Skip to Main Content


Skip Nav Destination



J Immunol (2021) 206 (8): 1679.


J Immunol (2021) 206 (8): 1681–1689.


J Immunol (2021) 206 (8): 1691–1696.

  • Severe COVID-19 is associated with reduced A-to-I editing of Alu dsRNAs.

  • Infection of dendritic cells with COVID-19 causes reduced A-to-I editing.

  • Unedited, but not edited, Alu dsRNAs activate IRF and NF-κB responses.


J Immunol (2021) 206 (8): 1697–1708.

  • SP subunits are not upregulated in IP-deficient mice during viral infection.

  • IP is not required to control protein homeostasis during viral infection.

  • There is no evidence for proteotoxic stress in IP-deficient mice during viral infection.

J Immunol (2021) 206 (8): 1709–1718.

  • BVDV-1– and -2–immunized cattle developed cross-reactive CD8+ T cells.

  • IFN-γ–inducing CD8+ T cell epitopes were identified from various BVDV Ags.

  • CD8+ T cell epitopes are highly conserved across >200 BVDV-1 and -2 strains.


J Immunol (2021) 206 (8): 1719–1728.

  • PPP2R2A promotes Th1 and Th17 but not Treg cell differentiation.

  • PPP2R2A deficiency impairs GEF-H1/RhoA/ROCK pathway in Th1 and Th17 cells.

  • PPP2R2A deficiency in T cells mitigates experimental autoimmune encephalomyelitis.

J Immunol (2021) 206 (8): 1729–1739.

  • Antiribosomal P protein Abs induced depressive behavior and anxiety in mice.

  • Brain and serum tryptophan were decreased in mice with behavioral deficits.

  • Serum tryptophan was decreased in SLE patients with anti-P Abs or with NPSLE.


J Immunol (2021) 206 (8): 1740–1751.

  • A TNFR2 agonist, R2agoTNF, selectively and preferentially expands Tregs in mice.

  • Structural optimization of R2agoTNF increased Tregs via enhanced TNFR2 signaling.

  • scR2agoTNF-Fc is a potential drug to suppress contact hypersensitivity.

J Immunol (2021) 206 (8): 1752–1764.

  • EPO exerts a significant therapeutic effect on the DAH murine model.

  • EPO protects against DAH by regulating macrophage polarization via the EPOR/JAK2/STAT3 axis.

J Immunol (2021) 206 (8): 1765–1775.

  • BALM affects trout B cell functionality in a manner similar to BAFF and APRIL.

  • Evidence suggests that BALM signals through the same receptors as BAFF and APRIL.

J Immunol (2021) 206 (8): 1776–1783.

  • PDK1 is required for Treg cell suppressive function.

  • PDK1-deficient Treg cells have impaired NF-κB signaling.

  • Forced activation of NF-κB rescues the phenotype of Foxp3YFP-crePdk1f/f mice.

J Immunol (2021) 206 (8): 1784–1792.

  • FXIa cleaves CFH at the R341/R342 bonds at the end of the CCP 6 domain of CFH.

  • FXIa reduces CFH cofactor and decay‐accelerating activity and binding to ECs.

  • CFH binds FXI and inhibits FXI activation by either thrombin or FXIIa.

J Immunol (2021) 206 (8): 1793–1805.

  • CD154-EM mutant is resistant to the spontaneous and induced cleavage from T cells.

  • Spontaneous and induced cleavage of CD154 from T cells is mediated by ADAM10/ADAM17.

  • The cleavage-resistant CD154 is a more prominent stimulant than cleavable CD154-WT.


J Immunol (2021) 206 (8): 1806–1816.

  • Glycolipid-adjuvanted vaccine activates iNKT cells to support humoral immunity.

  • Nanoparticle delivery of glycolipids avoids iNKT anergy and allows adjuvant dose sparing.

  • iNKT cells can either support or suppress vaccine responses, depending on context.

J Immunol (2021) 206 (8): 1817–1831.

  • Construction of a PfMSP2/8 immunogen improved vaccine potential.

