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J Immunol (2022) 209 (9): 1619.

PILLARS OF IMMUNOLOGY

J Immunol (2022) 209 (9): 1621–1623.

This Pillars of Immunology article is a commentary on “Positive Selection of Natural Autoreactive B Cells,” a pivotal article written by K. Hayakawa, M. Asano, S. A. Shinton, M. Gui, D. Allman, C. L. Stewart, J. Silver, and R. R. Hardy, and published in Science, in 1999. https://doi.org/10.1126/science.285.5424.113.

BRIEF REVIEWS

J Immunol (2022) 209 (9): 1625–1633.

ANTIGEN RECOGNITION AND RESPONSES

J Immunol (2022) 209 (9): 1635–1651.

  • Severe heat shock enhances the immunogenicity of necrotic tumor cells.

  • Severe heat shock promotes cross-presentation, but not increased adjuvanticity or phagocytosis.

  • Enhanced cross-presentation is mediated by tumor-derived calpains.

J Immunol (2022) 209 (9): 1652–1661.

  • A pair of public TCRs was identified from White and Japanese patients with HIV.

  • The public TCRs can recognize both wild-type and Y2F-mutated Nef138-8 epitopes.

  • Public TCRs binding to pHLA mostly rely on the interaction between TCR and HLA.

CLINICAL AND HUMAN IMMUNOLOGY

J Immunol (2022) 209 (9): 1662–1673.

  • The autocrine IFN response of CLL cells reflects their clinical behavior.

  • Increased sensitivity to IFN allows CLL cells to resist chemotherapeutic agents.

J Immunol (2022) 209 (9): 1674–1690.

  • Enhanced tryptophan catabolism with blocked NAD+ and UTP synthesis was seen in M1-Mϕs.

  • WGPs increased glucose utilization, UDPGlcNAc turnover, and gluconeogenesis in M2a-Mϕs.

  • WGPs variably impacted Krebs cycle and UTP synthesis in human NSCLC OTCs.

IMMUNE REGULATION

J Immunol (2022) 209 (9): 1691–1702.

  • We performed isolation and characterization of a novel LCMV strain from pet shop mice in Minnesota.

  • LCMV-MN exhibits intermediate viral persistence compared with LCMV-Arm and LCMV-Cl13.

  • LCMV-MN infection generates abundant stemlike exhausted progenitor CD8 T cells.

J Immunol (2022) 209 (9): 1703–1712.

  • Interactions between myelin Ag-specific T and B cells are of low quality.

  • Autoimmune B cells express low levels of molecules to support T cell interactions.

  • Myelin Ag-specific B cells are inherently less responsive to BCR stimulation.

IMMUNOGENETICS

J Immunol (2022) 209 (9): 1713–1723.

  • Shark genomes harbor more TNFSF genes than any other vertebrate examined to date.

  • Most human TNFSFs had already diversified in the jawed vertebrate ancestor.

  • Our data challenge the notion that immune regulation in sharks is “primitive”.

IMMUNOTHERAPY AND VACCINES

J Immunol (2022) 209 (9): 1724–1735.

  • Novel NK cell engagers were engineered that bridge EGFR and NKp30.

  • NK cell engagers displayed potent cytotoxic capacities.

  • NKp30-directed VHHs were isolated that do not interfere with the B7-H6/NKp30 axis.

INFECTIOUS DISEASE AND HOST RESPONSE

J Immunol (2022) 209 (9): 1736–1745.

  • Type I response induced by M. tuberculosis strains is dependent on lysosomal transit.

  • IFN1 expression correlates with the ability to induce proinflammatory responses.

  • Oxysterol expression is associated with a higher proinflammatory response.

J Immunol (2022) 209 (9): 1746–1759.

  • α1-Antitrypsin (AAT) binds to the glucocorticoid receptor (GR).

  • The AAT–GR interaction inhibits expression of inflammatory biomarkers.

  • The AAT–GR interaction augments macrophage control of mycobacterial infection.

J Immunol (2022) 209 (9): 1760–1767.

  • CpG ODNs activate the complement system dependent on their backbone structure.

  • CpG ODNs bind to C1q and factor H, indicating initial CP and direct AP activation.

  • CpG ODNs induced C5-C5aR1–dependent proinflammatory cytokines and chemokines.

MUCOSAL IMMUNOLOGY

J Immunol (2022) 209 (9): 1768–1777.

  • TNF-α induces IL-17C in colonic epithelial cells via an NF-κB–mediated pathway.

  • IL-17A and IL-22 synergistically increase IL-17C expression through p38 MAPK.

  • Primary colonic spheroids from UC versus non-UC patients express IL-17C differently.

J Immunol (2022) 209 (9): 1778–1787.

  • Alveolar macrophages harbor Ag after intranasal adenovirus immunization.

  • Depletion of this Ag depot impacts the longevity of respiratory CD8+ TRMs.

TRANSPLANTATION

J Immunol (2022) 209 (9): 1788–1795.

  • FBXO3/FBXL2 balance is significantly increased during lung allograft rejection.

  • TNF-α negatively regulates FBXL2 expression.

  • FBXL2 ubiquitinates and regulates T-bet expression.

TUMOR IMMUNOLOGY

J Immunol (2022) 209 (9): 1796–1805.

  • RNF186 and EPHB2 are required for TNF-induced signaling pathway activation.

  • Colorectal cancer–derived EPHB2 (D862N) is a gain-of-function mutant.

CORRECTIONS

J Immunol (2022) 209 (9): 1806.
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