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J Immunol (2020) 204 (5): 1073–1074.

BRIEF REVIEWS

J Immunol (2020) 204 (5): 1075–1083.

CUTTING EDGE

J Immunol (2020) 204 (5): 1085–1090.

  • EWS functions as a modulator downstream of LTβR stimulation.

  • TRAF3, but not TRAF2, links EWS to receptor activation.

  • EWS controls inflammatory responses mediated by GM-CSF.

AUTOIMMUNITY

J Immunol (2020) 204 (5): 1091–1100.

  • CSR and somatic hypermutation are required for the progression of lupus nephritis in BXSB mice.

  • AID deficient BXSB mice have prolonged survival with improved renal function.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2020) 204 (5): 1101–1110.

  • Circulating Tfh cell frequencies are reduced upon fingolimod treatment.

  • Fingolimod reduces circulating Tfr cell and CXCR5+ CD8+ T cell frequencies.

  • Blood CXCR5 Tmem, Treg, and Breg cell frequencies are elevated by fingolimod.

J Immunol (2020) 204 (5): 1111–1118.

  • Young adults with DS have elevated plasma sTREM2 and cytokines.

  • Cytokines and sTREM2 positively correlate in DS predementia.

  • There is a relationship between sTREM2 and peripheral inflammation predementia.

J Immunol (2020) 204 (5): 1119–1133.

  • MAIT cells in older adults retain functional responses to MR1-mediated stimulation.

  • Expanded MAIT cell TCRαβ clonotypes are apparent in older adults.

  • MAIT cells in older adults have a hyperinflammatory cytokine profile at baseline.

IMMUNE REGULATION

J Immunol (2020) 204 (5): 1134–1145.

  • ORP5L extracts and presents PIP2 to PLCγ1 for hydrolysis in the plasma membrane.

  • ORP5L maintains IP3/Ca2+ signaling in T cells.

  • ORP5L facilitates T cell proliferation via Ca2+-/NFAT-dependent pathway.

J Immunol (2020) 204 (5): 1146–1157.

  • RAB7 small GTPase colocalizes with engaged receptors on mature endosomes in B cells.

  • RAB7 directly interacts with TRAF6 to transduce receptor signals in NF-κB activation.

  • RAB7 overexpression in normal and lupus B cells enhances NF-κB and AID induction.

J Immunol (2020) 204 (5): 1158–1172.

  • Galectin-9 is abundantly expressed in the cytosol of T cells.

  • Intracellular galectin-9 potentiates proximal TCR signaling.

  • Galectin-9 in T cells positively modulates the pathogenesis of autoimmune diseases.

J Immunol (2020) 204 (5): 1173–1187.

  • VCAM1 is heterogeneously expressed in endothelial cells after TNF-α induction.

  • Heterogeneous VCAM1 promoter DNA methylation is mitotically heritable.

  • Heterogeneity in cytokine responsiveness occurs in many endothelial genes.

J Immunol (2020) 204 (5): 1188–1200.

  • Methadone use alters circulating CD8+ T cell subsets, decreasing TEMRA cell frequency.

  • Expression of the opioid receptors and TCRs is not modulated by methadone use.

  • Ex vivo stimulation of μ-OR or δ-OR produces distinct surface marker patterns.

J Immunol (2020) 204 (5): 1201–1213.

  • Calcitriol impairs Th9 cell development.

  • Calcitriol downregulates PU.1 expression and its binding to the Il9 gene.

  • Calcitriol regulates chromatin remodeling at the Il9 gene locus.

J Immunol (2020) 204 (5): 1214–1224.

  • DHEA limits leukocyte recruitment.

  • DHEA restores endothelial DEL-1 expression in inflammation.

  • This effect involves regulation of C/EBPβ in a TRKA/AKT-dependent manner.

IMMUNOGENETICS

J Immunol (2020) 204 (5): 1225–1241.

  • CXCR4a and CXCR4b prefer to bind LPS and SDF-1 in teleosts, respectively.

  • CXCR4b inhibits HSPC proliferation in ayu by regulating ROS levels.

  • CXCR4a+ HSPCs are prone to differentiate into myeloid cells in ayu.

