 (1_Supplement): 238.9.
Cellular Therapies and Vaccines for Cancer
CRS free T cell therapy: T cell membrane anchored and tumor targeted IL12 (ATTIL12)-T cell therapy eliminates large tumors, overcomes heterogeneity, and avoids adverse effects
Jiemiao Hu; Wendong Zhang; Xueqing Xia; Qing Yang; Yuhui Chen; Natalie W Fowlkes; John Andrew Livingston; Zhongting Zhang; Kris M Mahadeo; Jonathan B Gill; Gianpietro Dotti; Scott Kopetz; Richard Gorlick; Shulin Li
J Immunol (2020) 204 (1_Supplement): 239.1.
Anaplastic lymphoma kinase fusions as a target for TCR-directed cellular therapies
J Immunol (2020) 204 (1_Supplement): 239.10.
High affinity oligoclonal TCRs define effective adoptive T-cell therapy targeting mutant KRAS-G12D
Malcolm John Wyness Sim; Jinghua Lu; Matthew Spencer; Francis Hopkins; Eric Tran; Steven A Rosenberg; Eric O Long; Peter Daopin Sun
J Immunol (2020) 204 (1_Supplement): 239.11.
Mechanisms of “Peptide Alarm Therapy”: Can antiviral memory T cells directly kill cancer cells in an MHC Class I-dependent way?
J Immunol (2020) 204 (1_Supplement): 239.12.
Synthetic MyD88 co-stimulation in donor CD8+ T cells enhances T cell activation, function, and tumor control in experimental hematopoietic cell transplant
J Immunol (2020) 204 (1_Supplement): 239.13.
Identification of T cells specific for DNAJB1-PRKACA fusion neoantigens in fibrolamellar carcinoma
Allison M Kirk; Jeremy Chase Crawford; Anthony E Zamora; Kaity Allen; Xiaoyu Zhang; Scott E Strome; Paul G Thomas
J Immunol (2020) 204 (1_Supplement): 239.14.
Engineering Chimeric Antigen Receptor T cells Against Immune Checkpoint Inhibitors PD-1/PD-L1 for Treating Pancreatic Cancer
J Immunol (2020) 204 (1_Supplement): 239.15.
Unbiased analysis of all possible neoepitopes of MC38-FABF tumor reveals a new universe of cancer neoepitopes with unexpected properties
Mariam M George; Cory A Brennick; Marmar M Moussa; Adam T Hagymasi; Sahar Al Seesi; Tatiana V Shcheglova; Ryan P Englander; Grant L.J Keller; Jeremy L Balsbaugh; Brian M Baker; Ion I. Mandoiu; Pramod K Srivastava
J Immunol (2020) 204 (1_Supplement): 239.18.
Establishment and Preclinical Therapy of Patient-derived Hepatocellular Carcinoma Xenograft Model
J Immunol (2020) 204 (1_Supplement): 239.2.
Modulating extracellular TCR-CD3 interaction to identify new immunotherapy targets against cancer
Michelle Krogsgaard; Aswin Natarajan; Yogambigai Velmurugu; Zhou Yuan; Chenghao Ge; Vidushan Nadarajah; Timothy Cardozo; William C. Bracken; Cheng Zhu
J Immunol (2020) 204 (1_Supplement): 239.22.
Treatment of CEA-positive solid tumors with anti-CEA chimeric antigen receptor T-cells in CEA transgenic mice
J Immunol (2020) 204 (1_Supplement): 239.25.
Enhancing ADCC by human natural killer cells to improve tumor cell killing
Kristin M Snyder; Robert Hullsiek; Hemant Kumar Mishra; Kate J Dixon; Daniel C Mendez; Yunfang Li; Allison Rogich; Jianming Wu; Bruce Walcheck
J Immunol (2020) 204 (1_Supplement): 239.26.
Bispecific anti-CD22 T-cell engager efficiently promotes cell-mediated cytotoxicity of lymphoma, leukemia and sarcoma targets
J Immunol (2020) 204 (1_Supplement): 239.27.
