Issues

PRMT1 regulates 12 miRNAs relating to both PRMT1 and asthma in epithelial cells.

TGF-β1 recruited PRMT1/STAT1 and PRMT1/RUNX1 complexes in epithelial cells.

PRMT1 regulates miRNAs as a coactivator binding to pri-miRNA promoters.

Knowledge of patient immune status would enable appropriate immune therapies.

Whole blood ELISpot assay provides a functional readout on patient immunity.

Septic patients who die have marked suppression of innate and adaptive immunity.

SARS-CoV-2–specific CD4 T cell responses predominate over CD8 T cell responses.

SARS-CoV-2–specific recall CD4 T cell responses show a hierarchy of IL-2 > TNF > IFN-γ.

Influenza-specific memory CD4 T cell responses show a hierarchy of IFN-γ > IL-2 > TNF.

OSAS patients reveal decreased levels of CD14⁺⁺CD16⁻ classical monocytes.

Increased monocyte/T cell aggregation occurs in the blood of OSAS patients.

Alteration of T cell subsets and PD-1/PD-L1 cross-talk occurs in OSAS patients.

Fli-1 regulates expression of GM-CSF by both direct and indirect means.

Phosphorylation of Fli-1 negatively impacts the regulation of GM-CSF expression.

Fli-1 is a potential drug target.

NFATc2 is critical for production of mast cell–derived IL-3.

Sustained activation of STAT5 by IL-3 promotes IL-9 production in mast cells.

LjRNF114 was a suppressor of RLR signaling pathways.

LjRNF114 targeted and promoted K27- and K48-linked ubiquitination of MAVS and TRAF3.

Disrupting the Foxo1 Mst1-phosphoresidue Ser²⁰⁹ abrogates central memory T cells.

Foxo1 phosphomimetic S209D inhibits canonical target genes, including CD127.

S209D promotes distinct gene pathways and context-dependent survival advantages.

SHM hot- and cold-spot biases are largely consistent between different age and sex groups.

A shift in SHM targeting is observed between young and older male subjects.

This shift in SHM targeting influences the Ig amino acid composition.

Novel flexible ELISAs were developed for SARS-CoV-2 Ab detection.

Ab responses were mapped to areas on the nucleocapsid and spike protein.

IgM, IgA, and IgG titers are significantly correlated to COVID-19 severity.

Exogenous IL-4 reduces parasitemia and prevents experimental cerebral malaria.

IL-4 increases phagocytic receptor expression, B1 cell expansion, and IgM production.

IL-4 reduces cytotoxicity and infiltration of CD8⁺ T cells in cerebral malaria model.

IL-12, IL-18, and TLRs are dispensable for TCR-dependent activation of iNKT cells.

During TCR-independent activation, IL-12 is necessary but not sufficient.

Splenic but not hepatic iNKT cells need IL-18 during TCR-independent activation.

Male macrophages are intrinsically more migratory in the same culture conditions.

Male bone marrow cells and male adipose tissue macrophages are more inflammatory.

Male macrophages induce leptin receptor and GPR120 in response to free fatty acids.

NUDT21 forms a complex with mitochondrial IPS-1.

NUDT21 mediates IPS-1 localization to SGs upon poly(I:C) transfection.

NUDT21 plays a key role in induction of IFN-β in response to virus infection.

SPPL2a^−/− mice exhibit loss of cDC2 in lymphatic tissues.

SPPL2a deficiency shifts cytokine profiles of DCs activated by mycobacteria.

Accumulating CD74 N-terminal fragments lower the surface expression of Dectin-1.

PKCβ, Lyn, and Pyk2 are all involved in MCP-1–induced monocyte adhesion and migration.

MCP-1–stimulated F-actin polymerization requires PKCβ, Lyn, and Pyk2.

PKCβ is constitutively associated with Lyn and Pyk2 in primary human monocytes.

SLAMF7 signaling on T cells reprograms them to an exhaustion-like state.

SLAMF7 expression is prognostic in a cancer dominated by T cell exhaustion, ccRCC.

SLAMF7–SLAMF7 interactions between TAMs and T cells drive inhibitory receptor expression.

iMUBAC integrates multibatch cytometry datasets without shared technical replicates.

Streamlined immunophenotyping identifies disease-associated phenotypes across batches.

Phagocytosis measurements are typically sensitive to experimental conditions.

Phagocyte–prey persistent association analysis can be used for data normalization.

Persistent association normalization results in more robust and sensitive analysis.

B7-H6 was affinity matured by yeast surface display.

NK cell engagers harboring optimized B7-H6 have improved cytotoxic capacities.

NK cell engagers based on improved B7-H6 display a differentiated cytokine profile.