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J Immunol (2020) 205 (8): 1979–1980.

BRIEF REVIEWS

J Immunol (2020) 205 (8): 1981–1989.
J Immunol (2020) 205 (8): 1990–1997.

ALLERGY AND OTHER HYPERSENSITIVITIES

J Immunol (2020) 205 (8): 1999–2007.

  • Four human Der p 2–specific IgE mAbs were identified by a new hybridoma technology.

  • The human IgE mAbs recognize two nonoverlapping epitopes on Der p 2.

  • NMR identified residues in the epitopes of human IgE and murine IgG mAbs.

ANTIGEN RECOGNITION AND RESPONSES

J Immunol (2020) 205 (8): 2008–2015.

  • FcγRIIb2 expression in BMECs is upregulated by Epo.

  • Epo induces a capacity of incorporating soluble ICs selectively in BMECs.

  • Epo promotes the clearance of soluble ICs in the blood circulation.

AUTOIMMUNITY

J Immunol (2020) 205 (8): 2016–2025.

  • CD21low B cells occur in different autoimmune diseases with different frequencies.

  • CD21low B cells can present with naive and different memory phenotypes.

  • All subsets of CD21low B cells share a common core phenotype.

J Immunol (2020) 205 (8): 2026–2038.

  • T cells or whole spleen from NOD-PerIg mice transfer neuritis to NOD.scid recipients.

  • CD4+ T cells are necessary and sufficient to transfer neuritis.

  • Islet and sciatic nerve CD4+ T cells have differing patterns of CD95, PD-1, and Tim-3.

J Immunol (2020) 205 (8): 2039–2045.

  • IL-4/IL-13 in the thymus guide HR+ETP to give rise to DCs.

  • IL-4/IL-13–driven HR+ETP–derived DCs reinforce negative selection of T cells.

  • IL-4/IL-13 fine-tune central T cell tolerance to constrain CNS autoimmunity.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2020) 205 (8): 2046–2055.

  • CD8+ T cells release Wnts that suppress HIV transcription.

  • Antagonizing Wnts abrogates CD8+ T cell noncytotoxic anti-HIV activity.

  • Wnts correlate with HIV controller status.

IMMUNE REGULATION

J Immunol (2020) 205 (8): 2056–2065.

  • T cell–secreted GM-CSF is a key mediator of constitutive CCL22 expression.

  • Induction of CCL22 represents a novel immunoregulatory mechanism of GM-CSF.

J Immunol (2020) 205 (8): 2066–2076.

  • ST-4 induces CD8 T cell activation and increases TCRVβ 8.2 and 8.3 subgroup expression.

  • ST-4 promotes CD8 fatty acid metabolic program via mTOR/PPARγ/SREBP signal pathway.

  • ST-4 promotes CD8 mitochondrial energy metabolic program via p38 signal pathway.

J Immunol (2020) 205 (8): 2077–2090.

  • WIV immunization resulted in early but transient Ag presentation and CD4 responses.

  • Adding checkpoint Ag at day 5 promoted lung CD4 memory TRM and helper function.

  • High checkpoint Ag doses were required to drive the effectors to optimal memory.

J Immunol (2020) 205 (8): 2091–2099.

  • Tupaia MAVS can be cleaved by HCV NS3/4A.

  • tMAVS impaired the IRF3-mediated, but not NF-κB–mediated, antiviral signaling.

  • The activation of NF-κB inhibited HCV replication and persistent infection.

J Immunol (2020) 205 (8): 2100–2108.

  • PIK3IP1 is expressed in B cells and is downregulated late after activation.

  • Lack of PIK3IP1 impairs early class switching during T-dependent responses.

  • PIK3IP1 is not required for germinal center responses or T-independent responses.

IMMUNE SYSTEM DEVELOPMENT

J Immunol (2020) 205 (8): 2109–2116.

  • Anti-PC and anti-MDA IgMs develop differently during early human life.

  • The newborn IgM anti-PC level is much lower than anti-MDA compared with mothers’ levels.

  • Newborns have diverse clones with lower peptide abundance compared with the mothers.

J Immunol (2020) 205 (8): 2117–2127.

  • cDC subset differentiation from precommitted precursors is not proportional.

  • CD135 is differentially expressed in the cDC1 and cDC2 lineages.

  • Late stages of cDC1 differentiation are independent of FLT3L.

J Immunol (2020) 205 (8): 2128–2136.

  • Foxp3+ cells are more highly represented in newborn spleen, lung, and circulation.

  • Newborn Tregs express higher levels of Foxp3 and CD25 compared with adults.

  • Newborn and adult Tregs differ in their survival and response to TCR engagement.

