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J Immunol (2022) 209 (11): 2071.

BRIEF REVIEWS

J Immunol (2022) 209 (11): 2073–2081.

AUTOIMMUNITY

J Immunol (2022) 209 (11): 2083–2092.

  • CD40 supports distinct effector programs in B cells and DCs for EAE.

  • CD40 expression on DCs is required for priming pathogenic Th cells.

  • B cell CD40 is essential for class-switched MOG-specific Ab production.

J Immunol (2022) 209 (11): 2093–2103.

  • hM-R822Q Tg mice exhibit SMS-like disease phenotype.

  • Poly(I:C) injection induces lethal inflammation in female hM-R822Q Tg mice.

  • Lethal inflammation is mediated by MDA5 through MAVS, IFNAR, and JAK signaling.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2022) 209 (11): 2104–2113.

  • Memory T and B cells are present for long periods with different kinetics.

  • Circulating Tfh cells correlate to the Ab production of B cells.

  • Memory T cells, but not B cells, are fully reactive to the omicron variant.

IMMUNE REGULATION

J Immunol (2022) 209 (11): 2114–2132.

  • AQ and HAQ alleles underwent natural selection during the out-of-Africa migration.

  • Adult AQ knock-in mice are leaner than WT or HAQ mice on a chow diet.

  • The second transmembrane and TM2–TM3 linker of MPYS interacts with acyl-CoA.

J Immunol (2022) 209 (11): 2133–2140.

  • Numbers of CD19+ cells in B6.Baff−/− and B6.Br3−/− mice diverge as the mice age.

  • B cell subset profiles significantly differ between B6.Baff−/− and B6.Br3−/− mice.

  • CD4+Foxp3+ cells are greater in B6.Baff−/− mice than in B6.Br3−/− mice.

IMMUNOGENETICS

J Immunol (2022) 209 (11): 2141–2148.

  • Bovine ultralong CDR H3s use cysteine polymorphisms to generate structural diversity.

  • Different disulfides form between germline and mutated cysteines within CDR H3.

IMMUNOTHERAPY AND VACCINES

J Immunol (2022) 209 (11): 2149–2159.

  • Vaccine-induced T cell expansion is blunted in dirty mice compared with SPF mice.

  • XCR1+ DCs from dirty mice fail to produce IL-27p28 after vaccination.

  • Exogenous IL-27 restores T cell expansion in dirty mice.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2022) 209 (11): 2160–2171.

  • Helminth coinfection impairs the innate neutrophil response to T. gondii.

  • Coinfection impairs the CD8 T cell response quantitatively, but not qualitatively.

  • Helminth coinfection impairs disease tolerance during toxoplasmosis.

J Immunol (2022) 209 (11): 2172–2180.

  • K. pneumoniae triggers pleuritis, bacteremia, and early mortality in old mice.

  • Nlrp3-dependent IL-1β release is increased in K. pneumoniae–infected old mice.

  • Transplantation of young bone marrow rescues old mice from fatal K. pneumoniae pneumonia.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2022) 209 (11): 2181–2191.

  • FABP5 in myeloid cells controls LPS-induced liver injury and M1 polarization.

  • FABP5 deletion increases unsaturated fatty acids in LPS-treated macrophages.

  • FABP5 and oleic acid master LPS-induced M1 polarization by the AMPK/NF-κB pathway.

J Immunol (2022) 209 (11): 2192–2202.

  • STAT6-IP immunomodulatory peptide inhibits lung ILC2 expansion in response to IL-33.

  • Targeting innate immune cells by STAT6-IP durably reduces type 2 inflammation.

MOLECULAR AND STRUCTURAL IMMUNOLOGY

J Immunol (2022) 209 (11): 2203–2214.

  • Carp IFN-γrel dimer is connected by two pairs of disulphide bonds.

  • Carp IFN-γrel interacts with CRFB17 and CRFB13 to induce STAT1 phosphorylation.

  • Carp IFN-γrel has a narrower spectrum of functions than IFN-γ.

MUCOSAL IMMUNOLOGY

J Immunol (2022) 209 (11): 2215–2226.

  • Discovery of a lymphoid structure in the nasal cavity of rainbow trout called O-NALT.

  • Trout O-NALT expresses high levels of aicda at the steady state.

  • IgM+ B cells proliferate and enter apoptosis in trout O-NALT.

TUMOR IMMUNOLOGY

J Immunol (2022) 209 (11): 2227–2238.

  • CCL17 expression is increased in colitis-associated colon tumors.

  • Single-housed CCL17-deficient mice develop fewer tumors dependent on the microbiota.

  • Reduced tumor numbers coincide with increased apoptosis during tumor initiation.

NOVEL IMMUNOLOGICAL METHODS

J Immunol (2022) 209 (11): 2239–2247.

  • Easy-to-implement in vitro amplification of specific T cells from healthy donors is described.

  • Robust amplification of viral- or tumor-specific T cells with low frequencies in blood is shown.

  • Parameters required for amplification of epitope-specific T cells are identified.

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