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J Immunol (2020) 204 (8): 2009–2010.

TRANSLATING IMMUNOLOGY

J Immunol (2020) 204 (8): 2011–2020.

BRIEF REVIEWS

J Immunol (2020) 204 (8): 2021–2032.

ALLERGY AND OTHER HYPERSENSITIVITIES

J Immunol (2020) 204 (8): 2033–2042.

  • IL-33 promoted the rapid and robust induction of IκBζ in mast cells.

  • IκBζ enhanced cytokine production to assist NF-κB in IL-33/ST2L signaling.

AUTOIMMUNITY

J Immunol (2020) 204 (8): 2043–2052.

  • The PEPITEM/CDH15 axis is involved in homeostasis in pathological inflammation.

  • PEPITEM could be used as a therapeutic agent for systemic lupus erythematosus.

J Immunol (2020) 204 (8): 2053–2063.

  • Polyamide targeting IL-23 specifically inhibits the expression of IL-23.

  • Polyamide targeting IL-23 is effective in treating psoriasis and EAU in mice.

J Immunol (2020) 204 (8): 2064–2075.

  • miR-155 in T cells contributes to the shortened lifespan of miR-146a−/− mice.

  • Autoimmunity in aged miR-146a−/− mice is mediated in part by T cell miR-155.

  • Aerobic glycolysis is associated with increased Tfh and GC B cells during aging.

J Immunol (2020) 204 (8): 2076–2087.

  • HuR regulates Th17 cell and Th1-like Th17 cell differentiation.

  • HuR directly and indirectly modulates expression of RUNX1 and RORγt, respectively.

  • Targeting HuR by its inhibitor reduces severity of autoimmune neuroinflammation.

J Immunol (2020) 204 (8): 2088–2097.

  • Myeloid cells are the dominant cell type expressing DNase1L3 in human blood cells.

  • Homeostatic stimuli may be a key driver of DNase1L3 production in myeloid cells.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2020) 204 (8): 2098–2109.

  • Monocytes from MDS patients display low phagocytic activity.

  • MDS monocyte-derived DCs show morphological alterations and low expression of HLA-DR.

  • Monocytes from MDS patients downregulate genes that trigger immune responses.

IMMUNE REGULATION

J Immunol (2020) 204 (8): 2110–2121.

  • Free ISG15 causes tissue alert in the skin upon therapeutic vaccination in mice.

  • Free ISG15 is a potent adjuvant for the CTL response, acting, in part, via NK cells.

  • Free ISG15 function in mice requires amino acids defining ligand function in humans.

J Immunol (2020) 204 (8): 2122–2132.

  • SCFβ-TrCP E3 ubiquitin ligase governs TIPE2 protein stability.

  • TAK1 phosphorylates Ser3 to trigger TIPE2 for ubiquitination and degradation.

  • The amount of TIPE2 determines the strength of LPS-induced signaling.

J Immunol (2020) 204 (8): 2133–2142.

  • TLR stimulation of B cells into Ig-secreting plasma cells requires NOX-dependent ROS.

  • The high secretion of IgG per cell results in excessive ROS-dependent ER stress.

  • NAC selectively inhibits the secretion of IgG and not that of IgM.

J Immunol (2020) 204 (8): 2143–2155.

  • The chromatin modifying BAP complex regulates Drosophila immune mechanisms.

  • Transcriptome analysis of osa RNAi flies indicates a role for Osa in metabolism.

  • Osa negatively regulates immunity and enhances expression of metabolic genes.

IMMUNE SYSTEM DEVELOPMENT

J Immunol (2020) 204 (8): 2156–2168.

  • ADAR1 depletion from early developmental stages impairs T cell development in mice.

  • Concurrent MDA5 deletion partially ameliorates aberrant thymocyte development.

  • The RNA-editing–independent function of ADAR1 is required for early T cell development.

IMMUNOTHERAPY AND VACCINES

J Immunol (2020) 204 (8): 2169–2176.

  • RhCMV/HBV vectors engender MHC-E–restricted CD8+ T cell responses in RM.

  • HD and RM PH express MHC-E.

  • PH present HBV Ag to MHC-E–restricted CD8+ T cells from RhCMV/HBV-inoculated RM.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2020) 204 (8): 2177–2191.

  • IL-10 antagonizes IL-17 in determining clinical disease phenotypes of periodontitis.

  • IL-10 dampens an IL-17–mediated inflammatory response in innate immune cells.

  • Bone loss in Il10−/− mice is associated with an M1-skewing macrophage phenotype.

J Immunol (2020) 204 (8): 2192–2202.

  • Type I and III IFNs exacerbate pertussis lung inflammation in adult mice.

  • Infant mice do not upregulate IFN expression in response to pertussis.

  • Increased type I IFN signaling protects infant mice from pertussis lethality.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2020) 204 (8): 2203–2215.

  • IRCTX muscle injury results in muscle fibrosis through macrophage-derived TGF-β1.

  • FAPs respond to TGF-β1 by differentiating into fibroblasts.

  • Conditional knockout and systemic inhibition of TGF-β1 attenuates IRCTX fibrosis.

J Immunol (2020) 204 (8): 2216–2231.

  • NOD1 restricts replication of RNA viruses.

  • The cumulative effects between NOD1 and MDA5 normal form are conserved.

  • NOD1 degradation by the truncated form of MDA5 is specific to fish.

J Immunol (2020) 204 (8): 2232–2241.

  • Zhx2 in macrophages accelerates sepsis.

  • Zhx2 promotes glycolysis in macrophages via Pfkfb3.

J Immunol (2020) 204 (8): 2242–2256.

  • Type I IFN–mediated JAK–STAT signaling is impaired in Perforin-2–deficient cells.

  • Perforin-2 independently associates with IFNAR1 and IFNAR2 in resting cells.

  • Perforin-2 is critical for the activation of Jak1 and Tyk2 upon IFN-β stimulation.

J Immunol (2020) 204 (8): 2257–2268.

  • pDCs express LIFR.

  • LIF inhibits pDC production of type I IFN.

  • LIF biases DC development towards cDCs at the expense of pDCs.

MOLECULAR AND STRUCTURAL IMMUNOLOGY

J Immunol (2020) 204 (8): 2269–2276.

  • Dimerization of the BCAP Toll/IL1 domain is required for function.

  • BCAP TIR modulates the oligomerization state of TLR signaling adaptor MAL.

  • TIG domains are a promiscuous dimerization module in gene expression and signaling.

MUCOSAL IMMUNOLOGY

J Immunol (2020) 204 (8): 2277–2284.

  • Spontaneous colitis in Itch-deficient mice is associated with altered gut microbiota.

  • Alterations in gut microbiota are independent of elevated IL-17 in Itch-deficient mice.

  • Bacteroides vulgatus induces colonic inflammation in Itch−/− mice.

TUMOR IMMUNOLOGY

J Immunol (2020) 204 (8): 2285–2294.

  • CEACAM1 is an essential contributor in the NET–tumor cell interaction.

  • CEACAM1 is a potential target for preventing liver metastasis of colon cancer.

J Immunol (2020) 204 (8): 2295–2307.

  • Expression of csMHCII is a determinant of the composition of the TME.

  • csMHCII is a factor determining the response to anti–PD-1 therapy.

NOVEL IMMUNOLOGICAL METHODS

J Immunol (2020) 204 (8): 2308–2315.

  • Cas9 RNP electroporation deletes genes in naive CD8+ T cells transferred in vivo.

  • High efficiency gene deletion occurs even in the absence of T cell activation.

  • Multiple gene KO and HDR edited cells can be generated using this method.

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