Issues

Weight-normalized RAS vaccination dosing in mice models human immunity.

RAS+subunit prime-boost vaccination induces immunity to liver-stage malaria in mice.

Mast cell metabolism varies between IgE- and non-IgE–mediated degranulation.

Non-IgE mast cell degranulation induces a stress response from metabolic insult.

Vps33B in DCs suppresses house dust mite–induced allergic lung inflammation.

Vps33B in DCs inhibits CD4⁺ T cell proliferation and Th2 differentiation.

Vps33B deficiency in cDC1s enhances ROS-mediated Th2 polarization in vitro.

A type I IFN transcriptional profile is upregulated in SLE B cells.

Human B cells express type I IFN genes in response to IFN-λ (type III IFN).

IFN-λ may enhance TLR7-mediated B cell activation and PC differentiation in SLE.

Tree shrew GBP1 (tGBP1) binds to tSTING, tSQSTM1, and tLC3.

tGBP1 promotes autophagy upon HSV-1 infection.

tGBP1 inhibits HSV-1 infection.

FCRL1 recruits GRB2 to Y281 following BCR stimulus.

FCRL1 suppresses BCR-induced ERK1/2 phosphorylation through GRB2.

FCRL1 controls transitional and mature B cell numbers and tonic ERK signals.

IFI16-iso1 locates in the cytoplasm, and IFI16-iso2 locates in the nucleus.

IFI16-iso1 mainly recognizes cytoplasmic viral DNA.

IFI16-iso1 and IFI16-iso2 play differential roles in host antiviral immunity.

Hypomorphic SH2B3 improves the sepsis response in humans and mice.

SH2B3 deficiency results in enhanced phagocytosis and rapid bacterial clearance.

Lack of SH2B3 augments myelopoiesis in sepsis.

DPs reside in the mediastinal adipose tissue and aortic arch.

Extrathymic DP presence depends on the thymus and RAG2 expression.

Extrathymic DPs migrate locally.

Intracellular hemocyanin affects microbiota homeostasis in shrimp hepatopancreas.

Hemocyanin modulates ROS levels to change hepatopancreas bacterial composition.

Low hemocyanin induces mitochondrial dysfunction to affect energy and ROS production.

Deficiency of Acsl4 in rpMACs reduces arachidonic acid levels in phospholipids.

Arachidonic acid–derived mediators are reduced in stimulated Acsl4-deficient rpMACs.

In response to stimulation, myeloid Acsl4 deficiency reduces inflammation.

ASFV pI215L is the strongest inhibitory effector on the production of type I IFN.

pI215L recruits RNF138 to inhibit K63-linked ubiquitination of TBK1.

miR-29a-3p can inhibit STING expression in teleost fish.

circSamd4a can adsorb miR-29a-3p through ceRNA mechanism to promote STING expression.

circSamd4a enhances antiviral immunity by promoting STING expression.

β-Glucan protects mice from i.p. Pseudomonas aeruginosa infection.

Macrophages contribute to β-glucan–induced protection in vivo.

β-Glucan rewires macrophage function and metabolism independently of Dectin-1.

AIM2 is expressed in podocytes in normal kidney.

AIM2 suppresses glomerular epithelial proliferation and promotes podocyte phenotype.

AIM2 attenuates inflammation mediated by the ALR locus during glomerulonephritis.

HIF-1α amplifies inflammatory responses in mouse BMM following TLR3 engagement.

Amplification is more pronounced in low glucose and is independent of glycolysis.

Increased HIF-1α was linked to PKM2 in the nucleus and mitochondrial ROS production.

Air bubbles trigger a C3-driven thromboinflammation in human whole blood.

Blocking C3, but not C5, attenuates the air-induced inflammation.

Avoiding ambient air in test tubes attenuates thromboinflammation.

Tissue homing Ly-6C^hi monocytes express integrin α₄ during systemic inflammation.

Macrophages demonstrate an immunosuppressive phenotype in the lungs.

F4/80⁺CD206^hi macrophages express a high level of integrin α_v and TGFBR1.

We provide a structural basis for inhibition of complement by a bacterial protein.

This study improves our knowledge of how pathogens evade early complement steps.

IL-36 signaling is upregulated and protects mouse corneas from P. aeruginosa infection.

IL-36α modulates inflammation and enhances antimicrobial effectors.

IL-36 promotes IL-22 and Th2 response; IL-22 blocking worsens P. aeruginosa keratitis.

The single-cell transcriptomic landscape of duck PBLks defines 14 populations.

Myeloid cells may play important roles in avian flaviviral infection.