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J Immunol (2022) 208 (3): 529–530.


J Immunol (2022) 208 (3): 531–537.


J Immunol (2022) 208 (3): 539–547.


J Immunol (2022) 208 (3): 549–561.

  • Positions 1–3 in the Tp9 CTL epitope are required for binding to BoLA-1*023:01.

  • Positions 5–8 in the Tp9 epitope are required for TCR recognition in diverse CTLs.

  • Tp9-specific CTLs from Muguga-immunized animals can cross-react with variants 4 and 7.

J Immunol (2022) 208 (3): 562–570.

  • Naive CD8+ T cells from elderly humans are dysfunctional and respond poorly to Ags.

  • Naive CD8+ T cells from elderly humans display altered basal lipid metabolism.

  • Naive CD8+ T cells from elderly humans can be reinvigorated with lipid-lowering drugs.


J Immunol (2022) 208 (3): 571–581.

  • IDO2 has both enzymatic and nonenzymatic functions.

  • IDO2 mediates autoimmune arthritis via a nonenzymatic mechanism.

J Immunol (2022) 208 (3): 582–593.

  • Class switch did not occur in Dsg3-specific BCR knock-in mice in a steady state.

  • Stimulation driving anti-Dsg3 IgG production induced a pemphigus phenotype in mice.

  • Class switch–constraining immune state prevented pemphigus phenotype development.

J Immunol (2022) 208 (3): 594–602.

  • There are fewer LAG-3+ CD4 and CD8 T cells in subjects with RRMS and T1D.

  • LAG-3 protein expression is linked to alterations in mRNA expression.

  • Low LAG-3 may be associated with a decrease in T cell death in subjects with RRMS.


J Immunol (2022) 208 (3): 603–617.

  • miR-139 is downregulated in CD8+ T cells in response to TCR stimulation.

  • miR-139 is not required for anti-influenza CTL responses.

  • miR-139 is required for anti–Listeria monocytogenes CTL responses.

J Immunol (2022) 208 (3): 618–632.

  • lncRNA HOTAIRM1 contributed to immunosuppression during the late phase of sepsis.

  • HOTAIRM1 depletion inhibited T cell exhaustion and alleviated sepsis.

  • The Notch/Hes1/HOTAIRM1/HOXA1/PD-L1 axis was critical for immunosuppression in sepsis.

J Immunol (2022) 208 (3): 633–641.

  • CGRP signaling at ECs regulates Th cell responses in regional lymph nodes in vivo.

  • CGRP signaling at ECs plays a key role in the CHS response.

  • The EC CGRP signaling locus might prove useful for therapeutic manipulation.

J Immunol (2022) 208 (3): 642–650.

  • Traf5−/− CD4+ T cells show enhanced IL-27 receptor signaling.

  • IL-27 administration augments delayed-type hypersensitivity in Traf5−/− mice.


J Immunol (2022) 208 (3): 651–659.

  • Bcl-2 promotes survival of thymic precursors of TCRαβ+CD8αα+ IEL by antagonizing Bim.

  • CD122+ DN IELp that coexpress Runx3 and α4β7 display the highest Bcl-2 dependence.

  • Mice with thymic loss of Bcl-2 have an almost complete loss of gut TCRαβ+CD8αα+ IEL.


J Immunol (2022) 208 (3): 660–671.

  • IL-33 controls fungal clearance and renal inflammation during candidiasis.

  • The IL-33→IL-23→GM-CSF axis is a key defense line during candidiasis.

  • IL-33 reduces fungal burden by suppressing IL-10 production.

J Immunol (2022) 208 (3): 672–684.

  • HBV/HCV coinfection enhanced fibrogenesis compared with HBV or HCV monoinfection.

  • HBV, HCV, and HBV/HCV induced liver fibrogenesis through the TGF-β1–OCT4/Nanog pathway.

J Immunol (2022) 208 (3): 685–696.

  • CD56+ monocytes are upregulated in patients with severe COVID-19.

  • Severe COVID-19 is associated with an increase in peripheral blood circulating endothelial cells.

J Immunol (2022) 208 (3): 697–706.

  • We identified 28 CAgs in the serum of piglets with acute toxoplasmosis.

  • TgZFLP3 was proven to be a potential biomarker for acute toxoplasmosis.

J Immunol (2022) 208 (3): 707–719.

  • NS38 and NS80 facilitate GCRV replication and inhibit the production of ISGs.

  • NS38 and NS80 inhibit RLR signaling pathway via different regulatory mechanisms.

  • NS38 and NS80 hijack piscine TBK1 and IRF3 into viral inclusion bodies.

J Immunol (2022) 208 (3): 720–731.

  • RSV provides protection against a subsequent IAV infection for at least 30 d.

  • The order of successive viral infections can impact disease severity.

  • Innate and adaptive immunity contribute to protection induced by a prior infection.


J Immunol (2022) 208 (3): 732–744.

  • Siglec-F does not dampen A. fumigatus–elicited lung eosinophilia.

  • Siglec-F cross-linking enhances mediator release from IL-33–stimulated eosinophils.

  • This effect depends on the cytoplasmic tail, but not the ITIM/ITIM-like motifs.

J Immunol (2022) 208 (3): 745–752.

  • Monocytes from CFTRΔF508 mice have a defect in β2 integrin–dependent adhesion.

  • Transferring WT bone marrow rescues CF disease.

  • Monocyte-specific CFTR knockout retards weight gains and exacerbates DSS-induced colitis.

J Immunol (2022) 208 (3): 753–761.

  • SARS-CoV-2 NSP13 bridges TBK1 to p62 to form TBK1–NSP13–p62 complex.

  • NSP13 regulates degradation of TBK1 through selective autophagy.

  • SARS-CoV-2 degrades TBK1 and induces p62 aggregation.


J Immunol (2022) 208 (3): 762–771.

  • Single-cell–based rhesus-specific Ig and TCR repertoire sequencing is established.

  • All rhesus Ig and TCR isotypes and chain types are recovered.

J Immunol (2022) 208 (3): 772–779.

  • The Ig fragment IgCw-γεκ comprises the Cγ1-Cε2–4 and Cκ domains.

  • IgCw-γεκ binds human FcεRI and inhibits IgE-induced degranulation of RBL-2H3 cells.

  • IgCw-γεκ may be an alternative to the IgE references used for IgE quantification.

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