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J Immunol (2020) 205 (10): 2555–2556.


J Immunol (2020) 205 (10): 2557–2565.
J Immunol (2020) 205 (10): 2566–2575.


J Immunol (2020) 205 (10): 2577–2582.

  • Expression level of tissue Ag determines the fate of responding T cells in vivo.

  • Rapa rescues the generation of peripheral Foxp3+ T cells even at a high Ag dose.

  • A low level of endogenous tissue Ag differentiates stable Foxp3+ T cells in vivo.


J Immunol (2020) 205 (10): 2583–2594.

  • CTL responses require overlap of directly and cross-presented peptide repertoires.

  • Apoptosis, but not necrosis, is associated with global protein aggregation.

  • Aggregation aids overlap of directly and cross-presented epitopes.


J Immunol (2020) 205 (10): 2595–2605.

  • Siglec-15 on osteoclasts is crucial for bone erosion in an arthritis model.

  • Murine Siglec-15 is expressed almost exclusively on osteoclasts.

  • Human Siglec-15 is expressed broadly on myeloid cells of peripheral blood.

J Immunol (2020) 205 (10): 2606–2617.

  • A-to-I RNA editing of Alu dsRNAs is markedly decreased in MS.

  • Endogenous Alu dsRNAs are potent activators of IFN and NF-κB responses.

  • Minor RNA editing of active Alu dsRNAs abrogates this activity.


J Immunol (2020) 205 (10): 2618–2628.

  • Innate immune and stool microbiome signatures of HEU children are region specific.

  • Differences in HEU immune responses were unrelated to the microbiome.

  • Future immune studies of HEU children must be studied across diverse settings.

J Immunol (2020) 205 (10): 2629–2639.

  • IFN signaling is ongoing in CLL patients treated with ibrutinib.

  • Ibrutinib modulates IFN-stimulated gene expression but preserves survival signaling.


J Immunol (2020) 205 (10): 2640–2648.

  • Plasma-derived IgA induces death in neutrophils under inflammatory conditions.

  • IgA-mediated death involves PI3K-, p38 MAPK–, and JNK-dependent pathways.

J Immunol (2020) 205 (10): 2649–2666.

  • Zbtb20 is an important regulator of effector and memory CD8 T cell immunometabolism.

  • Differentiation to a memory precursor phenotype is favored by Zbtb20 deficiency.

  • CD8 T cells deficient in Zbtb20 confer enhanced protection against tumors.

J Immunol (2020) 205 (10): 2667–2678.

  • Neutralization of IL-2 in vivo does not immediately disrupt Treg cell function.

  • Treg cells maintain normal IL-2 signaling with the CD25 Ab PC61 in vivo.


J Immunol (2020) 205 (10): 2679–2693.

  • Stage 3 and 4A but not 4B NKDIs retain non–NK ILC developmental potential.

  • Notch activation in the presence of stroma promotes ILC2 and ILC3 differentiation.

  • NOTCH1 and NOTCH2 regulate ILC differentiation from stage 3 and 4A cells.

J Immunol (2020) 205 (10): 2694–2706.

  • Macrophages are “whistle blowers” to initiate emergency myelopoiesis in zebrafish.

  • The IL-1b–NF-κB&C/ebpβ axis is crucially involved in the emergency myelopoiesis.


J Immunol (2020) 205 (10): 2707–2718.

  • P. pentosaceus MVs possess potent anti-inflammatory immunotherapeutic potential.

  • P. pentosaceus MVs upregulate IL-10, Arg-1, and PD-L1 levels on myeloid cells.

  • MVs promote M2-like macrophage and MDSC differentiation.


J Immunol (2020) 205 (10): 2719–2725.

  • A substantial number of recovered subjects (20%) have no or low titers of NAbs.

  • Recovery from infection does not seem solely dependent on high NAb titers.

  • NAb titers are correlated well with severity of disease and age of the affected.

J Immunol (2020) 205 (10): 2726–2741.

  • HIV seeding occurs early in different tissues and anatomical sites.

  • HIV tissue spread is cell type–, tissue-, and ART-dependent.

  • HIV uses tunneling nanotube–like structures to infect neighboring cells.

J Immunol (2020) 205 (10): 2742–2749.

  • KSHV Abs mediate ADCC responses against lytically reactivated cells.

  • Over one-third of KSHV-seropositive individuals have ADCC responses.

  • ADCC does not differ between KS patients and asymptomatic controls.

J Immunol (2020) 205 (10): 2750–2762.

  • Mucosal TB vaccine induces memory AwMs.

  • Vaccine-trained AwMs enhance anti-TB innate immunity.

  • Macrophage-mediated anti-TB innate immunity is independent of T cells and monocytes.