Inhibition of TET (Ten-Eleven Translocation) enzymes enhances systemic anti-tumor immune responses in T cells
J Immunol (2020) 204 (1_Supplement): 239.3.
Metformin reduces PD-L1 expression in the tumor and enhances the efficacy of vaccine generated CD8 T cells in a murine model of triple negative breast cancer
J Immunol (2020) 204 (1_Supplement): 239.33.
Heteroclitic peptide cancer vaccine counters MHC-I skewing in mutant calreticulin-positive myeloproliferative neoplasms
Mathieu Gigoux; Roberta Zappasodi; Joseph J Park; Stephane Pourpe; Arnab Ghosh; Cansu Cimen Bozkus; Levi M.B. Mangarin; David Redmond; Svena Verma; Sara Schad; William Duke; Matthew Leventhal; Max Jan; Vincent Ho; Gabriella Hobbs; Trine Alma Knudsen; Vibe Skov; Lasse Kjær; Thomas Stauffer Larsen; Dennis Lund Hansen; R Coleman Lindsley; Hans Hasselbalch; Jacob H Grauslund; Mads H Andersen; Morten O Holmström; Timothy Chan; Raajit Rampal; Omar Abdel-Wahab; Nina Bhardwaj; Jedd D Wolchok; Ann Mullally; Taha Merghoub
J Immunol (2020) 204 (1_Supplement): 239.34.
Immunotherapy for solid tumors: Chimeric antigen receptor (CAR) T-cells and the tumor microenvironment
J Immunol (2020) 204 (1_Supplement): 239.36.
Targeting REGNASE-1 improves efficacy of chimeric antigen receptor T cell therapy for leukemia
J Immunol (2020) 204 (1_Supplement): 239.38.
THERAPEUTIC EFFECTS OF TRAIL-SECRETING MESENCHYMAL STEM CELLS WITH FOCUSED ULTRASOUND-INDUCED TEMPORARILY OPENING OF BLOOD-BRAIN BARRIERS IN THE BRAIN TUMOR
J Immunol (2020) 204 (1_Supplement): 239.39.
A New Cellular Cancer Immunotherapy Platform Technology Using Autologous Human Adipose-Derived Mast Cells
Mohammad Fereydouni; Mona Motaghed; Elnaz Ahani; Whitney Moorman; Sung Hyun Lee; Tal Kafri; Christopher L. Kepley
J Immunol (2020) 204 (1_Supplement): 239.4.
The importance of CD4+ Tumor-Infiltrating Lymphocytes (TIL) in Adoptive Cell Transfer
MacLean Hall; Autumn Joerger; Ellen Scott; Ben Schachner; Amy M. Weber; Luz Nagle; Jamie Blauvelt; Shayna Smeltzer; Jennifer Morse; M. Scott Kidd; Doris Wiener; Allison Richards; Carolyn Jeani Rich; Krithika Kodumudi; Matthew S. Beatty; Amod A. Sarnaik; Shari Pilon-Thomas
J Immunol (2020) 204 (1_Supplement): 239.6.
Super2-expressing CAR T cells generate improved anti-tumor responses against solid tumors
J Immunol (2020) 204 (1_Supplement): 239.8.
Amplification of neoantigen-specific antitumor responses using a long-lasting IL-2 fusion protein
J Immunol (2020) 204 (1_Supplement): 239.9.
Immunometabolism in Tumor Immunity and Immunotherapy
Immunometabolism regulation by PSGL-1 signaling in tumor-specific CD8 T cells
Jennifer L Hope; Dennis C Otero; Eun-ah Bae; Christopher J Stairiker; Ashley B Palete; Hannah A Faso; Petrus de Jong; Garth Powis; Linda M Bradley
J Immunol (2020) 204 (1_Supplement): 240.1.
Fasting Mimicking Diet promotes immunotherapy-associated changes and inhibits autophagy to promote cancer free survival in Acute Lymphoblastic Leukemia models
Roberta Buono; Jonathan Tucci; Raffaello Cutri; Novella Guidi; Serghei Mangul; Matteo Pellegrini; David A Fruman; Steven D. Mittelman; Valter Longo
J Immunol (2020) 204 (1_Supplement): 240.10.
