Cutting Edge: Systemic Autoimmunity in Murine STAT3 Gain-of-Function Syndrome Is Characterized by Effector T Cell Expansion in the Absence of Overt Regulatory T Cell Dysfunction
Human STAT3 gain-of-function mutation promotes autoimmunity in a murine model.
Regulatory T cell development and function in STAT3 GOF mice are preserved.
Enhanced STAT3 promotes in vivo expansion of Th1 and Th17 CD4+ T cells.
ANTIGEN RECOGNITION AND RESPONSES
Clinical Correlation of Function and TCR vβ Diversity of MAGE-C2–Specific CD8+ T Cell Response in Esophageal Cancer
The frequency of MAGE-C2–specific CD8+ T cells is a prognostic factor in ESCA patients.
TCR vβ16 usage by MAGE-C2–specific CD8+ T cells is associated with better prognosis.
CLINICAL AND HUMAN IMMUNOLOGY
Perivascular deposition of IgA is not the only major trigger in IgA vasculitis.
Perivascular deposition needs to be supplemented with priming of circulating PMNs by IgA complexes.
IgA-primed PMNs undergo vast NETosis when adhering to vessels with perivascular IgA.
BCR-Associated Protein 31 Regulates Macrophages Polarization and Wound Healing Function via Early Growth Response 2/C/EBPβ and IL-4Rα/C/EBPβ Pathways
BAP31 regulates macrophages polarization.
BAP31 knockdown inhibits IL-4Rα protein degradation.
BAP31 affects the wound healing function.
ADAR1 p150 but not the p110 isoform controls the GC response.
ADAR1 regulates the GC response partially through the MDA5 but not the PKR or RNase L pathway.
The dsRNA-binding but not the RNA-editing activity of ADAR1 is critical for the GC response.
T cell–specific AR-deficient mice have exacerbated allergic airway inflammation.
AR-deficient memory Th2 cells show enhanced proliferation and cytokine production.
Androgens induce DUSP-2 expression and suppress cytokine production in Th2 cells.
Fish B cell immune responses are regulated by mTORC1 signaling.
mTORC1 signaling is involved in Ab-mediated agglutination of Flavobacterium columnare.
CD8+ TEMRA cells respond better to IL-15 than do CD8+ TEM cells.
CD5 negatively regulates IL-15–induced proliferation of memory CD8+ T cells.
CD5 suppresses IL-15–induced proliferation by inhibiting the mTOR pathway.
IMMUNE SYSTEM DEVELOPMENT
TFH cell differentiation is regulated by FOXO1 via intronic elements in the Bcl6 gene.
Deletion of the FOXO1 binding sites changes the proportion of TFH and Th1 cells.
The Chicken A and E Blood Systems Arise from Genetic Variation in and around the Regulators of Complement Activation Region
Chicken alloantigen systems A and E are located on Galgal microchromosome 26.
Alloantigen A is C4BPM (complement component 4 binding protein, membrane).
Alloantigen E is FCAMR (Fc fragment of IgA and IgM receptor).
INFECTIOUS DISEASE AND HOST RESPONSE
We report creation of the new Arid5a−/− mouse strain.
Arid5a−/− mice are resistant to experimental autoimmune encephalomyelitis.
Arid5a−/− mice retain immunity to oral and disseminated candidiasis.
SpA inhibits the interaction of IgGs with FcγRIIa, FcγRIIIb, and FcRn.
Multiple SpA domains are needed to effectively block IgG1-mediated phagocytosis.
INNATE IMMUNITY AND INFLAMMATION
The Inhibition of Bruton Tyrosine Kinase Alleviates Acute Liver Failure via Downregulation of NLRP3 Inflammasome
Btk inhibition ameliorates ALF via reducing NLRP3 inflammasome activation.
Btk might be a valuable predictor of ALSS treatment effect in patients with ALF.
Zebrafish sirt5 Negatively Regulates Antiviral Innate Immunity by Attenuating Phosphorylation and Ubiquitination of mavs
Zebrafish sirt5 negatively regulates antiviral innate immunity.
Zebrafish sirt5 attenuates phosphorylation of mavs.
Zebrafish sirt5 diminishes ubiquitination of mavs.
FasL-treated macrophages display proteolytic cleavage of the gasdermin family.
TAK1 functions as a negative regulator of Fas signaling in macrophages.
TAK1 in macrophages protects mice from spontaneous tissue inflammation.
Structurally Altered, Not Wild-Type, Pentameric C-Reactive Protein Inhibits Formation of Amyloid-β Fibrils
Some proteins, when immobilized, express an Aβ epitope.
Aβ and amyloid-like structures are the ligands of structurally altered pentameric CRP.
Structurally altered pentameric CRP prevents the formation of Aβ fibrils.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
mRNA translation shapes early activation of CD8 memory T cells.
Ribosome footprinting identifies a translational program in CD8 memory T cells.
RNA-GQ, GC, and PRTE motifs regulate the translation of key genes in T cells.
Migrating Type 2 Dendritic Cells Prime Mucosal Th17 Cells Specific to Small Intestinal Commensal Bacteria
The gut Th17 response is type 2 DC driven.
IL-6 is required for Th17 differentiation but does not act directly on T cells.
IL-6 is derived from type 2 DCs enriched with CD40 and CCL17/CCL21.
Disruption of Nurse-like Cell Differentiation as a Therapeutic Strategy for Chronic Lymphocytic Leukemia
NLCs are essential for CLL, but their developmental program is unknown.
The MEK pathway is critical for NLC development.
MEK inhibition shifts myeloid phenotypes and increases survival in vivo.
On the cover: Nurse-like cells are monocyte-lineage cells that support development and progression of chronic lymphocytic leukemia (CLL). This image is of a spleen from the Eµ-TCL1 mouse model of CLL, stained for F4/80 (macrophages, red), ERK (green), and DNA (blue). Yellow indicates colocalization of macrophages and ERK. Merchand-Reyes, G., R. Santhanam, F. H. Robledo-Avila, C. Weigel, J. d. D. Ruiz-Rosado, X. Mo, S. Partida-Sánchez, J. A. Woyach, C. C. Oakes, S. Tridandapani, and J. P. Butchar. 2022. Disruption of nurse-like cell differentiation as a therapeutic strategy for chronic lymphocytic leukemia. J. Immunol. 209: 1212â€“1223.
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