LETTERS TO THE EDITOR
PILLARS OF IMMUNOLOGY
This Pillars of Immunology article is a commentary on “Induction of T cell development from hematopoietic progenitor cells by Delta-like-1 in vitro,” a pivotal article written by T.M. Schmitt and J.C. Zúñiga-Pflücker, and published in Immunity, in 2002.
Cutting Edge: The Expression of Transcription Inhibitor GFI1 Is Induced by Retinoic Acid to Rein in Th9 Polarization
Liganded RARα upregulates the expression of GFI1.
GFI1 binds the Il9 gene and suppresses Th9 polarization.
ALLERGY AND OTHER HYPERSENSITIVITIES
IgG Subclass-Dependent Pulmonary Antigen Retention during Acute IgG-Dependent Systemic Anaphylaxis in Mice
Active systemic anaphylaxis in mice shows Ag retention specifically in the lung.
Ag is predominantly captured by neutrophils and monocytes.
Neutrophils and monocytes activate locally in the lung during anaphylaxis.
ANTIGEN RECOGNITION AND RESPONSES
Natural Antibodies Alert the Adaptive Immune System of the Presence of Transformed Cells in Early Tumorigenesis
NAbs alert the immune system against nascent neoantigen-expressing cells.
NAbs are required to induce a CTL response against neoantigen-expressing cells.
NAb-tagged cells mount immunity against immunogenic and nonimmunogenic Ags.
CBLB Deficiency in Human CD4+ T Cells Results in Resistance to T Regulatory Suppression through Multiple Mechanisms
Human CBLB-KO CD4+ T cells are resistant to Treg suppression in vitro.
CBLB-KO cells overcome Treg suppression on transcriptional and translational levels.
Transcriptomic Profiling Identifies CD8+ T Cells in the Brain of Aged and Alzheimer’s Disease Transgenic Mice as Tissue-Resident Memory T Cells
Brain CD8+ T cells of aged WT and APP-PS1 mice are identified as Trm T cells.
Upregulated genes of brain CD8+ cells are involved in type I IFN signaling.
RNA-seq profiling delineates cDC1 responses to extracellular stimuli.
Poly(I:C) activates autocrine IFN-I signaling in cDC1s.
IL-10 inhibits autocrine IFN-I responses in cDC1s via STAT3.
IMMUNE SYSTEM DEVELOPMENT
Tracking Regulatory T Cell Development in the Thymus Using Single-Cell RNA Sequencing/TCR Sequencing
Tregs develop via distinct agonist and postagonist stages.
CD25+ TregP agonist cells are a main source of IL2 needed for Treg development.
Thymic recirculating Tregs have highly diverse transcriptomes and TCRs.
INFECTIOUS DISEASE AND HOST RESPONSE
Coronavirus Lung Infection Impairs Host Immunity against Secondary Bacterial Infection by Promoting Lysosomal Dysfunction
Coronavirus impairs host immunity against secondary bacterial infections.
Coronavirus-induced lysosomal dysfunction impairs bacterial killing.
Targeting lysosomal enzyme cathepsin B limits pyroptotic cell death.
Contribution of Lipid Mediators in Divergent Outcomes following Acute Bacterial and Viral Lung Infections in the Obese Host
Obesity reduced susceptibility to pulmonary bacterial infection.
Obesity resulted in a dysregulated lung lipidome and lipid response to infection.
Rapid production of COX-2 products was essential for survival of lung infection.
INNATE IMMUNITY AND INFLAMMATION
A finTRIM Family Protein Acquires RNA-Binding Activity and E3 Ligase Activity to Shape the IFN Response in Fish
FTRCA1 is a fish-specific E3 ligase with RNA-binding activity.
FTRCA1 impairs STING1 and IRF7 mRNA levels to downregulate the IFN response.
FTRCA1 targets TBK1 protein degradation to downregulate the IFN response.
Myeloid MCPIP1 controls the endotoxin tolerance.
MCPIP1 ensures the tolerance to LPS via restriction of the NF-κB signaling pathway.
MCPIP1 determines endotoxin tolerance independently of its RNase activity.
Cross-Talk between HLA Class I and TLR4 Mediates P-Selectin Surface Expression and Monocyte Capture to Human Endothelial Cells
Crosslinking of HLA I triggers complex formation between TLR4 and HLA I in ECs.
P-selectin externalization and monocyte binding induced by HLA I Ab depend on TLR4.
TLR4 functions as a coreceptor of HLA I in human ECs.
Ligature-induced periodontitis activates complement in a microbiota-dependent manner.
Complement C3 deficiency inhibits LIP-induced IL-6 and IL-23 and Th17 expansion.
Complement links the periodontal microbiota to Th17 expansion and bone loss.
Unique cell subpopulations predominant in atopic dermatitis samples were identified.
Putative biomarkers associated with disease progression were found.
Progressive Loss of Donor-Reactive CD4+ Effector Memory T Cells due to Apoptosis Underlies Donor-Specific Hyporesponsiveness in Stable Renal Transplant Recipients
A decrease in effector memory donor-reactive CD4 T cells after transplantation was shown.
A decrease in polyfunctional (producing ≥2 cytokines) donor-reactive CD4 T cells was also seen.
Increased apoptosis in donor-reactive CD4 T cells after transplantation is also demonstrated.
Tumor Environment Promotes Lnc57Rik-Mediated Suppressive Function of Myeloid-Derived Suppressor Cells
Lnc57Rik can be induced by tumor-associated factors.
Lnc57Rik promotes the immunosuppressive function of MDSCs.
Lnc57Rik binds with the C/EBPβ isoform LAP and WDR5.
Correction: Ig Light Chain Precedes Heavy Chain Gene Rearrangement during Development of B Cells in Swine
On the cover: Clustree analysis of single-cell RNA sequencing data from murine thymic Treg cell differentiation showing the relationships between different clusters across increasing resolutions, illustrating that recently differentiated thymic Treg cells are largely monomorphic. Highlighted are resolutions 1.0 (orange) and 1.9 (blue) and the mature de novo differentiated Treg cell cluster (red). Owen, D. L., R. S. La Rue, S. A. Munro, and M. A. Farrar. 2022. Tracking regulatory T cell development in the thymus using single-cell RNA sequencing/TCR sequencing. J. Immunol. 209: 1300â€“1313.
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkBack Matter
- PDF Icon PDF LinkEditorial Board