  • GLA-SE as adjuvant increased titer and functionality of vaccine-induced IgG.

  • Individual components of a trivalent malaria vaccine retained immunogenicity.


J Immunol (2021) 206 (8): 1832–1843.

  • OTUD1 deubiquitinates CARD9.

  • OTUD1 positively regulates CLR-induced signaling and cytokine production.

  • OTUD1 protects mice against C. albicans–induced fungal infection.

J Immunol (2021) 206 (8): 1844–1857.

  • ASFV MGF-505-7R inhibits cGAS–STING signaling.

  • MGF-505-7R–deficient ASFV was fully attenuated in pigs at a dose of 10 HAD50.

J Immunol (2021) 206 (8): 1858–1865.

  • PVB inhibits GM-CSF–induced neutrophil priming.

  • PVB may be used “off-label” to improve the survival of patients with sepsis.


J Immunol (2021) 206 (8): 1866–1877.

  • HSV-1 infection induces a strong IFN-λ response at the corneal epithelial surface.

  • IFN-λ differentially regulates antiviral and inflammatory responses in the cornea.

  • rIFN-λ treatment suppresses HSV-1–induced corneal immunopathology.

J Immunol (2021) 206 (8): 1878–1889.

  • Heme induces oligomerization of caspase-1, caspase-4, and caspase-5.

  • Heme-induced IL-1β release requires both caspase-4 and caspase-5.

  • Caspase-4 is the primary effector of heme-induced cell death.

J Immunol (2021) 206 (8): 1890–1900.

  • IFN-I signaling in CLPP-deficient cells and tissues depends on cGAS and STING.

  • CLPP-deficient cells are resistant to DNA and RNA viruses because of elevated ISGs.

  • CLPP-deficient cells exhibit mitochondrial DNA stress and release into the cytosol.

J Immunol (2021) 206 (8): 1901–1912.

  • M. smegmatis were killed by human neutrophils more slowly than other bacteria.

  • Phagosomal M. smegmatis kept their mycothiol reduced despite HOCl exposure.

  • Sensitizing mycobacteria to killing by HOCl would aid destruction by neutrophils.

J Immunol (2021) 206 (8): 1913–1922.

  • Zebrafish caspy2–GSDMEb axis contributes to neutrophil pyroptosis in vivo.

  • Depletion of caspy2 or GSDMEb impairs the process of NETosis.

  • Pyroptosis-gated NETosis plays a critical role in teleost innate immunity.

J Immunol (2021) 206 (8): 1923–1931.

  • Neutrophils actively internalize pulmonary surfactant during cigarette smoke exposure.

  • Absence of neutrophils alters surfactant homeostasis during smoking.

  • Absence of neutrophils exacerbates the proinflammatory response to smoking.

J Immunol (2021) 206 (8): 1932–1942.

  • Cell stress induces the expression of EGOT via the PI3K/AKT, MAPK, and NF-κB pathways.

  • EGOT favors the expression of PI3K/AKT target genes required for cell proliferation.

  • EGOT supports TBLR1 expression, contributing to transcription of NF-κB target genes.

J Immunol (2021) 206 (8): 1943–1956.

  • LL neutrophils express genes of peptidase inhibitor families.

  • The PI3 gene encoding elafin is the most highly expressed gene by LL neutrophils.

  • Elafin is produced because of a synergism between GM-CSF and TNF via C/EBPβ and NF-κB.


J Immunol (2021) 206 (8): 1957–1965.

  • Human HLA-reactive mAbs OK4F9 and OK4F10 cross-react to Mamu-B*008:01.

  • Human mAb MUS4H4 shows a more complex cross-reactivity in relation to Mamu allotypes.


J Immunol (2021) 206 (8): 1966–1975.

  • Presence of IL-1α in melanoma makes the disease resistant to immunotherapy.

  • IL-1 pathway blockade enhances the efficacy of CD40 agonist therapy.

  • IL-1 pathway blockade improves response to therapy through elimination of PMN-MDSCs.

Close Modal

or Create an Account

Close Modal
Close Modal