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J Immunol (2020) 205 (5): 1187–1188.

BRIEF REVIEWS

J Immunol (2020) 205 (5): 1189–1197.
J Immunol (2020) 205 (5): 1198–1206.

ANTIGEN RECOGNITION AND RESPONSES

J Immunol (2020) 205 (5): 1207–1216.

  • MHC II ubiquitination is dispensable for maintenance of conventional CD4+ T cells.

  • MHC II ubiquitination is required for thymic Treg development.

  • Lack of MHC II ubiquitination does not provoke autoimmunity.

J Immunol (2020) 205 (5): 1217–1227.

  • ITK regulated TCR signal strength and Ag affinity control development of CD8 memory.

  • Reducing TCR signal strength and Ag affinity enhances CD8 memory development.

  • TCR signal strength controls cytokine production independent of TCR Ag affinity.

J Immunol (2020) 205 (5): 1228–1238.

  • The floxed H-2Db mouse is a new tool for dissecting cell-specific Ag presentation.

  • Rapid priming of CNS-infiltrating antiviral CD8 T cells requires DCs.

  • LysM+ APCs are not equivalent to DCs in priming antiviral CD8 T cells.

AUTOIMMUNITY

J Immunol (2020) 205 (5): 1239–1247.

  • Bystander innate and adaptive signals can partially breach B cell anergy.

  • Self-reactive B cells can be recruited at low levels into the GC.

  • Ab production to self-antigen is rapid but transient and of low affinity.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2020) 205 (5): 1248–1255.

  • Confocal imaging microscopy uncovers Tfh cell dynamics in human lymphoid tissues.

  • Tfh cells show a heterogeneous distribution and migration in GC light zones.

  • In outer zones, Tfh cells move fast, forming brief homotypic interactions.

J Immunol (2020) 205 (5): 1256–1267.

  • Nrf2 is responsible for regulating CMA activity in COPD lungs.

  • Reduction of CMA activity causes enhanced UPR-mediated apoptosis in COPD.

IMMUNE REGULATION

J Immunol (2020) 205 (5): 1268–1280.

  • Thymic ECs express more MHC I molecules than extrathymic ECs.

  • Aire, Nlrc5, Stat1, and IFN-λ enhance constitutive MHC I expression in thymic ECs.

J Immunol (2020) 205 (5): 1281–1292.

  • HSV-2 inhibits type I IFN signaling mediated by viral protein ICP22.

  • ICP22 functions as a novel E3 ubiquitin protein ligase to degrade ISGF3.

J Immunol (2020) 205 (5): 1293–1305.

  • A novel cochlioquinone B derivative, CoB1, was purified.

  • CoB1 induces autophagy in mouse AMs against PAO1 infection.

  • CoB1 regulates autophagy through the PAK1/Akt1/mTOR signaling pathway.

IMMUNE SYSTEM DEVELOPMENT

J Immunol (2020) 205 (5): 1306–1317.

  • SWAP-70 and DEF6 are novel regulatory factors in DC differentiation.

  • Both factors act at separate stages in early DC precursors.

  • SWAP-70 and DEF6 regulate the functional maturation status of migDCs.

IMMUNOGENETICS

J Immunol (2020) 205 (5): 1318–1322.

  • GM 17/17 genotype was associated with a 4-fold increased risk of AD.

  • Association is independent of apolipoprotein E ε4 genotype and other AD risk genes.

  • Results unify the viral (HSV1) and genetic etiologies of AD.

J Immunol (2020) 205 (5): 1323–1330.

  • KIR3DL1 and HLA-Bw4 are associated with different PD clinical features.

  • Highly expressing KIR3DL1 variants protect against the more debilitating symptoms of PD.

IMMUNOTHERAPY AND VACCINES

J Immunol (2020) 205 (5): 1331–1344.

  • Deglycosylated SIV vaccine elicited protective response against heterologous SIV.