Macrophage repolarization via leptin increases immunotherapy efficacy in obesity
Stephanie O Dudzinski; Kathryn E. Beckermann; Kirsten Young; Rachel Hongo; Todd Giorgio; Jeffrey Rathmell
J Immunol (2020) 204 (1_Supplement): 240.12.
Metformin corrects immune dysfunction and modulates tumor gene expression in overweight individuals to yield context-specific improvement of lung cancer outcomes
Joseph J Barbi; Robert Zollo; Stephanie Sass; Aravind Srinivasan; Eric Kannisto; Santosh Patnaik; Sai Yendamuri
J Immunol (2020) 204 (1_Supplement): 240.13.
Consumption of the fish oil high fat diet uncouples obesity and tumor growth through induction of reactive oxygen species in pro-tumor macrophages
J Immunol (2020) 204 (1_Supplement): 240.14.
Tumor-derived lactate inhibits methylation levels of SGK1 in myeloid-derived suppressor cells to promote GLUT1-mediated glucose uptake and metabolic reprogramming
J Immunol (2020) 204 (1_Supplement): 240.15.
The Force Awakens: Illuminating the Role of Kynurenine in Cancer Progression and Treatment
Norah E Ashoura; Joseph Dekker; Todd A Triplett; Kendra Garrison; John Blazeck; Christos Karamitros; Candice Lamb; Yuri Tanno; Lauren Ilyse Richie Ehrlich; Michelle Zhang; Mark G. Manfredi; Everett Stone; George Georgiou
J Immunol (2020) 204 (1_Supplement): 240.16.
Pathways from glutamine to apoptosis: ROS and PP2A in SKW6.4
J Immunol (2020) 204 (1_Supplement): 240.17.
Increasing AMPK activity supports enhanced oxidative metabolism, proliferation, and in vitro recovery of human CD4+ T cells
J Immunol (2020) 204 (1_Supplement): 240.2.
Nutrient partitioning in the tumor microenvironment and FDG-PET imaging
Matthew Z Madden; Bradley I Reinfeld; Melissa M Wolf; Allison S Cohen; H Charles Manning; W Kimryn Rathmell; Jeffrey C Rathmell
J Immunol (2020) 204 (1_Supplement): 240.4.
Arid5a orchestrates immune evasion of pancreatic cancer via the Ido1-–mediated tryptophan metabolism
J Immunol (2020) 204 (1_Supplement): 240.5.
Role of heat shock factor 1 (HSF1) on activation-induced metabolic reprogramming of T cells
J Immunol (2020) 204 (1_Supplement): 240.7.
The role of CD36 in macrophage lipid metabolism and function in tumor microenvironment
J Immunol (2020) 204 (1_Supplement): 240.9.
Combination Therapies for Immuno-Oncology
Antifungals improve anti-PD1 efficacy in a murine breast cancer model
Kathleen Kershaw; Regina M. Henson; Brandon Abrajan; Rachel Y. Choi; David M. Underhill; Stephen L. Shiao
J Immunol (2020) 204 (1_Supplement): 241.10.
Agonistic-CD40 therapy alters the spatial localization of immune cells in the tumor microenvironment: implications for therapeutic responsiveness
J Immunol (2020) 204 (1_Supplement): 241.11.
Antibody-mediated Recruitment of Viral-specific Effector Cells via Recombinant Antibody-MHC T cells Engagers
J Immunol (2020) 204 (1_Supplement): 241.12.
Inhibition of Aurora-A recruited CD8+ T cells infiltration via mediating IL-10 production of cancer cells
Jing Yang; Jing Han; Zhen Jiang; Chennan Wang; Xin Chen; Rongqing Li; Na Sun; Xiangye Liu; Kuiyang Zheng; Takayuki Ikezoe
J Immunol (2020) 204 (1_Supplement): 241.13.
Suppressive effects of fucoidan-agaricus mix (CUA-fucoidan) on angiogenesis and tumor growth in B16 melanoma-bearing mice
J Immunol (2020) 204 (1_Supplement): 241.15.
