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J Immunol (2020) 205 (3): 553–554.


J Immunol (2020) 205 (3): 555–564.


J Immunol (2020) 205 (3): 567–572.

  • Blockade of Ly49/MHC-I interactions by anti–MHC-I results in the activation of NK cells.

  • IFN-γ produced by activated NK cells stimulates APC to produce IL-15.

  • Activated NK and T cells markedly augment antiviral and antitumor immunity.

J Immunol (2020) 205 (3): 573–578.

  • MHC I can be induced in skeletal muscle in a doxycycline dose–dependent manner.

  • Elevated muscle MHC I results in initial enhanced immune control of Trypanosoma cruzi.

  • Sustained elevation in muscle MHC I ultimately exhausts pathogen-specific responses.


J Immunol (2020) 205 (3): 579–586.

  • LPS increases cell surface expression of the SE receptor CRT.

  • SE–CRT interaction increases [Ca2+], PAD activation, and protein citrullination.

  • In SE-expressing Tg mice, LPS activates PAD, ACPA, and bone erosions.


J Immunol (2020) 205 (3): 587–594.

  • HIV RPs are an understudied patient population.

  • Globally, IgG SHM is inversely correlated with disease progression.

  • Longitudinal lineage tracking reveals ongoing SHM with disrupted selection in RPs.

J Immunol (2020) 205 (3): 595–607.

  • lncRNA BCALM (AC099524.1) is B cell specific and highly expressed in human lymphomas.

  • BCALM is necessary for the interaction of signal transduction proteins PLD1 and AKAP9.

  • BCALM promotes negative feedback that downmodulates BCR-stimulated Ca+ signaling.


J Immunol (2020) 205 (3): 608–618.

  • Dendritic cells transfer Ags to and activate B cells in vivo.

  • Ags released from dendritic cells by regurgitation promote B cell activation.

  • Early B cell activation by dendritic cell regurgitation requires NF-κB/cRel.

J Immunol (2020) 205 (3): 619–629.

  • Glucocorticoid binding to glucocorticoid receptors in B cells upregulates CXCR4.

  • Glucocorticoids control diurnal exchange of B cells between blood and bone marrow.

  • B cellGRKO mice exhibit impaired IgG response to T-independent (Type II) Ag.


J Immunol (2020) 205 (3): 630–636.

  • N-glycan branching is required for generation of mature B cells.

  • N-glycan branching inhibits development of pre-, immature, and T2 B cells.

  • N-glycan branching promotes CD19 surface expression to inhibit death by neglect.


J Immunol (2020) 205 (3): 637–647.

  • Chinese alligator has a complicated genomic organization of the TCRα/δ locus.

  • Unidirectional transfer of V from IgH to TCR locus occurred frequently in vertebrate.

  • A model explaining the evolutionary pattern of atypical VHδ genes was proposed.


J Immunol (2020) 205 (3): 648–660.

  • Neutralizing mAb 2–12C reduces influenza viral load and lung pathology in pigs.

  • DNA plasmid–encoded 2–12C reduces lung pathology.

  • The pig is a useful preclinical model for testing mAbs and mAb delivery platforms.

J Immunol (2020) 205 (3): 661–673.

  • Targeting different receptors on cDC1s impacts immune responses.

  • Targeting Xcr1 induces Th1 polarization in vivo and in vitro.

  • Targeting hemagglutinin to Xcr1 or Clec9A induces protection from influenza challenge.


J Immunol (2020) 205 (3): 674–685.

  • Pulmonary IL-25 expression is induced in response to C. neoformans infection.

  • IL-25 signaling supports fungal dissemination by promoting type 2 immune response.

  • Th2 cells are responsible for IL-25–mediated cryptococcal dissemination.

J Immunol (2020) 205 (3): 686–698.

  • γδT cells produce IL-17A after cryptococcal infection.

  • IL-17A regulates Th1-mediated protection against cryptococcal infection.

  • Tg mice highly expressing TCR specific for cryptococcal Ag were generated.

J Immunol (2020) 205 (3): 699–707.

  • TCR affinity is associated with CTL ability to kill reactivated HIV-infected cells.

  • Ag sensitivity correlates with CTL killing capacity.

  • Clonal selection of high-affinity clonotypes may contribute to HIV control.

J Immunol (2020) 205 (3): 708–719.

