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J Immunol (2020) 205 (4): 875–876.

IMMUNOLOGY NOTES AND RESOURCES

J Immunol (2020) 205 (4): 877–882.

BRIEF REVIEWS

J Immunol (2020) 205 (4): 883–891.
J Immunol (2020) 205 (4): 892–898.

CUTTING EDGE

J Immunol (2020) 205 (4): 901–906.

  • Batf3 expression by CD8 T cells critically regulates memory T cell development.

  • Batf3−/− CD8 T cells undergo increased apoptosis during contraction.

  • Batf3−/− CD8 T cells have an impaired recall ability but remain functional.

ALLERGY AND OTHER HYPERSENSITIVITIES

J Immunol (2020) 205 (4): 907–914.

  • NRF2 promotes keratinization and replenishes epidermal thiol gradient.

  • NRF2-dependent antioxidative response directs allergic contact dermatitis.

  • NRF2 may provide critical direction to the early phases of atopic disorders.

ANTIGEN RECOGNITION AND RESPONSES

J Immunol (2020) 205 (4): 915–922.

  • Generation and screening of anti–SARS-CoV-2 RBD mAbs reveal a potently protective Ab.

  • mAb 2B04 potently neutralizes SARS-CoV-2 in vitro.

  • mAb 2B04 protects mice from morbidity in a murine model of SARS-CoV-2 infection.

J Immunol (2020) 205 (4): 923–935.

  • Three of the four HLA-DOA common alleles have differential impact on DM function.

  • Fifty-two percent of all DOA variants tested displayed altered function.

  • Two DOA variants were genetically linked to the outcome of hepatitis B infection.

J Immunol (2020) 205 (4): 936–944.

  • A recent study proposes a new process as the dominant mechanism of human/mouse SHM.

  • We re-examine these results by estimating the false positive rates of their approach.

  • We find no evidence that templated mutagenesis is a major contributor to SHM.

AUTOIMMUNITY

J Immunol (2020) 205 (4): 945–956.

  • CLEC16A correlates to surface CLIP expression in human B-LCLs and primary B cells.

  • CLEC16A knockdown impairs BCR-mediated uptake of Ag into MIICs.

  • CLIP is abundant and not coregulated with CLEC16A in blood B cells of MS patients.

J Immunol (2020) 205 (4): 957–967.

  • Metformin + 2-DG represses human CD4+ T cell IFN-γ production and cell proliferation.

  • Metformin + 2-DG inhibits human CD4+ T cell Gln uptake and metabolic reprogramming.

  • Metformin + 2-DG reduces MYC and HIF-1A expression in human CD4+ T cells.

J Immunol (2020) 205 (4): 968–980.

  • Osteomacs are associated with endplate osteosclerosis in MCs.

  • Osteomacs can regulate osteogenesis through the OSM-STAT3/YAP1 signaling axis.

  • OSM blockade prevents endplate osteosclerosis in MCs.

IMMUNE REGULATION

J Immunol (2020) 205 (4): 981–986.

  • Tob2 inhibits TLR-induced proinflammatory cytokine expression.

  • Tob2 negatively regulates TLR4-induced NF-κB and MAPK activation.

  • Tob2 interacts with TRAF6 and MyD88 and inhibits signaling from them.

J Immunol (2020) 205 (4): 987–993.

  • lncRNA AW112010 expression is increased in proinflammatory T cells.

  • AW112010 associates with histone demethylase KDM5A.

  • AW112010 suppresses IL-10 expression through histone demethylation.

J Immunol (2020) 205 (4): 994–1008.

  • Zebrafish IL-4–like cytokines promote type 2 and suppress type 1 immunity.

  • Zebrafish IL-10 is potently anti-inflammatory and essential for gill homeostasis.

J Immunol (2020) 205 (4): 1009–1023.

  • Mice lacking VHL in their T cells are resistant to EAE.

  • VHL-deficient CD4 T cells have reduced capacity for Th17 differentiation.

  • VHL-deficient Th17 cells have altered cellular metabolism.

J Immunol (2020) 205 (4): 1024–1038.

  • Myeloid cell–intrinsic IRF5 regulates chemokine-dependent T cell migration.

