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J Immunol (2022) 209 (3): 429–430.


J Immunol (2022) 209 (3): 431–433.

This Pillars of Immunology article is a commentary on “Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors,” a pivotal article written by E. A. Leadbetter, I. R. Rifkin, A. M. Hohlbaum, B. C. Beaudette, M. J. Shlomchik and A. Marshak-Rothstein, and published in Nature in 2002.


J Immunol (2022) 209 (3): 435–445.

  • A functionally active SNP in the TOLLIP promoter is associated with decreased IL-12.

  • TOLLIP participates in DC maturation during M. tuberculosis infection.

J Immunol (2022) 209 (3): 446–455.

  • IL-22 is produced by conventional CD4+ T cells that require TCR engagement.

  • Th22 cells are markedly reduced during TB and HIV coinfection compared to Th1 cells.

  • Th22 cells exhibit shared and distinct features compared to Th1 and Th17 cells.


J Immunol (2022) 209 (3): 456–464.

  • Carma3−/− mice show exacerbated liver injury in Con A–induced hepatitis model.

  • Carma3 deficiency causes increased mitochondria damage in LSEC upon Con A stimulation.

  • Heparin pretreatment can prevent Con A–induced liver injury.

J Immunol (2022) 209 (3): 465–475.

  • T1D is initiated and driven by multiple diabetogenic CD4+ T cell epitopes.

  • Tolerance to individual epitopes/proteins fails to inhibit T1D development.

  • Tolerance to a cocktail of diabetogenic proteins inhibits T1D development.

J Immunol (2022) 209 (3): 476–487.

  • Deacetylation of hemocyanin increases its LPS binding and antibacterial activity.

  • The K481/484 residues on hemocyanin are critical for binding with bacteria or LPS.

  • HDAC3 and TIP60 regulate the acetylation of hemocyanin on K481/484.

J Immunol (2022) 209 (3): 488–497.

  • BspI negatively regulates proinflammatory responses during Brucella infection.

  • BspI suppresses proinflammatory responses via the IRE1–TRAF2–NF-κB pathway.

  • BspI-inhibited NF-κB activation requires its GAP domain.


J Immunol (2022) 209 (3): 498–509.

  • A CD135+ subset was identified within mouse CD115+CD11b+ monocytes.

  • CD135+ monocytes exhibited Ag-presenting functions.

  • CD135+ monocytes were direct progeny of MDPs but not of cMoPs.


J Immunol (2022) 209 (3): 510–525.

  • HVEM and LTβR are broadly expressed on tumor-infiltrating CD8+ T, NK, and myeloid cells.

  • LIGHT binding to HVEM/LTβR activates Fc-independent myeloid/T/NK cell activation.

  • TIGIT-Fc-LIGHT induces anti tumor responses in CPI primary/acquired resistant tumors.

J Immunol (2022) 209 (3): 526–534.

  • A novel multiplexed assay isolates polyfunctional T cells for downstream analyses.

  • We identified surface markers upregulated on vaccine-specific polyfunctional CD4 T cells.

  • A signature predicts a CD4 T cell profile correlated with reduced risk of HIV infection.


J Immunol (2022) 209 (3): 535–547.

  • rs610913 is a frequent, nonsynonymous variant in the cGAS-encoding gene MB21D1.

  • cGAS(WT) and cGAS (P261H) maintain a baseline cellular antiviral state.

  • cGAS(WT) and cGAS (P261H) share similar DNA-sensing and antiviral capacities.

J Immunol (2022) 209 (3): 548–558.

  • Neutrophils and monocytes produce IL-1α and IL-1β in P. aeruginosa–infected corneas.

  • P. aeruginosa is more rapidly killed in infected Il1a−/− compared with WT corneas.

  • Il1a−/− neutrophils have a more proinflammatory transcriptome with elevated C1q.


J Immunol (2022) 209 (3): 559–568.

  • Vitamin D generates a cell state less permissive for Chandipura virus infections.

  • Vitamin D triggers autoregulatory T1-IFN–IRF7 signaling, basally.

  • Downmodulating RelB NF-κB, vitamin D provokes antiviral type 1 IFN signaling.

J Immunol (2022) 209 (3): 569–581.

  • Icam1 mRNA is elevated in islets from female versus male NOD mice.

  • ICAM-1 protein abundance is greater in hyperglycemic female NOD mice.

  • IL-1β rapidly upregulates expression of the Icam1 gene in β-cells.

J Immunol (2022) 209 (3): 582–592.

  • LvHSP70 promotes PRR expression of LvTRL2, LvTRL5, and LvLGBP.

  • LvHSP70 interacts with LvLGBP-driven innate immunity and activates the proPO system.

  • LvHSP70 acts as a DAMP and activates the proPO cascade by interacting with free LvLGBP.


J Immunol (2022) 209 (3): 593–605.

  • Ag immunization significantly upregulates the tilapia IgM Ab affinity.

  • Affinity influences the isomeric structure and high mannose modification of IgM.

  • High-affinity IgM plays an important role in regulating phagocytosis.


J Immunol (2022) 209 (3): 606–620.

  • Human macrophages infiltrate human melanoma in mice, which is associated with metastasis.

  • Tumor-infiltrating macrophages have a unique transcriptional signature.

  • Similar macrophages are found in melanoma patient samples.

J Immunol (2022) 209 (3): 621–628.

  • PPP2R2D limits T cell exhaustion by controlling chromatin accessibility.

  • PPP2R2D deficiency in T cells promotes tumor growth of melanoma.

  • PPP2R2D deficiency in T cells expands the Treg population in tumor-infiltrating T cells.

J Immunol (2022) 209 (3): 629–640.

  • The NKG2A/Qa-1b axis inhibits RT-induced T cell responses.

  • Combined RT plus NKG2A/PD-1 blockade improved survival in B16F10 tumors.

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