Issues

Infliximab aggregates induce dendritic cell maturation and CD4 T cell activation.

Aggregate-induced immune response is mediated via the FcγRIIa–Syk axis.

B-1b cells mount superior TI-2 responses despite sharing the same BCR as B-2 cells.

B-1b and B-2 cells generate a TI-2 memory pool expressing CD80, PDL2, and CD73.

Ag-specific IgG and CD80 limit secondary Ab responses by memory B-1b cells.

Clozapine binds HLA class II at therapeutic concentrations to activate CD4⁺ T cells.

Clozapine and olanzapine interact with HLA class II in similar conformations.

Greater T cell protein expression changes are induced by clozapine.

Circulating plasmablasts are a major B cell subpopulation that expresses GZMB.

GZMB⁺ B cells can be efficiently expanded ex vivo from total B cells.

GZMB⁺ B cells strongly suppress both autologous and allogenic T cell proliferation.

CgIgIT was able to bind the hemolymph microbes and recruit CgSHP2.

IgIT-SHP2 pathway inhibited MAPK activities.

IgIT-SHP2 pathway protected microbes from ROS- and CgDef2-mediated elimination.

Disrupting TL1A–DR3 interactions abrogates mouse lung fibrosis and airway remodeling.

Airway fibroblasts and epithelial cells express DR3 and respond to TL1A.

Neutralizing TL1A might be a therapy for airway remodeling in asthma, SSc, and IPF.

VEGF acts directly and indirectly on stromal compartments of the neonatal thymus.

VEGF mediates its pleiotropic effects via both VEGFR2 and NRP1.

VEGF inhibition induces phenotypic and transcriptional neonatal thymic maturation.

SARS-CoV-2–specific Ab-secreting cells expand in acute COVID-19.

SARS-CoV-2–specific Ab levels correlate with neutralizing Ab titers.

HIV infection is associated with the loss of CD163⁺CD206⁺ AM.

Smoking increases surface expression of several activation markers on AM.

CyTOF is a valuable tool for evaluating the phenotypic profile of BALF from smokers.

IFN-I–inducible TRIM21 is degraded via CMA.

S. Typhimurium activates mTORC2/Akt to impair CMA resulting in TRIM21 accumulation.

High levels of TRIM21 contribute to S. Typhimurium–induced macrophage death.

This study explores a pathway that promotes Th2 cell inflammation in RV exacerbation.

Inhibiting factors in this pathway could potentially benefit asthmatic patients.

Epigenetic changes predict cell type–specific TNF/LT locus gene expression.

Distal element hHS-8 regulates TNF and LTA gene expression in activated T cells.

Cigarette Smoke reduces hepcidin levels in the lung, plasma, and urine of mice.

Cigarette smoke inhibits hepcidin production by murine AMs.

AMs from smokers and individuals with COPD have higher ferroportin.

LPS stimulates GFAT2 expression in macrophages via a FoxO1-dependent mechanism.

LPS-induced GFAT activity promotes a general increase in protein O-GlcNAcylation.

Protein O-GlcNAcylation limits excessive LPS-triggered inflammation in macrophages.

In brain tissue of the majority of MS patients, myelin is bound by IgG Abs.

IgG immune complexes break immune tolerance of primary human microglia.

Breaking of immune tolerance of microglia is dependent on FcγRI and IIa.

Tregs rapidly rise in the tumor microenvironment after nonablative irradiation.

Transient Treg depletion increases the efficiency of nonablative irradiation.

Treg depletion after three fractions of radiation induces systemic antitumor immunity.

NLRP3 R259W homozygous pigs can be generated by somatic cell nuclear transfer.

NLRP3 R259W homozygous pigs can survive to adulthood and give birth to offspring.

Both homozygous- and heterozygous-mutated pigs show systemic spontaneous inflammation.

Genetic activation of CD11b reduces leukocyte recruitment in acute peritonitis.

Genetic activation of CD11b decreases atherosclerosis in hyperlipidemic animals.

CD11b^I332G mice provide a system to study the pathways of active Mac-1 in vivo.