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J Immunol (2022) 209 (2): 193–195.


J Immunol (2022) 209 (2): 197.


J Immunol (2022) 209 (2): 199–207.
J Immunol (2022) 209 (2): 208–216.
J Immunol (2022) 209 (2): 217–225.


J Immunol (2022) 209 (2): 227–237.

  • Elevating expression of the NF-κB regulatory Nfkbid gene inhibits T1D in NOD mice.

  • Elevated Nfkbid levels enhance thymic deletion of diabetogenic CD8 T cells.

  • Elevating Nfkbid increases Treg numbers and activity partly inhibiting T1D.

J Immunol (2022) 209 (2): 238–249.

  • The proportions of immune cells and autoimmune and virus-related genes change in pSS.

  • Cell communication of TGF-β and CD30 among immune cells was abnormal in pSS patients.

  • Single-cell TCR and BCR repertoires do not change much in pSS patients.


J Immunol (2022) 209 (2): 250–261.

  • Acetylcholine and fatty acids/oxylipins are associated with severe COVID-19.

  • Glucocorticoids reduce acetylcholine levels and favor COVID-19 survival.

J Immunol (2022) 209 (2): 262–269.

  • Complement component C3 suppresses 1α-hydroxylase in sinonasal epithelial cells.

  • The active metabolite 1,25(OH)2D3 suppresses sinonasal epithelial cell release of C3.

J Immunol (2022) 209 (2): 270–279.

  • A rapid and specific tracing method quantifies circulating CD207+ and CD1a+ cells in LCH.

  • Cellular status will help prognostic accuracy and follow-up with a noninvasive procedure.

J Immunol (2022) 209 (2): 280–287.

  • Both CVA16 and EV-A71 infection induced a persistent humoral immune response.

  • Compared with EV-A71 infection, the CVA16-induced NAb response was significantly lower.

  • Our findings showed that sampling time and clinical severity had effects on the NAb response.


J Immunol (2022) 209 (2): 288–300.

  • CD11bhigh B cells are a distinct subset of B cells that increase with aging.

  • CD11bhigh B cells are increased in both young and aged brains after stroke.

  • CD11bhigh B cells can regulate microglia phenotypes and increase phagocytosis.

J Immunol (2022) 209 (2): 301–309.

  • ICOS-deficient Treg cells can suppress spontaneous autoimmunity.

  • ICOS-deficient Treg cells show impaired differentiation of Th1-Treg cells.

J Immunol (2022) 209 (2): 310–325.

  • Plasmalogen activates GPCR21 to regulate the cytolytic activity of human NK cells.

  • GPCR21 is glycosylated in the NK cells after recognition with the target cells.

  • Oral ingestion of plasmalogen inhibits tumor growth and viral proliferation in mice.


J Immunol (2022) 209 (2): 326–336.

  • CP potentiates RGNNV proliferation by suppressing the RLR-IFN signaling pathway.

  • CP promotes LjRNF114-mediated K48 ubiquitination and degradation of LjTRAF3.

  • CP promotes the K48-linked ubiquitination and degradation of LjIRF3.

J Immunol (2022) 209 (2): 337–345.

  • AGMs downregulate CD4 from their Th cells to avoid pathogenicity from SIV.

  • ATACseq showed the CD4 locus loses accessibility in these cells.

  • Additional changes reveal that epigenetics plays an important role.

J Immunol (2022) 209 (2): 346–353.

  • Mavs expression in alveolar macrophages maintains resistance against A. fumigatus.

  • An SNP in MAVS is associated with a risk of developing invasive aspergillosis.


J Immunol (2022) 209 (2): 354–367.

  • Chemorepulsion mechanisms are conserved between Dictyostelium and human neutrophils.

  • Male and female neutrophils have differences in chemorepulsion mechanisms.

  • Male and female neutrophils have differences in protein levels and localization.

J Immunol (2022) 209 (2): 368–378.

  • LRP5/6 signaling in myeloid cells protects against colitis-associated AKI.

  • LRP5/6 signaling in macrophages regulates the responsiveness to commensal microbiota.

  • LRP5/6 signaling limits microbiota-induced systemic and renal inflammation.

J Immunol (2022) 209 (2): 379–390.

• KIR2DS2 is associated with high functional activity of NK cells.

• KIR2DS2+ NK cells possess a transcriptomic profile associated with cytotoxicity.

J Immunol (2022) 209 (2): 391–400.

  • Endogenous β-glucosylceramide (β-GlcCer) is a specific NET-inducing ligand of Mincle.

  • β-GlcCer–induced NETs are antimicrobial and require glycolysis and autophagy.

  • Cell-free β-GlcCer in infection and inflammation may have diagnostic potential.

J Immunol (2022) 209 (2): 401–411.

  • Adenosine significantly relieves the severity of NEC via regulating MDSCs.

  • Adenosine enhances the immunosuppressive and antibacterial activity of MDSCs.

  • Adenosine facilitates the migration of MDSCs to gut via CXCR2.

J Immunol (2022) 209 (2): 412–426.

  • Porcine and chicken STING but not cGAS exhibit species disparity.

  • The species specificity of STING matches up to downstream IRF3/7.

  • IRF3 works with only porcine STING, whereas IRF7 works with both porcine and chicken STING.

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