Issues

Fgl2 is a soluble effector molecule highly expressed by TFR cells.

Fgl2 directly binds to B cells and TFH cells, regulating humoral responses.

Fgl2-deficient mice spontaneously develop an inflammatory, lupus-like autoimmunity.

Unlike autoimmune arthritis, insulitis and T1D develop without SAP.

B cell Ag presentation can drive SAP-deficient T cell proliferation.

SAP^−/− NOD mice show intact IFN-γ responses and TFH1 cell pancreatic infiltration.

A panel of inhibitors was screened for SFs of RA patients.

Inhibitors for PDGFR, PI3K, and GSK-3 suppressed invasion of SFs from RA patients.

The inhibitors also suppressed migration, proliferation, and IL-6 production from SFs.

There is currently no clinical tool to measure the immune reserve in patients.

A two-step, cell-based assay is sensitive and specific for over-immunosuppression.

Colchicine induces a neutrophil contractile response in a GEF-H1–dependent manner.

Colchicine induces GEF-H1–dependent inhibition of neutrophil rolling and adhesion.

GEF-H1 is required for colchicine inhibition of neutrophil response to MSU in vivo.

Inducible and constitutive enhancers cooperate to generate transcriptional outputs.

Identification of TF binding site clusters is critical in Il13 gene transcription.

Rhesus FcγR2A allotypes differ in their interactions with different IgG subclasses.

Rhesus FcγR3A allotypes show little variation in IgG subclass interactions.

Human and macaque IgG1 but not IgG2–4 exhibit similar IgG–FcγR interactions.

Neutrophils play critical roles in Leishmania vaccine–induced protective immunity.

Depletion of neutrophils impairs Leishmania vaccine efficacy.

DR3 levels are associated with spontaneous in vivo control of HIV.

Upon treatment, TL1A is associated with Tregs and sDR3 with effector CD8 T cells.

DR3 agonists can be used to boost HIV-specific T cell responses in vitro.

Agonism of CD28 improves sepsis mortality in memory but not naive hosts.

CD28 agonism results in enhanced production of IL-10 from Foxp3⁺ Treg cells in memory mice.

IL-10 is required for the survival benefit of CD28 agonism in septic memory mice.

Perforin is a dominant control mechanism of B lymphoma in γHV infection.

Immune effector hierarchies differ in control of B lymphoma and γHV replication.

CD4 T cell help is not essential to control B lymphoma in γHV immune mice.

Cells show immunological learning to prior exposure to Borrelia burgdorferi.

Learned responses differ by cell type and include both training and tolerance.

Learned responses correlate with infectious symptoms observed in murine models.

The role of Mincle overexpression in bacterial pneumonia is currently unsettled.

Mincle overexpression rendered mice more susceptible to pneumococcal pneumonia.

Mincle receptor expression must be inducible in response to microbial challenge.

Human IgG subclasses elicit distinct cytokine profiles by myeloid immune cells.

Subclass-specific effects are mediated by distinct metabolic reprogramming by FcγRs.

IgG subclasses provide pathogen- and cell type–specific immunity.

NSUN5 effectively restricted RNA virus infection in vitro and in vivo.

NSUN5 acted as a novel RIG-I coreceptor.

NSUN5 synergized the recognition of RNA virus by RIG-I.

Tupaia OASL1 is critical for RNA virus–induced antiviral signaling transduction.

tOASL1 is associated with mitochondria.

tOASL1 is a positive regulator of type I IFN induction by recruiting tMDA5 to tMAVS.

A rare subset of FcRγ^– NK cells is highly expanded in chronic HIV-1 infection.

IL-18Rα impairment renders FcRγ^– NK cells deficient in helper cell differentiation.

Deficits in IFN-γ due to FcRγ^– NK cell expansions lead to inferior NK–DC cross-talk.

OnMBL was able to bind and agglutinate with pathogens.

OnMBL was able to significantly reduce the proliferation of pathogens.

OnMBL could promote phagocytosis of macrophages with OnCRT interaction.

Deletion of Gly236 in human IgG1, naturally lacking in IgG2, silences FcγR.

Deletion of Gly236 has no effect on complement-mediated effector functions.

Data suggest how IgG2 may have lost FcγRI binding during evolution.

SHM targeting for a DNA 5-mer motif can differ by position.

Direction of differential targeting conserved across subjects and alleles.

Differential targeting correlates with mutability of wider neighborhood of motifs.

Kras deficiency subtly changes TCR- and IL-6–induced gene expression.

Deletion of Kras in donor T cells dramatically reduces aGVHD but maintains graft-versus-leukemia.

We developed a sensitive total Ab bridging assay to detect SARS-CoV-2 Abs.

The assay reliably detects SARS-CoV-2 Abs also in nonhospitalized patients.

Fewer Abs arise but with similar kinetics compared with hospitalized patients.