  • Myeloid cell IRF5 regulates key checkpoints in T cell activation/differentiation.

  • IRF5 risk variants modulate myeloid cell–dependent T cell–conditioning outcomes.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2020) 205 (4): 1039–1049.

  • S. aureus–infected DCs induce Vδ2+ cell IFN-γ secretion via cell contact and IL-12.

  • Vδ2+ IFN-γ secretion promotes reciprocal enhancement of DC activation.

  • Coculturing infected DCs with γδ T cells enhances CD4+ cell responses to S. aureus.

J Immunol (2020) 205 (4): 1050–1058.

  • Developing CD11c+ T-bet+ B cells require TFH1 cells that produce both IFN-γ and IL-21.

  • Obligate IFN-γ and CD40L signals are provided at distinct times following infection.

  • CD11c+ B cells lacking T-bet undergo normal differentiation but improper switching.

J Immunol (2020) 205 (4): 1059–1069.

  • LLEC exhibit transcriptional characteristics common to effector and memory T cells.

  • LLEC undergo homeostatic proliferation but do not critically depend on IL-15.

  • LLEC are predominantly derived from KLRG1hi effector cells at 12 d postinfection.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2020) 205 (4): 1070–1083.

  • Macrophages of different cellular origins remodel chromatin differently.

  • DNA shape features flanking PU.1 motifs may regulate chromatin remodeling.

J Immunol (2020) 205 (4): 1084–1101.

  • ILC2s are activated even after injury from respiratory viral infection is resolved.

  • ILC2s contribute to a chronic type 2 immune response after viral infection.

  • ILC2s depend on myeloid–macrophage lineage cells to drive postviral disease.

J Immunol (2020) 205 (4): 1102–1112.

  • C5aR2 agonism dampens C5aR1-, C3aR-, and CMKLR1-mediated ERK signaling in macrophages.

  • C5aR2 agonism modulates C5aR1-, C3aR-, and LTB4R-mediated calcium mobilization.

  • C5aR2 activation downregulates TLRs 3, 4, 7, Mincle-, and STING-mediated cytokines.

J Immunol (2020) 205 (4): 1113–1124.

  • Macrophages expressing CD122 accumulate in the uterus and maternal–fetal interface.

  • M-CSF and IFNs drive macrophages to express CD122.

  • IL-15 causes CD122+ macrophages to activate ERK and enhance cytokine production.

J Immunol (2020) 205 (4): 1125–1134.

  • Mitochondrial catalase regulates inflammation by altering cellular metabolism.

  • NAD(H) levels modulate NF-κB activation in macrophages.

J Immunol (2020) 205 (4): 1135–1146.

  • Zebrafish phd3 negatively regulates antiviral responses.

  • Zebrafish phd3 suppresses irf7 transactivity.

  • Phd3 suppresses irf7 transactivity independent of its enzymatic activity.

J Immunol (2020) 205 (4): 1147–1156.

  • Active Gsk3 promotes hepatocyte autophagy in response to TNF-α.

  • Gsk3 N-terminal phosphorylation inhibits macrophage TLR activation.

J Immunol (2020) 205 (4): 1157–1166.

  • COX inhibition increased Alternaria extract–induced pulmonary ILC2 responses.

  • COX inhibition promoted Alternaria extract–induced IL-33 release in the lung.

  • COX inhibition augmented rIL-33–induced pulmonary ILC2 responses.

J Immunol (2020) 205 (4): 1167–1175.

  • Both radioresistant and radiosensitive cells produce Il-18bp during CpG-induced MAS.

  • Il-18bp behaves as Ifn-γ signature gene during CpG-induced MAS.

  • Elevated circulating levels of Il-18bp prevent systemic effects of Il-18 in MAS.

NOVEL IMMUNOLOGICAL METHODS

J Immunol (2020) 205 (4): 1176–1184.

  • Single-cell/Ab resolution characterizes recall with unprecedented resolution.

  • Recalled IgG-SCs appear fast and, at this early stage, free of naive IgG-SCs.

  • Recalled IgG-SCs correlated strongly with the IgG-SCs generated during boost.

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