Issues

N_219-227 is a dominant B6 mouse epitope of SARS-CoV-2 nucleoprotein.

SARS-CoV-2 infection in hACE2 mice and humans promotes CD8 T cells against N_219-227.

Vaccine route affects the location and number of SARS-CoV-2 N memory CD8 T cells.

SUMOylation of ROR-γt is defective in the inflamed colon tissue of UC patients.

HIF-1α inhibits Ubc9 expression via promoter DNA methylation.

HIF-1α–depleted Th17 cells are less colitogenic.

SFB-mediated CTLA-4 reduction is associated with increased Tfr glycolytic activity.

Reduced Nur77, an indicator of TCR signal strength, is linked to SFB-reduced CTLA-4.

Nur77 deficiency causes an increased glycolysis and decreased CTLA-4 in Tfr cells.

SZB120 inhibits Th17 cell differentiation by enhancing eIF2α phosphorylation.

SZB120 efficiently alleviates autoimmune diseases involving the CNS and skin.

Beneficial effects of Ts-serpin regulation on T. spiralis survival were identified.

A Ts-serpin–triggered mechanism was found in macrophages independent of IL-4Rα.

The anti-inflammatory effect of Ts-serpin in a TNBS-induced IBD model was verified.

Interrupting thymic activity in adult mice favors effector T cells.

Thymectomy in adult mice perturbs Treg homeostasis.

Thymectomy in adult mice potentiates antitumor immunotherapies.

Mn delivered by silica-based nanoparticles conveys ROS-associated adjuvancy.

Nanoadjuvant drives DC activation and Ag cross-presentation.

Nanoadjuvant induces tumor-eliminating cytotoxic cellular immune response in vivo.

A total of 58 mAbs were cloned after HIV-1 DNA + unconstrained protein trimer coimmunization.

Cloned mAbs targeting V3 and CD4bs were capable of tier 2 neutralization.

Alleles mapped with an individualized database show low somatic hypermutation from germline.

PEPCK-deficient Leishmania major was generated using CRISPR-Cas9 technology.

Deficiency of PEPCK results in altered metabolism and mitochondrial integrity.

PEPCK^−/− parasites are attenuated in vivo and induced blunted immune response.

Non-Vδ2 γδ T cells expand at the acute phase of HEV infection in HCMV carriers.

HEV promotes IL-10 production and suppressive activity in Th1-type γδ T cells.

Serum IL-10 is specifically elevated in HEV-infected HCMV carriers.

FM-activated neutrophils propagate FM inflammation and weakening.

ERK signaling mediates activated neutrophil-induced FM inflammation and weakening.

NETs drive FM weakening via TLR-9 activation.

We found a gene for Md-2, a key protein that senses bacterial products, in zebrafish.

Zebrafish Md-2 has functional and physiological similarities to amniote MD-2.

LPS sensing in zebrafish may be more similar to humans than previously thought.

IL-38 ablation reduces the severity of EAE.

Reduced macrophage infiltration and activation are seen in the CNS of IL-38 KO mice with EAE.

IL-38 expression is needed for the glycolytic switch in inflammatory macrophages.

Anti-CCL20 has unexpectedly high binding to C1q and CDC activity.

Injection of anti-CCL20 into humans and monkeys leads to immune complex accumulation.

Rapid deamidation of N100 in the CDR region does not impact Ag binding.

tRNA wobble uridine–modifying enzymes promote T cell cycle entry and TFH responses.

Wobble uridine modifications regulate Atf4 signaling in activated T cells.

Overactivated Atf4 delays Elp3-deficient T cell cycle entry and impairs TFH responses.

Strong IgT responds to bacterial infection in fish skin mucosal immunity.

The skin represents a mucosal Ig-inductive site in fish.

A combination of CTLA4-Ig and anti-ICOSL dissolves ongoing GC responses.

Blocking CD28 and ICOS with bispecific Ab should ameliorate IgG-mediated diseases.