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EDITORIAL

J Immunol (2022) 209 (8): 1417–1418.

TOP READS

J Immunol (2022) 209 (8): 1419–1420.

BRIEF REVIEWS

J Immunol (2022) 209 (8): 1421–1425.
J Immunol (2022) 209 (8): 1426–1436.
J Immunol (2022) 209 (8): 1437–1449.
J Immunol (2022) 209 (8): 1450–1464.
J Immunol (2022) 209 (8): 1465–1473.

CUTTING EDGE

J Immunol (2022) 209 (8): 1475–1480.

  • Costimulation is required for butyrophilin-mediated activation of Vγ9Vδ2+ TCR.

  • Heterodimeric BTN2A1/3A1 γδ T cell engager efficiently targets CD19+ lymphoma cells.

ANTIGEN RECOGNITION AND RESPONSES

J Immunol (2022) 209 (8): 1481–1491.

  • The HLA-A*24:02 A81L mutation increases the immunogenicity of cognate Ags.

  • The HLA-A*24:02 A81L mutation enhances expansion of tumor Ag-specific T cells.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2022) 209 (8): 1492–1498.

  • p53 directly upregulates miR-1246 expression in B cells.

  • p53 regulates histone H3K27me3 and H3K9/K14ac in the miR-1246 promoter.

  • p53 recruits JMJD3 and EP300/CBP to bind to the miR-1246 promoter.

J Immunol (2022) 209 (8): 1499–1512.

  • In acute COVID-19, heat-liable plasma components contribute to phagocytosis.

  • Anti-Spike IgG is the most important variable for Ab-dependent phagocytosis.

  • Ab affinity increases longitudinally, whereas Ab titer decreased by >90% and functions decreased by 42%–65%.

J Immunol (2022) 209 (8): 1513–1522.

  • Diminished IL-4R is a signature of naive B cells in ISGhi patients with SLE.

  • IL-4 counteracts IFNs to direct aNAV B cells toward DN1 and cMEM B cells.

  • IL-4RIFN-β+ naive B cells are increased in autoantibody-positive patients with SLE.

IMMUNOTHERAPY AND VACCINES

J Immunol (2022) 209 (8): 1523–1531.

  • MAIT cells expressing CARs effectively kill CD19- and Her2-expressing targets.

  • CAR-MAIT cells display strong cytotoxicity with lower IFN-γ compared with CD8+ CAR-T cells.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2022) 209 (8): 1532–1544.

  • S. pneumoniae induces AMPKα1 activation in the middle ear in vitro and in vivo.

  • Activation of AMPKα1 is required for S. pneumoniae–induced MUC5AC expression.

  • AMPKα1 mediates S. pneumoniae–induced MUC5AC expression via inhibiting JNK.

J Immunol (2022) 209 (8): 1545–1554.

  • Ly49R sensing of MCMV-infected targets requires MHC I Dk and MCMV gp34 expression.

  • MCMV gp34 selectively impedes antiviral immunity in mice lacking the Ly49G2 IR.

  • Ly49G2 licenses IL-12R signaling to enhance CD25 expression on antiviral NK cells.

J Immunol (2022) 209 (8): 1555–1565.

  • Improved prediction algorithm identifies novel Mtb-derived HLA-E binding peptides.

  • Novel HLA-E binding Mtb peptides induce CD8+ T cell activation.

  • HLA-E tetramers loaded with novel peptides detected T cells in Mtb-exposed humans.

J Immunol (2022) 209 (8): 1566–1573.

  • YY-1 is a novel transcription factor regulating TFH differentiation.

  • The zinc fingers of YY-1 are critical to support TFH differentiation.

INNATE IMMUNITY AND INFLAMMATION

J Immunol (2022) 209 (8): 1574–1585.

  • Nexinhib20 inhibits neutrophil adhesion and β2 integrin activation.

  • Nexinhib20 antagonizes the binding of Rac-1 and GTP.

  • Nexinhib20 prevents mice from myocardial I/R injury.

MOLECULAR AND STRUCTURAL IMMUNOLOGY

J Immunol (2022) 209 (8): 1586–1594.

  • Seven therapeutic anti-LAG3 Abs bind four distinct epitopes.

  • Three antibodies target a unique 30-residue loop in the D1 Ig-like domain of LAG3.

  • Four antibodies primarily recognize D1 determinants outside this loop.

MUCOSAL IMMUNOLOGY

J Immunol (2022) 209 (8): 1595–1605.

  • Tregs are important in maintaining epithelial barrier function.

  • Treg depletion increases lung IL-33 and IL-4, contributing to a disrupted epithelium.

SYSTEMS IMMUNOLOGY

J Immunol (2022) 209 (8): 1606–1614.

  • Patients with the IS2 subtypes of EC were more sensitive to PD-1 inhibitors.

  • SIRPG and SLAMF1 may be novel immune-related biomarkers of EC.

CORRECTIONS

J Immunol (2022) 209 (8): 1615.
J Immunol (2022) 209 (8): 1617.
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