Issues

Pathogen-specific bystander memory CD8 T cells infiltrate tumors in the absence of Ag.

1°M bystander CD8 T cells are relatively inert in the tumor.

4°M bystander cells gain effector functions independent of cognate Ag recognition.

Airway epithelial cGAS plays a key role in asthma pathogenesis.

cGAS may be a promising target against allergic airway inflammation.

Tris DBA ameliorates lupus nephritis in a murine lupus model.

Tris DBA regulates the NLRP3 inflammasome by blunting MAPK and enhancing autophagy.

Tris DBA enhances Treg cell function and inhibits DC-mediated T cell activation.

The number of MAIT cells significantly correlated with time after CBT.

Significantly decreased numbers of circulating MAIT cells were observed in patients with cGVHD.

The riboflavin pathway of microbiomes correlated with MAIT cell reconstitution.

Ly6C^lo nonclassical monocytes infiltrate the pulmonary vasculature and promote PH.

Hif1α regulates the maturation of nonclassical monocytes into infiltrating IMØ.

Infiltrating IMØ promote PH by modulating local immune and cytokine responses.

IL-13 improves neurologic outcomes after traumatic brain injury.

IL-13 adjusts microglia/macrophage phenotypes and inhibits inflammatory responses.

IL-13 enhances microglia/macrophage phagocytic activities.

TRIM25 functions as a positive regulator in NF-κB signaling in response to TNF-α.

TRIM25 interacts with TRAF2 and enhances its K63-linked polyubiquitination.

TRIM25 promotes the interaction between TRAF2 and TAK1 or IKKβ.

BAFF increases in myeloid subsets in a cell- and tissue-specific manner.

Neutrophil and DC BAFF are required for optimal T cell–independent 2 humoral responses.

BAFF produced by DCs is required for protective immunity to West Nile virus.

γδ T cell subsets possess distinct SLAM family receptor coexpression profiles.

SLAMF1 and SLAMF6 identify IL-17– and IFN-γ–producing γδ T cells, respectively.

SAP regulates the development of both IL-17– and IFN-γ–producing γδ T cell subsets.

Loss of Fbw7 during B cell development reduces mature B1 and B2 cells.

Fbw7 controls survival pathway signaling to prevent apoptosis in mature B cells.

Ectopic expression of BCL2 partially overcomes apoptosis upon Fbw7 deficiency.

The receptor binding site (CD4bs) of HIV Env is a desirable vaccine target.

Envs lacking CD4bs-flanking glycans and bearing CD4i Ab moieties were generated.

CD4bs-directed Ab responses have been elicited by these modified Envs.

Vaccination with RHΔtkl1 in mice induces a strong humoral and cellular response.

RHΔtkl1-vaccinated mice are protected against acute, chronic, and congenital toxoplasmosis.

Immunity induced by RHΔtkl1 vaccine is primarily Th1 biased and CD8⁺ T cell mediated.

Novel T. cruzi T cell epitopes were identified by immunoinformatics and immunoassaying.

Six class II and 1 class I epitopes activate T cells from chronic Chagas patients.

Epitope-specific T cells have different memory phenotype across donors.

α2β1 deficiency does not alter the balance of NK cell/ILC1 generation.

α2β1 deficiency does not alter NK cell maturation.

α2β1-deficient NK cells efficiently protect from lethal mousepox and control MCMV.

IL-33 autoamplifies the IL-33/ST2 pathway by inducing its own and ST2 expression.

Airway epithelial cells are the major source of endogenous IL-33 production.

An intact endogenous IL-33/ST2 pathway is necessary for asthma-like mouse models.

CTRP6 binds selectively to ligands, carbohydrates, and live bacteria.

CTRP6 guides collectin-11 to surfaces and facilitates complement activation.

NADPH oxidase hyperactivity accompanies autoinflammation in Pstpip2^cmo mice.

This hyperactivity is cell intrinsic and not caused by an inflamed environment.

NADPH oxidase deletion prevents autoinflammatory bone damage in Pstpip2^cmo mice.

MHC-II recycling through early endosomes in mature DCs is regulated by Rab11a.

MHC-II synthesis enhances presentation of late endosome Ags by immature DCs.

MHC-II recycling enhances presentation of early endosome Ags by mature DCs.

The chicken pBL2*019:01 structure reveals a conserved α- and β-chain–pairing mechanism.

The variable β1 domain of chicken MHC-II determines peptide-presentation profiles.

The interaction between pBL2*019:01 and CD4 differs from the corresponding pMHC-II.

The MMC-specific genes Mcpt1 and Mcpt2 are induced by TGF-β.

The GATA–Smad motifs around −3 kb of these genes are crucial for transcription.

TGF-β–Smad2/4 axis accelerates GATA2 recruitment to the GATA–Smad motifs.

IL-33 mediates eosinophilic recruitment and Th2 inflammation in Tg+ airways.

MUC5AC, not MUC5B, is significantly suppressed in the airways of IL-33^KO/Tg+ mice.

Mucous cell density, not muco-obstruction, is suppressed in IL-33^KO/Tg+ airways.

Consistent transcriptional signatures were identified 28 d after influenza vaccination.

A new end point (maxRBA) characterizes Ab response relative to baseline.

Genes related to Ab response behave differently in young and older adults.

Notch signaling regulates Gcnt1-mediated core-2 O-glycosylation in activated T cells.

The core-2 O-glycoform of CD43 reports Notch signals in multiple mouse T cell subsets.

Historical CD8 T cell epitope discovery methods are labor intensive and scale poorly.

Ultradense peptide arrays can streamline identification of MHC binding peptides.

Substitution arrays can be used to define MHC molecules’ binding motifs.