  • SIV-specific CD8+ T cells did not account for the protective response.

  • IL-15–responding NK and CD8+ T cells were associated with the protective response.

J Immunol (2020) 205 (5): 1345–1354.

  • Highly diluted Abs to IFN-γ induce conformational changes in IFN-γ.

  • Highly diluted Abs to IFN-γ improve binding of IFN-γ to the IFN-γ receptor.

  • Highly diluted Abs to IFN-γ increase survival of mice with influenza A infection.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2020) 205 (5): 1355–1364.

  • A naturally processed L. major peptide was identified and used to make a tetramer.

  • DLD-specific CD4+ T cells produce effector cytokines and display memory function.

  • Vaccination with rDLD protein induces strong protection against virulent challenge.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2020) 205 (5): 1365–1375.

  • Deficiency of ArhGAP15 leads to increased affinity of integrin Mac-1 on leukocytes.

  • ArhGAP15 affects leukocyte recruitment by control of postadhesion steps.

J Immunol (2020) 205 (5): 1376–1384.

  • AKI is a serious condition affecting one fifth of hospital patients.

  • In AKI, B cells produce CCL7 and facilitate neutrophil and monocyte recruitment.

  • CCL7 blockade in mice reduces myeloid cell infiltration and ameliorates AKI.

J Immunol (2020) 205 (5): 1385–1392.

  • MBL interacts with bound β2-GPI.

  • The MBL/β2-GPI complex activates the lectin pathway of the complement system.

  • Complement activated by the MBL/β2-GPI complex promotes thrombin generation.

J Immunol (2020) 205 (5): 1393–1405.

  • Deficiency of NLRP3 inflammasome and IL-1β prolongs survival after intestinal I/R.

  • NLRP3 inflammasome in LVECs plays an important role in intestinal I/R-induced ALI.

  • I/R-derived lipid mediators enhance NLRP3 inflammasome activation in LVECs.

J Immunol (2020) 205 (5): 1406–1418.

  • A disease-associated genetic variant regulates expression of both STAT1 and STAT4.

  • STAT1/STAT4 regulate autocrine/paracrine cytokine responses to microbial products.

  • STAT1/STAT4 cooperate to regulate antimicrobial pathways in human macrophages.

MOLECULAR AND STRUCTURAL IMMUNOLOGY

J Immunol (2020) 205 (5): 1419–1432.

  • BioID analysis reveals extensive transcription factor interactions.

  • GATA3 and TCF7 share binding sites with ARID1a in T cell progenitors.

  • ARID1a is essential for normal T cell development.

TRANSPLANTATION

J Immunol (2020) 205 (5): 1433–1440.

  • G-CSFR blockade with VR81 mAb is highly protective in a mouse model of renal IRI.

  • VR81 mAb reduces tubular injury, innate cell infiltration, and complement activation.

  • IR-induced changes in renal gene expression are prevented by VR81 mAb treatment.

J Immunol (2020) 205 (5): 1441–1448.

  • PTCY + ATG versus PTCY limits the occurrence of grade 2–4 acute GVHD after RIC PBSC h-HSCT.

  • Quicker reconstitution of some NK cell subtypes may help to avoid relapse.

TUMOR IMMUNOLOGY

J Immunol (2020) 205 (5): 1449–1460.

  • Low-avidity T cells provide poor tumor control and exhibit an exhausted phenotype.

  • IL-12 cytokine priming corrects low-avidity T cell defects and prevents exhaustion.

  • Low- and high-avidity T cells function equivalently with increased tumor Ag.

J Immunol (2020) 205 (5): 1461–1472.

  • Macrophage function is modulated by the surrounding ECM protein collagen.

  • A high collagen density makes macrophages more immunosuppressive.

  • Collagen could affect the immunosuppressive nature of tumor-associated macrophages.

CORRECTIONS

J Immunol (2020) 205 (5): 1473.
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