IMMUNOLOGY NOTES AND RESOURCES
ALLERGY AND OTHER HYPERSENSITIVITIES
The Developmental Transcription Factor p63 Is Redeployed to Drive Allergic Skin Inflammation through Phosphorylation by p38α
p38α signaling reshapes keratinocyte gene expression during allergic dermatitis.
p63 phosphorylation by p38α is essential for epidermal MMP13 induction.
Topical p38α and MMP13 inhibitors suppress atopic dermatitis–like disease in mice.
A contact allergen, DNCB, binds proteins in a short time frame.
DNCB directly binds HSP90, which appears to contribute to contact hypersensitivity.
Inhibition of HSP90 can attenuate DNCB-induced contact hypersensitivity.
ANTIGEN RECOGNITION AND RESPONSES
Inducible AID-knockout model shows that AID impacts the primary B cell repertoire in naive mice.
Natural Ags and microbiome may potentiate AID footprints.
CD47 Promotes Autoimmune Valvular Carditis by Impairing Macrophage Efferocytosis and Enhancing Cytokine Production
CD47-expressing apoptotic cells accumulate in autoimmune valvular carditis.
CD47 blockade promotes efferocytosis and reduces inflammatory cytokine production.
CD47 blockade reduces the severity of autoimmune valvular carditis in mice.
The IL-33/ST2 Axis Promotes Primary Sjögren’s Syndrome by Enhancing Salivary Epithelial Cell Activation and Type 1 Immune Response
In ESS mice, significant nuclear translocation of IL-33 occurred during the disease.
IL-33 stimulates the epithelium to play a proinflammatory and chemotactic role.
IL-33 indirectly promotes T cell differentiation in a variety of ways.
CLINICAL AND HUMAN IMMUNOLOGY
T Cell Immunogenicity, Gene Expression Profile, and Safety of Four Heterologous Prime-Boost Combinations of HIV Vaccine Candidates in Healthy Volunteers: Results of the Randomized Multi-Arm Phase I/II ANRS VRI01 Trial
We evaluated four heterologous prime-boost HIV vaccine strategies in a clinical trial.
Three strategies, all including the HIV MVA-B vaccine, led to T cell responses.
A gene expression signature related to the HIV MVA-B vaccine was identified.
Ab repertoire can serve as a biomarker for immune status classification.
Various infections share a set of public repertoire features.
Private features can distinguish one infection from another.
Zbtb46 Controls Dendritic Cell Activation by Reprogramming Epigenetic Regulation of cd80/86 and cd40 Costimulatory Signals in a Zebrafish Model
Zbtb46 has a dominant role in maintaining homeostasis of dendritic cells.
Zbtb46 controls dendritic cell activation by suppressing Cd80/86 and Cd40 signals.
Zbtb46 regulates cd80/86 and cd40 expression by reprogramming epigenetic regulation.
Translational Control by 4E-BP1/2 Suppressor Proteins Regulates Mitochondrial Biosynthesis and Function during CD8+ T Cell Proliferation
The suppressor proteins 4E-BP1/2 regulate mTORC1 activation in CD8 T cells.
4E-BP1/2 proteins are required for CD8 T cell proliferation and differentiation.
4E-BP proteins exert translational control on mitochondrial biogenesis in CD8 T cells.
IMMUNE SYSTEM DEVELOPMENT
We studied the ontogeny of the Ig repertoires and microbiome in mice aged 0–8 wk.
Gut–spleen shared clones initiate in the gut and then expand to the spleen.
Diversity indices of the Ig repertoire and microbiome change in a correlated manner.
IMMUNOTHERAPY AND VACCINES
SM03, an Anti-CD22 Antibody, Converts Cis-to-Trans Ligand Binding of CD22 against α2,6-Linked Sialic Acid Glycans and Immunomodulates Systemic Autoimmune Diseases
SM03 (an anti-CD22 mAb) immunomodulates B cells in autoimmunity in a novel mechanism of action.
SM03 converts cis-to-trans binding of CD22 to α2,6-linked sialic acid glycans.
SM03 induces immunomodulation and immune tolerance of B cells to autoantigens.
INFECTIOUS DISEASE AND HOST RESPONSE
Interactions with Asialo-Glycoprotein Receptors and Platelets Are Dispensable for CD8+ T Cell Localization in the Murine Liver
Asialo-glycoproteins mediate CD8+ T cell localization to the spleen, not the liver.
Asialo-glycoprotein–expressing effector CD8+ T cells are removed from the spleen.
Platelets have a minimal role in CD8+ T cell localization to the liver.
T-bet+ B cells Dominate the Peritoneal Cavity B Cell Response during Murine Intracellular Bacterial Infection
Peritoneal cavity B cells express T-bet following infection.
