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J Immunol (2022) 209 (5): 841.

PILLARS OF IMMUNOLOGY

J Immunol (2022) 209 (5): 843–844.

This Pillars of Immunology article is a commentary on “Neutrophil extracellular traps kill bacteria,” a pivotal article written by V. Brinkmann, U. Reichard, C. Goosmann, B. Fauler, Y. Uhlemann, D. S. Weiss, Y. Weinrauch, and A. Zychlinksy, and published in Science, in 2004. https://www.science.org/doi/10.1126/science.1092385. The Journal of Immunology, 2022, 209: 843–844.

BRIEF REVIEWS

J Immunol (2022) 209 (5): 845–854.

ANTIGEN RECOGNITION AND RESPONSES

J Immunol (2022) 209 (5): 855–863.

  • Med1 controls T cell differentiation and survival during acute bacterial infection.

  • Med1 deficiency in T cells impairs T-bet–mediated transcriptional programs.

  • C/EBPβ promotes T-bet expression by interacting with Med1 in effector T cells.

J Immunol (2022) 209 (5): 864–873.

  • Activated TCD4+s can present MHC II–restricted antigen derived from infectious HIV-1.

  • Activated TCD4+s use endogenous processing to process and present HIV-1 antigen.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2022) 209 (5): 874–885.

  • Differential T cell gene expression is noted in chromosome 22q11.2 deletion syndrome.

  • Defective communication between immune cells plays a role in chromosome 22q11.2 deletion syndrome.

IMMUNE REGULATION

J Immunol (2022) 209 (5): 886–895.

  • Zfp335 is vital in regulating memory CD8+ T cell differentiation and maintenance.

  • Zfp335 controls memory CD8+ T cell survival by directly regulating Tcf7.

J Immunol (2022) 209 (5): 896–906.

  • TCR engagement induces CK2 expression and kinase activity in CD8+ T cells.

  • CK2α impacts CD8+ T cell activation, proliferation, and metabolic reprogramming.

  • CK2α regulates CD8+ T cell effector and memory differentiation during infection.

J Immunol (2022) 209 (5): 907–915.

  • CRISPR activation screening identifies VGLL3 as a transcriptional regulator of PD-L1.

  • Autoimmunity-associated VGLL3 controls IFN-γ–induced PD-L1 in keratinocytes.

  • VGLL3 forms a complex with RUNX1/3 and TEAD1 to drive PD-L1 expression.

IMMUNE SYSTEM DEVELOPMENT

J Immunol (2022) 209 (5): 916–925.

  • ISP cells are active in the cell cycle.

  • NPAT is essential for ISP cell proliferation and thymic development.

J Immunol (2022) 209 (5): 926–937.

  • Survival signals drive distinct gene expression programs in human plasmablasts.

  • APRIL and CD40L share activation of cell growth–related gene programs.

  • APRIL-driven growth programs are uncoupled from support of the B cell state.

J Immunol (2022) 209 (5): 938–949.

  • The RAG1 ubiquitin ligase domain stimulates TCRα and TCRβ gene assembly in vivo.

  • The RAG1 ubiquitin ligase domain influences development of αβ T cell lineages.

  • The RAG1 ubiquitin ligase domain limits autoreactive conventional αβ T cells.

J Immunol (2022) 209 (5): 950–959.

  • Notch signals promote thymic generation of CCR10+ skin-homing NK1.1+ ILC1s.

  • DL4-KO differently affects thymic CCR10+ ILC1 generation in newborn and adult mice.

  • IL-7R is also involved in thymic generation of CCR10+ NK1.1+ ILC1s.

IMMUNOGENETICS

J Immunol (2022) 209 (5): 960–969.

  • Flt3/Flt3lg genes were maintained on both homeolog chromosomes in X. laevis.

  • Gene expression analysis suggests a subfunctionalization of the Flt3/Flt3lg genes.

  • Flt3 is expressed at the surface of dendritic-like cells and a B cell subpopulation.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2022) 209 (5): 970–978.

  • IL-32 inhibits HIV-1 production in MDMs in an SAMHD1-dependent manner.

  • IL-32 upregulates the expression of IDO1, IDO2, TDO, and PD-L1 in MDMs.

  • IL-32 enhances the motility of MDMs.

J Immunol (2022) 209 (5): 979–990.

  • The duck CD8high+ population was increased with H5N1 AIV stimulation.

  • Duck CD8high+ cells seemed to play important roles in defending H5N1 AIV infection.

J Immunol (2022) 209 (5): 991–1000.

  • Akt-2 but not Akt-1 inhibits antifungal innate immune responses.

  • Akt-2 suppresses fungal killing in neutrophils and macrophages.

  • Targeting Akt-2 may represent a therapeutic approach for disseminated candidiasis.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2022) 209 (5): 1001–1012.

  • Human CD99L2 is expressed on human leukocytes and human endothelial cells.

  • Human CD99L2 regulates TEM of leukocytes between PECAM and CD99-dependent steps.

  • Human CD99L2 is required for continuous targeted recycling of the LBRC.

MOLECULAR AND STRUCTURAL IMMUNOLOGY

J Immunol (2022) 209 (5): 1013–1020.

  • The lamprey Petromyzon marinus genome is likely to encode numerous helical cytokines.

  • These include potential regulators of immune cell ontogenesis and polarization.

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