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J Immunol (2022) 208 (12): 2595–2596.

IMMUNOLOGY NOTES AND RESOURCES

J Immunol (2022) 208 (12): 2597–2612.

ALLERGY AND OTHER HYPERSENSITIVITIES

J Immunol (2022) 208 (12): 2613–2621.

  • p38α signaling reshapes keratinocyte gene expression during allergic dermatitis.

  • p63 phosphorylation by p38α is essential for epidermal MMP13 induction.

  • Topical p38α and MMP13 inhibitors suppress atopic dermatitis–like disease in mice.

J Immunol (2022) 208 (12): 2622–2631.

  • A contact allergen, DNCB, binds proteins in a short time frame.

  • DNCB directly binds HSP90, which appears to contribute to contact hypersensitivity.

  • Inhibition of HSP90 can attenuate DNCB-induced contact hypersensitivity.

ANTIGEN RECOGNITION AND RESPONSES

J Immunol (2022) 208 (12): 2632–2642.

  • Inducible AID-knockout model shows that AID impacts the primary B cell repertoire in naive mice.

  • Natural Ags and microbiome may potentiate AID footprints.

AUTOIMMUNITY

J Immunol (2022) 208 (12): 2643–2651.

  • CD47-expressing apoptotic cells accumulate in autoimmune valvular carditis.

  • CD47 blockade promotes efferocytosis and reduces inflammatory cytokine production.

  • CD47 blockade reduces the severity of autoimmune valvular carditis in mice.

J Immunol (2022) 208 (12): 2652–2662.

  • In ESS mice, significant nuclear translocation of IL-33 occurred during the disease.

  • IL-33 stimulates the epithelium to play a proinflammatory and chemotactic role.

  • IL-33 indirectly promotes T cell differentiation in a variety of ways.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2022) 208 (12): 2663–2674.

  • We evaluated four heterologous prime-boost HIV vaccine strategies in a clinical trial.

  • Three strategies, all including the HIV MVA-B vaccine, led to T cell responses.

  • A gene expression signature related to the HIV MVA-B vaccine was identified.

J Immunol (2022) 208 (12): 2675–2685.

  • Ab repertoire can serve as a biomarker for immune status classification.

  • Various infections share a set of public repertoire features.

  • Private features can distinguish one infection from another.

IMMUNE REGULATION

J Immunol (2022) 208 (12): 2686–2701.

  • Zbtb46 has a dominant role in maintaining homeostasis of dendritic cells.

  • Zbtb46 controls dendritic cell activation by suppressing Cd80/86 and Cd40 signals.

  • Zbtb46 regulates cd80/86 and cd40 expression by reprogramming epigenetic regulation.

J Immunol (2022) 208 (12): 2702–2712.

  • The suppressor proteins 4E-BP1/2 regulate mTORC1 activation in CD8 T cells.

  • 4E-BP1/2 proteins are required for CD8 T cell proliferation and differentiation.

  • 4E-BP proteins exert translational control on mitochondrial biogenesis in CD8 T cells.

IMMUNE SYSTEM DEVELOPMENT

J Immunol (2022) 208 (12): 2713–2725.

  • We studied the ontogeny of the Ig repertoires and microbiome in mice aged 0–8 wk.

  • Gut–spleen shared clones initiate in the gut and then expand to the spleen.

  • Diversity indices of the Ig repertoire and microbiome change in a correlated manner.

IMMUNOTHERAPY AND VACCINES

J Immunol (2022) 208 (12): 2726–2737.

  • SM03 (an anti-CD22 mAb) immunomodulates B cells in autoimmunity in a novel mechanism of action.

  • SM03 converts cis-to-trans binding of CD22 to α2,6-linked sialic acid glycans.

  • SM03 induces immunomodulation and immune tolerance of B cells to autoantigens.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2022) 208 (12): 2738–2748.

  • Asialo-glycoproteins mediate CD8+ T cell localization to the spleen, not the liver.

  • Asialo-glycoprotein–expressing effector CD8+ T cells are removed from the spleen.

  • Platelets have a minimal role in CD8+ T cell localization to the liver.

J Immunol (2022) 208 (12): 2749–2760.

  • Peritoneal cavity B cells express T-bet following infection.

  • Peritoneal cavity CXCR3+ and CXCR3 B cells are transcriptionally distinct.

  • T-bet+ MBCs dominate the peritoneal cavity B cell pool during chronic infection.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2022) 208 (12): 2761–2770.

  • TSCs and TSC-TBs have functional IFN antiviral mechanisms.

  • ESCs are deficient in expressing IFN-α/β, but they can respond to IFN-α/β.

  • TSCs/TSC-TBs can provide IFN antiviral effect to ESCs via paracrine signaling.

J Immunol (2022) 208 (12): 2771–2778.

  • Thrombin substantially modulated bacteria-induced inflammation in human whole blood.

  • Complement C5 and CD14 inhibition reduced the overall cytokine release significantly.

J Immunol (2022) 208 (12): 2779–2794.

  • The TCA cycle intermediates citrate and succinate modulate cytokine expression.

  • SDH subunits exert different effects on IL-1β, IL-10, and IL-23 induction.

  • NAD+/NADH redox balance supports cytokine production through mitochondrial shuttles.

J Immunol (2022) 208 (12): 2795–2805.

  • PBD-2 can actively enter cells and interacts with VASH1.

  • PBD-2 inhibits LPS-induced downregulation of VASH1.

  • PBD-2 inhibits the LPS-induced Akt/NF-κB signaling pathway via VASH1.

MUCOSAL IMMUNOLOGY

J Immunol (2022) 208 (12): 2806–2816.

  • IFN-λ limits neutrophil-induced immunopathology during severe viral bronchiolitis.

  • IFN-λ signaling in neutrophils regulates ROS production.

  • IFN-λ signaling in neutrophils regulates PAD4-independent NETosis.

TUMOR IMMUNOLOGY

J Immunol (2022) 208 (12): 2817–2828.

  • Splicing efficiency by the four proteasome subtypes depends on the peptide sequence.

  • Availability of the splice reactants is a factor controlling splicing efficiency.

  • Affinity of the C-terminal splice reactant for the primed binding site also seems key.

J Immunol (2022) 208 (12): 2829–2836.

  • Hyaluronan-enriched tumor stroma supports the development of PD-L1+ cell clusters.

  • Fibroblasts and epithelial tumor cells serve as the main source of hyaluronan.

  • Hyal2-expressing myeloid cells contribute to the development of PD-L1+ macrophages.

J Immunol (2022) 208 (12): 2837–2846.

  • CD4+ TRM cells can initiate an antitumor immune response.

  • The CD4+ TRM/NK cell axis shapes the TME and orchestrates antitumor immunity.

  • CD4+ T cells dominate antitumor immunity.

J Immunol (2022) 208 (12): 2847–2855.

  • Constitutively activated STAT3 induces the expression of pentraxin-related protein 3 in chronic lymphocytic leukemia cells.

  • Pentraxin-related protein 3 attenuates spontaneous apoptosis rate of chronic lymphocytic leukemia cells.

J Immunol (2022) 208 (12): 2856–2865.

  • We performed a comprehensive analysis of PSPs by mass spectrometry–based de novo sequencing.

  • We validated proteasome splicing–dependent HLA presentation using reactive T cells.

J Immunol (2022) 208 (12): 2866–2876.

  • Murine Bc.DLFL1 lymphoma originates from an age-associated B cell subset.

  • BAFF-R antagonization blocks the in vivo expansion of lymphoma cells.

  • The extranodal growth of lymphoma cells alters their local cytokine milieu.

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