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J Immunol (2022) 209 (1): 1–2.

PILLARS OF IMMUNOLOGY

J Immunol (2022) 209 (1): 3–4.

This Pillars of Immunology article is a commentary on “Humoral immunity due to long-lived plasma cells,” a pivotal article written by M. K. Slifka, R. Antia, J. K. Whitmire, and R. Ahmed, and published in Immunity, in 1998. https://pubmed.ncbi.nlm.nih.gov/9529153/. The Journal of Immunology, 2022, 209: 3–4.

ANTIGEN RECOGNITION AND RESPONSES

J Immunol (2022) 209 (1): 5–15.

  • Seasonally vaccinated subjects possess functional Abs to H1 COBRA HAs.

  • H1 COBRA HA-reactive B cell responses were similar across vaccine seasons.

J Immunol (2022) 209 (1): 16–25.

  • Complement is activated more potently by hexameric IgM versus pentameric IgM or IgG1.

  • These differences in activity are observed at low, but not high, Ag densities.

J Immunol (2022) 209 (1): 26–37.

  • Phagocytic B cells induced anti-PspA IgG production in the hosts.

  • Phagocytic B cells presented bacterial peptides to spleen CD4+ T cells.

  • Phagocytic B cells were not involved in affinity maturation.

AUTOIMMUNITY

J Immunol (2022) 209 (1): 38–48.

  • Fibroblasts from fibrotic mouse skin overexpress Hsp90α mRNA.

  • Hsp90α-deficient fibrotic mice exhibit reduced skin thickness compared with wild-type mice.

  • Higher serum levels of Hsp90α are associated with dSSc and pulmonary fibrosis.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2022) 209 (1): 49–56.

  • Anti-CD52 mAb suppresses EAE via Treg expansion.

  • IL-7 induces expansion of CD4+CD25+CD127 Tregs from RRMS patients.

  • Anti-CD52 mAb induces suppression of IL-17+ and IFN-γ+ CD4+ cell responses.

IMMUNE REGULATION

J Immunol (2022) 209 (1): 57–68.

  • STAP-2 enhances TCR signaling via the binding to CD3ζ ITAM and LCK.

  • STAP-2-deficient mice show an impaired induction of autoimmune diseases.

  • STAP-2-overexpressing transgenic mice show severe phenotypes of autoimmune diseases.

J Immunol (2022) 209 (1): 69–76.

  • Obesity blunts the Ag-presenting capacity of mouse splenic DCs.

  • These dysfunctional DCs show major transcriptomic and mitochondrial alterations.

  • Enhanced mitochondrial fatty acid oxidation drives DC dysfunction in obesity.

IMMUNE SYSTEM DEVELOPMENT

J Immunol (2022) 209 (1): 77–92.

  • GATA3 is required for a Notch-induced program of T lineage differentiation.

  • GATA3 is required for Bcl11b expression, and together they repress the Cdkn2 locus.

  • Dysregulated Cdkn2 expression leads to apoptosis of early T lineage cells.

J Immunol (2022) 209 (1): 93–98.

  • TCR protein pairing restrictions can shape the αβ TCR repertoire.

  • These restrictions have a negligible role for uniform specificity of αβ T cells.

  • Monogenic TCRβ assembly is fundamental for uniform specificity of αβ T cells.

IMMUNOTHERAPY AND VACCINES

J Immunol (2022) 209 (1): 99–117.

  • MVA-vectorized IL-7 stimulates cells from the innate and adaptive lineage.

  • It confers protection in sepsis mice.

  • Its mechanism of action is broader than a nonvectorized IL-7 formulation.

J Immunol (2022) 209 (1): 118–127.

  • ADA-1 enhances humoral responses by inducing durable, high-affinity, and neutralizing Abs.

  • ADA-1 enhances cellular responses by inducing durable Ag-specific T and B cells.

  • ADA-1–enhanced humoral and cellular responses translated to increased protection.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2022) 209 (1): 128–135.

  • IFN-γ plays a dominant role in the deterioration of IAV/bacterial coinfection.

  • IFN-γ induces alveolar macrophage depletion during IAV/bacterial coinfection.

  • IFN-α/β signaling prevents IFN-γ hyperproduction during IAV/bacterial coinfection.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2022) 209 (1): 136–144.

  • Neutrophil chemotaxis towards C5a depends on intracellular and extracellular pH.

  • pH controls LTB4 secretion and Cdc42 activation.

  • Chemotaxis requires the activity of the Na+/H+ exchanger NHE1.

MOLECULAR AND STRUCTURAL IMMUNOLOGY

J Immunol (2022) 209 (1): 145–156.

  • A new scheme to identify CTL epitopes of unknown MHC-I based on RPLD-MS technology is described.

  • The crystal structure of Anpl-UAA*76 is detailed.

  • The conserved Anpl-UAA*76–restricted TMUV CTL epitopes are discussed.

SYSTEMS IMMUNOLOGY

J Immunol (2022) 209 (1): 157–170.

  • SCI impairs leukocyte recruitment and transcriptional control of lung immunity.

  • Impaired lung immunity after SCI creates a microenvironment permissive for infection.

  • Boosting leukocyte recruitment to the lung does not reduce bacterial burden after SCI.

TUMOR IMMUNOLOGY

J Immunol (2022) 209 (1): 171–179.

  • RPL15 is identified as a novel TPT target.

  • TPT induces DAMP secretion from cancer cells via its binding to RPL15.

  • RPL15 inhibition sensitizes B16-F10 tumors against PD-1 blockade.

J Immunol (2022) 209 (1): 180–191.

  • A novel apo-IDO1 inhibitor with potent in vitro and in vivo activity was developed.

  • The cocrystal of B37 and IDO1 complex helps elucidate its inhibition mechanism.

  • The combination of B37 and anti-PD1 Ab synergistically inhibited tumor growth.

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