Issues

This Pillars of Immunology article is a commentary on “Induction of T cell development from hematopoietic progenitor cells by Delta-like-1 in vitro,” a pivotal article written by T.M. Schmitt and J.C. Zúñiga-Pflücker, and published in Immunity, in 2002.

• Liganded RARα upregulates the expression of GFI1.

• GFI1 binds the Il9 gene and suppresses Th9 polarization.

• Active systemic anaphylaxis in mice shows Ag retention specifically in the lung.

• Ag is predominantly captured by neutrophils and monocytes.

• Neutrophils and monocytes activate locally in the lung during anaphylaxis.

• NAbs alert the immune system against nascent neoantigen-expressing cells.

• NAbs are required to induce a CTL response against neoantigen-expressing cells.

• NAb-tagged cells mount immunity against immunogenic and nonimmunogenic Ags.

• Human CBLB-KO CD4⁺ T cells are resistant to Treg suppression in vitro.

• CBLB-KO cells overcome Treg suppression on transcriptional and translational levels.

• Brain CD8⁺ T cells of aged WT and APP-PS1 mice are identified as Trm T cells.

• Upregulated genes of brain CD8⁺ cells are involved in type I IFN signaling.

• RNA-seq profiling delineates cDC1 responses to extracellular stimuli.

• Poly(I:C) activates autocrine IFN-I signaling in cDC1s.

• IL-10 inhibits autocrine IFN-I responses in cDC1s via STAT3.

• T_regs develop via distinct agonist and postagonist stages.

• CD25⁺ T_regP agonist cells are a main source of IL2 needed for T_reg development.

• Thymic recirculating T_regs have highly diverse transcriptomes and TCRs.

• Coronavirus impairs host immunity against secondary bacterial infections.

• Coronavirus-induced lysosomal dysfunction impairs bacterial killing.

• Targeting lysosomal enzyme cathepsin B limits pyroptotic cell death.

• Obesity reduced susceptibility to pulmonary bacterial infection.

• Obesity resulted in a dysregulated lung lipidome and lipid response to infection.

• Rapid production of COX-2 products was essential for survival of lung infection.

• FTRCA1 is a fish-specific E3 ligase with RNA-binding activity.

• FTRCA1 impairs STING1 and IRF7 mRNA levels to downregulate the IFN response.

• FTRCA1 targets TBK1 protein degradation to downregulate the IFN response.

• Myeloid MCPIP1 controls the endotoxin tolerance.

• MCPIP1 ensures the tolerance to LPS via restriction of the NF-κB signaling pathway.

• MCPIP1 determines endotoxin tolerance independently of its RNase activity.

• Crosslinking of HLA I triggers complex formation between TLR4 and HLA I in ECs.

• P-selectin externalization and monocyte binding induced by HLA I Ab depend on TLR4.

• TLR4 functions as a coreceptor of HLA I in human ECs.

• Ligature-induced periodontitis activates complement in a microbiota-dependent manner.

• Complement C3 deficiency inhibits LIP-induced IL-6 and IL-23 and Th17 expansion.

• Complement links the periodontal microbiota to Th17 expansion and bone loss.

• Unique cell subpopulations predominant in atopic dermatitis samples were identified.

• Putative biomarkers associated with disease progression were found.

• A decrease in effector memory donor-reactive CD4 T cells after transplantation was shown.

• A decrease in polyfunctional (producing ≥2 cytokines) donor-reactive CD4 T cells was also seen.

• Increased apoptosis in donor-reactive CD4 T cells after transplantation is also demonstrated.

• Lnc57Rik can be induced by tumor-associated factors.

• Lnc57Rik promotes the immunosuppressive function of MDSCs.

• Lnc57Rik binds with the C/EBPβ isoform LAP and WDR5.