Apigenin modulates immune checkpoint molecules in pancreatic cancer enhancing anti-tumor immunity
Krystal Villalobos-Ayala; Jessica Luongo; Ari Marsh; Javier Areas; Bradley Miller; Tanika Williamson; Kazim Husain; Tomar Ghansah
J Immunol (2020) 204 (1_Supplement): 241.17.
Combining a novel dual RAF/MEK inhibitor with immunomodulation to promote an anti-tumor response
Lauren Dong; Hyejin Choi; Sadna Budhu; Nezar Mehanna; Nouraiz Falik; Neal Rosen; Taha Merghoub; Jedd D Wolchok
J Immunol (2020) 204 (1_Supplement): 241.19.
Determining the mechanism of the immune response to histotripsy ablation of pancreatic cancer
Alissa Danielle Hendricks; Rebecca Michaela Brock; Jessica Gannon; Allison Zeher; Jacqueline Sereno; Eli Vlaisavljevich; Irving C Allen
J Immunol (2020) 204 (1_Supplement): 241.2.
CD4 Cytotoxic T cells play a critical role in anti-tumor protection
J Immunol (2020) 204 (1_Supplement): 241.20.
Response to FOLFIRINOX neoadjuvant chemotherapy is associated with a high prevalence of Tbet expressing T cells in pancreatic cancer patients
Hui Peng; Alston James; Darren R Cullinan; Jacqueline Mudd; Rony Takchi; David G DeNardo; Ryan C Fields; Simon Peter Goedegebuure; William G Hawkins
J Immunol (2020) 204 (1_Supplement): 241.21.
BCG immunotherapy response associated immune transcriptomic and spatial immune profiles of non-muscle invasive bladder tumors
Stephen Chenard; Runhan Ren; Chelsea Jackson; Amanda Xu; David Berman; D. Robert Siemens; Madhuri Koti
J Immunol (2020) 204 (1_Supplement): 241.22.
Intradermal delivery of a combination of immunomodulatory antibodies can promote rejection of hyperplastic skin in a mouse model of actinic keratosis
J Immunol (2020) 204 (1_Supplement): 241.23.
NKG2A inhibits the anti-tumor CD8 T cell immune response elicited by radiotherapy
J Immunol (2020) 204 (1_Supplement): 241.24.
Humanized Rag2 mice as patient-derived orthotopic mouse models for immune checkpoint blockade and conventional chemotherapeutic drug treatment for human solid tumors
Li Li; Xin Zhang; Grace Maresh; Neeha Mathew; Amita Bhattarai; Linh Hellmers; Henry Yip; Ravan Moret; Lara McKean Baste; Heather Green; Maria Latsis; Stephen Bardot; David Margolin
J Immunol (2020) 204 (1_Supplement): 241.26.
Radiation-Induced Immunity in Kidney Cancer Patients: Seq-ing Commonality Between Peripheral and Intratumoral T cell Repertoires
Jacky Louis Chow; Nicholas Hoffend; Scott I Abrams; Thomas Schwaab; Anurag Singh; Jason Bryan Muhitch
J Immunol (2020) 204 (1_Supplement): 241.27.
Tumor RIPK1 signaling mediates intrinsic and extrinsic mechanisms of resistance to immune checkpoint blockade therapy
J Immunol (2020) 204 (1_Supplement): 241.29.
Harnessing the power of trained immunity using yeast-derived β-glucan to prevent pancreatic cancer
J Immunol (2020) 204 (1_Supplement): 241.3.
The tumor associated antigen LEDGFp75 interacts with oncogenic transcription factors in docetaxel resistant prostate cancer cells
J Immunol (2020) 204 (1_Supplement): 241.31.
T-cell Enriching Therapy using combination of IL-12 gene electrotransfer and anti-PD-1 attenuates the resistance of anti-PD1 in preclinical metastatic cancer
J Immunol (2020) 204 (1_Supplement): 241.32.
