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J Immunol (2020) 204 (9): 2319–2320.

BRIEF REVIEWS

J Immunol (2020) 204 (9): 2321–2328.

CUTTING EDGE

J Immunol (2020) 204 (9): 2331–2336.

  • Patients with TB exhibit a high frequency of TRMs at different infection sites.

  • These TRMs exhibit memory, with an activated and multifunctional phenotype.

  • TRMs limit intracellular M. tuberculosis replication in macrophages.

ALLERGY AND OTHER HYPERSENSITIVITIES

J Immunol (2020) 204 (9): 2337–2348.

  • The MALT1 protease plays a dual role in allergic response.

  • MALT1 protease activity is required for IgE-dependent mast cell cytokine production.

  • MALT1 protease activity is required for histamine-induced endothelial permeability.

AUTOIMMUNITY

J Immunol (2020) 204 (9): 2349–2359.

  • Proinsulin contains several T cell epitopes recognized by human CD4+ T cells.

  • HLA-DQ2–restricted proinsulin epitopes B18-26 and C22-33 are naturally processed.

  • Proinsulin-reactive TCR sequences are enriched in pancreatic lymph node samples.

J Immunol (2020) 204 (9): 2360–2373.

  • A COPA syndrome mouse model develops lung disease that mirrors that in patients.

  • Mutant Copa in thymic epithelial cells impairs thymocyte selection.

  • T cells are important drivers of lung disease in CopaE241K/+ mice.

J Immunol (2020) 204 (9): 2374–2379.

  • Anti-NET/cit-H2B RA-rmAb immunoreactivity is dependent on somatic hypermutation.

  • SHM in the HC and/or LC is necessary for the anti-NET/cit-H2B immunoreactivity.

  • Fab–N-linked–glycosylation introduced by SHM can influence NET–Ag binding.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2020) 204 (9): 2380–2391.

  • HC exhibit a more inflammatory phenotype early in gestation.

  • HC responses to some pathogenic stimuli reduce with advancing gestational age.

IMMUNE REGULATION

J Immunol (2020) 204 (9): 2392–2400.

  • The lack of 4E-BPs promotes Mϕ inflammatory responses.

  • 4E-BP–null mice are prone to HFD-induced obesity.

  • 4E-BPs control translation of Irf8.

J Immunol (2020) 204 (9): 2401–2415.

  • Two promoters, p1 and p2, and two variants of CIITA are found in zebrafish.

  • IFN-γ–IRF1–CIITA–MHCII signaling cascade is conservative in zebrafish.

J Immunol (2020) 204 (9): 2416–2428.

  • B cells can promote expansion of Treg cells in a BAFF-independent manner.

  • BAFF can promote expansion of Treg cells beyond promotion of B cell expansion.

  • BAFF-driven promotion of Treg cell expansion requires a threshold level of B cells.

J Immunol (2020) 204 (9): 2429–2438.

  • Depletion of Tregs worsens exacerbation of lung fibrosis in mice.

  • IL-2­–dependent expansion of Tregs attenuates exacerbation of lung fibrosis in mice.

  • Tregs contribute to regulation of exacerbation of lung fibrosis.

J Immunol (2020) 204 (9): 2439–2446.

  • PKCη deletion does not impair immunity against LCMV infection.

  • PKCη-depleted murine or human CD8+ display intact activation and effector functions.

IMMUNE SYSTEM DEVELOPMENT

J Immunol (2020) 204 (9): 2447–2454.

  • Rac2 controls T lymphoid progenitor migration towards the thymus.

  • The Pak1–AKT pathway mediates Rac2 regulation of T lymphoid progenitor homing.

IMMUNOGENETICS

J Immunol (2020) 204 (9): 2455–2463.

  • Two divergent allele lineages of KLRA have become fixed in the cattle population.

  • The two cattle KLRA allele lineages likely have contrasting functions.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2020) 204 (9): 2464–2473.

  • Fprs (FPRs in humans) interact with E. coli–derived chemotactic ligands.

  • Fprs mediate neutrophil recruitment in response to E. coli products.

  • Fpr-deficient mice show increased mortality to E. coli infection.

J Immunol (2020) 204 (9): 2474–2491.

  • Gal-9 and VISTA are highly expressed on T cells of HIV-infected individuals.

  • Upregulation of Gal-9 and VISTA is associated with impaired T cell functions.

  • CD44 clustering by Gal-9 influences cytoskeleton rearrangement of TCR.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2020) 204 (9): 2492–2502.

  • CXCL13 is expressed in alveolar macrophages from patients with IPF.

  • TNF-α and IL-10 control CXCL13 expression through NF-κB and JAK/STAT, respectively.

J Immunol (2020) 204 (9): 2503–2513.

  • Human and murine diabetic macrophages demonstrate dynamic TLR4 expression.

  • MLL1 regulates diabetic macrophage TLR4 expression during pathologic wound healing.

  • Myeloid depletion of TLR4 or pharmaceutical inhibition improves diabetic wound repair.

J Immunol (2020) 204 (9): 2514–2522.

  • IRF8 promotes NLRP3 inflammasome activation in response to Gram-negative bacteria.

  • IRF8 contributes to caspase-11 and caspase-8 cleavage to enhance cell death.

  • Phosphorylation of IRF3 mediated by IRF8 is required for the type I IFN response.

J Immunol (2020) 204 (9): 2523–2534.

  • Lactobacillus and Salmonella secretomes differentially impact IEC immune activity.

  • LrS induces DUSP1, ATF3, and TRIB3 expression in STS- and TNF-α–challenged IEC.

  • LrS induces MIF and attenuates proinflammatory mediator induction by STS or TNF-α.

J Immunol (2020) 204 (9): 2535–2551.

  • GPBAR1 attenuates liver recruitment of monocyte-derived macrophages after DILI.

  • GPBAR1 modulates CCL2/CCR2 axis at the sinusoidal cell/macrophage interface.

J Immunol (2020) 204 (9): 2552–2561.

  • Steady-state neutrophils in lymph nodes exit by efferent lymphatics to recirculate.

  • Neutrophil entry into lymph nodes at steady state is mediated by L-selectin.

  • Postinfection, lymph node neutrophils recruit more neutrophils via LTB4 release.

J Immunol (2020) 204 (9): 2562–2574.

  • HSP70 decreased the secretion of IFN-α.

  • HSP70 inhibited the phosphorylation of IRF7.

  • HSP70 competed with IKKε to bind IRF7.

TUMOR IMMUNOLOGY

J Immunol (2020) 204 (9): 2575–2588.

  • Metformin promoted the differentiation of memory CD8+ T cells.

  • Metformin regulates the AMPK–miR-107–Eomes–PD-1 pathway.

  • The antitumor ability of CAR-T cells was enhanced by metformin treatment.

J Immunol (2020) 204 (9): 2589–2599.

  • S100A8 upregulates PD-L1 expression in macrophages but not in cancer cells.

  • S100A-pretreated macrophages attenuate antitumor ability of CTLs.

NOVEL IMMUNOLOGICAL METHODS

J Immunol (2020) 204 (9): 2600–2611.

  • New Gata3 reporter mice allow noninvasive monitoring of Th2 polarization.

  • Gata3-driven fluorescent marker expression highlights ILC2 progenitor cells.

  • Patterns of reporter expression disprove claims of monoallelic Gata3 expression.

CORRECTIONS

J Immunol (2020) 204 (9): 2612.
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