Peritoneal cavity CXCR3+ and CXCR3− B cells are transcriptionally distinct.
T-bet+ MBCs dominate the peritoneal cavity B cell pool during chronic infection.
INNATE IMMUNITY AND INFLAMMATION
Mouse Trophoblast Cells Can Provide IFN-Based Antiviral Protection to Embryonic Stem Cells via Paracrine Signaling
TSCs and TSC-TBs have functional IFN antiviral mechanisms.
ESCs are deficient in expressing IFN-α/β, but they can respond to IFN-α/β.
TSCs/TSC-TBs can provide IFN antiviral effect to ESCs via paracrine signaling.
Thrombin Differentially Modulates the Acute Inflammatory Response to Escherichia coli and Staphylococcus aureus in Human Whole Blood
Thrombin substantially modulated bacteria-induced inflammation in human whole blood.
Complement C5 and CD14 inhibition reduced the overall cytokine release significantly.
Fungal Patterns Induce Cytokine Expression through Fluxes of Metabolic Intermediates That Support Glycolysis and Oxidative Phosphorylation
The TCA cycle intermediates citrate and succinate modulate cytokine expression.
SDH subunits exert different effects on IL-1β, IL-10, and IL-23 induction.
NAD+/NADH redox balance supports cytokine production through mitochondrial shuttles.
The Intracellular Interaction of Porcine β-Defensin 2 with VASH1 Alleviates Inflammation via Akt Signaling Pathway
PBD-2 can actively enter cells and interacts with VASH1.
PBD-2 inhibits LPS-induced downregulation of VASH1.
PBD-2 inhibits the LPS-induced Akt/NF-κB signaling pathway via VASH1.
IFN-λ Diminishes the Severity of Viral Bronchiolitis in Neonatal Mice by Limiting NADPH Oxidase–Induced PAD4-Independent NETosis
IFN-λ limits neutrophil-induced immunopathology during severe viral bronchiolitis.
IFN-λ signaling in neutrophils regulates ROS production.
IFN-λ signaling in neutrophils regulates PAD4-independent NETosis.
New Insights into the Mechanisms of Proteasome-Mediated Peptide Splicing Learned from Comparing Splicing Efficiency by Different Proteasome Subtypes
Splicing efficiency by the four proteasome subtypes depends on the peptide sequence.
Availability of the splice reactants is a factor controlling splicing efficiency.
Affinity of the C-terminal splice reactant for the primed binding site also seems key.
Detection of PD-L1–Expressing Myeloid Cell Clusters in the Hyaluronan-Enriched Stroma in Tumor Tissue and Tumor-Draining Lymph Nodes
Hyaluronan-enriched tumor stroma supports the development of PD-L1+ cell clusters.
Fibroblasts and epithelial tumor cells serve as the main source of hyaluronan.
Hyal2-expressing myeloid cells contribute to the development of PD-L1+ macrophages.
CD4+ TRM cells can initiate an antitumor immune response.
The CD4+ TRM/NK cell axis shapes the TME and orchestrates antitumor immunity.
CD4+ T cells dominate antitumor immunity.
Constitutively activated STAT3 induces the expression of pentraxin-related protein 3 in chronic lymphocytic leukemia cells.
Pentraxin-related protein 3 attenuates spontaneous apoptosis rate of chronic lymphocytic leukemia cells.
We performed a comprehensive analysis of PSPs by mass spectrometry–based de novo sequencing.
We validated proteasome splicing–dependent HLA presentation using reactive T cells.
Age-Associated B Cell Features of the Murine High-Grade B Cell Lymphoma Bc.DLFL1 and Its Extranodal Expansion in Abdominal Adipose Tissues
Murine Bc.DLFL1 lymphoma originates from an age-associated B cell subset.
BAFF-R antagonization blocks the in vivo expansion of lymphoma cells.
The extranodal growth of lymphoma cells alters their local cytokine milieu.
On the cover: Following intraperitoneal injection, the growth of a murine high-grade B cell lymphoma of age-associated B cell origin (stained with Hoechst 33342 nuclear dye, blue) in the adipose mesentery of recipient mice (with ubiquitous expression of eGFP, green) induces the expansion of gp38+ fibroblastic reticular stromal cells (red/yellow). Jia, X., J. Bene, N. Balázs, K. Szabó, G. Berta, R. Herczeg, A. Gyenesei, and P. Balogh. 2022. Age-associated B cell features of the murine high-grade B cell lymphoma Bc.DLFL1 and its extranodal expansion in abdominal adipose tissues. J. Immunol. 208: 2866-2876.
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