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J Immunol (2022) 209 (10): 1809–1810.

TRANSLATING IMMUNOLOGY

J Immunol (2022) 209 (10): 1811–1816.

BRIEF REVIEWS

J Immunol (2022) 209 (10): 1817–1825.

CUTTING EDGE

J Immunol (2022) 209 (10): 1827–1831.

  • Monocytes have impaired antifungal effector function in neutropenic mice.

  • STAT1 expression on CCR2+ monocytes is required for defense against IA.

  • Neutrophils are a relevant direct source of IFN-γ during aspergillosis.

J Immunol (2022) 209 (10): 1832–1836.

  • Influenza-reactive Abs block CD8+ T cell responses to an LAIV.

  • High-dose LAIV immunization overcomes Ab-mediated block in CD8 T cell priming.

  • The immunological landscape of a vaccinee can impact LAIV-induced T cell responses.

ALLERGY AND OTHER HYPERSENSITIVITIES

J Immunol (2022) 209 (10): 1837–1850.

  • β-Glucosylceramides increased development of CD11b+CD11c+ dendritic cells via PKC.

  • Tocopherol isoforms modified this development of dendritic cells.

  • DC function was not altered, but increased DC numbers elevated T cell activation.

J Immunol (2022) 209 (10): 1851–1859.

  • HRF secretion is enhanced by cytokines, HDM allergens, ATP, and adenosine.

  • Several HDM allergens enhance HRF secretion in a TLR2-dependent manner.

  • HRF elicits neutrophilic airway inflammation in HDM-sensitized mice.

J Immunol (2022) 209 (10): 1860–1869.

  • Blood LCN2 and SAA levels may be associated with a type 17 asthma subtype.

  • LCN2 and SAAs are steroid-resistant IL-17A target genes in airway cells.

  • IL-17A–Act1/CEBPB axis is an important regulatory mechanism of LCN2 and SAAs.

ANTIGEN RECOGNITION AND RESPONSES

J Immunol (2022) 209 (10): 1870–1879.

  • This is the first description, to our knowledge, of bovine γδ TCR repertoires using the NGS approach.

  • In the bovine γδ T cell response against Leptospira, TCRs function as innate-like receptors.

AUTOIMMUNITY

J Immunol (2022) 209 (10): 1880–1891.

  • CD4 T cells cause spontaneous EAE using an MHC class I–restricted MBP-specific TCR.

  • Spontaneous disease is dependent on TNF-α without IL-17, IFN-γ, and GM-CSF.

  • B cells cross-present MBP to drive spontaneous disease.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2022) 209 (10): 1892–1905.

  • CMV-seropositive older adults have more EMRA and terminally differentiated T cells.

  • CMV seropositivity does not prevent Ab maintenance after SARS-CoV-2 vaccination.

  • CMV seropositivity does not impede SARS-CoV-2 vaccine T cell memory recall responses.

IMMUNE REGULATION

J Immunol (2022) 209 (10): 1906–1917.

  • pDCs represent an important source of TNF-α in RA pathogenesis.

  • IL-6 exerts an anti-inflammatory role by limiting pDC-derived TNF-α secretion.

J Immunol (2022) 209 (10): 1918–1929.

  • CyHV-3 evades host antiviral immunity by its ORF89 protein.

  • ORF89 negatively regulates host IFN expression via degrading IRF3.

  • ORF89 is identified and validated as a target gene of host miR-722.

J Immunol (2022) 209 (10): 1930–1941.

  • Effector IFN-stimulated genes (ISGs) are induced robustly by I-IFNs.

  • Most effector ISGs have at least one TSS-proximal ISGF3 binding region.

  • Promoter regions of effector ISGs are accessible and contain “strong” ISRE motifs.

IMMUNE SYSTEM DEVELOPMENT

J Immunol (2022) 209 (10): 1942–1949.

  • IL-7R–deficient ETPs have defects in cell cycle and survival.

  • The most immature Flt3+ ETPs are enriched in IL-7R–expressing cells.

  • IL-7/IL-7R signaling in the thymus is required to generate Flt3+ ETPs.

IMMUNOTHERAPY AND VACCINES

J Immunol (2022) 209 (10): 1950–1959.

  • WT and TLR4-SNP mice respond comparably to T-dependent and -independent Ags alone.

  • TLR4-SNP mice exhibit reduced Ab titers to NP-OVA and TLR4 adjuvant (E6020).

  • TLR4-SNP mice exhibit reduced isotype class switching to NP-OVA with E6020.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2022) 209 (10): 1960–1972.

  • Alveolar macrophage NOX2 limits germination of inhaled Aspergillus fumigatus conidia in mice.

  • Reduced neutrophil NOX2 activity promotes invasive A. fumigatus and enhances inflammation.

J Immunol (2022) 209 (10): 1973–1986.

  • Tissue microenvironment influences microglial and leukocyte phagocytosis.

  • Phagocytic versus nonphagocytic cells exhibit transcriptional heterogeneity.

  • NOX2 prevents Staphylococcus aureus outgrowth during craniotomy infection.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2022) 209 (10): 1987–1998.

  • TRIM21 regulates virus-induced pyroptosis.

  • ISG12a is required for TRIM21-mediated pyroptosis.

  • TRIM21 promotes ISG12a mitochondrial migration by ubiquitination of ISG12a.

J Immunol (2022) 209 (10): 1999–2011.

  • Mos/Mϕs exhibit complex and dynamic heterogeneity during skin wound healing.

  • Mos/Mϕs transit from proinflammatory to healing-associated transcriptional states.

  • An early increase of Ccl7 preferentially induces accumulation of proinflammatory Mos/Mϕs.

J Immunol (2022) 209 (10): 2012–2021.

  • RNF215 is upregulated by viral infection in human macrophages.

  • RNF215 inhibits the production of IFN-β via blocking NF-κB p65 activation.

  • The expression of RNF215 is negatively correlated with IFN-β in patients with SLE.

J Immunol (2022) 209 (10): 2022–2032.

  • A homolog of the AhR family named LvAhR was cloned and identified from L. vannamei.

  • Caspases are novel target genes of LvAhR.

  • The AhR–caspase axis restrains virus replication by promoting antiviral apoptosis.

MOLECULAR AND STRUCTURAL IMMUNOLOGY

J Immunol (2022) 209 (10): 2033–2041.

  • Mutating the TCR Cα C-strand enhances positive selection of CD4+CD8 thymocytes.

  • Mutating the TCR Cα C-strand increases homeostatic survival of naive CD4+ T cells.

  • We infer that the TCR Cα surface regulates tonic signaling to self-pMHC-II.

J Immunol (2022) 209 (10): 2042–2053.

  • High surface expression of IgM protects against apoptosis in human GC B cells.

  • CD79A/B depletion resulted in loss of IgM surface expression and reduced fitness.

  • Glycan maturation of BCR complex components was interrupted upon CD79A or CD79B KO.

NOVEL IMMUNOLOGICAL METHODS

J Immunol (2022) 209 (10): 2054–2067.

  • We generated a large repertoire of anti-DENV NS1 mouse mAbs.

  • We identified high-affinity mAbs with recognition sites outside the wing domain.

  • We developed a highly sensitive NS1 Ag ELISA for dengue diagnosis.

CORRECTIONS

J Immunol (2022) 209 (10): 2068.
J Immunol (2022) 209 (10): 2069.
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