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J Immunol (2020) 204 (4): 731–732.


J Immunol (2020) 204 (4): 733–744.


J Immunol (2020) 204 (4): 747–751.

  • Constitutive IL-6 overproduction promotes myeloid cell–driven inflammation.

  • IL-6Rα (CD126) is indispensable for IL-6–mediated STAT3 activation in mice.


J Immunol (2020) 204 (4): 753–762.

  • Allergin-1 inhibits HDM-induced Syk activation via SHP-1 in CD11b+ DC.

  • Allergin-1 suppresses Th2 response by inhibiting Syk-mediated PGE2 production in DC.

J Immunol (2020) 204 (4): 763–774.

  • A small molecular activator of PKM2 attenuates allergic airways disease in mice.

  • Activation of PKM2 decreases IL-1β–induced airway inflammation.

  • PKM2 activation decreases IL-1β–induced nuclear phosphorylation of STAT3.


J Immunol (2020) 204 (4): 775–787.

  • ICD of CT26 cells relies mainly on AH1 tumor Ag expression.

  • AH1-deficient necroptosis remains more immunogenic compared with apoptosis.

  • Necroptotic, but not apoptotic, CT26 cells generate immunity against neoepitopes.


J Immunol (2020) 204 (4): 788–795.

  • Anticancer VR23 also effectively downregulates inflammatory cytokines in monocytes.

  • VR23 effectively downregulates MCP-1, IL-6, and cell migration in human synoviocytes.

  • VR23 effectively downregulates lung inflammation caused by LPS in mice.

J Immunol (2020) 204 (4): 796–809.

  • IFN-γ but not type I IFN signaling is indispensable for TLR7-driven autoimmunity.

  • IFN-γ promotes TLR7-accelerated SLE by regulating multiple cellular pathways.

  • IFN-γ signaling in B cells is required for development of TLR7-accelerated SLE.

J Immunol (2020) 204 (4): 810–818.

  • IMP761 is a humanized IgG4 LAG-3–specific Ab with agonistic properties.

  • IMP761 is immunosuppressive in vitro and in vivo.

  • Targeting LAG-3 represents a promising novel therapeutic approach for treating AID.


J Immunol (2020) 204 (4): 819–831.

  • Activated human Th cells show IL-3R surface expression, which is increased by IL-4.

  • IL-3R+ cells show a Th2 phenotype, and their effector functions are enhanced by IL-3.

  • A higher number of IL-3– and IL-3R–expressing Th cells were seen in allergic patients.


J Immunol (2020) 204 (4): 832–843.

  • Amphioxus has IRAK4 and Pelle; Pelle was displaced by IRAK1/2/3 in vertebrates.

  • IRAK4 and Pelle show different function in amphioxus, vertebrates, and Drosophila.

  • IRAKs may confer plasticity to the evolution of the TLR/IL-1R pathways.

J Immunol (2020) 204 (4): 844–857.

  • PI3K competes with STAT5 in IL-7R signaling and maintains an appropriate signal balance.

  • Early and memory T cell development is modulated by a competition between IL-7R signals.

  • A competition in IL-7R signaling modulates the population size of peripheral T cells.


J Immunol (2020) 204 (4): 858–867.

  • αβ TCR sequences of tTreg and Tconv are distinguished by an ML algorithm.

  • A fraction of αβ TCR sequences of tTreg and Tconv are conserved across mice.

J Immunol (2020) 204 (4): 868–878.

  • OCP express CX3CR1 and, in unperturbed conditions, differentiate into osteoclasts.

  • The contribution of circulating CX3CR1+ OCP to OC development is low during homeostasis.

  • Mature OC can originate from circulating CX3CR1+ cells during fracture repair.

J Immunol (2020) 204 (4): 879–891.

  • SP induces the HMGB1 gene in BM stroma.

  • NK-A, via HMGB1, negatively regulates SP effects on hematopoiesis.

  • Humanized mice confirmed HMGB1 exerting negative hematopoietic effects.


J Immunol (2020) 204 (4): 892–902.

  • A new, MHC-linked class I gene (UDA) was found in cartilaginous fishes.

  • UDA is monomorphic and in single/low copy number in elasmobranchs.

  • Chondrichtyans have at least four class I lineages, one classical and three nonclassical.


J Immunol (2020) 204 (4): 903–913.

  • Bicistronic Ag–molecular adjuvant vectors induce distinct immune profiles.