IMMUNOTHERAPY AND VACCINES

J Immunol (2020) 204 (5): 1242–1254.

  • Blocking CTLA-4 or PD-1 combined with T cell activation reverses HIV latency.

  • Without T cell activation, blocking multiple ICs reverses latency.

J Immunol (2020) 204 (5): 1255–1262.

  • Gut bacteria–associated sepsis in irradiated mice was controlled by GL.

  • This compound inhibited M2bMϕ polarization at the bacteria translocation site.

  • Expression of Gas5 (down) and miR-222 (up) in Mϕ was improved by GL.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2020) 204 (5): 1263–1273.

  • B. anthracis PGA elicits fewer cytokines in smaller amounts than B. subtilis PGA and B. licheniformis PGA.

  • B. anthracis PGA is recognized less effectively by human TLRs 2 and 4.

  • B. anthracis PGA is more resistant to human degradative enzymes than B. subtilis PGA and B. licheniformis PGA.

J Immunol (2020) 204 (5): 1274–1286.

  • Helminth infections alter monocyte activation and function in latent TB.

  • Helminth infections also alter T cell activation in latent TB.

  • These alterations are for the most part reversed by anthelmintic chemotherapy.

J Immunol (2020) 204 (5): 1287–1298.

  • JEV NS1′, not NS1, inhibits IFN-I production by targeting MAVS.

  • NS1′ antagonizes host MAVS through regulating miR-22.

  • NS1′ upregulates miR-22 by enhancing the binding of TFs to its promoter.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2020) 204 (5): 1299–1309.

  • LETMD1 regulates phagocytosis and inflammatory responses in macrophages.

  • LETMD1 regulates NF-κB activities through mitochondrial hyperpolarization.

J Immunol (2020) 204 (5): 1310–1321.

  • TRPV4 mediates the host defense and lung injury response to bacterial pneumonia.

  • TRPV4 mediates these effects through MAPK switching from JNK to p38 through DUSP1.

J Immunol (2020) 204 (5): 1322–1333.

  • Roquin-1 in recruited mø alleviated liver IR injury.

  • Roquin-1 modulated the polarization of mø via AMPK–STAT3–mTOR.

  • Roquin-1 promoted the ubiquitination of AMPKα and inhibited its activation.

MOLECULAR AND STRUCTURAL IMMUNOLOGY

J Immunol (2020) 204 (5): 1334–1344.

  • Enhancer RNAs are functionally important for IL1A and IL1B mRNA transcription.

  • MAPKs and NF-κB regulate distinct transcriptional processes.

  • Enhancer RNAs bind pausing proteins to release RNA polymerase II.

J Immunol (2020) 204 (5): 1345–1361.

  • CR4 binds fibrillar αSN but not monomeric species.

  • Clearance of fibrillar αSN is strongly dependent on receptor conformation.

  • In fibrillar αSN, anionic side chain ladders may be critical for clearance.

TUMOR IMMUNOLOGY

J Immunol (2020) 204 (5): 1362–1372.

  • ATC-derived CM selectively induced NET release.

  • ATC-derived CM–induced NET release was ROS dependent and cell death independent.

  • ATC CM–induced NETs contained mitochondrial DNA and promoted cancer cell growth.

J Immunol (2020) 204 (5): 1373–1385.

  • 2DG induces T cells to acquire NK cell properties and enhanced cytotoxicity.

  • 2DG makes T cells resistant to the apoptotic effect of galectin-3.

  • The effects of 2DG on T cells are based on blockade of N-glycosylation.

J Immunol (2020) 204 (5): 1386–1394.

  • Immunostimulation by CMP-001 requires anti-Qβ Ab.

  • In mice, IT CMP-001 induces lymphoma regression that is enhanced by anti–PD-1.

NOVEL IMMUNOLOGICAL METHODS

J Immunol (2020) 204 (5): 1395–1407.

  • The influence of various clearing methods on LN tissue was assessed.

  • CUBIC and Ce3D are optimal clearing methods for mouse LN investigation.

  • Immunostaining of LNs should be performed before TOC.

CORRECTIONS

J Immunol (2020) 204 (5): 1408–1409.
J Immunol (2020) 204 (5): 1410.
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