Tumor cell-intrinsic PD-L1 signals promote DNA damage responses that mediate resistance to Chk1 and PARP inhibitors in vivo
Anand V Kornepati; Deyi Zhang; Alvaro S Padron; Jacob T Boyd; Yilun Deng; Erica G Osta; Ryan M Reyes; Hailian Shen; Juan Wang; Suresh Kari; Curtis A Clark; Yanfen Hu; Rong Li; Harshita B Gupta; Weixing Zhao; Tyler J Curiel
J Immunol (2020) 204 (1_Supplement): 241.33.
Androgen receptor targeted therapy sensitizes tumor bearing mice to effective immunotherapy
J Immunol (2020) 204 (1_Supplement): 241.34.
Targeting GARP-TGFβ axis enhances anti-tumor efficacy of immune checkpoint blockade therapy
J Immunol (2020) 204 (1_Supplement): 241.35.
DNMTi plus anti-4-1BB therapy reverses suppressive tumor microenvironment and reduces tumor burden in ovarian cancer
J Immunol (2020) 204 (1_Supplement): 241.36.
CD40 signaling induces type I interferon and immune control in mouse pancreatic cancer lacking the CXCL12-coat
J Immunol (2020) 204 (1_Supplement): 241.37.
Optimal Treatment Regimen of Using Chemo-Immunotherapy for Solid Tumors
J Immunol (2020) 204 (1_Supplement): 241.38.
Promoting antitumor immunity and increased T-cell function by depletion and blockade of the immunosuppressive cell compartment in murine cancer
J Immunol (2020) 204 (1_Supplement): 241.39.
Topoisomerase-I inhibitors induce the expression of clinically relevant immunomodulators in colon cancer cells
J Immunol (2020) 204 (1_Supplement): 241.4.
Metronomic low dose cyclophosphamide in combination with a DNA methyltransferase inhibitor limits tumor growth in murine triple negative breast cancer
J Immunol (2020) 204 (1_Supplement): 241.40.
Characterization of the immune microenvironment in melanoma patients resistant to targeted and immunotherapies by a multidisciplinary approach
Florencia Veigas; Yamil D Mahmoud; Ana Flores; Rosa Morales; Sabrina Gatto; Juan Manuel Perez Saez; Elmer Fernandez; Gabriel A Rabinovich; María Romina Girotti
J Immunol (2020) 204 (1_Supplement): 241.41.
Glutamate receptor signaling is critical for T cell function and antitumor activity
J Immunol (2020) 204 (1_Supplement): 241.42.
A new Natural Killer cell therapy to target relapse Acute Lymphoblastic Leukemia
Yorleny M Vicioso; Rose Beck; Herman Gram; Keman Zhang; Abhishek Asthana; Derek Wong; John Letterio; Reshmi Parameswaran
J Immunol (2020) 204 (1_Supplement): 241.43.
Combination of TEW-7197 and adoptively transferred NK cells leads to Improved Antitumor Responses in vivo
Jungwon Kim; Seon Ah Lim; Tae-Jin Kim; Siyoung Lim; Jiyoung Kim; Jeongsoo Kim; Junghee Kim; Eunju Lee; Sunghee Park; Seong-Jin Kim; Kyung-mi Lee
J Immunol (2020) 204 (1_Supplement): 241.45.
Artemisinin improves the efficiency of anti-PD-L1 therapy in T-cell lymphoma
J Immunol (2020) 204 (1_Supplement): 241.46.
Neuropilin-1, an immune checkpoint for controlling tumor-specific CD8 T-cell functions whose blockade improves anti-PD-1 immunotherapy
J Immunol (2020) 204 (1_Supplement): 241.5.
All-trans Retinoic Acid (atRA) promotes tumor resistence to NK cells by downregulating tumor B7-H6 expression
J Immunol (2020) 204 (1_Supplement): 241.6.
Paradoxical Role of MLK3-CTLA-4 axis in Triple-negative Breast Cancer and CD8+ T cells
Sandeep Kumar; Sunil Kumar Singh; Navin Viswakarma; Gautam Sondarva; Rakesh Sathish Nair; Gregory Thatcher; Basabi Rana; Ajay Rana
J Immunol (2020) 204 (1_Supplement): 241.7.