Issues

This Pillars of Immunology article is a commentary on “Humoral immunity due to long-lived plasma cells,” a pivotal article written by M. K. Slifka, R. Antia, J. K. Whitmire, and R. Ahmed, and published in Immunity, in 1998. https://pubmed.ncbi.nlm.nih.gov/9529153/. The Journal of Immunology, 2022, 209: 3–4.

• Seasonally vaccinated subjects possess functional Abs to H1 COBRA HAs.

• H1 COBRA HA-reactive B cell responses were similar across vaccine seasons.

• Complement is activated more potently by hexameric IgM versus pentameric IgM or IgG1.

• These differences in activity are observed at low, but not high, Ag densities.

• Phagocytic B cells induced anti-PspA IgG production in the hosts.

• Phagocytic B cells presented bacterial peptides to spleen CD4⁺ T cells.

• Phagocytic B cells were not involved in affinity maturation.

• Fibroblasts from fibrotic mouse skin overexpress Hsp90α mRNA.

• Hsp90α-deficient fibrotic mice exhibit reduced skin thickness compared with wild-type mice.

• Higher serum levels of Hsp90α are associated with dSSc and pulmonary fibrosis.

• Anti-CD52 mAb suppresses EAE via Treg expansion.

• IL-7 induces expansion of CD4⁺CD25⁺CD127⁻ Tregs from RRMS patients.

• Anti-CD52 mAb induces suppression of IL-17⁺ and IFN-γ⁺ CD4⁺ cell responses.

• STAP-2 enhances TCR signaling via the binding to CD3ζ ITAM and LCK.

• STAP-2-deficient mice show an impaired induction of autoimmune diseases.

• STAP-2-overexpressing transgenic mice show severe phenotypes of autoimmune diseases.

• Obesity blunts the Ag-presenting capacity of mouse splenic DCs.

• These dysfunctional DCs show major transcriptomic and mitochondrial alterations.

• Enhanced mitochondrial fatty acid oxidation drives DC dysfunction in obesity.

• GATA3 is required for a Notch-induced program of T lineage differentiation.

• GATA3 is required for Bcl11b expression, and together they repress the Cdkn2 locus.

• Dysregulated Cdkn2 expression leads to apoptosis of early T lineage cells.

• TCR protein pairing restrictions can shape the αβ TCR repertoire.

• These restrictions have a negligible role for uniform specificity of αβ T cells.

• Monogenic TCRβ assembly is fundamental for uniform specificity of αβ T cells.

• MVA-vectorized IL-7 stimulates cells from the innate and adaptive lineage.

• It confers protection in sepsis mice.

• Its mechanism of action is broader than a nonvectorized IL-7 formulation.

• ADA-1 enhances humoral responses by inducing durable, high-affinity, and neutralizing Abs.

• ADA-1 enhances cellular responses by inducing durable Ag-specific T and B cells.

• ADA-1–enhanced humoral and cellular responses translated to increased protection.

• IFN-γ plays a dominant role in the deterioration of IAV/bacterial coinfection.

• IFN-γ induces alveolar macrophage depletion during IAV/bacterial coinfection.

• IFN-α/β signaling prevents IFN-γ hyperproduction during IAV/bacterial coinfection.

• Neutrophil chemotaxis towards C5a depends on intracellular and extracellular pH.

• pH controls LTB₄ secretion and Cdc42 activation.

• Chemotaxis requires the activity of the Na⁺/H⁺ exchanger NHE1.

• A new scheme to identify CTL epitopes of unknown MHC-I based on RPLD-MS technology is described.

• The crystal structure of Anpl-UAA*76 is detailed.

• The conserved Anpl-UAA*76–restricted TMUV CTL epitopes are discussed.

• SCI impairs leukocyte recruitment and transcriptional control of lung immunity.

• Impaired lung immunity after SCI creates a microenvironment permissive for infection.

• Boosting leukocyte recruitment to the lung does not reduce bacterial burden after SCI.

• RPL15 is identified as a novel TPT target.

• TPT induces DAMP secretion from cancer cells via its binding to RPL15.

• RPL15 inhibition sensitizes B16-F10 tumors against PD-1 blockade.

• A novel apo-IDO1 inhibitor with potent in vitro and in vivo activity was developed.

• The cocrystal of B37 and IDO1 complex helps elucidate its inhibition mechanism.

• The combination of B37 and anti-PD1 Ab synergistically inhibited tumor growth.