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EDITORIAL

J Immunol (2021) 207 (7): 1695–1696.

TOP READS

J Immunol (2021) 207 (7): 1697.

PILLARS OF IMMUNOLOGY

J Immunol (2021) 207 (7): 1699–1701.

BRIEF REVIEWS

J Immunol (2021) 207 (7): 1703–1709.
J Immunol (2021) 207 (7): 1710–1718.
J Immunol (2021) 207 (7): 1719–1724.
J Immunol (2021) 207 (7): 1725–1733.

ALLERGY AND OTHER HYPERSENSITIVITIES

J Immunol (2021) 207 (7): 1735–1746.

  • Der p 38 is a novel allergen binding to TLR4.

  • Der p 38 drives mixed granulocyte asthma in the mouse model.

  • Der p 38 induces antiapoptotic effects on leukocytes and cytokine secretion.

J Immunol (2021) 207 (7): 1747–1754.

  • REDD1 drives inflammation in oxalozone-induced allergic contact dermatitis.

  • REDD1 is required for T cell activation and immune cell migration to affected tissues.

  • REDD1 may be an attractive target for therapeutics in T cell–mediated diseases.

AUTOIMMUNITY

J Immunol (2021) 207 (7): 1755–1762.

  • We developed mAbs that distinguished mCRP from pCRP.

  • Anti-mCRP Abs have therapeutic potential against arthritis and nephritis.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2021) 207 (7): 1763–1775.

  • Layilin is expressed by highly activated Tregs in healthy and diseased human skin.

  • In vivo, layilin attenuates Treg suppressive capacity.

  • Layilin contributes to anchor Tregs in skin and enhances their accumulation.

J Immunol (2021) 207 (7): 1776–1784.

  • During critical illness, PI3Kδ activation impairs neutrophil phagocytosis.

  • PI3Kδ inhibition consistently restores neutrophil phagocytosis and bacterial killing.

  • PI3Kδ inhibition represents a potential strategy for prevention of infection in ICUs.

IMMUNE REGULATION

J Immunol (2021) 207 (7): 1785–1797.

  • CD11b deficiency on B cells results in an enhanced Ab response.

  • CD11b regulates BCR signaling through the Syk–Lyn–CD22 circuit.

  • CD11b expression on plasma cells impacts BCR repertoire selection and diversity.

J Immunol (2021) 207 (7): 1798–1811.

  • IRF4 controls cell growth, metabolism, and proliferation during B cell activation.

  • IRF4 is critical for B cell proliferation through proper induction of Myc.

  • IRF4 regulates B cell growth and mTORC1 signaling upon B cell activation.

J Immunol (2021) 207 (7): 1812–1823.

  • Senescent macrophages are poor efferocytes, and RvD1 rescues this function.

  • RvD1 limits necrosis and senescent cells in plaques from irradiated Ldlr−/− mice.

  • Hematopoietic-derived senescent cells promote plaque necrosis and decrease SPM.

IMMUNE SYSTEM DEVELOPMENT

J Immunol (2021) 207 (7): 1824–1835.

  • Therapy with 2DG reduces the expression of ocular eye lesions by HSV.

  • Inhibiting glucose metabolism results in encephalitis in mice.

  • HSE occurred in response to break down of immune control in the TG.

IMMUNOTHERAPY AND VACCINES

J Immunol (2021) 207 (7): 1836–1847.

  • DEC-205 facilitates uptake of some classes of CpG ODN.

  • DEC-205 binds single-stranded, phosphorothioated ODN, preferring thymidine.

  • CpG ODN can be designed to promote CD8 T cell responses and resident memory.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2021) 207 (7): 1848–1856.

  • The number and function of MAIT cells were impaired in patients with severe COVID-19.

  • MAIT cell dysfunction in severe COVID-19 correlated with MDSC-like cells.

  • MAIT cell dysfunction and MDSC-like cell expansion were through the IFN-I/IL-10 pathway.

J Immunol (2021) 207 (7): 1857–1870.

  • Lactobacillus murinus increases lung Th17 and RORγt+ Tregs in naive and infected mice.

  • L. murinus enhances the immunosuppressive phenotype of lung Th17 and RORγt+ Tregs.

  • L. murinus reduces lung inflammation without affecting the bacilli burden.

J Immunol (2021) 207 (7): 1871–1881.

  • The severity of sepsis influences the cytokine storm and vascular permeability.

  • Skin CD103+ CD8 TRM undergo apoptosis and numerical loss following severe sepsis.

  • Severe sepsis leads to loss of TRM-mediated protection to local viral rechallenge.

J Immunol (2021) 207 (7): 1882–1890.

  • The individual adaptive NKG2C+ NK cell response to CMV viremia in KTR is variable.

  • NKG2C+ NK, CD8+, and TcRγδ T cells remain increased long-term after viremia resolution.

  • Adaptive NKG2C+ NK cells may contribute with T cells to restore CMV control in KTR.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2021) 207 (7): 1891–1902.

  • Hepatic STAT3 activity remodels lung transcription and proteomics during endotoxemia.

  • Cytokine responses to secondary lung infection are altered without intact liver input.

  • Airspace accumulation of coagulation mediators and APPs is liver dependent.

J Immunol (2021) 207 (7): 1903–1910.

  • KAP1 inhibits RLR pathway.

  • KAP1 deficiency enhances anti-RNA viral innate responses.

  • KAP1 promotes repressive histone marks establishment at promoters of Ddx58 and Ifih1.

J Immunol (2021) 207 (7): 1911–1925.

  • CXCL20a clears infections by bactericidal and phagocytosis-promoting activities.

  • CXCL20a mainly targets acidic lipids for bacterial membrane perforation and death.

  • To our knowledge, it was first discovered that chemokine aggregates bacteria.

J Immunol (2021) 207 (7): 1926–1936.

  • AIM2 is directly ubiquitinated in basal state.

  • USP21 deubiquitinates AIM2 upon DNA stimulation.

  • USP21 is crucial for AIM2 inflammasome activation.

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