  • T-bet−/− mice induce significant IFN-γ responses after Salmonella infection.

  • Infection of T-bet−/− mice enhances nonprotective Th17/neutrophil responses.

  • iNOS+ granulomas that fail to constrain Salmonella are induced in T-bet−/− mice.

J Immunol (2020) 205 (3): 720–730.

  • A murine IL-17F.S65L ortholog recapitulates the impaired signaling function in vitro.

  • IL-17F.S65L knock-in mice are susceptible to oral candidiasis, unlike Il17f−/− mice.

  • Il17fS65L/S65L mice may be a broadly valuable tool to interrogate IL-17F function.


J Immunol (2020) 205 (3): 731–740.

  • Immunity to chronic filarial worm infection is apparent in IL-4Rα–deficient mice.

  • Delayed immunity in IL-4Rα−/− mice is due to suboptimal tissue eosinophilia.

  • Eosinophil recruitment in the absence of IL-4R signaling requires CCR3 and IL-5.

J Immunol (2020) 205 (3): 741–759.

  • Disparate selection occurs with age upon B-1a cells with different specificities.

  • Disparate selection occurs with age upon B-1a cells in distinct locations.

J Immunol (2020) 205 (3): 760–766.

  • P2X5 is required for early protective immunity to L. monocytogenes.

  • Macrophages use P2X5 for L. monocytogenes–induced inflammasome activation and L. monocytogenes killing.

  • P2X5-dependent anti–L. monocytogenes functions are independent of both P2X7 and extracellular ATP.

J Immunol (2020) 205 (3): 767–775.

  • The cell surface receptors RAGE and TLR4 regulate HMGB1-induced inflammation.

  • RAGE promotes TLR4 trafficking to the cell surface but does not affect its translation.

  • TLR4 regulates the translation of RAGE, which translocates to the cell surface.

J Immunol (2020) 205 (3): 776–788.

  • GH reprograms inflammatory macrophages to an anti-inflammatory phenotype.

  • GH modulates inflammation by altering activin A secretion and MAFB-dependent genes.

J Immunol (2020) 205 (3): 789–800.

  • Soluble but not crystalline UA acts as a negative regulator of innate immunity.

  • sUA suppresses activated monocytes via SLC2A9-mediated intracellular uptake.

  • Asymptomatic HU attenuates MSU crystal–induced tissue inflammation.

J Immunol (2020) 205 (3): 801–810.

  • Dexamethasone impairs NK cell cytotoxicity by suppressing LIMK F-actin regulation.

  • Lipoxin A4 induces LIMK to promote lytic granule trafficking and NK cell killing.

J Immunol (2020) 205 (3): 811–821.

  • L. paracasei inhibits NLRP3 inflammasome activation in vitro.

  • The inhibitory effect of L. paracasei on the inflammasome is dependent on IL-10.

  • Oral administration of L. paracasei prevents inflammation-related disorders.


J Immunol (2020) 205 (3): 822–829.

  • PU.1 and IRF4 are required for PD-L2 expression in dendritic cells.

  • PU.1 and IRF4 transactivate the Pdcd1lg2 gene via direct binding to an EICE sequence.

  • PU.1 is involved in the p300-mediated histone acetylation of the Pdcd1lg2 gene.

J Immunol (2020) 205 (3): 830–841.

  • We identify checkpoints restricting the BCR-induced class switch recombination.

  • TRAF3 maintains B cell homeostasis by fine-tuning the BCR signaling strength.


J Immunol (2020) 205 (3): 842–852.

  • Impaired TFH/IgA axis in ATF3-deficient mice leads to dysbiosis of gut microbiota.

  • Dysbiosis of gut microbiota aggravates colitis in the absence of ATF3.

J Immunol (2020) 205 (3): 853–863.

  • ILC3-derived LT and IEC-derived LTβR regulate innate defense against Listeria.

  • LT–LTβR axis increases GC numbers and MUC2 expression during Listeria infection.

  • LTβR signaling and downstream RelB are associated with GC differentiation.


J Immunol (2020) 205 (3): 864–871.

  • High-dimensional single-cell analysis uncovers heterogeneity in flow cytometry data.

  • Correct data transformation of flow cytometry data is crucial for interpretation.

  • Extensively documented R code incorporates existing single-cell analysis tools.

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