Issues

Four human Der p 2–specific IgE mAbs were identified by a new hybridoma technology.

The human IgE mAbs recognize two nonoverlapping epitopes on Der p 2.

NMR identified residues in the epitopes of human IgE and murine IgG mAbs.

FcγRIIb2 expression in BMECs is upregulated by Epo.

Epo induces a capacity of incorporating soluble ICs selectively in BMECs.

Epo promotes the clearance of soluble ICs in the blood circulation.

CD21^low B cells occur in different autoimmune diseases with different frequencies.

CD21^low B cells can present with naive and different memory phenotypes.

All subsets of CD21^low B cells share a common core phenotype.

T cells or whole spleen from NOD-PerIg mice transfer neuritis to NOD.scid recipients.

CD4⁺ T cells are necessary and sufficient to transfer neuritis.

Islet and sciatic nerve CD4⁺ T cells have differing patterns of CD95, PD-1, and Tim-3.

IL-4/IL-13 in the thymus guide HR⁺ETP to give rise to DCs.

IL-4/IL-13–driven HR⁺ETP–derived DCs reinforce negative selection of T cells.

IL-4/IL-13 fine-tune central T cell tolerance to constrain CNS autoimmunity.

CD8⁺ T cells release Wnts that suppress HIV transcription.

Antagonizing Wnts abrogates CD8⁺ T cell noncytotoxic anti-HIV activity.

Wnts correlate with HIV controller status.

T cell–secreted GM-CSF is a key mediator of constitutive CCL22 expression.

Induction of CCL22 represents a novel immunoregulatory mechanism of GM-CSF.

ST-4 induces CD8 T cell activation and increases TCRVβ 8.2 and 8.3 subgroup expression.

ST-4 promotes CD8 fatty acid metabolic program via mTOR/PPARγ/SREBP signal pathway.

ST-4 promotes CD8 mitochondrial energy metabolic program via p38 signal pathway.

WIV immunization resulted in early but transient Ag presentation and CD4 responses.

Adding checkpoint Ag at day 5 promoted lung CD4 memory T_RM and helper function.

High checkpoint Ag doses were required to drive the effectors to optimal memory.

Tupaia MAVS can be cleaved by HCV NS3/4A.

tMAVS impaired the IRF3-mediated, but not NF-κB–mediated, antiviral signaling.

The activation of NF-κB inhibited HCV replication and persistent infection.

PIK3IP1 is expressed in B cells and is downregulated late after activation.

Lack of PIK3IP1 impairs early class switching during T-dependent responses.

PIK3IP1 is not required for germinal center responses or T-independent responses.

Anti-PC and anti-MDA IgMs develop differently during early human life.

The newborn IgM anti-PC level is much lower than anti-MDA compared with mothers’ levels.

Newborns have diverse clones with lower peptide abundance compared with the mothers.

cDC subset differentiation from precommitted precursors is not proportional.

CD135 is differentially expressed in the cDC1 and cDC2 lineages.

Late stages of cDC1 differentiation are independent of FLT3L.

Foxp3⁺ cells are more highly represented in newborn spleen, lung, and circulation.

Newborn Tregs express higher levels of Foxp3 and CD25 compared with adults.

Newborn and adult Tregs differ in their survival and response to TCR engagement.

Pig IGHG genes can be classified into nine subclasses.

An evolutionary model for pig IGHG genes was proposed.

A mouse mAb 4A4 specific to the pig IgG3 was developed.

Pre-existing BCG immunity influences T cell responses of subunit booster vaccines.

M. tuberculosis–specific subunit vaccines bypass this mechanism and improve protection.

A TIGIT-blocking Ab (T4) requires CD8⁺ T and NK cells to confer antitumor effects.

T4-mediated Fc-dependent Treg depletion via NKs induces additional CD8⁺ T responses.

T4 Ab treatment confers durable T cell immune memory against multiple tumor types.

Pathogen-specific T_E are a prodigious source of chemokines.

The complete T_E chemokine spectrum is CCL3, CCL4, CCL5 > XCL1 ≥ CCL1 > CCL9/10 >> CXCL2.

T_E exhibit unique and shared chemokine synthesis/expression/secretion patterns.

Pathogen-specific T_M are a prodigious source of chemokines.

The chemokine-expression patterns of T_M largely resemble those of T_E.

Unique T_M chemokine signatures in acute/chronic infection are of diagnostic value.

FMDV 3B protein inhibits type I IFN production.

FMDV 3B protein interacts with RIG-I to block RIG-I–mediated immune signaling.

The aa 17A in each copy of 3B is critical for suppression of IFN response.

p53 precludes Cas9-mediated gene disruption in memory CD8 T cells.

Temporarily subduing p53 enables gene editing in memory CD8 T cells in vivo.

Cas9-mediated gene ablations in memory CD8 T cells are retained through recall.

OGG1 inhibitor SU0268 facilitates antibacterial immunity in PA14 infection.

SU0268 mitigates bacterial infection via an mtDNA-mediated cGAS pathway.

SU0268 attenuates lung injury caused by PA14 infection in vivo.

ADAMTS5 is upregulated in human IgA nephropathy lesions.

ADAMTS5 is related to inflammatory infiltrates in affected kidneys.

ADAMTS5 digests kidney matrix proteins and cleaves complement C3 and fibronectin.

AKT phosphorylates NLRP3 at S5, preventing self-oligomerization and IL-1β release.

NLRP3 S5 phosphorylation prevents TRIM31-mediated degradation during LPS priming.

The canonical Wnt pathway in intestinal APCs protects against CAC.

LRP5/6–β-catenin–IL-10 signaling in APCs suppresses chronic intestinal inflammation.

This pathway plays an important role in regulating intestinal commensal homeostasis.

CD28^null T cells show high reactivity of β₂ integrin upon chemokine stimulation.

ROS-mediated Ca²⁺ release is critical for β₂ integrin activation in T cells.

Spontaneous β₂ integrin activity of CD28^null T cells in ACS is ROS dependent.

hC3Nb3 inhibits classical pathway–mediated hemolysis.

hC3Nb3 inhibits alternative pathway–mediated C3 fragment deposition.

hC3Nb3 provides a new tool for studies of the complement system.

HIF-α subunits differentially regulate Tie2 expression on macrophages.

Myeloid HIF-1α deficiency enhances tumor oxygenation and chemotherapeutic response.

Rectal balloon collections minimize blood contamination of mucosal Ig.

Rectal balloon collections require ring lubrication to reduce blood contamination.

Rectal balloon collection is quick and well tolerated in humans.