Issues

Human STAT3 gain-of-function mutation promotes autoimmunity in a murine model.

Regulatory T cell development and function in STAT3 GOF mice are preserved.

Enhanced STAT3 promotes in vivo expansion of Th1 and Th17 CD4⁺ T cells.

The frequency of MAGE-C2–specific CD8⁺ T cells is a prognostic factor in ESCA patients.

TCR vβ16 usage by MAGE-C2–specific CD8⁺ T cells is associated with better prognosis.

Perivascular deposition of IgA is not the only major trigger in IgA vasculitis.

Perivascular deposition needs to be supplemented with priming of circulating PMNs by IgA complexes.

IgA-primed PMNs undergo vast NETosis when adhering to vessels with perivascular IgA.

BAP31 regulates macrophages polarization.

BAP31 knockdown inhibits IL-4Rα protein degradation.

BAP31 affects the wound healing function.

ADAR1 p150 but not the p110 isoform controls the GC response.

ADAR1 regulates the GC response partially through the MDA5 but not the PKR or RNase L pathway.

The dsRNA-binding but not the RNA-editing activity of ADAR1 is critical for the GC response.

T cell–specific AR-deficient mice have exacerbated allergic airway inflammation.

AR-deficient memory Th2 cells show enhanced proliferation and cytokine production.

Androgens induce DUSP-2 expression and suppress cytokine production in Th2 cells.

Fish B cell immune responses are regulated by mTORC1 signaling.

mTORC1 signaling is involved in Ab-mediated agglutination of Flavobacterium columnare.

T_FH cell differentiation is regulated by FOXO1 via intronic elements in the Bcl6 gene.

Deletion of the FOXO1 binding sites changes the proportion of T_FH and Th1 cells.

Chicken alloantigen systems A and E are located on Galgal microchromosome 26.

Alloantigen A is C4BPM (complement component 4 binding protein, membrane).

Alloantigen E is FCAMR (Fc fragment of IgA and IgM receptor).

We report creation of the new Arid5a^−/− mouse strain.

Arid5a^−/− mice are resistant to experimental autoimmune encephalomyelitis.

Arid5a^−/− mice retain immunity to oral and disseminated candidiasis.

SpA inhibits the interaction of IgGs with FcγRIIa, FcγRIIIb, and FcRn.

Multiple SpA domains are needed to effectively block IgG1-mediated phagocytosis.

Btk inhibition ameliorates ALF via reducing NLRP3 inflammasome activation.

Btk might be a valuable predictor of ALSS treatment effect in patients with ALF.

Zebrafish sirt5 negatively regulates antiviral innate immunity.

Zebrafish sirt5 attenuates phosphorylation of mavs.

Zebrafish sirt5 diminishes ubiquitination of mavs.

FasL-treated macrophages display proteolytic cleavage of the gasdermin family.

TAK1 functions as a negative regulator of Fas signaling in macrophages.

TAK1 in macrophages protects mice from spontaneous tissue inflammation.

Some proteins, when immobilized, express an Aβ epitope.

Aβ and amyloid-like structures are the ligands of structurally altered pentameric CRP.

Structurally altered pentameric CRP prevents the formation of Aβ fibrils.

mRNA translation shapes early activation of CD8 memory T cells.

Ribosome footprinting identifies a translational program in CD8 memory T cells.

RNA-GQ, GC, and PRTE motifs regulate the translation of key genes in T cells.

The gut Th17 response is type 2 DC driven.

IL-6 is required for Th17 differentiation but does not act directly on T cells.

IL-6 is derived from type 2 DCs enriched with CD40 and CCL17/CCL21.

NLCs are essential for CLL, but their developmental program is unknown.

The MEK pathway is critical for NLC development.

MEK inhibition shifts myeloid phenotypes and increases survival in vivo.