J Immunol (2020) 205 (10): 2763–2777.

  • UPEC and E. faecalis have a tropism for the mouse prostate over the bladder.

  • There is no protective immune memory to a second bacterial prostate infection.

  • Bacterial uptake is altered in challenge infection compared with primary.


J Immunol (2020) 205 (10): 2778–2785.

  • RIPK3 promotes pyrin inflammasome activation independent of its role in necroptosis.

  • RIPK3 modulates the mTOR pathway to regulate pyrin inflammasome activation.

  • Inhibition of mTOR promotes Mefv expression and pyrin inflammasome activation.

J Immunol (2020) 205 (10): 2786–2794.

  • BP180 is expressed in bone marrow mesenchymal stem cells.

  • BP180 in bone marrow mesenchymal stem cells regulates granulopoiesis.

J Immunol (2020) 205 (10): 2795–2805.

  • Activation of TLR4 by heme or LPS triggers distinct signaling outcomes.

  • Heme signals via TLR4, Syk, and ROS to induce cytokine expression in macrophages.

  • Death due to hemolysis in mice depends on TLR4, TNFR1, and mitochondrial ROS.

J Immunol (2020) 205 (10): 2806–2820.

  • iMo recruitment via CD11c and VLA-4 binding VCAM-1 is enhanced in cardiac patients.

  • CD11c mechanosignals phenotypic conversion of iMo to an inflammatory state.

  • ADAM17 on iMo cleaves membrane CD16, marking inflammatory gene activation.

J Immunol (2020) 205 (10): 2821–2833.

  • SIRPα deficiency enables various inflammatory stimuli to confer sHLH/CSS in mice.

  • Macrophage depletion, but not IFN-γ neutralization, precludes sHLH in SIRPα−/− mice.

  • SIRPα negatively regulates TLR9 signaling by inhibiting Erk1/2 and p38 activation.

J Immunol (2020) 205 (10): 2834–2839.

  • C5aR2 is protective in gut ischemia-reperfusion injury.

  • C5aR2 negatively regulates C5aR1-induced neutrophil infiltration.

  • C5aR2 promotes neutrophil mobilization/egress from bone marrow.

J Immunol (2020) 205 (10): 2840–2849.

  • Adrenic acid is the first omega-6 fatty acid with proresolving functions.

  • Adrenic acid inhibits leukotriene B4 production, specifically in neutrophils.

  • Adrenic acid treatment alleviates leukotriene B4–mediated experimental arthritis.


J Immunol (2020) 205 (10): 2850–2860.

  • IgG1 Abs with different V regions bind to FcRn with different affinity.

  • The V region of IgG1 dictates the mechanism of molecular recognition by FcRn.

  • Formation of immune complexes modifies the mechanism of IgG binding to FcRn.

J Immunol (2020) 205 (10): 2861–2872.

  • HLA-E*01:01, HLA-E*01:03, Mamu-E, and Qa-1b have unique motifs.

  • Each MHC-E molecule binds alternative peptides with conserved main anchor residues.

  • Nonanchor residues can play an important role in peptide binding to MHC-E.


J Immunol (2020) 205 (10): 2873–2882.

  • Flagellin induces GM-CSF production by AECs.

  • GM-CSF transactivates lung conventional dendritic cells.

  • GM-CSF drives the mucosal adjuvant activity of flagellin/TLR5.


J Immunol (2020) 205 (10): 2883–2892.

  • MARCH E3 ubiquitin ligases regulate responses to anti-tumor Abs.

  • The tumor’s MARCH protein repertoire may determine sensitivity to those Abs.

J Immunol (2020) 205 (10): 2893–2904.

  • Intratumoral 41BB agonism induces tumor regression in mouse models.

  • 41BB agonism potentiates myeloid-mediated costimulation in tumors.

  • Activation of 41BBL but not 41BB in human APCs promotes costimulatory responses.

J Immunol (2020) 205 (10): 2905–2915.

  • An MSS CRC patient responded rapidly to fruquintinib plus anti–PD-1 therapy.

  • Fruquintinib plus anti–PD-1 treatment significantly inhibited tumor growth in mice.

  • Fruquintinib plus anti–PD-1 treatment led to an antitumor tumor microenvironment.

J Immunol (2020) 205 (10): 2916–2925.

  • Tumor exosome–derived miR-183 regulates macrophage cytokine production.

  • miR-183 contributes to metastatic spread of breast tumors in vivo.

J Immunol (2020) 205 (10): 2926–2935.

  • Myo9b deficiency in tumor cells and host mice both suppress the development of MPE.

  • TSAd expression mediated by Myo9b associates with TH1/TH17 cell differentiation.

  • Myo9b mediates MPE suppression by TSAd-dependent TH1/TH17 cell response regulation.

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