IMMUNOGENETICS

J Immunol (2020) 205 (8): 2137–2145.

  • Pig IGHG genes can be classified into nine subclasses.

  • An evolutionary model for pig IGHG genes was proposed.

  • A mouse mAb 4A4 specific to the pig IgG3 was developed.

IMMUNOTHERAPY AND VACCINES

J Immunol (2020) 205 (8): 2146–2155.

  • Pre-existing BCG immunity influences T cell responses of subunit booster vaccines.

  • M. tuberculosis–specific subunit vaccines bypass this mechanism and improve protection.

J Immunol (2020) 205 (8): 2156–2168.

  • A TIGIT-blocking Ab (T4) requires CD8+ T and NK cells to confer antitumor effects.

  • T4-mediated Fc-dependent Treg depletion via NKs induces additional CD8+ T responses.

  • T4 Ab treatment confers durable T cell immune memory against multiple tumor types.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2020) 205 (8): 2169–2187.

  • Pathogen-specific TE are a prodigious source of chemokines.

  • The complete TE chemokine spectrum is CCL3, CCL4, CCL5 > XCL1 ≥ CCL1 > CCL9/10 >> CXCL2.

  • TE exhibit unique and shared chemokine synthesis/expression/secretion patterns.

J Immunol (2020) 205 (8): 2188–2206.

  • Pathogen-specific TM are a prodigious source of chemokines.

  • The chemokine-expression patterns of TM largely resemble those of TE.

  • Unique TM chemokine signatures in acute/chronic infection are of diagnostic value.

J Immunol (2020) 205 (8): 2207–2221.

  • FMDV 3B protein inhibits type I IFN production.

  • FMDV 3B protein interacts with RIG-I to block RIG-I–mediated immune signaling.

  • The aa 17A in each copy of 3B is critical for suppression of IFN response.

J Immunol (2020) 205 (8): 2222–2230.

  • p53 precludes Cas9-mediated gene disruption in memory CD8 T cells.

  • Temporarily subduing p53 enables gene editing in memory CD8 T cells in vivo.

  • Cas9-mediated gene ablations in memory CD8 T cells are retained through recall.

J Immunol (2020) 205 (8): 2231–2242.

  • OGG1 inhibitor SU0268 facilitates antibacterial immunity in PA14 infection.

  • SU0268 mitigates bacterial infection via an mtDNA-mediated cGAS pathway.

  • SU0268 attenuates lung injury caused by PA14 infection in vivo.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2020) 205 (8): 2243–2254.

  • ADAMTS5 is upregulated in human IgA nephropathy lesions.

  • ADAMTS5 is related to inflammatory infiltrates in affected kidneys.

  • ADAMTS5 digests kidney matrix proteins and cleaves complement C3 and fibronectin.

J Immunol (2020) 205 (8): 2255–2264.

  • AKT phosphorylates NLRP3 at S5, preventing self-oligomerization and IL-1β release.

  • NLRP3 S5 phosphorylation prevents TRIM31-mediated degradation during LPS priming.

J Immunol (2020) 205 (8): 2265–2275.

  • The canonical Wnt pathway in intestinal APCs protects against CAC.

  • LRP5/6–β-catenin–IL-10 signaling in APCs suppresses chronic intestinal inflammation.

  • This pathway plays an important role in regulating intestinal commensal homeostasis.

J Immunol (2020) 205 (8): 2276–2286.

  • CD28null T cells show high reactivity of β2 integrin upon chemokine stimulation.

  • ROS-mediated Ca2+ release is critical for β2 integrin activation in T cells.

  • Spontaneous β2 integrin activity of CD28null T cells in ACS is ROS dependent.

MOLECULAR AND STRUCTURAL IMMUNOLOGY

J Immunol (2020) 205 (8): 2287–2300.

  • hC3Nb3 inhibits classical pathway–mediated hemolysis.

  • hC3Nb3 inhibits alternative pathway–mediated C3 fragment deposition.

  • hC3Nb3 provides a new tool for studies of the complement system.

TUMOR IMMUNOLOGY

J Immunol (2020) 205 (8): 2301–2311.

  • HIF-α subunits differentially regulate Tie2 expression on macrophages.

  • Myeloid HIF-1α deficiency enhances tumor oxygenation and chemotherapeutic response.

NOVEL IMMUNOLOGICAL METHODS

J Immunol (2020) 205 (8): 2312–2320.

  • Rectal balloon collections minimize blood contamination of mucosal Ig.

  • Rectal balloon collections require ring lubrication to reduce blood contamination.

  • Rectal balloon collection is quick and well tolerated in humans.

CORRECTIONS

J Immunol (2020) 205 (8): 2321.
J Immunol (2020) 205 (8): 2322.
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