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J Immunol (2022) 209 (6): 1023.

BRIEF REVIEWS

J Immunol (2022) 209 (6): 1025–1032.

CUTTING EDGE

J Immunol (2022) 209 (6): 1033–1038.

  • Human STAT3 gain-of-function mutation promotes autoimmunity in a murine model.

  • Regulatory T cell development and function in STAT3 GOF mice are preserved.

  • Enhanced STAT3 promotes in vivo expansion of Th1 and Th17 CD4+ T cells.

ANTIGEN RECOGNITION AND RESPONSES

J Immunol (2022) 209 (6): 1039–1047.

  • The frequency of MAGE-C2–specific CD8+ T cells is a prognostic factor in ESCA patients.

  • TCR vβ16 usage by MAGE-C2–specific CD8+ T cells is associated with better prognosis.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2022) 209 (6): 1048–1058.

  • Perivascular deposition of IgA is not the only major trigger in IgA vasculitis.

  • Perivascular deposition needs to be supplemented with priming of circulating PMNs by IgA complexes.

  • IgA-primed PMNs undergo vast NETosis when adhering to vessels with perivascular IgA.

IMMUNE REGULATION

J Immunol (2022) 209 (6): 1059–1070.

  • BAP31 regulates macrophages polarization.

  • BAP31 knockdown inhibits IL-4Rα protein degradation.

  • BAP31 affects the wound healing function.

J Immunol (2022) 209 (6): 1071–1082.

  • ADAR1 p150 but not the p110 isoform controls the GC response.

  • ADAR1 regulates the GC response partially through the MDA5 but not the PKR or RNase L pathway.

  • The dsRNA-binding but not the RNA-editing activity of ADAR1 is critical for the GC response.

J Immunol (2022) 209 (6): 1083–1094.

  • T cell–specific AR-deficient mice have exacerbated allergic airway inflammation.

  • AR-deficient memory Th2 cells show enhanced proliferation and cytokine production.

  • Androgens induce DUSP-2 expression and suppress cytokine production in Th2 cells.

J Immunol (2022) 209 (6): 1095–1107.

  • Fish B cell immune responses are regulated by mTORC1 signaling.

  • mTORC1 signaling is involved in Ab-mediated agglutination of Flavobacterium columnare.

J Immunol (2022) 209 (6): 1108–1117.

  • CD8+ TEMRA cells respond better to IL-15 than do CD8+ TEM cells.

  • CD5 negatively regulates IL-15–induced proliferation of memory CD8+ T cells.

  • CD5 suppresses IL-15–induced proliferation by inhibiting the mTOR pathway.

IMMUNE SYSTEM DEVELOPMENT

J Immunol (2022) 209 (6): 1118–1127.

  • TFH cell differentiation is regulated by FOXO1 via intronic elements in the Bcl6 gene.

  • Deletion of the FOXO1 binding sites changes the proportion of TFH and Th1 cells.

IMMUNOGENETICS

J Immunol (2022) 209 (6): 1128–1137.

  • Chicken alloantigen systems A and E are located on Galgal microchromosome 26.

  • Alloantigen A is C4BPM (complement component 4 binding protein, membrane).

  • Alloantigen E is FCAMR (Fc fragment of IgA and IgM receptor).

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2022) 209 (6): 1138–1145.

  • We report creation of the new Arid5a−/− mouse strain.

  • Arid5a−/− mice are resistant to experimental autoimmune encephalomyelitis.

  • Arid5a−/− mice retain immunity to oral and disseminated candidiasis.

J Immunol (2022) 209 (6): 1146–1155.

  • SpA inhibits the interaction of IgGs with FcγRIIa, FcγRIIIb, and FcRn.

  • Multiple SpA domains are needed to effectively block IgG1-mediated phagocytosis.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2022) 209 (6): 1156–1164.

  • Btk inhibition ameliorates ALF via reducing NLRP3 inflammasome activation.

  • Btk might be a valuable predictor of ALSS treatment effect in patients with ALF.

J Immunol (2022) 209 (6): 1165–1172.

  • Zebrafish sirt5 negatively regulates antiviral innate immunity.

  • Zebrafish sirt5 attenuates phosphorylation of mavs.

  • Zebrafish sirt5 diminishes ubiquitination of mavs.

J Immunol (2022) 209 (6): 1173–1179.

  • FasL-treated macrophages display proteolytic cleavage of the gasdermin family.

  • TAK1 functions as a negative regulator of Fas signaling in macrophages.

  • TAK1 in macrophages protects mice from spontaneous tissue inflammation.

J Immunol (2022) 209 (6): 1180–1188.

  • Some proteins, when immobilized, express an Aβ epitope.

  • Aβ and amyloid-like structures are the ligands of structurally altered pentameric CRP.

  • Structurally altered pentameric CRP prevents the formation of Aβ fibrils.

MOLECULAR AND STRUCTURAL IMMUNOLOGY

J Immunol (2022) 209 (6): 1189–1199.

  • mRNA translation shapes early activation of CD8 memory T cells.

  • Ribosome footprinting identifies a translational program in CD8 memory T cells.

  • RNA-GQ, GC, and PRTE motifs regulate the translation of key genes in T cells.

MUCOSAL IMMUNOLOGY

J Immunol (2022) 209 (6): 1200–1211.

  • The gut Th17 response is type 2 DC driven.

  • IL-6 is required for Th17 differentiation but does not act directly on T cells.

  • IL-6 is derived from type 2 DCs enriched with CD40 and CCL17/CCL21.

TUMOR IMMUNOLOGY

J Immunol (2022) 209 (6): 1212–1223.

  • NLCs are essential for CLL, but their developmental program is unknown.

  • The MEK pathway is critical for NLC development.

  • MEK inhibition shifts myeloid phenotypes and increases survival in vivo.

CORRECTIONS

J Immunol (2022) 209 (6): 1224.
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