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J Immunol (2022) 208 (8): 1831–1832.

LETTERS TO THE EDITOR

J Immunol (2022) 208 (8): 1833.
J Immunol (2022) 208 (8): 1833–1834.

BRIEF REVIEWS

J Immunol (2022) 208 (8): 1835–1843.

CUTTING EDGE

J Immunol (2022) 208 (8): 1845–1850.

  • Loss of ST8Sia6 in mice reduces tumor growth.

  • Loss of ST8Sia6 increases inflammatory factors in macrophages and dendritic cells.

  • Loss of ST8Sia6 in APCs is responsible for enhanced antitumor response.

J Immunol (2022) 208 (8): 1851–1856.

  • HLA-A2–bound 20mer peptide contains C-terminal peptide tail hanging from HLA-I cleft.

  • C-terminal tail of this 20mer peptide can play a critical role in T cell recognition.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2022) 208 (8): 1857–1872.

  • SARS-CoV-2 particle/protein exposure induces monocyte activation during pregnancy.

  • SARS-CoV-2 protein exposure mildly enhances T cell activation during pregnancy.

  • SARS-CoV-2 challenge triggers pregnancy-specific cytokine responses in the mother.

IMMUNE REGULATION

J Immunol (2022) 208 (8): 1873–1885.

  • Utx and Jmjd3 deletion leads to an increase in plasma cells poststimulation.

  • UTX/JMJD3 regulate cell growth, oxidative phosphorylation, and cell death genes.

  • UTX/JMJD3 alter chromatin accessibility at ETS and IRF motifs.

J Immunol (2022) 208 (8): 1886–1900.

  • lincRNA-Cox2 is highly expressed in the lung and most inducible in AMs after LPS.

  • We show lincRNA-Cox2 functions in trans to regulate gene expression after ALI.

  • lincRNA-Cox2’s function is mediated by BM-derived cells, likely infiltrating AMs.

J Immunol (2022) 208 (8): 1901–1911.

  • During influenza infection, bystander memory CD8+ T cells are activated.

  • The IFN-induced gene signature is upregulated in bystander-activated CD8+ T cells.

  • IFITM3 distinguishes bystander activation from TCR-dependently activated T cells.

J Immunol (2022) 208 (8): 1912–1923.

  • PGE2-EP4 signal is essential for IgM response to TI Ags.

  • PGE2-EP4 provides an unrecognized link between ER stress response and SLPC life span.

  • PGE2’s support of SLPC survival is vital for the immune protection against bacteria.

J Immunol (2022) 208 (8): 1924–1936.

  • Mettl14-mediated m6A controls the GC reaction and Ab response.

  • Mettl14 regulates Ythdf2-dependent but Myc-independent positive selection of the GC.

  • m6A modification promotes mRNA degradation of negative immune regulators.

IMMUNE SYSTEM DEVELOPMENT

J Immunol (2022) 208 (8): 1937–1946.

  • SATB1 expression increases in naive B cells and decreases upon BCR activation.

  • SATB1 has roles in the growth and maturation of naive B cells upon BCR activation.

  • SATB1 supports the survival of naive B cells by regulating antiapoptotic genes.

J Immunol (2022) 208 (8): 1947–1959.

  • Neonatal alveolar macrophages express a proinflammatory expression signature.

  • Neonatal and adult alveolar macrophages respond similarly to inhaled LPS.

  • Unique features of alveolar macrophages are lost upon removal from the lung.

IMMUNOGENETICS

J Immunol (2022) 208 (8): 1960–1967.

  • Squamate reptiles, the lizards and snakes, have lost the γδ T cell lineage.

  • The loss is due to genomic deletions of the genes encoding TCRγ and TCRδ.

  • Squamates are a natural knockout of a major, but enigmatic, T cell lineage.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2022) 208 (8): 1968–1977.

  • Expressions of many inflammation-related genes are altered in COVID-19 patients.

  • Some of these changes correlate with their histone methylation marks.

J Immunol (2022) 208 (8): 1978–1988.

  • Drosophila lncRNA-CR33942 is mainly expressed in the nucleus.

  • lncRNA-CR33942 enhances Toll immune responses and the survival of Drosophila.

  • lncRNA-CR33942 facilitates antimicrobial peptide transcriptions via interacting with Dif/Dorsal.

J Immunol (2022) 208 (8): 1989–1997.

  • Neurotropic coronavirus-specific Tregs persist after infection as memory cells.

  • Memory Tregs are better able to proliferate than naive counterparts.

  • Memory Tregs better inhibit effector T cell responses in the CNS than do naive Tregs.

J Immunol (2022) 208 (8): 1998–2007.

  • T-bet and Eomes conjointly repress Th17 development during influenza infection.

  • Th17 effectors that cannot gain Th1 functionality in vivo protect against influenza.

  • Mice lacking T-bet and Eomes survive primary and heterosubtypic influenza infection.

J Immunol (2022) 208 (8): 2008–2018.

  • Deletion of IL-27RA confers susceptibility to primary hookworm lung infection.

  • Recombinant IL-27 treatment reduces lung parasite burden and injury in mice.

  • IL-27 promotes antihelminthic responses via IL-27RA+ γδ T cells in the lungs.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2022) 208 (8): 2019–2028.

  • Stroke-associated lung infection increases with advanced age.

  • Stroke accentuates the age-dependent impairment of neutrophil function.

J Immunol (2022) 208 (8): 2029–2036.

  • The NEK7 catalytic domain is required for NLRP3 activation.

  • A single residue differentiates between NEK7 and NEK6 in NLRP3 activation.

  • A NEK7 structural pocket is essential for NLRP3 activation.

MOLECULAR AND STRUCTURAL IMMUNOLOGY

J Immunol (2022) 208 (8): 2037–2053.

  • LECT2 is a novel antibacterial protein in vertebrates.

  • LECT2 is a bifunctional protein with bactericidal and immunoregulatory activities.

  • Two LECT2 genes exist in teleost fish with one specialized in mucosal immunity.

MUCOSAL IMMUNOLOGY

J Immunol (2022) 208 (8): 2054–2066.

  • CD4+ T cells infiltrate into the brain during chronic colitis.

  • Brain-infiltrating CD4+ T cells causing neuropathology resemble pathogenic Th17 cells.

  • In the absence of RORγt, CD4+ T cells fail to infiltrate into the brain.

TUMOR IMMUNOLOGY

J Immunol (2022) 208 (8): 2067–2076.

  • Riplet is expressed in T cells and upregulated in activated CD8+ T cells.

  • Riplet regulates the effector function of CD8+ T cells via TCR stimulation.

  • Riplet suppresses the T cell–mediated antitumor immune response.

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