  • CCL20 and CCL28 induce homing of Ag-specific T cells to the female genital tract.

  • CCL20 and CCL25 induce homing of Ag-specific B cells to the intestinal mucosa.

J Immunol (2020) 204 (4): 914–922.

  • Primary TBE immunization induces heterogenous magnitude of CD4+ T cell response.

  • The response is marked by IL-2, TNF, and CD154 expression after each vaccine dose.

  • IFN-γ response by memory CD4+ T cells in TBE vaccinees is lower than in TBE patients.


J Immunol (2020) 204 (4): 923–932.

  • BHLHE40 is required for protective immunity to the helminth H. polygyrus.

  • BHLHE40 is required for normal TH2 gene transcription and cytokine production.

  • CSF2RB-dependent cytokines can compensate for each other during type 2 immunity.

J Immunol (2020) 204 (4): 933–942.

  • Vinpocetine suppresses S. pneumoniae–induced inflammation in vitro and in vivo.

  • Vinpocetine inhibits S. pneumoniae–induced inflammation via upregulating CYLD.

  • CYLD suppresses S. pneumoniae–induced inflammation via inhibiting ERK.

J Immunol (2020) 204 (4): 943–953.

  • The genetic variation in the proximal promoter region alters MHCII expression.

  • Lower MHCII-DRB expression leads to poor parasite clearance.

  • MHCII gene regulation determines the immunity to malaria.


J Immunol (2020) 204 (4): 954–966.

  • Neutrophils express LILRB3, which is released in a soluble form upon activation.

  • LILRB3 inhibits FcαR-mediated neutrophil activation and effector functions.

J Immunol (2020) 204 (4): 967–979.

  • Deficiency in icIL-1Ra1 aggravates psoriasis-like skin inflammation in mice.

  • icIL-1Ra1 is released from keratinocytes during lytic cell death.

  • icIL-1Ra1 counteracts the inflammatory effects of the alarmin IL-1α.

J Immunol (2020) 204 (4): 980–989.

  • NI in the colon affects barrier function later in life.

  • NI sensitizes the Mir155 promoter for aberrant epigenetic activation.

  • miR-155 suppresses E-cadherin protein expression in the colonic epithelium.

J Immunol (2020) 204 (4): 990–1000.

  • Angiogenesis contributes to the lung premetastatic niche in a model of breast cancer.

  • This angiogenesis is initiated by C5a/C5aR1-regulated MDSC.

  • Inhibition of C5aR1 combined with antiangiogenic vaccines reduces lung metastasis.

J Immunol (2020) 204 (4): 1001–1011.

  • IL-33 treatment upregulated PGD2 synthesis genes.

  • IL-33–elicited lung ILC2 accumulation was partially dependent on the PGD2 receptor CRTH2.

  • CRTH2 controlled IL-33–elicited ILC2 lung accumulation via migration/tissue retention.

J Immunol (2020) 204 (4): 1012–1021.

  • ARF6 regulates the polarization of RPH3A and RAB21 at the plasma membrane.

  • ARF6 binds to RPH3A and augments the interaction between plasma membrane PtdIns4P and RPH3A.

  • ARF6 is important for neutrophil adhesion on the inflamed endothelia.


J Immunol (2020) 204 (4): 1022–1034.

  • Choice of cell line is critical for functional glycosylation of human IgG1-Fc.

  • Sialylated IgG1-Fc monomers block influenza B only when made by CHO-K1 cells.


J Immunol (2020) 204 (4): 1035–1046.

  • B. thetaiotaomicron CPSs control the activation of T cells and the clearance of Ag in vivo.

  • Antistimulatory CPSs activate innate immunity weaker than prostimulatory CPSs.

  • Antistimulatory CPSs block APC access, which can be rescued by opsonization.

J Immunol (2020) 204 (4): 1047–1055.

  • IRF4-expressing cDC2 promote early T cell–dependent colitis.

  • IRF4-expressing cDC2 promote the generation of colitogenic CD4+ T cells.

  • IRF4-expressing cDC2 are not required for Treg-mediated suppression of colitis.


J Immunol (2020) 204 (4): 1056–1068.

  • MCs are mainly located in hypoxic zones of murine melanoma tumors.

  • Hypoxia induces CCL-2 production via ROS generation and LVDCCs activation.

  • Hypoxia promotes glutathionylation and membrane translocation of LVDCCs in BMMCs.


J Immunol (2020) 204 (4): 1070–1071.
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