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J Immunol (2021) 206 (4): 665.

LETTERS TO THE EDITOR

J Immunol (2021) 206 (4): 667.
J Immunol (2021) 206 (4): 667–668.

BRIEF REVIEWS

J Immunol (2021) 206 (4): 669–675.

IMMUNE REGULATION

J Immunol (2021) 206 (4): 677–685.

  • Cbl-b is induced in IL-15/IL-2/K562–activated primary human NK cells.

  • Abrogation of Cbl-b enhances cytotoxicity of primary human NK cells.

IMMUNOTHERAPY AND VACCINES

J Immunol (2021) 206 (4): 686–699.

  • Multimerization of p67C Ag as nanoparticle increases its immunogenicity.

  • Vaccine efficacy of p67C Ag increases delivered as nanoparticles.

J Immunol (2021) 206 (4): 700–711.

  • The combination of cdAMP and Nano-11 has synergistic effects on activation of DCs.

  • ID immunization with cdAMP/Nano-11 adjuvant induces a robust balanced immune response.

  • The cdAMP/Nano-11 adjuvant increases uptake of Ag by migratory and resident DCs.

J Immunol (2021) 206 (4): 712–721.

  • SIRP Abs SIRP-1 and SIRP-2 induce macrophage phagocytosis of cancer cells.

  • They employ unique mechanisms to disrupt SIRPα/CD47 checkpoint and engage FcγRs.

  • SIRP-1 and SIRP-2 combine with targeted Abs including anti-CD47 mAb AO-176.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2021) 206 (4): 722–736.

  • aiPLA2-mediated production of inflammatory lipids drives lung pathological condition during TPE.

  • IgG cross-linking on eosinophils activates aiPLA2 activity.

  • Pharmacological inhibition of aiPLA2 improves TPE-associated lung histopathology.

J Immunol (2021) 206 (4): 737–750.

  • HRG induces the phagocytic activity of human neutrophils against E. coli and S. aureus.

  • HRG induces shape change of human neutrophils and prolongs the survival time.

  • The effect of HRG on human neutrophils is mediated by CLEC1A receptor.

J Immunol (2021) 206 (4): 751–765.

  • Leukocyte influx occurs in specific niches during S. aureus craniotomy infection.

  • S. aureus craniotomy infection elicits transcriptional diversity in myeloid cells.

  • PMNs are critical for S. aureus containment but not biofilm clearance.

J Immunol (2021) 206 (4): 766–775.

  • Intestinal IL-17R signaling plays a beneficial role in infectious colitis.

  • Intestinal IL-17R signaling regulates ASC generation and transport of SIgA.

  • Expression of oxidases during infectious colitis requires intestinal IL-17R.

J Immunol (2021) 206 (4): 776–784.

  • Replication-competent VACV inhibits skin DC migration to draining lymph node.

  • The VACV-suppressive effect is a general phenomenon of VACV infection in the skin.

  • VACV can access the lymph node in the absence of DC transport and prime CD4+ T cells.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2021) 206 (4): 785–796.

  • TNF downregulates IFN-α and TNF production by human pDCs.

  • TNF downregulates IRF7 and NF-κB pathways and upregulates Ag processing in pDCs.

  • TNF enhances Ag presentation and T cell activation properties in pDCs.

J Immunol (2021) 206 (4): 797–806.

  • eCIRP induces NET formation, causing inhibition of efferocytosis during sepsis.

  • NE of NETs disrupts αvβ3 and αvβ5 integrins in macrophages to inhibit efferocytosis.

J Immunol (2021) 206 (4): 807–813.

  • Hyperglycemia promotes trained immunity of monocytes/macrophages.

  • MLL mediates hyperglycemia-induced trained immunity.

J Immunol (2021) 206 (4): 814–826.

  • Loss of ADAP enhances TLR4-mediated M1 polarization via attenuating STAT3 activation.

  • LPS triggers ADAP Y571 phosphorylation, which is required to prime STAT3 activation.

  • ADAP modulates STAT3 phosphorylation selectively via IL-6 signaling.

J Immunol (2021) 206 (4): 827–838.

  • Nonadherent monocytes produce more TNF and IL-1β upon LPS stimulation.

  • Adherent, but not nonadherent, monocytes induce glycolysis upon stimulation.

  • Treatment with 2DG, but not glucose deprivation, influences monocyte functions.

J Immunol (2021) 206 (4): 839–848.

  • Ablation of the IL-23/T17 axis restrains the skin inflammation in Card14E138A/+ mice.

  • CBM complex in keratinocyte initiates psoriasis-like skin inflammation.

  • MALT1 paracaspase activity could be a promising therapeutic target for psoriasis.

MOLECULAR AND STRUCTURAL IMMUNOLOGY

J Immunol (2021) 206 (4): 849–860.

  • NK cells are differentially inhibited by HLA-ABw4 interactions with KIR3DL1.

  • Residues within the HLA class I α2 helix contribute to defining KIR3DL1 ligands.

  • KIR3DL1 binds HLA-ABw4 ligands via the same contacts as HLA-BBw4 ligands.

J Immunol (2021) 206 (4): 861–873.

  • We have identified a family of modified DNA aptamers that bind to human factor B.

  • Studies on these modified aptamers reveal how they inhibit C3 convertase formation.

  • These modified aptamers may prove useful for therapeutic inhibition of factor B.

SYSTEMS IMMUNOLOGY

J Immunol (2021) 206 (4): 874–882.

  • Most maternal (28-wk gestation) 25(OH)D3 levels were above 50 nmol/l.

  • Maternal 25(OH)D3 levels were positively associated with cord blood Treg levels.

  • Cord blood 25(OH)D3 levels were associated with activated Treg levels.

J Immunol (2021) 206 (4): 883–891.

  • A computational model of the signaling network for macrophage activation is developed.

  • Conflicting cues induced a “mixed” activation state not seen with single cues.

  • Knockdown simulations predict mechanisms underlying mutual inhibition or activation.

TRANSPLANTATION

J Immunol (2021) 206 (4): 892–903.

  • MyD88 costimulation in donor CD8+ T cells improves the graft-versus-tumor effect.

  • MyD88-costimulated CD8+ T cells are more activated with improved cytotoxic function.

TUMOR IMMUNOLOGY

J Immunol (2021) 206 (4): 904–916.

  • Moderate exercise reduces inflammaging, liver tumors, and chronic liver disease.

  • Key molecular changes include lipid metabolism, oxidative damage, and senescence.

  • Increased NAD+, sirtuin activity, and inflammatory and metabolic reprogramming occur.

CORRECTIONS

J Immunol (2021) 206 (4): 917–918.
J Immunol (2021) 206 (4): 919.
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