LETTERS TO THE EDITOR
Response to Comment on “Cutting Edge: Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer-BioNTech) Vaccination prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines”
Loss of ST8Sia6 in mice reduces tumor growth.
Loss of ST8Sia6 increases inflammatory factors in macrophages and dendritic cells.
Loss of ST8Sia6 in APCs is responsible for enhanced antitumor response.
Cutting Edge: Unconventional CD8+ T Cell Recognition of a Naturally Occurring HLA-A*02:01–Restricted 20mer Epitope
HLA-A2–bound 20mer peptide contains C-terminal peptide tail hanging from HLA-I cleft.
C-terminal tail of this 20mer peptide can play a critical role in T cell recognition.
CLINICAL AND HUMAN IMMUNOLOGY
SARS-CoV-2 particle/protein exposure induces monocyte activation during pregnancy.
SARS-CoV-2 protein exposure mildly enhances T cell activation during pregnancy.
SARS-CoV-2 challenge triggers pregnancy-specific cytokine responses in the mother.
Utx and Jmjd3 deletion leads to an increase in plasma cells poststimulation.
UTX/JMJD3 regulate cell growth, oxidative phosphorylation, and cell death genes.
UTX/JMJD3 alter chromatin accessibility at ETS and IRF motifs.
lincRNA-Cox2 is highly expressed in the lung and most inducible in AMs after LPS.
We show lincRNA-Cox2 functions in trans to regulate gene expression after ALI.
lincRNA-Cox2’s function is mediated by BM-derived cells, likely infiltrating AMs.
IFITM3 Is Upregulated Characteristically in IL-15–Mediated Bystander-Activated CD8+ T Cells during Influenza Infection
During influenza infection, bystander memory CD8+ T cells are activated.
The IFN-induced gene signature is upregulated in bystander-activated CD8+ T cells.
IFITM3 distinguishes bystander activation from TCR-dependently activated T cells.
Prostaglandin E2–Induced AKT Activation Regulates the Life Span of Short-Lived Plasma Cells by Attenuating IRE1α Hyperactivation
PGE2-EP4 signal is essential for IgM response to TI Ags.
PGE2-EP4 provides an unrecognized link between ER stress response and SLPC life span.
PGE2’s support of SLPC survival is vital for the immune protection against bacteria.
Mettl14-mediated m6A controls the GC reaction and Ab response.
Mettl14 regulates Ythdf2-dependent but Myc-independent positive selection of the GC.
m6A modification promotes mRNA degradation of negative immune regulators.
IMMUNE SYSTEM DEVELOPMENT
Special AT-Rich Sequence-Binding Protein 1 Supports Survival and Maturation of Naive B Cells Stimulated by B Cell Receptors
SATB1 expression increases in naive B cells and decreases upon BCR activation.
SATB1 has roles in the growth and maturation of naive B cells upon BCR activation.
SATB1 supports the survival of naive B cells by regulating antiapoptotic genes.
Neonatal alveolar macrophages express a proinflammatory expression signature.
Neonatal and adult alveolar macrophages respond similarly to inhaled LPS.
Unique features of alveolar macrophages are lost upon removal from the lung.
Comparison of Reptilian Genomes Reveals Deletions Associated with the Natural Loss of γδ T Cells in Squamates
Squamate reptiles, the lizards and snakes, have lost the γδ T cell lineage.
The loss is due to genomic deletions of the genes encoding TCRγ and TCRδ.
Squamates are a natural knockout of a major, but enigmatic, T cell lineage.
INFECTIOUS DISEASE AND HOST RESPONSE
Characterization of Altered Gene Expression and Histone Methylation in Peripheral Blood Mononuclear Cells Regulating Inflammation in COVID-19 Patients
Expressions of many inflammation-related genes are altered in COVID-19 patients.
Some of these changes correlate with their histone methylation marks.
Interaction of lncRNA-CR33942 with Dif/Dorsal Facilitates Antimicrobial Peptide Transcriptions and Enhances Drosophila Toll Immune Responses
Drosophila lncRNA-CR33942 is mainly expressed in the nucleus.
lncRNA-CR33942 enhances Toll immune responses and the survival of Drosophila.
lncRNA-CR33942 facilitates antimicrobial peptide transcriptions via interacting with Dif/Dorsal.
Neurotropic coronavirus-specific Tregs persist after infection as memory cells.
Memory Tregs are better able to proliferate than naive counterparts.
Memory Tregs better inhibit effector T cell responses in the CNS than do naive Tregs.
T-bet and Eomes conjointly repress Th17 development during influenza infection.
Th17 effectors that cannot gain Th1 functionality in vivo protect against influenza.
Mice lacking T-bet and Eomes survive primary and heterosubtypic influenza infection.
Deletion of IL-27RA confers susceptibility to primary hookworm lung infection.
Recombinant IL-27 treatment reduces lung parasite burden and injury in mice.
IL-27 promotes antihelminthic responses via IL-27RA+ γδ T cells in the lungs.
INNATE IMMUNITY AND INFLAMMATION
Lung Imaging Reveals Stroke-Induced Impairment in Pulmonary Intravascular Neutrophil Function, a Response Exacerbated with Aging
Stroke-associated lung infection increases with advanced age.
Stroke accentuates the age-dependent impairment of neutrophil function.
A Single Amino Acid Residue Defines the Difference in NLRP3 Inflammasome Activation between NEK7 and NEK6
The NEK7 catalytic domain is required for NLRP3 activation.
A single residue differentiates between NEK7 and NEK6 in NLRP3 activation.
A NEK7 structural pocket is essential for NLRP3 activation.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
LECT2 is a novel antibacterial protein in vertebrates.
LECT2 is a bifunctional protein with bactericidal and immunoregulatory activities.
Two LECT2 genes exist in teleost fish with one specialized in mucosal immunity.
CD4+ T cells infiltrate into the brain during chronic colitis.
Brain-infiltrating CD4+ T cells causing neuropathology resemble pathogenic Th17 cells.
In the absence of RORγt, CD4+ T cells fail to infiltrate into the brain.
E3 Ubiquitin Ligase Riplet Is Expressed in T Cells and Suppresses T Cell–Mediated Antitumor Immune Responses
Riplet is expressed in T cells and upregulated in activated CD8+ T cells.
Riplet regulates the effector function of CD8+ T cells via TCR stimulation.
Riplet suppresses the T cell–mediated antitumor immune response.
On the cover: Tiliqua rugosa male/female pair from South Australia. They are a viviparous skink species broadly distributed across the southern half of Australia. Development of genomic resources and a 40-year record of their biogeography, behavior, and pathogens make theman emergingmodel for immunological research. Morrissey, K. A., J. M. Sampson, M. Rivera, L. Bu, V. L. Hansen, N. J. Gemmell, M. G. Gardner, T. Bertozzi, and R. D. Miller. 2022. Comparison of reptilian genomes reveals deletions associated with the natural loss of γδ T cells in squamates. J. Immunol. 208: 1960–1967.
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