Uterine NK Cells Ace an “A” in Education: NKG2A Sets Up Crucial Functions at the Maternal–Fetal Interface
Cutting Edge: Bispecific γδ T Cell Engager Containing Heterodimeric BTN2A1 and BTN3A1 Promotes Targeted Activation of Vγ9Vδ2+ T Cells in the Presence of Costimulation by CD28 or NKG2D
Costimulation is required for butyrophilin-mediated activation of Vγ9Vδ2+ TCR.
Heterodimeric BTN2A1/3A1 γδ T cell engager efficiently targets CD19+ lymphoma cells.
ANTIGEN RECOGNITION AND RESPONSES
Modification of the HLA-A*24:02 Peptide Binding Pocket Enhances Cognate Peptide-Binding Capacity and Antigen-Specific T Cell Activation
The HLA-A*24:02 A81L mutation increases the immunogenicity of cognate Ags.
The HLA-A*24:02 A81L mutation enhances expansion of tumor Ag-specific T cells.
CLINICAL AND HUMAN IMMUNOLOGY
Deficiency of p53 Causes the Inadequate Expression of miR-1246 in B Cells of Systemic Lupus Erythematosus
p53 directly upregulates miR-1246 expression in B cells.
p53 regulates histone H3K27me3 and H3K9/K14ac in the miR-1246 promoter.
p53 recruits JMJD3 and EP300/CBP to bind to the miR-1246 promoter.
Longitudinal Characterization of Phagocytic and Neutralization Functions of Anti-Spike Antibodies in Plasma of Patients after Severe Acute Respiratory Syndrome Coronavirus 2 Infection
In acute COVID-19, heat-liable plasma components contribute to phagocytosis.
Anti-Spike IgG is the most important variable for Ab-dependent phagocytosis.
Ab affinity increases longitudinally, whereas Ab titer decreased by >90% and functions decreased by 42%–65%.
Diminished IL-4R is a signature of naive B cells in ISGhi patients with SLE.
IL-4 counteracts IFNs to direct aNAV B cells toward DN1 and cMEM B cells.
IL-4R−IFN-β+ naive B cells are increased in autoantibody-positive patients with SLE.
IMMUNOTHERAPY AND VACCINES
MAIT cells expressing CARs effectively kill CD19- and Her2-expressing targets.
CAR-MAIT cells display strong cytotoxicity with lower IFN-γ compared with CD8+ CAR-T cells.
INFECTIOUS DISEASE AND HOST RESPONSE
Negative Cross-Talk between TLR2/4-Independent AMPKα1 and TLR2/4-Dependent JNK Regulates S. pneumoniae–Induced Mucosal Innate Immune Response
S. pneumoniae induces AMPKα1 activation in the middle ear in vitro and in vivo.
Activation of AMPKα1 is required for S. pneumoniae–induced MUC5AC expression.
AMPKα1 mediates S. pneumoniae–induced MUC5AC expression via inhibiting JNK.
Altered-Self MHC Class I Sensing via Functionally Disparate Paired NK Cell Receptors Counters Murine Cytomegalovirus gp34–Mediated Immune Evasion
Ly49R sensing of MCMV-infected targets requires MHC I Dk and MCMV gp34 expression.
MCMV gp34 selectively impedes antiviral immunity in mice lacking the Ly49G2 IR.
Ly49G2 licenses IL-12R signaling to enhance CD25 expression on antiviral NK cells.
Identification of HLA-E Binding Mycobacterium tuberculosis–Derived Epitopes through Improved Prediction Models
Improved prediction algorithm identifies novel Mtb-derived HLA-E binding peptides.
Novel HLA-E binding Mtb peptides induce CD8+ T cell activation.
HLA-E tetramers loaded with novel peptides detected T cells in Mtb-exposed humans.
YY-1 is a novel transcription factor regulating TFH differentiation.
The zinc fingers of YY-1 are critical to support TFH differentiation.
INNATE IMMUNITY AND INFLAMMATION
Nexinhib20 Inhibits Neutrophil Adhesion and β2 Integrin Activation by Antagonizing Rac-1–Guanosine 5′-Triphosphate Interaction
Nexinhib20 inhibits neutrophil adhesion and β2 integrin activation.
Nexinhib20 antagonizes the binding of Rac-1 and GTP.
Nexinhib20 prevents mice from myocardial I/R injury.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
Seven therapeutic anti-LAG3 Abs bind four distinct epitopes.
Three antibodies target a unique 30-residue loop in the D1 Ig-like domain of LAG3.
Four antibodies primarily recognize D1 determinants outside this loop.
Peribronchial Inflammation Resulting from Regulatory T Cell Deficiency Damages the Respiratory Epithelium and Disturbs Barrier Function
Tregs are important in maintaining epithelial barrier function.
Treg depletion increases lung IL-33 and IL-4, contributing to a disrupted epithelium.
Patients with the IS2 subtypes of EC were more sensitive to PD-1 inhibitors.
SIRPG and SLAMF1 may be novel immune-related biomarkers of EC.
Correction: Macrophage-Specific TLR2 Signaling Mediates Pathogen-Induced TNF-Dependent Inflammatory Oral Bone Loss
On the cover: This special issue of The Journal of Immunology, entitled Maternal–Fetal Immunology, highlights an outstanding cadre of immunologists who have been recognized as current and future thought leaders. The reviews in this special issue provide novel insights into different aspects of maternal–fetal immunology, together with their translational relevance for reproductive health and obstetrical complications. The cover was designed to represent the intricate relationship between the mother, fetus, and the immune system. Cover design by Julian Conde.
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