Issues

Spike-specific B cells are maintained following recovery from SARS-CoV-2 infection.

Tonsil germinal center spike-specific B cells are present after SARS-CoV-2 infection.

Tonsil B and Tfh cell responses could play a role in durable SARS-CoV-2 immunity.

NEDD8 fusion to a model protein results in proteasome and autophagosome degradation.

NEDD8 fusion is less efficient than ubiquitin fusion for peptide presentation.

DRiP Ag presentation is diminished by MLN4924 treatment.

Early-stage alterations were evident in peripheral sTREM2-related inflammatory activity.

These alterations implicate early inflammatory cell development and recruitment signaling in AD.

Patterns of inflammatory activity are altered across all AD stages.

IL-33 expression is increased in the gut of HIV-infected patients.

IL-33 is associated with fibrosis and low CD4⁺ T cell reconstitution.

Despite the presence of IL-33, tTreg cells do not produce amphiregulin.

Berberine induces aerobic glycolysis and expression of GLUT1/HK2 in BMDMs.

Berberine priming increases cytokine secretion by BMDMs triggered with LPS.

Berberine alleviates Salmonella typhimurium enteritis and endotoxic shock.

AHR modulates Tfh cell responses during infection in a CD4⁺ T cell–intrinsic manner.

AHR alters the Tfr/Tfh cell ratio and levels of BCL6 and FOXP3 in CD4⁺ T cells.

AHR requires a functional DBD to modulate Tfh and Tfr cells during IAV infection.

CysLT receptors are expressed at high basal levels within the cornea.

CysLT₁ and CysLT₂ expressed in the cornea are not solely proinflammatory in nature.

CysLT receptors may play homeostatic and proresolving roles in the cornea.

Polymeric EsIgLectin generates higher antibacterial activities than monomer.

EsIg bound to EspIgR-Ig1 to promote hemocyte phagocytosis.

Hemocyte-derived EsIgLectin entered the intestine at the later phase of inflammation.

High CO₂ (hypercapnia) reduces macrophage activation and migration.

Our data implicate a novel CA2/[pH]_i axis in CO₂ sensing in cells.

Patients with lung disease are at risk of developing surgical complications.

HuR-HNS3 interrupts PARylation of HuR and HuR dimerization.

TAT-HuR-HNS3 blocks HuR cytoplasmic distribution and association with target mRNAs.

TAT-HuR-HNS3 lowers proinflammatory mediators’ mRNA production.

ATP and histamine suppress virus-mediated IFN release from airway epithelial cells.

Inhibition of IFN release by ATP/histamine occurs through Gq–PKC signaling.

P2Y₂ and H₁ receptor blockade reverses ATP/histamine inhibition of IFN release.

Lupus susceptibility loci lead to emergence of novel myeloid subpopulations.

Myeloid cells from lupus mice have decreased metabolism and Ag presentation.

Algorithmic specificity prediction distinguishes TCRs from autoimmune mice.

CXCL13 contributes to tumor metastasis by recruiting regulatory B cells.

Recruited regulatory B cells affect both innate and adaptive immunity.

Lack of CXCL13 increases the efficacy of chemotherapy and PD-1 blockade.

We describe a highly effective and accessible approach for the purification of human serum IgE.

This method is useful for experimental models in the field of allergy and clinical immunology.

It is possible that this method can be scaled up to larger volumes if needed.