IMMUNOLOGY NOTES AND RESOURCES
Shedding Light on Immunological Research in Lyon, France. IRCI2022 Brings the Scientific World to Lyon and Bridges the Latest Immunological Findings in Cancer and Infection
Cutting Edge: CCR9 Promotes CD8+ T Cell Recruitment to the Brain during Congenital Cytomegalovirus Infection
CCR9 is selectively expressed on CD8+ T cells in the CMV-infected brain.
CCL25 is upregulated in the brain after congenital CMV infection.
Inhibition of CCR9/CCL25 impairs CD8+ T cell migration to the brain.
Cutting Edge: mTORC2 Regulates CD8+ Effector and Memory T Cell Differentiation through Serum and Glucocorticoid Kinase 1
SGK1, downstream of mTORC2 signaling, inhibits memory CD8+ T cell formation.
Inhibiting or deleting SGK1 promotes memory CD8+ T cells and antitumor immunity.
ALLERGY AND OTHER HYPERSENSITIVITIES
Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and Suppresses Allergic Lung Inflammation
Macrophage P2Y6 receptors selectively activate NFATC2 through Gαq/PLC.
NFATC2 mediates the P2Y6-potentiated IL-12 production and IFN-γ expression.
Macrophage P2Y6 and NFATC2 control innate and type 2 immune responses.
The G307S mutation augmented the activating signal of DNAM-1 in CD4+ conventional T cells.
The G307S mutation promoted the interaction with Lck and p-Tyr322 of DNAM-1.
The G307S DNAM-1 mutation exacerbated CD4+ T cell–mediated autoimmune encephalomyelitis.
IMMUNOTHERAPY AND VACCINES
CD96 Blockade Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis via Suppression of IL-17A Production by Dermal γδ T Cells
CD96 mediated a costimulatory signal in both human and mouse γδ T cells.
CD96 on dermal γδ T cells augmented IL-17A production and exacerbated psoriasis.
The blockade of CD96 ameliorates psoriasis.
INNATE IMMUNITY AND INFLAMMATION
IL-1β is key to inflammatory responses of fetal membranes at parturition.
IL-1β induces collagen degradation via ER-phagy in membrane mesenchymal cells.
IL-1β promotes removal of redundant collagen via autophagy in membrane rupture.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
Insights into the Antibacterial Properties of Complement Peptides C3a, C4a, and C5a across Vertebrates
The antibacterial properties of vertebrate C3a, C4a, and C5a have evolved divergently.
Net charge is the determining factor of the antibacterial properties.
Vertebrate C3a, C4a, and C5a are all resources of peptide antibiotics.
A Deficiency in the Cytokine TNFSF14/LIGHT Limits Inflammation and Remodeling in Murine Eosinophilic Esophagitis
LIGHT contributes to esophageal T cell infiltration and IL-13 levels in a model of EoE.
LIGHT regulates esophageal tissue remodeling in a model of EoE.
LIGHT drives esophagus fibroblast proliferation and potentiates fibroblast responses to IL-13.
The Human Dendritic Cell Atlas: An Integrated Transcriptional Tool to Study Human Dendritic Cell Biology
The Stemformatics DC atlas provides a reference tool to study human DC biology.
DC subsets group by tissue and remember their origin in culture.
In vitro–derived cDCs do not recapitulate the biology of their in vivo equivalents.
LETTERS OF RETRACTION
Retraction: IL-21/IL-21R Signaling Aggravated Respiratory Inflammation Induced by Intracellular Bacteria through Regulation of CD4+ T Cell Subset Responses
On the cover: Ionomycin induces nuclear translocation of NFATC2. Bone marrow—derived macrophages from P2ry6fl/fl/Cre/+ mice were treated with 10 μM ionomycin for 10 min. Cells were stained with anti-NFATC2 and anti-Iba1 Abs and visualized with Alexa Fluor 555 (red)– and Alexa Fluor 488 (green)–conjugated secondary Abs with nuclei stain DAPI (blue). Nagai, J., J. Lin, and J. A. Boyce. 2022. Macrophage P2Y6 receptor signaling selectively activates NFATC2 and suppresses allergic lung inflammation. J. Immunol. 209: 2293–2303.
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