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J Immunol (2021) 206 (5): 921–922.

BRIEF REVIEWS

J Immunol (2021) 206 (5): 923–929.

CUTTING EDGE

J Immunol (2021) 206 (5): 931–935.

  • N219-227 is a dominant B6 mouse epitope of SARS-CoV-2 nucleoprotein.

  • SARS-CoV-2 infection in hACE2 mice and humans promotes CD8 T cells against N219-227.

  • Vaccine route affects the location and number of SARS-CoV-2 N memory CD8 T cells.

J Immunol (2021) 206 (5): 936–940.

  • SUMOylation of ROR-γt is defective in the inflamed colon tissue of UC patients.

  • HIF-1α inhibits Ubc9 expression via promoter DNA methylation.

  • HIF-1α–depleted Th17 cells are less colitogenic.

AUTOIMMUNITY

J Immunol (2021) 206 (5): 941–952.

  • SFB-mediated CTLA-4 reduction is associated with increased Tfr glycolytic activity.

  • Reduced Nur77, an indicator of TCR signal strength, is linked to SFB-reduced CTLA-4.

  • Nur77 deficiency causes an increased glycolysis and decreased CTLA-4 in Tfr cells.

J Immunol (2021) 206 (5): 953–962.

  • SZB120 inhibits Th17 cell differentiation by enhancing eIF2α phosphorylation.

  • SZB120 efficiently alleviates autoimmune diseases involving the CNS and skin.

IMMUNE REGULATION

J Immunol (2021) 206 (5): 963–977.

  • Beneficial effects of Ts-serpin regulation on T. spiralis survival were identified.

  • A Ts-serpin–triggered mechanism was found in macrophages independent of IL-4Rα.

  • The anti-inflammatory effect of Ts-serpin in a TNBS-induced IBD model was verified.

IMMUNOTHERAPY AND VACCINES

J Immunol (2021) 206 (5): 978–986.

  • Interrupting thymic activity in adult mice favors effector T cells.

  • Thymectomy in adult mice perturbs Treg homeostasis.

  • Thymectomy in adult mice potentiates antitumor immunotherapies.

J Immunol (2021) 206 (5): 987–998.

  • Mn delivered by silica-based nanoparticles conveys ROS-associated adjuvancy.

  • Nanoadjuvant drives DC activation and Ag cross-presentation.

  • Nanoadjuvant induces tumor-eliminating cytotoxic cellular immune response in vivo.

J Immunol (2021) 206 (5): 999–1012.

  • A total of 58 mAbs were cloned after HIV-1 DNA + unconstrained protein trimer coimmunization.

  • Cloned mAbs targeting V3 and CD4bs were capable of tier 2 neutralization.

  • Alleles mapped with an individualized database show low somatic hypermutation from germline.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2021) 206 (5): 1013–1026.

  • PEPCK-deficient Leishmania major was generated using CRISPR-Cas9 technology.

  • Deficiency of PEPCK results in altered metabolism and mitochondrial integrity.

  • PEPCK−/− parasites are attenuated in vivo and induced blunted immune response.

J Immunol (2021) 206 (5): 1027–1038.

  • Non-Vδ2 γδ T cells expand at the acute phase of HEV infection in HCMV carriers.

  • HEV promotes IL-10 production and suppressive activity in Th1-type γδ T cells.

  • Serum IL-10 is specifically elevated in HEV-infected HCMV carriers.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2021) 206 (5): 1039–1045.

  • FM-activated neutrophils propagate FM inflammation and weakening.

  • ERK signaling mediates activated neutrophil-induced FM inflammation and weakening.

  • NETs drive FM weakening via TLR-9 activation.

J Immunol (2021) 206 (5): 1046–1057.

  • We found a gene for Md-2, a key protein that senses bacterial products, in zebrafish.

  • Zebrafish Md-2 has functional and physiological similarities to amniote MD-2.

  • LPS sensing in zebrafish may be more similar to humans than previously thought.

J Immunol (2021) 206 (5): 1058–1066.

  • IL-38 ablation reduces the severity of EAE.

  • Reduced macrophage infiltration and activation are seen in the CNS of IL-38 KO mice with EAE.

  • IL-38 expression is needed for the glycolytic switch in inflammatory macrophages.

MOLECULAR AND STRUCTURAL IMMUNOLOGY

J Immunol (2021) 206 (5): 1067–1076.

  • Anti-CCL20 has unexpectedly high binding to C1q and CDC activity.

  • Injection of anti-CCL20 into humans and monkeys leads to immune complex accumulation.

  • Rapid deamidation of N100 in the CDR region does not impact Ag binding.

J Immunol (2021) 206 (5): 1077–1087.

  • tRNA wobble uridine–modifying enzymes promote T cell cycle entry and TFH responses.

  • Wobble uridine modifications regulate Atf4 signaling in activated T cells.

  • Overactivated Atf4 delays Elp3-deficient T cell cycle entry and impairs TFH responses.

MUCOSAL IMMUNOLOGY

J Immunol (2021) 206 (5): 1088–1101.

  • Strong IgT responds to bacterial infection in fish skin mucosal immunity.

  • The skin represents a mucosal Ig-inductive site in fish.

NOVEL IMMUNOLOGICAL METHODS

J Immunol (2021) 206 (5): 1102–1113.

  • A combination of CTLA4-Ig and anti-ICOSL dissolves ongoing GC responses.

  • Blocking CD28 and ICOS with bispecific Ab should ameliorate IgG-mediated diseases.

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