Issues

An atypical monocyte subset expressing CD56 is associated with COVID-19 severity.

CD56⁺ monocytes, showing a hyperinflammatory profile, can be induced by IFN-α.

A high CD56⁺/CD16⁺ monocyte ratio is associated with mortality of COVID-19 patients.

Self-renewing T cells responsive to PD-1 blockade are depleted from growing tumors.

Stability of self-renewing TCF1⁺CD8⁺ T cells correlates with immunotherapy response.

PI3Kδ inhibitor added to anti–PD-1 boosts TCF1⁺ T cell pool and lessens tumor growth.

IgE⁺ plasmablasts secrete IgE, supporting the vicious cycle of allergy.

IgE⁺ plasmablasts correlate with clinical allergy severity and IgE secretion.

An acid wash approach quantifies IgE⁺ plasmablasts as an allergy severity biomarker.

pDCs bind Aspergillus hyphae, inducing activation/maturation.

pDC–A. fumigatus binding is mediated by CLRs, predominantly dectin-1.

Dectin-1 ligation indirectly and directly induces pDC activation and maturation.

Neutralizing mAb 6C8 binds a unique epitope involving domain III and H1 of E protein.

6C8 pressure leads to antigenic variation of TMUV in vitro.

Tumor-bearing NOD mice model immune checkpoint inhibitor–associated autoimmunity.

γδT17 and Th17 type 3 immune cells contribute to ICI-associated thyroiditis.

IL-17A inhibition reduces thyroid autoimmunity but preserves the ICI antitumor response.

SpRab11a drives bacterial resistance by regulating exosome formation.

Exosome drives bacterial resistance through exosomal Sp14-3-3.

Exosomal Sp14-3-3 promotes ALFs expression by affecting Dorsal translocation.

Pazopanib ameliorates MHV-1-induced lung injury in A/J mice.

Pazopanib reduces lung cell apoptosis induced by MHV-1 in A/J mice.

Palmitate priming increases IL-6 secretion by monocytes stimulated with LPS.

Palmitate increases H3K9/H3K18 acetylation in monocytes.

H3K9/H3K18 acetylation associates with Il6 gene transcription.

Soluble Msln and Muc16 regulate GATA6 expression in LCMs.

Monocyte-derived macrophages in cavity spaces are main target of Msln and Muc16.

NK cell inhibitory receptor repertoire skewing is observed already in bone marrow.

Repertoire skewing may partly be accounted for by selective proliferation.

NK cells expressing self-specific inhibitory receptors have increased DNAM-1.

Preexisting influenza memory protects against secondary bacterial superinfection.

Memory improves epithelial function and reduces inflammation in superinfection.

Preexisting memory alters T cells and innate immune cells during superinfection.

Human neutrophils can be classified into distinct subsets based on transcriptomics.

A modified analysis pipeline provides enhanced detection of neutrophil transcripts.

These subsets cannot be classified using common surface markers.

β-Glucan induces trained immunity for bacterial clearance in turbot.

Neutrophil is the key cell type mediating trained immunity via the IL-1R pathway.

Epithelial ODC contributes to H. pylori–induced pathogenesis.

Genetic deletion of ODC in epithelial cells reduces gastric inflammation.

DFMO limits inflammation through inhibition of epithelial ODC.

We solved the first structure of a type I IFN with three disulfide bonds, LcIFNi.

LcIFNi activates the conserved JAK-STAT pathway by binding with LcCRFB2 and LcCRFB5.

We proposed a structural model of LcIFNi bound to a heterodimeric receptor.

C202-2729 significantly attenuates endotoxin shock and EAE.

C202-2729 selectively binds to the N terminus of GSDMD.

C202-2729 blocks the migration of GSDMD^NT to cell membrane.

AF-M2637 is a monovalent adalimumab variant designed to release TNF-α at acidic pH.

AF-M2637 potently neutralizes TNF-α stimulation of THP1 monocytes in vitro.

AF-M2637 is less immunogenic than adalimumab in mice following a single dose.