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Issues

PRESIDENT'S ADDRESS

J Immunol (2022) 208 (11): 2445–2449.

In their AAI President’s Addresses reproduced in this issue, Jeremy M. Boss, Ph.D. (AAI ’94; AAI President 2019–2020) and Jenny P.-Y. Ting, Ph.D. (AAI ’97; AAI President 2020–2021) welcomed attendees to the AAI annual meeting, Virtual IMMUNOLOGY2021™. Due to the SARS-CoV-2 pandemic and the cancellation of IMMUNOLOGY2020™, Dr. Boss and Dr. Ting each presented their respective President’s Address to open the meeting.

J Immunol (2022) 208 (11): 2450–2455.

In their AAI President's Addresses reproduced in this issue, Jeremy M. Boss, Ph.D. (AAI '94; AAI president 2019–2020), and Jenny P.-Y. Ting, Ph.D. (AAI '97; AAI president 2020–2021), welcomed attendees to the AAI annual meeting, Virtual IMMUNOLOGY2021™. Due to the SARS-CoV-2 pandemic and the cancellation of IMMUNOLOGY2020™, Dr. Boss and Dr. Ting each presented their respective president's address to open the meeting.

TOP READS

J Immunol (2022) 208 (11): 2457.

PILLARS OF IMMUNOLOGY

J Immunol (2022) 208 (11): 2459–2460.

This Pillars of Immunology article is a commentary on “Identification of a major co-receptor for primary isolates of HIV-1,” a pivotal article written by H. Deng, R. Liu, W. Ellmeier, S. Choe, D. Unutmaz, M. Burkhart, P. Di Marzio, S. Marmon, R. E. Sutton, C. M. Hill, et al., and published in Nature, in 1996. https://www.nature.com/articles/381661a0.

CUTTING EDGE

J Immunol (2022) 208 (11): 2461–2465.

  • T cell responses against Omicron are well preserved after COVID-19 or mRNA vaccination.

  • Recipients of two mRNA vaccine doses only have lower T cell responses.

AUTOIMMUNITY

J Immunol (2022) 208 (11): 2467–2481.

  • TFR/TFH cell ratio is impaired during the onset of lupus nephritis in NZBWF1/j mice.

  • OX40L–JAG1 cotreatment expands TFR cells and suppresses TFH cells.

  • Restoration of TFR/TFH balance ameliorates lupus nephritis in NZBWF1/j mice.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2022) 208 (11): 2482–2496.

  • The complement system plays a pathophysiologic role in the synovium of early RA.

  • Correlations were found between DAS28 and complement genes in the early RA synovium.

  • Early RA synovium shows complement activation versus regulatory protein imbalance.

IMMUNE REGULATION

J Immunol (2022) 208 (11): 2497–2507.

  • Anti-idiotypes to ADAMTS13 autoantibodies are part of the immune response in iTTP.

  • ITTP patients have shared ADAMTS13 autoantibodies but private anti-idiotypes.

  • Anti-idiotypes are capable of neutralizing their own and foreign ADAMTS13 autoantibodies.

IMMUNOGENETICS

J Immunol (2022) 208 (11): 2508–2514.

  • We identified potentially causal associations of IgG N-glycans with RA.

  • Our findings shed light on IgG N-glycosylation involvement in RA.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2022) 208 (11): 2515–2522.

  • CB2 signaling activation led to elevated mortality in septic mice.

  • CD4+ cell–derived CB2 was responsible for decreased survival.

  • CD4+ cell–derived CB2 exacerbated sepsis by inhibiting IL-10 production.

J Immunol (2022) 208 (11): 2523–2539.

  • Dietary cholesterol increases morbidity during IAV infection in mice.

  • Dietary cholesterol neither causes immunosuppression nor alters viral load.

  • Morbidity is correlated with cytokine-producing lymphocytes and granulocytes.

J Immunol (2022) 208 (11): 2540–2548.

  • Leishmania induces host antiapoptotic proteins MCL-1 and TCTP to inhibit apoptosis.

  • TCTP–MCL-1 interaction prevents ubiquitination-mediated degradation of labile MCL-1.

  • TCTP silencing led to reduction of organ parasite burden in visceral leishmaniasis.

J Immunol (2022) 208 (11): 2549–2557.

  • BCG-triggered PGE2 release mobilizes skin DCs to the draining lymph node.

  • Migrating DCs use EP2 and EP4 to relocate to the draining lymph node.

  • Live BCG bacilli are needed for PGE2-mediated DC migration.

J Immunol (2022) 208 (11): 2558–2572.

  • The abundant miR-146a in KCs plays a key role in maintaining immune homeostasis.

  • miR-146a promotes HBV persistence by inhibiting KCs proinflammatory polarization.

J Immunol (2022) 208 (11): 2573–2582.

  • Anti-VHSV Ab response decreases 4 wk after boost of vaccinated individuals.

  • Similar frequencies of anti-VHSV public clonotypes occur in pronephros and spleen.

  • Fish spleen and pronephros are different B cell compartments with distinct repertoires.

MOLECULAR AND STRUCTURAL IMMUNOLOGY

J Immunol (2022) 208 (11): 2583–2592.

  • ATM prevents aberrant resolution of attempted deletional Vβ rearrangements.

  • ATM and weak Vβ RSSs facilitate interallelic competition for Vβ recombination.

  • ATM and poor-quality Vβ RSSs cooperate to help enforce TCRβ allelic exclusion.

CORRECTIONS

J Immunol (2022) 208 (11): 2593.
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